Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPARGC1A (PPARG coactivator 1 alpha)

Identity

Alias (NCBI)LEM6
PGC-1(alpha)
PGC-1alpha
PGC-1v
PGC1
PGC1A
PPARGC1
HGNC (Hugo) PPARGC1A
HGNC Alias symbPGC1
PGC1A
PGC-1alpha
HGNC Alias namePPARgamma coactivator 1alpha
HGNC Previous namePPARGC1
HGNC Previous nameperoxisome proliferative activated receptor, gamma, coactivator 1
 peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
LocusID (NCBI) 10891
Atlas_Id 41795
Location 4p15.2  [Link to chromosome band 4p15]
Location_base_pair Starts at 23792021 and ends at 23890047 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRBA (4q31.3) / PPARGC1A (4p15.2)PPARGC1A (4p15.2) / NXN (17p13.3)LRBA 4q31.3 / PPARGC1A 4p15.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Soft tissue tumors: an overview
t(4;4)(p15;q31) LRBA/PPARGC1A
t(4;7)(p15;p11) EGFR/PPARGC1A

External links

Nomenclature
HGNC (Hugo)PPARGC1A   9237
Cards
Entrez_Gene (NCBI)PPARGC1A  10891  PPARG coactivator 1 alpha
AliasesLEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; 
PGC1; PGC1A; PPARGC1
GeneCards (Weizmann)PPARGC1A
Ensembl hg19 (Hinxton)ENSG00000109819 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109819 [Gene_View]  ENSG00000109819 [Sequence]  chr4:23792021-23890047 [Contig_View]  PPARGC1A [Vega]
ICGC DataPortalENSG00000109819
TCGA cBioPortalPPARGC1A
AceView (NCBI)PPARGC1A
Genatlas (Paris)PPARGC1A
WikiGenes10891
SOURCE (Princeton)PPARGC1A
Genetics Home Reference (NIH)PPARGC1A
Genomic and cartography
GoldenPath hg38 (UCSC)PPARGC1A  -     chr4:23792021-23890047 -  4p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPARGC1A  -     4p15.2   [Description]    (hg19-Feb_2009)
GoldenPathPPARGC1A - 4p15.2 [CytoView hg19]  PPARGC1A - 4p15.2 [CytoView hg38]
ImmunoBaseENSG00000109819
genome Data Viewer NCBIPPARGC1A [Mapview hg19]  
OMIM604517   
Gene and transcription
Genbank (Entrez)AB061325 AF106698 AF159714 AF186379 AK024990
RefSeq transcript (Entrez)NM_001330751 NM_001330752 NM_001330753 NM_001354825 NM_001354826 NM_001354827 NM_001354828 NM_013261
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPARGC1A
Alternative Splicing GalleryENSG00000109819
Gene ExpressionPPARGC1A [ NCBI-GEO ]   PPARGC1A [ EBI - ARRAY_EXPRESS ]   PPARGC1A [ SEEK ]   PPARGC1A [ MEM ]
Gene Expression Viewer (FireBrowse)PPARGC1A [ Firebrowse - Broad ]
GenevisibleExpression of PPARGC1A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10891
GTEX Portal (Tissue expression)PPARGC1A
Human Protein AtlasENSG00000109819-PPARGC1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBK2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBK2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBK2
Splice isoforms : SwissVarQ9UBK2
PhosPhoSitePlusQ9UBK2
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    PGC-1    PGC-1alpha    PPARGC1A_RRM    RBD_domain_sf    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)PPARGC1A
DMDM Disease mutations10891
Blocks (Seattle)PPARGC1A
PDB (RSDB)1XB7    3B1M    3CS8    3D24    3U9Q    3V9T    3V9V    4QJR    4QK4    5Q0I    5TWO    5UNJ    5Z5S    5Z6S    6AD9    6FZF    6FZP    6IZM    6IZN    6K0T    6MS7    6NWK    6NWL   
PDB Europe1XB7    3B1M    3CS8    3D24    3U9Q    3V9T    3V9V    4QJR    4QK4    5Q0I    5TWO    5UNJ    5Z5S    5Z6S    6AD9    6FZF    6FZP    6IZM    6IZN    6K0T    6MS7    6NWK    6NWL   
PDB (PDBSum)1XB7    3B1M    3CS8    3D24    3U9Q    3V9T    3V9V    4QJR    4QK4    5Q0I    5TWO    5UNJ    5Z5S    5Z6S    6AD9    6FZF    6FZP    6IZM    6IZN    6K0T    6MS7    6NWK    6NWL   
PDB (IMB)1XB7    3B1M    3CS8    3D24    3U9Q    3V9T    3V9V    4QJR    4QK4    5Q0I    5TWO    5UNJ    5Z5S    5Z6S    6AD9    6FZF    6FZP    6IZM    6IZN    6K0T    6MS7    6NWK    6NWL   
Structural Biology KnowledgeBase1XB7    3B1M    3CS8    3D24    3U9Q    3V9T    3V9V    4QJR    4QK4    5Q0I    5TWO    5UNJ    5Z5S    5Z6S    6AD9    6FZF    6FZP    6IZM    6IZN    6K0T    6MS7    6NWK    6NWL   
SCOP (Structural Classification of Proteins)1XB7    3B1M    3CS8    3D24    3U9Q    3V9T    3V9V    4QJR    4QK4    5Q0I    5TWO    5UNJ    5Z5S    5Z6S    6AD9    6FZF    6FZP    6IZM    6IZN    6K0T    6MS7    6NWK    6NWL   
CATH (Classification of proteins structures)1XB7    3B1M    3CS8    3D24    3U9Q    3V9T    3V9V    4QJR    4QK4    5Q0I    5TWO    5UNJ    5Z5S    5Z6S    6AD9    6FZF    6FZP    6IZM    6IZN    6K0T    6MS7    6NWK    6NWL   
SuperfamilyQ9UBK2
Human Protein Atlas [tissue]ENSG00000109819-PPARGC1A [tissue]
Peptide AtlasQ9UBK2
HPRD05155
IPIIPI00033138   IPI00963964   IPI00965951   IPI00964571   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBK2
IntAct (EBI)Q9UBK2
FunCoupENSG00000109819
BioGRIDPPARGC1A
STRING (EMBL)PPARGC1A
ZODIACPPARGC1A
Ontologies - Pathways
QuickGOQ9UBK2
Ontology : AmiGOresponse to reactive oxygen species  autophagy of mitochondrion  temperature homeostasis  cellular glucose homeostasis  negative regulation of protein phosphorylation  response to dietary excess  response to ischemia  DNA binding  DNA binding  transcription coregulator activity  transcription coregulator activity  transcription coactivator activity  RNA binding  protein binding  nucleus  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  nuclear euchromatin  galactose metabolic process  gluconeogenesis  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  mRNA processing  mitochondrion organization  mitochondrion organization  aging  digestion  circadian rhythm  transcription factor binding  transcription factor binding  androgen metabolic process  RNA splicing  response to cold  positive regulation of gene expression  positive regulation of mitochondrion organization  positive regulation of mitochondrion organization  skeletal muscle atrophy  response to muscle activity  response to electrical stimulus involved in regulation of muscle adaptation  negative regulation of smooth muscle cell migration  PML body  nuclear receptor binding  fatty acid oxidation  cerebellum development  cytosolic ribosome  respiratory electron transport chain  estrogen receptor binding  nuclear receptor transcription coactivator activity  nuclear receptor transcription coactivator activity  androgen receptor signaling pathway  forebrain development  chromatin DNA binding  ubiquitin protein ligase binding  circadian regulation of gene expression  cellular response to oxidative stress  positive regulation of histone acetylation  cellular response to potassium ion  response to starvation  regulation of circadian rhythm  peroxisome proliferator activated receptor binding  alpha-tubulin binding  neuronal cell body  response to leucine  intracellular membrane-bounded organelle  negative regulation of neuron apoptotic process  sequence-specific DNA binding  cellular respiration  positive regulation of gluconeogenesis  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of fatty acid oxidation  positive regulation of smooth muscle cell proliferation  negative regulation of smooth muscle cell proliferation  androgen receptor binding  protein stabilization  brown fat cell differentiation  positive regulation of DNA-binding transcription factor activity  positive regulation of DNA-binding transcription factor activity  flavone metabolic process  adipose tissue development  protein-containing complex assembly  cellular response to lipopolysaccharide  cellular response to nitrite  cellular response to caffeine  cellular response to fructose stimulus  cellular response to glucose stimulus  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to follicle-stimulating hormone stimulus  cellular response to estradiol stimulus  cellular response to hypoxia  cellular response to transforming growth factor beta stimulus  response to epinephrine  response to norepinephrine  negative regulation of mitochondrial fission  energy homeostasis  cellular response to thyroid hormone stimulus  apical dendrite  positive regulation of cold-induced thermogenesis  negative regulation of neuron death  response to metformin  positive regulation of cellular respiration  positive regulation of mitochondrial DNA metabolic process  positive regulation of muscle tissue development  positive regulation of glomerular visceral epithelial cell apoptotic process  cellular response to ionomycin  cellular response to resveratrol  response to methionine  promoter-specific chromatin binding  subsarcolemmal mitochondrion  interfibrillar mitochondrion  adaptive thermogenesis  positive regulation of progesterone biosynthetic process  negative regulation of signaling receptor activity  regulation of NMDA receptor activity  positive regulation of ATP biosynthetic process  
Ontology : EGO-EBIresponse to reactive oxygen species  autophagy of mitochondrion  temperature homeostasis  cellular glucose homeostasis  negative regulation of protein phosphorylation  response to dietary excess  response to ischemia  DNA binding  DNA binding  transcription coregulator activity  transcription coregulator activity  transcription coactivator activity  RNA binding  protein binding  nucleus  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  nuclear euchromatin  galactose metabolic process  gluconeogenesis  regulation of transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  mRNA processing  mitochondrion organization  mitochondrion organization  aging  digestion  circadian rhythm  transcription factor binding  transcription factor binding  androgen metabolic process  RNA splicing  response to cold  positive regulation of gene expression  positive regulation of mitochondrion organization  positive regulation of mitochondrion organization  skeletal muscle atrophy  response to muscle activity  response to electrical stimulus involved in regulation of muscle adaptation  negative regulation of smooth muscle cell migration  PML body  nuclear receptor binding  fatty acid oxidation  cerebellum development  cytosolic ribosome  respiratory electron transport chain  estrogen receptor binding  nuclear receptor transcription coactivator activity  nuclear receptor transcription coactivator activity  androgen receptor signaling pathway  forebrain development  chromatin DNA binding  ubiquitin protein ligase binding  circadian regulation of gene expression  cellular response to oxidative stress  positive regulation of histone acetylation  cellular response to potassium ion  response to starvation  regulation of circadian rhythm  peroxisome proliferator activated receptor binding  alpha-tubulin binding  neuronal cell body  response to leucine  intracellular membrane-bounded organelle  negative regulation of neuron apoptotic process  sequence-specific DNA binding  cellular respiration  positive regulation of gluconeogenesis  negative regulation of glycolytic process  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of fatty acid oxidation  positive regulation of smooth muscle cell proliferation  negative regulation of smooth muscle cell proliferation  androgen receptor binding  protein stabilization  brown fat cell differentiation  positive regulation of DNA-binding transcription factor activity  positive regulation of DNA-binding transcription factor activity  flavone metabolic process  adipose tissue development  protein-containing complex assembly  cellular response to lipopolysaccharide  cellular response to nitrite  cellular response to caffeine  cellular response to fructose stimulus  cellular response to glucose stimulus  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to follicle-stimulating hormone stimulus  cellular response to estradiol stimulus  cellular response to hypoxia  cellular response to transforming growth factor beta stimulus  response to epinephrine  response to norepinephrine  negative regulation of mitochondrial fission  energy homeostasis  cellular response to thyroid hormone stimulus  apical dendrite  positive regulation of cold-induced thermogenesis  negative regulation of neuron death  response to metformin  positive regulation of cellular respiration  positive regulation of mitochondrial DNA metabolic process  positive regulation of muscle tissue development  positive regulation of glomerular visceral epithelial cell apoptotic process  cellular response to ionomycin  cellular response to resveratrol  response to methionine  promoter-specific chromatin binding  subsarcolemmal mitochondrion  interfibrillar mitochondrion  adaptive thermogenesis  positive regulation of progesterone biosynthetic process  negative regulation of signaling receptor activity  regulation of NMDA receptor activity  positive regulation of ATP biosynthetic process  
Pathways : KEGGInsulin signaling pathway    Adipocytokine signaling pathway    Huntington's disease   
NDEx NetworkPPARGC1A
Atlas of Cancer Signalling NetworkPPARGC1A
Wikipedia pathwaysPPARGC1A
Orthology - Evolution
OrthoDB10891
GeneTree (enSembl)ENSG00000109819
Phylogenetic Trees/Animal Genes : TreeFamPPARGC1A
HOGENOMQ9UBK2
Homologs : HomoloGenePPARGC1A
Homology/Alignments : Family Browser (UCSC)PPARGC1A
Gene fusions - Rearrangements
Fusion : MitelmanLRBA/PPARGC1A [4q31.3/4p15.2]  
Fusion PortalLRBA 4q31.3 PPARGC1A 4p15.2 BRCA
Fusion : QuiverPPARGC1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPARGC1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPARGC1A
dbVarPPARGC1A
ClinVarPPARGC1A
MonarchPPARGC1A
1000_GenomesPPARGC1A 
Exome Variant ServerPPARGC1A
GNOMAD BrowserENSG00000109819
Varsome BrowserPPARGC1A
Genetic variants : HAPMAP10891
Genomic Variants (DGV)PPARGC1A [DGVbeta]
DECIPHERPPARGC1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPARGC1A 
Mutations
ICGC Data PortalPPARGC1A 
TCGA Data PortalPPARGC1A 
Broad Tumor PortalPPARGC1A
OASIS PortalPPARGC1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPARGC1A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPARGC1A
Mutations and Diseases : HGMDPPARGC1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPARGC1A
DgiDB (Drug Gene Interaction Database)PPARGC1A
DoCM (Curated mutations)PPARGC1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPARGC1A (select a term)
intoGenPPARGC1A
Cancer3DPPARGC1A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604517   
Orphanet106   
DisGeNETPPARGC1A
MedgenPPARGC1A
Genetic Testing Registry PPARGC1A
NextProtQ9UBK2 [Medical]
TSGene10891
GENETestsPPARGC1A
Target ValidationPPARGC1A
Huge Navigator PPARGC1A [HugePedia]
snp3D : Map Gene to Disease10891
BioCentury BCIQPPARGC1A
ClinGenPPARGC1A
Clinical trials, drugs, therapy
Protein Interactions : CTD10891
Pharm GKB GenePA33558
Pharm GKB PathwaysPA165948566   
Clinical trialPPARGC1A
Miscellaneous
canSAR (ICR)PPARGC1A (select the gene name)
HarmonizomePPARGC1A
DataMed IndexPPARGC1A
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPARGC1A
EVEXPPARGC1A
GoPubMedPPARGC1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:27:42 CEST 2020
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.