Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPFIBP2 (PPFIA binding protein 2)

Identity

Alias_namesPTPRF interacting protein
Alias_symbol (synonym)Cclp1
Other alias
HGNC (Hugo) PPFIBP2
LocusID (NCBI) 8495
Atlas_Id 55776
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 7513765 and ends at 7653765 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DENND5A (11p15.4) / PPFIBP2 (11p15.4)PDE12 (3p14.3) / PPFIBP2 (11p15.4)PPFIBP2 (11p15.4) / OLFML1 (11p15.4)
PPFIBP2 (11p15.4) / PPFIBP2 (11p15.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(3;11)(p14;p15) PDE12/PPFIBP2
t(11;11)(p15;p15) PPFIBP2/OLFML1
t(11;11)(p15;p15) PPFIBP2/TSG101

External links

Nomenclature
HGNC (Hugo)PPFIBP2   9250
Cards
Entrez_Gene (NCBI)PPFIBP2  8495  PPFIA binding protein 2
AliasesCclp1
GeneCards (Weizmann)PPFIBP2
Ensembl hg19 (Hinxton)ENSG00000166387 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166387 [Gene_View]  chr11:7513765-7653765 [Contig_View]  PPFIBP2 [Vega]
ICGC DataPortalENSG00000166387
TCGA cBioPortalPPFIBP2
AceView (NCBI)PPFIBP2
Genatlas (Paris)PPFIBP2
WikiGenes8495
SOURCE (Princeton)PPFIBP2
Genetics Home Reference (NIH)PPFIBP2
Genomic and cartography
GoldenPath hg38 (UCSC)PPFIBP2  -     chr11:7513765-7653765 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPFIBP2  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblPPFIBP2 - 11p15.4 [CytoView hg19]  PPFIBP2 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBIPPFIBP2 [Mapview hg19]  PPFIBP2 [Mapview hg38]
OMIM603142   
Gene and transcription
Genbank (Entrez)AF034803 AK001131 AK025337 AK097449 AK293669
RefSeq transcript (Entrez)NM_001256568 NM_001256569 NM_001351853 NM_001351854 NM_001351855 NM_001351856 NM_001351857 NM_001351858 NM_001351859 NM_001351860 NM_001351861 NM_001351862 NM_003621
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPFIBP2
Cluster EST : UnigeneHs.740974 [ NCBI ]
CGAP (NCI)Hs.740974
Alternative Splicing GalleryENSG00000166387
Gene ExpressionPPFIBP2 [ NCBI-GEO ]   PPFIBP2 [ EBI - ARRAY_EXPRESS ]   PPFIBP2 [ SEEK ]   PPFIBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)PPFIBP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8495
GTEX Portal (Tissue expression)PPFIBP2
Human Protein AtlasENSG00000166387-PPFIBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8ND30   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8ND30  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8ND30
Splice isoforms : SwissVarQ8ND30
PhosPhoSitePlusQ8ND30
Domaine pattern : Prosite (Expaxy)SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Liprin    PPFIBP2    SAM    SAM/pointed   
Domain families : Pfam (Sanger)SAM_1 (PF00536)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam00536    pfam07647   
Domain families : Smart (EMBL)SAM (SM00454)  
Conserved Domain (NCBI)PPFIBP2
DMDM Disease mutations8495
Blocks (Seattle)PPFIBP2
PDB (SRS)3QH9   
PDB (PDBSum)3QH9   
PDB (IMB)3QH9   
PDB (RSDB)3QH9   
Structural Biology KnowledgeBase3QH9   
SCOP (Structural Classification of Proteins)3QH9   
CATH (Classification of proteins structures)3QH9   
SuperfamilyQ8ND30
Human Protein Atlas [tissue]ENSG00000166387-PPFIBP2 [tissue]
Peptide AtlasQ8ND30
HPRD04391
IPIIPI00301689   IPI01015534   IPI00982335   IPI01013181   IPI00979966   IPI00975981   IPI00984057   IPI00979430   IPI00982647   IPI00977997   IPI00982552   IPI00980850   IPI00977794   IPI00979202   IPI00980753   
Protein Interaction databases
DIP (DOE-UCLA)Q8ND30
IntAct (EBI)Q8ND30
FunCoupENSG00000166387
BioGRIDPPFIBP2
STRING (EMBL)PPFIBP2
ZODIACPPFIBP2
Ontologies - Pathways
QuickGOQ8ND30
Ontology : AmiGOmolecular_function  protein binding  extracellular space  intracellular  cytosol  identical protein binding  
Ontology : EGO-EBImolecular_function  protein binding  extracellular space  intracellular  cytosol  identical protein binding  
NDEx NetworkPPFIBP2
Atlas of Cancer Signalling NetworkPPFIBP2
Wikipedia pathwaysPPFIBP2
Orthology - Evolution
OrthoDB8495
GeneTree (enSembl)ENSG00000166387
Phylogenetic Trees/Animal Genes : TreeFamPPFIBP2
HOVERGENQ8ND30
HOGENOMQ8ND30
Homologs : HomoloGenePPFIBP2
Homology/Alignments : Family Browser (UCSC)PPFIBP2
Gene fusions - Rearrangements
Fusion : QuiverPPFIBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPFIBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPFIBP2
dbVarPPFIBP2
ClinVarPPFIBP2
1000_GenomesPPFIBP2 
Exome Variant ServerPPFIBP2
ExAC (Exome Aggregation Consortium)ENSG00000166387
GNOMAD BrowserENSG00000166387
Genetic variants : HAPMAP8495
Genomic Variants (DGV)PPFIBP2 [DGVbeta]
DECIPHERPPFIBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPFIBP2 
Mutations
ICGC Data PortalPPFIBP2 
TCGA Data PortalPPFIBP2 
Broad Tumor PortalPPFIBP2
OASIS PortalPPFIBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPFIBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPFIBP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPFIBP2
DgiDB (Drug Gene Interaction Database)PPFIBP2
DoCM (Curated mutations)PPFIBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPFIBP2 (select a term)
intoGenPPFIBP2
Cancer3DPPFIBP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603142   
Orphanet
DisGeNETPPFIBP2
MedgenPPFIBP2
Genetic Testing Registry PPFIBP2
NextProtQ8ND30 [Medical]
TSGene8495
GENETestsPPFIBP2
Target ValidationPPFIBP2
Huge Navigator PPFIBP2 [HugePedia]
snp3D : Map Gene to Disease8495
BioCentury BCIQPPFIBP2
ClinGenPPFIBP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8495
Chemical/Pharm GKB GenePA33571
Clinical trialPPFIBP2
Miscellaneous
canSAR (ICR)PPFIBP2 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPFIBP2
EVEXPPFIBP2
GoPubMedPPFIBP2
iHOPPPFIBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:31:49 CET 2018
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