Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PPARGC1B (PPARG coactivator 1 beta)

Identity

Alias_namesperoxisome proliferative activated receptor, gamma, coactivator 1, beta
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Alias_symbol (synonym)PERC
PGC1B
Other aliasERRL1
PGC-1(beta)
HGNC (Hugo) PPARGC1B
LocusID (NCBI) 133522
Atlas_Id 45586
Location 5q32  [Link to chromosome band 5q32]
Location_base_pair Starts at 149730252 and ends at 149855022 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PTPN2 (18p11.21) / PPARGC1B (5q32)TRAK1 (3p22.1) / PPARGC1B (5q32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPARGC1B   30022
Cards
Entrez_Gene (NCBI)PPARGC1B  133522  PPARG coactivator 1 beta
AliasesERRL1; PERC; PGC-1(beta); PGC1B
GeneCards (Weizmann)PPARGC1B
Ensembl hg19 (Hinxton)ENSG00000155846 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155846 [Gene_View]  chr5:149730252-149855022 [Contig_View]  PPARGC1B [Vega]
ICGC DataPortalENSG00000155846
TCGA cBioPortalPPARGC1B
AceView (NCBI)PPARGC1B
Genatlas (Paris)PPARGC1B
WikiGenes133522
SOURCE (Princeton)PPARGC1B
Genetics Home Reference (NIH)PPARGC1B
Genomic and cartography
GoldenPath hg38 (UCSC)PPARGC1B  -     chr5:149730252-149855022 +  5q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPARGC1B  -     5q32   [Description]    (hg19-Feb_2009)
EnsemblPPARGC1B - 5q32 [CytoView hg19]  PPARGC1B - 5q32 [CytoView hg38]
Mapping of homologs : NCBIPPARGC1B [Mapview hg19]  PPARGC1B [Mapview hg38]
OMIM601665   608886   
Gene and transcription
Genbank (Entrez)AF468496 AF468497 AK024346 AK095391 AK123614
RefSeq transcript (Entrez)NM_001172698 NM_001172699 NM_133263
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPARGC1B
Cluster EST : UnigeneHs.483816 [ NCBI ]
CGAP (NCI)Hs.483816
Alternative Splicing GalleryENSG00000155846
Gene ExpressionPPARGC1B [ NCBI-GEO ]   PPARGC1B [ EBI - ARRAY_EXPRESS ]   PPARGC1B [ SEEK ]   PPARGC1B [ MEM ]
Gene Expression Viewer (FireBrowse)PPARGC1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)133522
GTEX Portal (Tissue expression)PPARGC1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YN6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YN6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YN6
Splice isoforms : SwissVarQ86YN6
PhosPhoSitePlusQ86YN6
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    PPARGC1B_RRM    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)PPARGC1B
DMDM Disease mutations133522
Blocks (Seattle)PPARGC1B
PDB (SRS)3SP6   
PDB (PDBSum)3SP6   
PDB (IMB)3SP6   
PDB (RSDB)3SP6   
Structural Biology KnowledgeBase3SP6   
SCOP (Structural Classification of Proteins)3SP6   
CATH (Classification of proteins structures)3SP6   
SuperfamilyQ86YN6
Human Protein AtlasENSG00000155846
Peptide AtlasQ86YN6
HPRD10594
IPIIPI00152517   IPI00759685   IPI00759561   IPI00759533   IPI00163514   IPI00977272   IPI00883834   IPI00382763   
Protein Interaction databases
DIP (DOE-UCLA)Q86YN6
IntAct (EBI)Q86YN6
FunCoupENSG00000155846
BioGRIDPPARGC1B
STRING (EMBL)PPARGC1B
ZODIACPPARGC1B
Ontologies - Pathways
QuickGOQ86YN6
Ontology : AmiGORNA polymerase II transcription cofactor activity  ossification  RNA binding  nucleus  nucleoplasm  mitochondrion  regulation of transcription, DNA-templated  transcription from mitochondrial promoter  mitochondrion organization  actin filament organization  transcription factor binding  positive regulation of alkaline phosphatase activity  mediator complex  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  intracellular estrogen receptor signaling pathway  receptor activator activity  cellular response to reactive oxygen species  positive regulation of phosphorylation  positive regulation of osteoclast differentiation  positive regulation of bone resorption  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  AF-2 domain binding  positive regulation of sequence-specific DNA binding transcription factor activity  response to glucocorticoid  response to cAMP  bone trabecula formation  positive regulation of receptor activity  
Ontology : EGO-EBIRNA polymerase II transcription cofactor activity  ossification  RNA binding  nucleus  nucleoplasm  mitochondrion  regulation of transcription, DNA-templated  transcription from mitochondrial promoter  mitochondrion organization  actin filament organization  transcription factor binding  positive regulation of alkaline phosphatase activity  mediator complex  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  intracellular estrogen receptor signaling pathway  receptor activator activity  cellular response to reactive oxygen species  positive regulation of phosphorylation  positive regulation of osteoclast differentiation  positive regulation of bone resorption  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  AF-2 domain binding  positive regulation of sequence-specific DNA binding transcription factor activity  response to glucocorticoid  response to cAMP  bone trabecula formation  positive regulation of receptor activity  
NDEx NetworkPPARGC1B
Atlas of Cancer Signalling NetworkPPARGC1B
Wikipedia pathwaysPPARGC1B
Orthology - Evolution
OrthoDB133522
GeneTree (enSembl)ENSG00000155846
Phylogenetic Trees/Animal Genes : TreeFamPPARGC1B
HOVERGENQ86YN6
HOGENOMQ86YN6
Homologs : HomoloGenePPARGC1B
Homology/Alignments : Family Browser (UCSC)PPARGC1B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPARGC1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPARGC1B
dbVarPPARGC1B
ClinVarPPARGC1B
1000_GenomesPPARGC1B 
Exome Variant ServerPPARGC1B
ExAC (Exome Aggregation Consortium)PPARGC1B (select the gene name)
Genetic variants : HAPMAP133522
Genomic Variants (DGV)PPARGC1B [DGVbeta]
DECIPHERPPARGC1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPARGC1B 
Mutations
ICGC Data PortalPPARGC1B 
TCGA Data PortalPPARGC1B 
Broad Tumor PortalPPARGC1B
OASIS PortalPPARGC1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPARGC1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPARGC1B
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch PPARGC1B
DgiDB (Drug Gene Interaction Database)PPARGC1B
DoCM (Curated mutations)PPARGC1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPARGC1B (select a term)
intoGenPPARGC1B
Cancer3DPPARGC1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601665    608886   
Orphanet
MedgenPPARGC1B
Genetic Testing Registry PPARGC1B
NextProtQ86YN6 [Medical]
TSGene133522
GENETestsPPARGC1B
Target ValidationPPARGC1B
Huge Navigator PPARGC1B [HugePedia]
snp3D : Map Gene to Disease133522
BioCentury BCIQPPARGC1B
ClinGenPPARGC1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD133522
Chemical/Pharm GKB GenePA134953410
Clinical trialPPARGC1B
Miscellaneous
canSAR (ICR)PPARGC1B (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPARGC1B
EVEXPPARGC1B
GoPubMedPPARGC1B
iHOPPPARGC1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:28 CEST 2017

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