PPARGC1B (PPARG coactivator 1 beta)

2007-02-01  

Identity

HGNC
LOCATION
5q32
LOCUSID
ALIAS
ERRL1,PERC,PGC-1(beta),PGC1B
FUSION GENES

Other Information

Locus ID:

NCBI: 133522
MIM: 608886
HGNC: 30022
Ensembl: ENSG00000155846

Variants:

dbSNP: 133522
ClinVar: 133522
TCGA: ENSG00000155846
COSMIC: PPARGC1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155846ENST00000309241Q86YN6
ENSG00000155846ENST00000360453Q86YN6
ENSG00000155846ENST00000394320Q86YN6
ENSG00000155846ENST00000403750Q86YN6
ENSG00000155846ENST00000434684H0Y713

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Insulin resistanceKEGGhsa04931

References

Pubmed IDYearTitleCitations
170188372006Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.420
121813192002Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.163
208891272010miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway.102
206826872010Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
118542982002The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha.84
189748842008Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.59
194910972009GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.47
192973902009PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.34
232011262013PGC-1 coactivators regulate MITF and the tanning response.32

Citation

Dessen P

PPARGC1B (PPARG coactivator 1 beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45586/ppargc1b