PPIB (peptidylprolyl isomerase B)

2007-02-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
B,CYP-S1,CYPB,HEL-S-39,OI9,SCYLP
FUSION GENES

Other Information

Locus ID:

NCBI: 5479
MIM: 123841
HGNC: 9255
Ensembl: ENSG00000166794

Variants:

dbSNP: 5479
ClinVar: 5479
TCGA: ENSG00000166794
COSMIC: PPIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166794ENST00000300026P23284

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159899692005Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.157
197816812009PPIB mutations cause severe osteogenesis imperfecta.86
192973212009Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B.74
118677262002Interaction with glycosaminoglycans is required for cyclophilin B to trigger integrin-mediated adhesion of peripheral blood T lymphocytes to extracellular matrix.44
212821882011Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.39
116889762001CD147 is a signaling receptor for cyclophilin B.37
208018782010Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.32
147296112004Cyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor.29
212819542011Involvement of cyclophilin B in the replication of Japanese encephalitis virus.23
247135752014Functional aspects of extracellular cyclophilins.22

Citation

Dessen P

PPIB (peptidylprolyl isomerase B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46463/ppib