PPCDC (phosphopantothenoylcysteine decarboxylase)

2014-11-01  

Identity

HGNC
PPCDC
LOCATION
15q24.2
LOCUSID
60490
ALIAS
MDS018,PPC-DC,coaC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 60490
MIM: 609854
HGNC: 28107
Ensembl: ENSG00000138621

Variants:

dbSNP: 60490
ClinVar: 60490
TCGA: ENSG00000138621
COSMIC: PPCDC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138621ENST00000342932Q96CD2
ENSG00000138621ENST00000562095H3BU34
ENSG00000138621ENST00000563393H3BU63
ENSG00000138621ENST00000564923H3BSE3
ENSG00000138621ENST00000567336H3BRQ0
ENSG00000138621ENST00000568649H3BQB0
ENSG00000138621ENST00000569562H3BPW5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pantothenate and CoA biosynthesisKEGGko00770
Pantothenate and CoA biosynthesisKEGGhsa00770
Metabolic pathwaysKEGGhsa01100
Coenzyme A biosynthesis, pantothenate => CoAKEGGhsa_M00120
Coenzyme A biosynthesis, pantothenate => CoAKEGGM00120
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B5 (pantothenate) metabolismREACTOMER-HSA-199220
Coenzyme A biosynthesisREACTOMER-HSA-196783

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10235zoledronateChemicalClinicalAnnotationassociatedPD
PA166185677FEC100ChemicalClinicalAnnotationassociatedPD
PA443324AmenorrheaDiseaseClinicalAnnotationassociatedPD
PA449383docetaxelChemicalClinicalAnnotationassociatedPD
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD
PA451743trastuzumabChemicalClinicalAnnotationassociatedPD

Citation

Dessen P

PPCDC (phosphopantothenoylcysteine decarboxylase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72117/ppcdc