| Nomenclature |
|---|
| HGNC (Hugo) | PPARGC1A 9237 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PPARGC1A 10891 PPARG coactivator 1 alpha |
| Aliases | LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; |
| PGC1; PGC1A; PPARGC1 |
| GeneCards (Weizmann) | PPARGC1A |
| Ensembl hg19 (Hinxton) | ENSG00000109819 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000109819 [Gene_View] ENSG00000109819 [Sequence] chr4:23792021-23890077 [Contig_View] PPARGC1A [Vega] |
| ICGC DataPortal | ENSG00000109819 |
| TCGA cBioPortal | PPARGC1A |
| AceView (NCBI) | PPARGC1A |
| Genatlas (Paris) | PPARGC1A |
| WikiGenes | 10891 |
| SOURCE (Princeton) | PPARGC1A |
| Genetics Home Reference (NIH) | PPARGC1A |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PPARGC1A - chr4:23792021-23890077 - 4p15.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PPARGC1A - 4p15.2 [Description] (hg19-Feb_2009) |
PPARGC1A - 4p15.2 [CytoView hg19] PPARGC1A - 4p15.2 [CytoView hg38] |
| Mapping of homologs : NCBI | PPARGC1A [Mapview hg19] PPARGC1A [Mapview hg38] |
| OMIM | 604517 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB061325 AF106698 AF159714 AF186379 AK024990 |
| RefSeq transcript (Entrez) | NM_001330751 NM_001330752 NM_001330753 NM_001354825 NM_001354826 NM_001354827 NM_001354828 NM_013261 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PPARGC1A |
| Cluster EST : Unigene | Hs.527078 [ NCBI ] |
| CGAP (NCI) | Hs.527078 |
| Alternative Splicing Gallery | ENSG00000109819 |
| Gene Expression | PPARGC1A [ NCBI-GEO ] PPARGC1A [ EBI - ARRAY_EXPRESS ]
PPARGC1A [ SEEK ] PPARGC1A [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PPARGC1A [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 10891 |
| GTEX Portal (Tissue expression) | PPARGC1A |
| Human Protein Atlas | ENSG00000109819-PPARGC1A [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9UBK2 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9UBK2 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9UBK2 |
| Splice isoforms : SwissVar | Q9UBK2 |
| PhosPhoSitePlus | Q9UBK2 |
| Domaine pattern : Prosite (Expaxy) | RRM (PS50102) |
| Domains : Interpro (EBI) | Nucleotide-bd_a/b_plait_sf PGC-1 PGC-1alpha PPARGC1A_RRM RBD_domain_sf RRM_dom |
| Domain families : Pfam (Sanger) | RRM_1 (PF00076) |
| Domain families : Pfam (NCBI) | pfam00076 |
| Domain families : Smart (EMBL) | RRM (SM00360) |
| Conserved Domain (NCBI) | PPARGC1A |
| DMDM Disease mutations | 10891 |
| Blocks (Seattle) | PPARGC1A |
| PDB (RSDB) | 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ |
| PDB Europe | 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ |
| PDB (PDBSum) | 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ |
| PDB (IMB) | 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ |
| Structural Biology KnowledgeBase | 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ |
| SCOP (Structural Classification of Proteins) | 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ |
| CATH (Classification of proteins structures) | 1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ |
| Superfamily | Q9UBK2 |
| Human Protein Atlas [tissue] | ENSG00000109819-PPARGC1A [tissue] |
| Peptide Atlas | Q9UBK2 |
| HPRD | 05155 |
| IPI | IPI00033138 IPI00963964 IPI00965951 IPI00964571 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9UBK2 |
| IntAct (EBI) | Q9UBK2 |
| FunCoup | ENSG00000109819 |
| BioGRID | PPARGC1A |
| STRING (EMBL) | PPARGC1A |
| ZODIAC | PPARGC1A |
| Ontologies - Pathways |
|---|
| QuickGO | Q9UBK2 |
| Ontology : AmiGO | response to reactive oxygen species autophagy of mitochondrion temperature homeostasis cellular glucose homeostasis negative regulation of protein phosphorylation response to dietary excess response to ischemia DNA binding DNA binding transcription coregulator activity transcription coregulator activity transcription coactivator activity RNA binding protein binding nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm nuclear euchromatin galactose metabolic process gluconeogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter mRNA processing mitochondrion organization mitochondrion organization aging digestion circadian rhythm transcription factor binding transcription factor binding androgen metabolic process RNA splicing response to cold positive regulation of gene expression positive regulation of mitochondrion organization positive regulation of mitochondrion organization skeletal muscle atrophy response to muscle activity response to electrical stimulus involved in regulation of muscle adaptation negative regulation of smooth muscle cell migration PML body nuclear receptor binding fatty acid oxidation cerebellum development cytosolic ribosome respiratory electron transport chain estrogen receptor binding nuclear receptor transcription coactivator activity nuclear receptor transcription coactivator activity androgen receptor signaling pathway forebrain development chromatin DNA binding ubiquitin protein ligase binding circadian regulation of gene expression cellular response to oxidative stress positive regulation of histone acetylation cellular response to potassium ion response to starvation regulation of circadian rhythm peroxisome proliferator activated receptor binding alpha-tubulin binding neuronal cell body response to leucine intracellular membrane-bounded organelle negative regulation of neuron apoptotic process sequence-specific DNA binding cellular respiration positive regulation of gluconeogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation androgen receptor binding protein stabilization brown fat cell differentiation positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity flavone metabolic process adipose tissue development protein-containing complex assembly cellular response to lipopolysaccharide cellular response to nitrite cellular response to caffeine cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus response to epinephrine response to norepinephrine negative regulation of mitochondrial fission energy homeostasis cellular response to thyroid hormone stimulus apical dendrite positive regulation of cold-induced thermogenesis negative regulation of neuron death response to metformin positive regulation of cellular respiration positive regulation of mitochondrial DNA metabolic process positive regulation of muscle tissue development positive regulation of glomerular visceral epithelial cell apoptotic process cellular response to ionomycin cellular response to resveratrol response to methionine promoter-specific chromatin binding subsarcolemmal mitochondrion interfibrillar mitochondrion adaptive thermogenesis positive regulation of progesterone biosynthetic process negative regulation of signaling receptor activity regulation of NMDA receptor activity positive regulation of ATP biosynthetic process |
| Ontology : EGO-EBI | response to reactive oxygen species autophagy of mitochondrion temperature homeostasis cellular glucose homeostasis negative regulation of protein phosphorylation response to dietary excess response to ischemia DNA binding DNA binding transcription coregulator activity transcription coregulator activity transcription coactivator activity RNA binding protein binding nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm nuclear euchromatin galactose metabolic process gluconeogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter mRNA processing mitochondrion organization mitochondrion organization aging digestion circadian rhythm transcription factor binding transcription factor binding androgen metabolic process RNA splicing response to cold positive regulation of gene expression positive regulation of mitochondrion organization positive regulation of mitochondrion organization skeletal muscle atrophy response to muscle activity response to electrical stimulus involved in regulation of muscle adaptation negative regulation of smooth muscle cell migration PML body nuclear receptor binding fatty acid oxidation cerebellum development cytosolic ribosome respiratory electron transport chain estrogen receptor binding nuclear receptor transcription coactivator activity nuclear receptor transcription coactivator activity androgen receptor signaling pathway forebrain development chromatin DNA binding ubiquitin protein ligase binding circadian regulation of gene expression cellular response to oxidative stress positive regulation of histone acetylation cellular response to potassium ion response to starvation regulation of circadian rhythm peroxisome proliferator activated receptor binding alpha-tubulin binding neuronal cell body response to leucine intracellular membrane-bounded organelle negative regulation of neuron apoptotic process sequence-specific DNA binding cellular respiration positive regulation of gluconeogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of fatty acid oxidation positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation androgen receptor binding protein stabilization brown fat cell differentiation positive regulation of DNA-binding transcription factor activity positive regulation of DNA-binding transcription factor activity flavone metabolic process adipose tissue development protein-containing complex assembly cellular response to lipopolysaccharide cellular response to nitrite cellular response to caffeine cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus response to epinephrine response to norepinephrine negative regulation of mitochondrial fission energy homeostasis cellular response to thyroid hormone stimulus apical dendrite positive regulation of cold-induced thermogenesis negative regulation of neuron death response to metformin positive regulation of cellular respiration positive regulation of mitochondrial DNA metabolic process positive regulation of muscle tissue development positive regulation of glomerular visceral epithelial cell apoptotic process cellular response to ionomycin cellular response to resveratrol response to methionine promoter-specific chromatin binding subsarcolemmal mitochondrion interfibrillar mitochondrion adaptive thermogenesis positive regulation of progesterone biosynthetic process negative regulation of signaling receptor activity regulation of NMDA receptor activity positive regulation of ATP biosynthetic process |
| Pathways : KEGG | Insulin signaling pathway Adipocytokine signaling pathway Huntington's disease |
| NDEx Network | PPARGC1A |
| Atlas of Cancer Signalling Network | PPARGC1A |
| Wikipedia pathways | PPARGC1A |
| Orthology - Evolution |
|---|
| OrthoDB | 10891 |
| GeneTree (enSembl) | ENSG00000109819 |
| Phylogenetic Trees/Animal Genes : TreeFam | PPARGC1A |
| HOGENOM | Q9UBK2 |
| Homologs : HomoloGene | PPARGC1A |
| Homology/Alignments : Family Browser (UCSC) | PPARGC1A |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | LRBA/PPARGC1A [4q31.3/4p15.2] [t(4;4)(p15;q31)] |
| Fusion Portal | LRBA 4q31.3 PPARGC1A 4p15.2 BRCA |
| Fusion : Quiver | PPARGC1A |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PPARGC1A [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PPARGC1A |
| dbVar | PPARGC1A |
| ClinVar | PPARGC1A |
| 1000_Genomes | PPARGC1A |
| Exome Variant Server | PPARGC1A |
| ExAC (Exome Aggregation Consortium) | ENSG00000109819 |
| GNOMAD Browser | ENSG00000109819 |
| Varsome Browser | PPARGC1A |
| Genetic variants : HAPMAP | 10891 |
| Genomic Variants (DGV) | PPARGC1A [DGVbeta] |
| DECIPHER | PPARGC1A [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PPARGC1A |
| Mutations |
|---|
| ICGC Data Portal | PPARGC1A |
| TCGA Data Portal | PPARGC1A |
| Broad Tumor Portal | PPARGC1A |
| OASIS Portal | PPARGC1A [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PPARGC1A [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | PPARGC1A |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PPARGC1A |
| DgiDB (Drug Gene Interaction Database) | PPARGC1A |
| DoCM (Curated mutations) | PPARGC1A (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PPARGC1A (select a term) |
| intoGen | PPARGC1A |
| Cancer3D | PPARGC1A(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 604517 |
| Orphanet | 106 |
| DisGeNET | PPARGC1A |
| Medgen | PPARGC1A |
| Genetic Testing Registry | PPARGC1A
|
| NextProt | Q9UBK2 [Medical] |
| TSGene | 10891 |
| GENETests | PPARGC1A |
| Target Validation | PPARGC1A |
| Huge Navigator |
PPARGC1A [HugePedia] |
| snp3D : Map Gene to Disease | 10891 |
| BioCentury BCIQ | PPARGC1A |
| ClinGen | PPARGC1A |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 10891 |
| Chemical/Pharm GKB Gene | PA33558 |
| Clinical trial | PPARGC1A |
| Miscellaneous |
|---|
| canSAR (ICR) | PPARGC1A (select the gene name) |
| DataMed Index | PPARGC1A |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PPARGC1A |
| EVEX | PPARGC1A |
| GoPubMed | PPARGC1A |
| iHOP | PPARGC1A |
