Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPFIBP2 (PPFIA binding protein 2)

Identity

Alias (NCBI)Cclp1
HGNC (Hugo) PPFIBP2
HGNC Alias symbCclp1
HGNC Alias nameliprin beta 2
HGNC Previous namePTPRF interacting protein, binding protein 2 (liprin beta 2)
LocusID (NCBI) 8495
Atlas_Id 55776
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 7513999 and ends at 7653755 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DENND5A (11p15.4) / PPFIBP2 (11p15.4)PDE12 (3p14.3) / PPFIBP2 (11p15.4)PPFIBP2 (11p15.4) / OLFML1 (11p15.4)
PPFIBP2 (11p15.4) / PPFIBP2 (11p15.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(3;11)(p14;p15) PDE12/PPFIBP2
PPFIBP2/OLFML1 (11p15)
PPFIBP2/TSG101 (11p15)

External links

Nomenclature
HGNC (Hugo)PPFIBP2   9250
Cards
Entrez_Gene (NCBI)PPFIBP2    PPFIA binding protein 2
AliasesCclp1
GeneCards (Weizmann)PPFIBP2
Ensembl hg19 (Hinxton)ENSG00000166387 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166387 [Gene_View]  ENSG00000166387 [Sequence]  chr11:7513999-7653755 [Contig_View]  PPFIBP2 [Vega]
ICGC DataPortalENSG00000166387
TCGA cBioPortalPPFIBP2
AceView (NCBI)PPFIBP2
Genatlas (Paris)PPFIBP2
SOURCE (Princeton)PPFIBP2
Genetics Home Reference (NIH)PPFIBP2
Genomic and cartography
GoldenPath hg38 (UCSC)PPFIBP2  -     chr11:7513999-7653755 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPFIBP2  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathPPFIBP2 - 11p15.4 [CytoView hg19]  PPFIBP2 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000166387
genome Data Viewer NCBIPPFIBP2 [Mapview hg19]  
OMIM603142   
Gene and transcription
Genbank (Entrez)AF034803 AK001131 AK025337 AK097449 AK293669
RefSeq transcript (Entrez)NM_001256568 NM_001256569 NM_001351853 NM_001351854 NM_001351855 NM_001351856 NM_001351857 NM_001351858 NM_001351859 NM_001351860 NM_001351861 NM_001351862 NM_003621
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPFIBP2
Alternative Splicing GalleryENSG00000166387
Gene ExpressionPPFIBP2 [ NCBI-GEO ]   PPFIBP2 [ EBI - ARRAY_EXPRESS ]   PPFIBP2 [ SEEK ]   PPFIBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)PPFIBP2 [ Firebrowse - Broad ]
GenevisibleExpression of PPFIBP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8495
GTEX Portal (Tissue expression)PPFIBP2
Human Protein AtlasENSG00000166387-PPFIBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8ND30   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8ND30  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8ND30
Splice isoforms : SwissVarQ8ND30
PhosPhoSitePlusQ8ND30
Domaine pattern : Prosite (Expaxy)SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)IF_rod_dom_coil1B    Liprin    Liprin-beta_SAM_rpt_1    Liprin-beta_SAM_rpt_2    Liprin-beta_SAM_rpt_3    PPFIBP2    SAM    SAM/pointed_sf   
Domain families : Pfam (Sanger)SAM_1 (PF00536)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam00536    pfam07647   
Domain families : Smart (EMBL)SAM (SM00454)  
Conserved Domain (NCBI)PPFIBP2
Blocks (Seattle)PPFIBP2
PDB (RSDB)3QH9   
PDB Europe3QH9   
PDB (PDBSum)3QH9   
PDB (IMB)3QH9   
Structural Biology KnowledgeBase3QH9   
SCOP (Structural Classification of Proteins)3QH9   
CATH (Classification of proteins structures)3QH9   
SuperfamilyQ8ND30
Human Protein Atlas [tissue]ENSG00000166387-PPFIBP2 [tissue]
Peptide AtlasQ8ND30
HPRD04391
IPIIPI00301689   IPI01015534   IPI00982335   IPI01013181   IPI00979966   IPI00975981   IPI00984057   IPI00979430   IPI00982647   IPI00977997   IPI00982552   IPI00980850   IPI00977794   IPI00979202   IPI00980753   
Protein Interaction databases
DIP (DOE-UCLA)Q8ND30
IntAct (EBI)Q8ND30
BioGRIDPPFIBP2
STRING (EMBL)PPFIBP2
ZODIACPPFIBP2
Ontologies - Pathways
QuickGOQ8ND30
Ontology : AmiGOmolecular_function  protein binding  extracellular space  cytosol  neuromuscular junction development  identical protein binding  presynaptic active zone  synapse organization  
Ontology : EGO-EBImolecular_function  protein binding  extracellular space  cytosol  neuromuscular junction development  identical protein binding  presynaptic active zone  synapse organization  
NDEx NetworkPPFIBP2
Atlas of Cancer Signalling NetworkPPFIBP2
Wikipedia pathwaysPPFIBP2
Orthology - Evolution
OrthoDB8495
GeneTree (enSembl)ENSG00000166387
Phylogenetic Trees/Animal Genes : TreeFamPPFIBP2
HOGENOMQ8ND30
Homologs : HomoloGenePPFIBP2
Homology/Alignments : Family Browser (UCSC)PPFIBP2
Gene fusions - Rearrangements
Fusion : QuiverPPFIBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPFIBP2 [hg38]
dbVarPPFIBP2
ClinVarPPFIBP2
MonarchPPFIBP2
1000_GenomesPPFIBP2 
Exome Variant ServerPPFIBP2
GNOMAD BrowserENSG00000166387
Varsome BrowserPPFIBP2
Genomic Variants (DGV)PPFIBP2 [DGVbeta]
DECIPHERPPFIBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPFIBP2 
Mutations
ICGC Data PortalPPFIBP2 
TCGA Data PortalPPFIBP2 
Broad Tumor PortalPPFIBP2
OASIS PortalPPFIBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPFIBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPFIBP2
Mutations and Diseases : HGMDPPFIBP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPFIBP2
DgiDB (Drug Gene Interaction Database)PPFIBP2
DoCM (Curated mutations)PPFIBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPFIBP2 (select a term)
intoGenPPFIBP2
Cancer3DPPFIBP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603142   
Orphanet
DisGeNETPPFIBP2
MedgenPPFIBP2
Genetic Testing Registry PPFIBP2
NextProtQ8ND30 [Medical]
GENETestsPPFIBP2
Target ValidationPPFIBP2
Huge Navigator PPFIBP2 [HugePedia]
ClinGenPPFIBP2
Clinical trials, drugs, therapy
MyCancerGenomePPFIBP2
Protein Interactions : CTD
Pharm GKB GenePA33571
PharosQ8ND30
Clinical trialPPFIBP2
Miscellaneous
canSAR (ICR)PPFIBP2 (select the gene name)
HarmonizomePPFIBP2
DataMed IndexPPFIBP2
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPFIBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:32:26 CET 2021
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