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PPIA (peptidylprolyl isomerase A)

Identity

Alias_symbol (synonym)CYPA
Other aliasCYPH
HEL-S-69p
HGNC (Hugo) PPIA
LocusID (NCBI) 5478
Atlas_Id 46137
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 44796636 and ends at 44803123 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CORO1C (12q24.11) / PPIA (7p13)ESYT2 (7q36.3) / PPIA (7p13)HNRNPA2B1 (7p15.2) / PPIA (7p13)
MRFAP1 (4p16.1) / PPIA (7p13)PPIA (7p13) / OGDH (7p13)PPIB (15q22.31) / PPIA (7p13)
RPL37A (2q35) / PPIA (7p13)TBC1D10B (16p11.2) / PPIA (7p13)TMED2 (12q24.31) / PPIA (7p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPIA   9253
Cards
Entrez_Gene (NCBI)PPIA  5478  peptidylprolyl isomerase A
AliasesCYPA; CYPH; HEL-S-69p
GeneCards (Weizmann)PPIA
Ensembl hg19 (Hinxton)ENSG00000196262 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196262 [Gene_View]  ENSG00000196262 [Sequence]  chr7:44796636-44803123 [Contig_View]  PPIA [Vega]
ICGC DataPortalENSG00000196262
TCGA cBioPortalPPIA
AceView (NCBI)PPIA
Genatlas (Paris)PPIA
WikiGenes5478
SOURCE (Princeton)PPIA
Genetics Home Reference (NIH)PPIA
Genomic and cartography
GoldenPath hg38 (UCSC)PPIA  -     chr7:44796636-44803123 +  7p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIA  -     7p13   [Description]    (hg19-Feb_2009)
EnsemblPPIA - 7p13 [CytoView hg19]  PPIA - 7p13 [CytoView hg38]
Mapping of homologs : NCBIPPIA [Mapview hg19]  PPIA [Mapview hg38]
OMIM123840   
Gene and transcription
Genbank (Entrez)AB451307 AB451438 AK026569 AK130101 AK290085
RefSeq transcript (Entrez)NM_001300981 NM_021130 NM_203430 NM_203431
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPIA
Cluster EST : UnigeneHs.356331 [ NCBI ]
CGAP (NCI)Hs.356331
Alternative Splicing GalleryENSG00000196262
Gene ExpressionPPIA [ NCBI-GEO ]   PPIA [ EBI - ARRAY_EXPRESS ]   PPIA [ SEEK ]   PPIA [ MEM ]
Gene Expression Viewer (FireBrowse)PPIA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5478
GTEX Portal (Tissue expression)PPIA
Human Protein AtlasENSG00000196262-PPIA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62937   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62937  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62937
Splice isoforms : SwissVarP62937
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusP62937
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)   
Domains : Interpro (EBI)Cyclophilin-like_dom_sf    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)   
Domain families : Pfam (NCBI)pfam00160   
Conserved Domain (NCBI)PPIA
DMDM Disease mutations5478
Blocks (Seattle)PPIA
PDB (SRS)1AK4    1AWQ    1AWR    1AWS    1AWT    1AWU    1AWV    1BCK    1CWA    1CWB    1CWC    1CWF    1CWH    1CWI    1CWJ    1CWK    1CWL    1CWM    1CWO    1FGL    1M63    1M9C    1M9D    1M9E    1M9F    1M9X    1M9Y    1MF8    1MIK    1NMK    1OCA    1RMH    1VBS    1VBT    1W8L    1W8M    1W8V    1YND    1ZKF    2ALF    2CPL    2CYH    2MS4    2MZU    2N0T    2RMA    2RMB    2X25    2X2A    2X2C    2X2D    2XGY    3CYH    3CYS    3K0M    3K0N    3K0O    3K0P    3K0Q    3K0R    3ODI    3ODL    3RDD    4CYH    4IPZ    4N1M    4N1N    4N1O    4N1P    4N1Q    4N1R    4N1S    4YUG    4YUH    4YUI    4YUJ    4YUK    4YUL    4YUM    4YUN    4YUO    4YUP    5CYH    5F66    5FJB    5KUL    5KUN    5KUO    5KUQ    5KUR    5KUS    5KUU    5KUV    5KUW    5KUZ    5KV0    5KV1    5KV2    5KV3    5KV4    5KV5    5KV6    5KV7    5LUD    5NOQ    5NOR    5NOS    5NOT    5NOU    5NOV    5NOW    5NOX    5NOY    5NOZ    5T9U    5T9W    5T9Z    5TA2    5TA4   
PDB (PDBSum)1AK4    1AWQ    1AWR    1AWS    1AWT    1AWU    1AWV    1BCK    1CWA    1CWB    1CWC    1CWF    1CWH    1CWI    1CWJ    1CWK    1CWL    1CWM    1CWO    1FGL    1M63    1M9C    1M9D    1M9E    1M9F    1M9X    1M9Y    1MF8    1MIK    1NMK    1OCA    1RMH    1VBS    1VBT    1W8L    1W8M    1W8V    1YND    1ZKF    2ALF    2CPL    2CYH    2MS4    2MZU    2N0T    2RMA    2RMB    2X25    2X2A    2X2C    2X2D    2XGY    3CYH    3CYS    3K0M    3K0N    3K0O    3K0P    3K0Q    3K0R    3ODI    3ODL    3RDD    4CYH    4IPZ    4N1M    4N1N    4N1O    4N1P    4N1Q    4N1R    4N1S    4YUG    4YUH    4YUI    4YUJ    4YUK    4YUL    4YUM    4YUN    4YUO    4YUP    5CYH    5F66    5FJB    5KUL    5KUN    5KUO    5KUQ    5KUR    5KUS    5KUU    5KUV    5KUW    5KUZ    5KV0    5KV1    5KV2    5KV3    5KV4    5KV5    5KV6    5KV7    5LUD    5NOQ    5NOR    5NOS    5NOT    5NOU    5NOV    5NOW    5NOX    5NOY    5NOZ    5T9U    5T9W    5T9Z    5TA2    5TA4   
PDB (IMB)1AK4    1AWQ    1AWR    1AWS    1AWT    1AWU    1AWV    1BCK    1CWA    1CWB    1CWC    1CWF    1CWH    1CWI    1CWJ    1CWK    1CWL    1CWM    1CWO    1FGL    1M63    1M9C    1M9D    1M9E    1M9F    1M9X    1M9Y    1MF8    1MIK    1NMK    1OCA    1RMH    1VBS    1VBT    1W8L    1W8M    1W8V    1YND    1ZKF    2ALF    2CPL    2CYH    2MS4    2MZU    2N0T    2RMA    2RMB    2X25    2X2A    2X2C    2X2D    2XGY    3CYH    3CYS    3K0M    3K0N    3K0O    3K0P    3K0Q    3K0R    3ODI    3ODL    3RDD    4CYH    4IPZ    4N1M    4N1N    4N1O    4N1P    4N1Q    4N1R    4N1S    4YUG    4YUH    4YUI    4YUJ    4YUK    4YUL    4YUM    4YUN    4YUO    4YUP    5CYH    5F66    5FJB    5KUL    5KUN    5KUO    5KUQ    5KUR    5KUS    5KUU    5KUV    5KUW    5KUZ    5KV0    5KV1    5KV2    5KV3    5KV4    5KV5    5KV6    5KV7    5LUD    5NOQ    5NOR    5NOS    5NOT    5NOU    5NOV    5NOW    5NOX    5NOY    5NOZ    5T9U    5T9W    5T9Z    5TA2    5TA4   
PDB (RSDB)1AK4    1AWQ    1AWR    1AWS    1AWT    1AWU    1AWV    1BCK    1CWA    1CWB    1CWC    1CWF    1CWH    1CWI    1CWJ    1CWK    1CWL    1CWM    1CWO    1FGL    1M63    1M9C    1M9D    1M9E    1M9F    1M9X    1M9Y    1MF8    1MIK    1NMK    1OCA    1RMH    1VBS    1VBT    1W8L    1W8M    1W8V    1YND    1ZKF    2ALF    2CPL    2CYH    2MS4    2MZU    2N0T    2RMA    2RMB    2X25    2X2A    2X2C    2X2D    2XGY    3CYH    3CYS    3K0M    3K0N    3K0O    3K0P    3K0Q    3K0R    3ODI    3ODL    3RDD    4CYH    4IPZ    4N1M    4N1N    4N1O    4N1P    4N1Q    4N1R    4N1S    4YUG    4YUH    4YUI    4YUJ    4YUK    4YUL    4YUM    4YUN    4YUO    4YUP    5CYH    5F66    5FJB    5KUL    5KUN    5KUO    5KUQ    5KUR    5KUS    5KUU    5KUV    5KUW    5KUZ    5KV0    5KV1    5KV2    5KV3    5KV4    5KV5    5KV6    5KV7    5LUD    5NOQ    5NOR    5NOS    5NOT    5NOU    5NOV    5NOW    5NOX    5NOY    5NOZ    5T9U    5T9W    5T9Z    5TA2    5TA4   
Structural Biology KnowledgeBase1AK4    1AWQ    1AWR    1AWS    1AWT    1AWU    1AWV    1BCK    1CWA    1CWB    1CWC    1CWF    1CWH    1CWI    1CWJ    1CWK    1CWL    1CWM    1CWO    1FGL    1M63    1M9C    1M9D    1M9E    1M9F    1M9X    1M9Y    1MF8    1MIK    1NMK    1OCA    1RMH    1VBS    1VBT    1W8L    1W8M    1W8V    1YND    1ZKF    2ALF    2CPL    2CYH    2MS4    2MZU    2N0T    2RMA    2RMB    2X25    2X2A    2X2C    2X2D    2XGY    3CYH    3CYS    3K0M    3K0N    3K0O    3K0P    3K0Q    3K0R    3ODI    3ODL    3RDD    4CYH    4IPZ    4N1M    4N1N    4N1O    4N1P    4N1Q    4N1R    4N1S    4YUG    4YUH    4YUI    4YUJ    4YUK    4YUL    4YUM    4YUN    4YUO    4YUP    5CYH    5F66    5FJB    5KUL    5KUN    5KUO    5KUQ    5KUR    5KUS    5KUU    5KUV    5KUW    5KUZ    5KV0    5KV1    5KV2    5KV3    5KV4    5KV5    5KV6    5KV7    5LUD    5NOQ    5NOR    5NOS    5NOT    5NOU    5NOV    5NOW    5NOX    5NOY    5NOZ    5T9U    5T9W    5T9Z    5TA2    5TA4   
SCOP (Structural Classification of Proteins)1AK4    1AWQ    1AWR    1AWS    1AWT    1AWU    1AWV    1BCK    1CWA    1CWB    1CWC    1CWF    1CWH    1CWI    1CWJ    1CWK    1CWL    1CWM    1CWO    1FGL    1M63    1M9C    1M9D    1M9E    1M9F    1M9X    1M9Y    1MF8    1MIK    1NMK    1OCA    1RMH    1VBS    1VBT    1W8L    1W8M    1W8V    1YND    1ZKF    2ALF    2CPL    2CYH    2MS4    2MZU    2N0T    2RMA    2RMB    2X25    2X2A    2X2C    2X2D    2XGY    3CYH    3CYS    3K0M    3K0N    3K0O    3K0P    3K0Q    3K0R    3ODI    3ODL    3RDD    4CYH    4IPZ    4N1M    4N1N    4N1O    4N1P    4N1Q    4N1R    4N1S    4YUG    4YUH    4YUI    4YUJ    4YUK    4YUL    4YUM    4YUN    4YUO    4YUP    5CYH    5F66    5FJB    5KUL    5KUN    5KUO    5KUQ    5KUR    5KUS    5KUU    5KUV    5KUW    5KUZ    5KV0    5KV1    5KV2    5KV3    5KV4    5KV5    5KV6    5KV7    5LUD    5NOQ    5NOR    5NOS    5NOT    5NOU    5NOV    5NOW    5NOX    5NOY    5NOZ    5T9U    5T9W    5T9Z    5TA2    5TA4   
CATH (Classification of proteins structures)1AK4    1AWQ    1AWR    1AWS    1AWT    1AWU    1AWV    1BCK    1CWA    1CWB    1CWC    1CWF    1CWH    1CWI    1CWJ    1CWK    1CWL    1CWM    1CWO    1FGL    1M63    1M9C    1M9D    1M9E    1M9F    1M9X    1M9Y    1MF8    1MIK    1NMK    1OCA    1RMH    1VBS    1VBT    1W8L    1W8M    1W8V    1YND    1ZKF    2ALF    2CPL    2CYH    2MS4    2MZU    2N0T    2RMA    2RMB    2X25    2X2A    2X2C    2X2D    2XGY    3CYH    3CYS    3K0M    3K0N    3K0O    3K0P    3K0Q    3K0R    3ODI    3ODL    3RDD    4CYH    4IPZ    4N1M    4N1N    4N1O    4N1P    4N1Q    4N1R    4N1S    4YUG    4YUH    4YUI    4YUJ    4YUK    4YUL    4YUM    4YUN    4YUO    4YUP    5CYH    5F66    5FJB    5KUL    5KUN    5KUO    5KUQ    5KUR    5KUS    5KUU    5KUV    5KUW    5KUZ    5KV0    5KV1    5KV2    5KV3    5KV4    5KV5    5KV6    5KV7    5LUD    5NOQ    5NOR    5NOS    5NOT    5NOU    5NOV    5NOW    5NOX    5NOY    5NOZ    5T9U    5T9W    5T9Z    5TA2    5TA4   
SuperfamilyP62937
Human Protein Atlas [tissue]ENSG00000196262-PPIA [tissue]
Peptide AtlasP62937
HPRD00457
IPIIPI00419585   IPI00910407   IPI00925747   IPI00925411   IPI00981317   IPI00974374   
Protein Interaction databases
DIP (DOE-UCLA)P62937
IntAct (EBI)P62937
FunCoupENSG00000196262
BioGRIDPPIA
STRING (EMBL)PPIA
ZODIACPPIA
Ontologies - Pathways
QuickGOP62937
Ontology : AmiGOprotein peptidyl-prolyl isomerization  RNA binding  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  extracellular region  extracellular space  nucleus  mitochondrion  cytosol  cytosol  focal adhesion  RNA-dependent DNA biosynthetic process  protein folding  cyclosporin A binding  cyclosporin A binding  membrane  viral life cycle  uncoating of virus  fusion of virus membrane with host plasma membrane  virion assembly  viral release from host cell  entry into host cell  vesicle  protein-containing complex  lipid droplet organization  secretory granule lumen  interleukin-12-mediated signaling pathway  neutrophil degranulation  regulation of viral genome replication  regulation of viral genome replication  positive regulation of viral genome replication  virion binding  positive regulation of protein secretion  leukocyte migration  unfolded protein binding  unfolded protein binding  extracellular exosome  extracellular exosome  establishment of integrated proviral latency  ficolin-1-rich granule lumen  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  RNA binding  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  extracellular region  extracellular space  nucleus  mitochondrion  cytosol  cytosol  focal adhesion  RNA-dependent DNA biosynthetic process  protein folding  cyclosporin A binding  cyclosporin A binding  membrane  viral life cycle  uncoating of virus  fusion of virus membrane with host plasma membrane  virion assembly  viral release from host cell  entry into host cell  vesicle  protein-containing complex  lipid droplet organization  secretory granule lumen  interleukin-12-mediated signaling pathway  neutrophil degranulation  regulation of viral genome replication  regulation of viral genome replication  positive regulation of viral genome replication  virion binding  positive regulation of protein secretion  leukocyte migration  unfolded protein binding  unfolded protein binding  extracellular exosome  extracellular exosome  establishment of integrated proviral latency  ficolin-1-rich granule lumen  
NDEx NetworkPPIA
Atlas of Cancer Signalling NetworkPPIA
Wikipedia pathwaysPPIA
Orthology - Evolution
OrthoDB5478
GeneTree (enSembl)ENSG00000196262
Phylogenetic Trees/Animal Genes : TreeFamPPIA
HOVERGENP62937
HOGENOMP62937
Homologs : HomoloGenePPIA
Homology/Alignments : Family Browser (UCSC)PPIA
Gene fusions - Rearrangements
Fusion Cancer (Beijing)CORO1C [12q24.11]  -  PPIA [7p13]  [FUSC001347]
Fusion : QuiverPPIA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIA
dbVarPPIA
ClinVarPPIA
1000_GenomesPPIA 
Exome Variant ServerPPIA
ExAC (Exome Aggregation Consortium)ENSG00000196262
GNOMAD BrowserENSG00000196262
Varsome BrowserPPIA
Genetic variants : HAPMAP5478
Genomic Variants (DGV)PPIA [DGVbeta]
DECIPHERPPIA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIA 
Mutations
ICGC Data PortalPPIA 
TCGA Data PortalPPIA 
Broad Tumor PortalPPIA
OASIS PortalPPIA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPIA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPIA
DgiDB (Drug Gene Interaction Database)PPIA
DoCM (Curated mutations)PPIA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPIA (select a term)
intoGenPPIA
Cancer3DPPIA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123840   
Orphanet
DisGeNETPPIA
MedgenPPIA
Genetic Testing Registry PPIA
NextProtP62937 [Medical]
TSGene5478
GENETestsPPIA
Target ValidationPPIA
Huge Navigator PPIA [HugePedia]
snp3D : Map Gene to Disease5478
BioCentury BCIQPPIA
ClinGenPPIA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5478
Chemical/Pharm GKB GenePA33574
Clinical trialPPIA
Miscellaneous
canSAR (ICR)PPIA (select the gene name)
Probes
Litterature
PubMed412 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPIA
EVEXPPIA
GoPubMedPPIA
iHOPPPIA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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