PPIA (peptidylprolyl isomerase A)

2007-02-01  

Identity

HGNC
LOCATION
7p13
LOCUSID
ALIAS
CYPA,CYPH,HEL-S-69p
FUSION GENES

Other Information

Locus ID:

NCBI: 5478
MIM: 123840
HGNC: 9253
Ensembl: ENSG00000196262

Variants:

dbSNP: 5478
ClinVar: 5478
TCGA: ENSG00000196262
COSMIC: PPIA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196262ENST00000355968P62937
ENSG00000196262ENST00000415933F8WE65
ENSG00000196262ENST00000451562C9J5S7
ENSG00000196262ENST00000468812P62937
ENSG00000196262ENST00000468812V9HWF5
ENSG00000196262ENST00000479021E5RIZ5
ENSG00000196262ENST00000489459P62937
ENSG00000196262ENST00000620047P62937

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Early Phase of HIV Life CycleREACTOMER-HSA-162594
Binding and entry of HIV virionREACTOMER-HSA-173107
Uncoating of the HIV VirionREACTOMER-HSA-162585
Reverse Transcription of HIV RNAREACTOMER-HSA-162589
Minus-strand DNA synthesisREACTOMER-HSA-164516
Plus-strand DNA synthesisREACTOMER-HSA-164525
Integration of provirusREACTOMER-HSA-162592
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Assembly Of The HIV VirionREACTOMER-HSA-175474
Budding and maturation of HIV virionREACTOMER-HSA-162588
Host Interactions of HIV factorsREACTOMER-HSA-162909
APOBEC3G mediated resistance to HIV-1 infectionREACTOMER-HSA-180689
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199562612009Hidden alternative structures of proline isomerase essential for catalysis.185
118591942002Enzyme dynamics during catalysis.184
240556052013The interferon-inducible MxB protein inhibits HIV-1 infection.136
196805342009Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics.128
183852302008Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro.108
155968132005Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.103
119437752002Active site residues of cyclophilin A are crucial for its signaling activity via CD147.95
193805792009The isomerase active site of cyclophilin A is critical for hepatitis C virus replication.90
119299832002Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A.89
192973212009Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B.74

Citation

Dessen P

PPIA (peptidylprolyl isomerase A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46137/ppia