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PPFIA1 (PTPRF interacting protein alpha 1)

Identity

Alias_namesprotein tyrosine phosphatase
Alias_symbol (synonym)LIP.1
LIPRIN
Other aliasLIP1
HGNC (Hugo) PPFIA1
LocusID (NCBI) 8500
Atlas_Id 50099
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 70270700 and ends at 70384501 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
INTS4 (11q14.1) / PPFIA1 (11q13.3)MTL5 (11q13.3) / PPFIA1 (11q13.3)POLA2 (11q13.1) / PPFIA1 (11q13.3)
PPFIA1 (11q13.3) / PPFIA1 (11q13.3)INTS4 11q14.1 / PPFIA1 11q13.3MTL5 11q13.3 / PPFIA1 11q13.3
POLA2 11q13.1 / PPFIA1 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPFIA1   9245
Cards
Entrez_Gene (NCBI)PPFIA1  8500  PTPRF interacting protein alpha 1
AliasesLIP.1; LIP1; LIPRIN
GeneCards (Weizmann)PPFIA1
Ensembl hg19 (Hinxton)ENSG00000131626 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131626 [Gene_View]  chr11:70270700-70384501 [Contig_View]  PPFIA1 [Vega]
ICGC DataPortalENSG00000131626
TCGA cBioPortalPPFIA1
AceView (NCBI)PPFIA1
Genatlas (Paris)PPFIA1
WikiGenes8500
SOURCE (Princeton)PPFIA1
Genetics Home Reference (NIH)PPFIA1
Genomic and cartography
GoldenPath hg38 (UCSC)PPFIA1  -     chr11:70270700-70384501 +  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPFIA1  -     11q13.3   [Description]    (hg19-Feb_2009)
EnsemblPPFIA1 - 11q13.3 [CytoView hg19]  PPFIA1 - 11q13.3 [CytoView hg38]
Mapping of homologs : NCBIPPFIA1 [Mapview hg19]  PPFIA1 [Mapview hg38]
OMIM611054   
Gene and transcription
Genbank (Entrez)AB209314 AK123331 AK124621 AW163189 BC034046
RefSeq transcript (Entrez)NM_003626 NM_177423
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPFIA1
Cluster EST : UnigeneHs.708791 [ NCBI ]
CGAP (NCI)Hs.708791
Alternative Splicing GalleryENSG00000131626
Gene ExpressionPPFIA1 [ NCBI-GEO ]   PPFIA1 [ EBI - ARRAY_EXPRESS ]   PPFIA1 [ SEEK ]   PPFIA1 [ MEM ]
Gene Expression Viewer (FireBrowse)PPFIA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8500
GTEX Portal (Tissue expression)PPFIA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13136   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13136  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13136
Splice isoforms : SwissVarQ13136
PhosPhoSitePlusQ13136
Domaine pattern : Prosite (Expaxy)SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Liprin    PPFIA1    SAM    SAM/pointed   
Domain families : Pfam (Sanger)SAM_1 (PF00536)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam00536    pfam07647   
Domain families : Smart (EMBL)SAM (SM00454)  
Conserved Domain (NCBI)PPFIA1
DMDM Disease mutations8500
Blocks (Seattle)PPFIA1
PDB (SRS)1N7F   
PDB (PDBSum)1N7F   
PDB (IMB)1N7F   
PDB (RSDB)1N7F   
Structural Biology KnowledgeBase1N7F   
SCOP (Structural Classification of Proteins)1N7F   
CATH (Classification of proteins structures)1N7F   
SuperfamilyQ13136
Human Protein AtlasENSG00000131626
Peptide AtlasQ13136
HPRD11451
IPIIPI00163496   IPI00219754   IPI01011270   IPI00978294   IPI00980396   IPI00979736   IPI00977583   IPI00979037   IPI00984401   IPI00981112   IPI00981721   IPI00978994   IPI00978342   IPI00975615   IPI00976296   IPI00976930   
Protein Interaction databases
DIP (DOE-UCLA)Q13136
IntAct (EBI)Q13136
FunCoupENSG00000131626
BioGRIDPPFIA1
STRING (EMBL)PPFIA1
ZODIACPPFIA1
Ontologies - Pathways
QuickGOQ13136
Ontology : AmiGOsignal transducer activity  protein binding  cytoplasm  cytosol  cytosol  focal adhesion  cell-matrix adhesion  signal transduction  neurotransmitter secretion  glutamate secretion  presynaptic active zone  negative regulation of stress fiber assembly  negative regulation of establishment of protein localization to plasma membrane  
Ontology : EGO-EBIsignal transducer activity  protein binding  cytoplasm  cytosol  cytosol  focal adhesion  cell-matrix adhesion  signal transduction  neurotransmitter secretion  glutamate secretion  presynaptic active zone  negative regulation of stress fiber assembly  negative regulation of establishment of protein localization to plasma membrane  
NDEx NetworkPPFIA1
Atlas of Cancer Signalling NetworkPPFIA1
Wikipedia pathwaysPPFIA1
Orthology - Evolution
OrthoDB8500
GeneTree (enSembl)ENSG00000131626
Phylogenetic Trees/Animal Genes : TreeFamPPFIA1
HOVERGENQ13136
HOGENOMQ13136
Homologs : HomoloGenePPFIA1
Homology/Alignments : Family Browser (UCSC)PPFIA1
Gene fusions - Rearrangements
Fusion : MitelmanINTS4/PPFIA1 [11q14.1/11q13.3]  [t(11;11)(q13;q14)]  
Fusion : MitelmanMTL5/PPFIA1 [11q13.3/11q13.3]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPOLA2/PPFIA1 [11q13.1/11q13.3]  [t(11;11)(q13;q13)]  
Fusion: TCGAINTS4 11q14.1 PPFIA1 11q13.3 BRCA
Fusion: TCGAMTL5 11q13.3 PPFIA1 11q13.3 BRCA
Fusion: TCGAPOLA2 11q13.1 PPFIA1 11q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPFIA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPFIA1
dbVarPPFIA1
ClinVarPPFIA1
1000_GenomesPPFIA1 
Exome Variant ServerPPFIA1
ExAC (Exome Aggregation Consortium)PPFIA1 (select the gene name)
Genetic variants : HAPMAP8500
Genomic Variants (DGV)PPFIA1 [DGVbeta]
DECIPHERPPFIA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPFIA1 
Mutations
ICGC Data PortalPPFIA1 
TCGA Data PortalPPFIA1 
Broad Tumor PortalPPFIA1
OASIS PortalPPFIA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPFIA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPFIA1
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch PPFIA1
DgiDB (Drug Gene Interaction Database)PPFIA1
DoCM (Curated mutations)PPFIA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPFIA1 (select a term)
intoGenPPFIA1
Cancer3DPPFIA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611054   
Orphanet
MedgenPPFIA1
Genetic Testing Registry PPFIA1
NextProtQ13136 [Medical]
TSGene8500
GENETestsPPFIA1
Huge Navigator PPFIA1 [HugePedia]
snp3D : Map Gene to Disease8500
BioCentury BCIQPPFIA1
ClinGenPPFIA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8500
Chemical/Pharm GKB GenePA33566
Clinical trialPPFIA1
Miscellaneous
canSAR (ICR)PPFIA1 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPFIA1
EVEXPPFIA1
GoPubMedPPFIA1
iHOPPPFIA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:32:13 CEST 2017

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