Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PPBP (pro-platelet basic protein (chemokine (C-X-C motif) ligand 7))

Identity

Other namesB-TG1
Beta-TG
CTAP-III
CTAP3
CTAPIII
CXCL7
LA-PF4
LDGF
MDGF
NAP-2
PBP
SCYB7
TC1
TC2
TGB
TGB1
THBGB
THBGB1
HGNC (Hugo) PPBP
LocusID (NCBI) 5473
Atlas_Id 51614
Location 4q13.3
Location_base_pair Starts at 74852156 and ends at 74853907 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPBP   9240
Cards
Entrez_Gene (NCBI)PPBP  5473  pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
GeneCards (Weizmann)PPBP
Ensembl hg19 (Hinxton) [Gene_View]  chr4:74852156-74853907 [Contig_View]  PPBP [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr4:74852156-74853907 [Contig_View]  PPBP [Vega]
TCGA cBioPortalPPBP
AceView (NCBI)PPBP
Genatlas (Paris)PPBP
WikiGenes5473
SOURCE (Princeton)PPBP
Genomic and cartography
GoldenPath hg19 (UCSC)PPBP  -     chr4:74852156-74853907 -  4q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPBP  -     4q13.3   [Description]    (hg38-Dec_2013)
EnsemblPPBP - 4q13.3 [CytoView hg19]  PPBP - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBIPPBP [Mapview hg19]  PPBP [Mapview hg38]
OMIM121010   
Gene and transcription
Genbank (Entrez)AK312166 BC028217 BQ447470 BX443846 CB112845
RefSeq transcript (Entrez)NM_002704
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)PPBP
Cluster EST : UnigeneHs.2164 [ NCBI ]
CGAP (NCI)Hs.2164
Alternative Splicing : Fast-db (Paris)GSHG0023317
Gene ExpressionPPBP [ NCBI-GEO ]     PPBP [ SEEK ]   PPBP [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02775 (Uniprot)
NextProtP02775  [Medical]
With graphics : InterProP02775
Splice isoforms : SwissVarP02775 (Swissvar)
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom   
Related proteins : CluSTrP02775
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
DMDM Disease mutations5473
Blocks (Seattle)P02775
PDB (SRS)1F9P    1NAP    1TVX   
PDB (PDBSum)1F9P    1NAP    1TVX   
PDB (IMB)1F9P    1NAP    1TVX   
PDB (RSDB)1F9P    1NAP    1TVX   
Peptide AtlasP02775
HPRD07171
IPIIPI00022445   
Protein Interaction databases
DIP (DOE-UCLA)P02775
IntAct (EBI)P02775
BioGRIDPPBP
IntegromeDBPPBP
STRING (EMBL)PPBP
Ontologies - Pathways
QuickGOP02775
Ontology : AmiGOleukocyte migration involved in inflammatory response  platelet degranulation  positive regulation of leukocyte chemotaxis  glucose transmembrane transporter activity  extracellular region  extracellular space  inflammatory response  immune response  G-protein coupled receptor signaling pathway  blood coagulation  chemokine activity  growth factor activity  glucose transport  platelet activation  platelet alpha granule lumen  response to lipopolysaccharide  regulation of cell proliferation  defense response to bacterium  CXCR chemokine receptor binding  positive regulation of cell division  cell chemotaxis  cell chemotaxis  chemokine-mediated signaling pathway  
Ontology : EGO-EBIleukocyte migration involved in inflammatory response  platelet degranulation  positive regulation of leukocyte chemotaxis  glucose transmembrane transporter activity  extracellular region  extracellular space  inflammatory response  immune response  G-protein coupled receptor signaling pathway  blood coagulation  chemokine activity  growth factor activity  glucose transport  platelet activation  platelet alpha granule lumen  response to lipopolysaccharide  regulation of cell proliferation  defense response to bacterium  CXCR chemokine receptor binding  positive regulation of cell division  cell chemotaxis  cell chemotaxis  chemokine-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
Protein Interaction DatabasePPBP
DoCM (Curated mutations)PPBP
Wikipedia pathwaysPPBP
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerPPBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPBP
dbVarPPBP
ClinVarPPBP
1000_GenomesPPBP 
Exome Variant ServerPPBP
SNP (GeneSNP Utah)PPBP
SNP : HGBasePPBP
Genetic variants : HAPMAPPPBP
Genomic Variants (DGV)PPBP [DGVbeta]
Mutations
ICGC Data PortalPPBP 
TCGA Data PortalPPBP 
Tumor PortalPPBP
Somatic Mutations in Cancer : COSMICPPBP 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:74852156-74853907
CONAN: Copy Number AnalysisPPBP 
Mutations and Diseases : HGMDPPBP
OMIM121010   
MedgenPPBP
NextProtP02775 [Medical]
GENETestsPPBP
Disease Genetic AssociationPPBP
Huge Navigator PPBP [HugePedia]  PPBP [HugeCancerGEM]
snp3D : Map Gene to Disease5473
DGIdb (Drug Gene Interaction db)PPBP
General knowledge
Homologs : HomoloGenePPBP
Homology/Alignments : Family Browser (UCSC)PPBP
Phylogenetic Trees/Animal Genes : TreeFamPPBP
Chemical/Protein Interactions : CTD5473
Chemical/Pharm GKB GenePA33561
Clinical trialPPBP
Other databases
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
CoreMinePPBP
GoPubMedPPBP
iHOPPPBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 15:01:58 CEST 2015

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