PPARGC1A (PPARG coactivator 1 alpha)

2003-08-01 Affiliation

Identity

HGNC

PPARGC1A

LOCATION

4p15.2

LOCUSID

10891

ALIAS

LEM6,PGC-1(alpha),PGC-1alpha,PGC-1v,PGC1,PGC1A,PPARGC1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10891
MIM: 604517
HGNC: 9237
Ensembl: ENSG00000109819

Variants:

dbSNP: 10891
ClinVar: 10891
TCGA: ENSG00000109819
COSMIC: PPARGC1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109819	ENST00000264867	Q9UBK2
ENSG00000109819	ENST00000264867	A0A024R9Q9
ENSG00000109819	ENST00000506055	Q9UBK2
ENSG00000109819	ENST00000507380	D6RBF3
ENSG00000109819	ENST00000513205	Q9UBK2
ENSG00000109819	ENST00000612355	A0A087WVW3
ENSG00000109819	ENST00000613098	Q9UBK2
ENSG00000109819	ENST00000617484	A0A087WTJ3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Insulin signaling pathway	KEGG	ko04910
Adipocytokine signaling pathway	KEGG	ko04920
Huntington's disease	KEGG	ko05016
Insulin signaling pathway	KEGG	hsa04910
Adipocytokine signaling pathway	KEGG	hsa04920
Huntington's disease	KEGG	hsa05016
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Mitochondrial biogenesis	REACTOME	R-HSA-1592230
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	REACTOME	R-HSA-2151209
Transcriptional activation of mitochondrial biogenesis	REACTOME	R-HSA-2151201
Circadian Clock	REACTOME	R-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expression	REACTOME	R-HSA-1368108
RORA activates gene expression	REACTOME	R-HSA-1368082
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340
Insulin resistance	KEGG	hsa04931
Longevity regulating pathway	KEGG	hsa04211
Apelin signaling pathway	KEGG	hsa04371

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA37935	SIRT1	Gene	Pathway	associated			22722338

References

Pubmed ID	Year	Title	Citations
12832613	2003	Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.	586
17018837	2006	Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.	420
17018277	2006	Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.	375
25241037	2014	PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.	353
23477830	2013	Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.	263
17108241	2006	PGC-1alpha: a key regulator of energy metabolism.	252
12563009	2003	Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle.	241
23416000	2013	PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.	223
20661474	2010	Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.	214
19723495	2009	Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.	194

Citation

Dessen P

PPARGC1A (PPARG coactivator 1 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41795/ppargc1a