Identity
HGNC
LOCATION
4p15.2
LOCUSID
ALIAS
LEM6,PGC-1(alpha),PGC-1alpha,PGC-1v,PGC1,PGC1A,PPARGC1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10891
MIM: 604517
HGNC: 9237
Ensembl: ENSG00000109819
Variants:
dbSNP: 10891
ClinVar: 10891
TCGA: ENSG00000109819
COSMIC: PPARGC1A
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA37935 | SIRT1 | Gene | Pathway | associated | 22722338 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37758066 | 2024 | PGC1-α-driven mitochondrial biogenesis contributes to a cancer stem cell phenotype in melanoma. | 0 |
| 38216792 | 2024 | Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. | 0 |
| 38361088 | 2024 | PGC1-α in diabetic kidney disease: unraveling renoprotection and molecular mechanisms. | 0 |
| 38395376 | 2024 | Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage. | 0 |
| 38447939 | 2024 | CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival. | 0 |
| 38824126 | 2024 | PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium. | 0 |
| 37758066 | 2024 | PGC1-α-driven mitochondrial biogenesis contributes to a cancer stem cell phenotype in melanoma. | 0 |
| 38216792 | 2024 | Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. | 0 |
| 38361088 | 2024 | PGC1-α in diabetic kidney disease: unraveling renoprotection and molecular mechanisms. | 0 |
| 38395376 | 2024 | Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage. | 0 |
| 38447939 | 2024 | CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival. | 0 |
| 38824126 | 2024 | PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium. | 0 |
| 35680515 | 2023 | Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA. | 4 |
| 35713741 | 2023 | PGC-1α participates in tumor chemoresistance by regulating glucose metabolism and mitochondrial function. | 6 |
| 36197633 | 2023 | Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis. | 1 |
Citation
Dessen P
PPARGC1A (PPARG coactivator 1 alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41795/ppargc1a
