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PPIB (peptidylprolyl isomerase B)

Identity

Alias_symbol (synonym)CYPB
OI9
Other aliasCYP-S1
HEL-S-39
SCYLP
HGNC (Hugo) PPIB
LocusID (NCBI) 5479
Atlas_Id 46463
Location 15q22.31  [Link to chromosome band 15q22]
Location_base_pair Starts at 64155815 and ends at 64163155 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EEF2 (19p13.3) / PPIB (15q22.31)PPIB (15q22.31) / NCAPD3 (11q25)PPIB (15q22.31) / PPIA (7p13)
PPIB (15q22.31) / SRSF3 (6p21.31)SNX22 (15q22.31) / PPIB (15q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPIB   9255
LRG (Locus Reference Genomic)LRG_10
Cards
Entrez_Gene (NCBI)PPIB  5479  peptidylprolyl isomerase B
AliasesCYP-S1; CYPB; HEL-S-39; OI9; 
SCYLP
GeneCards (Weizmann)PPIB
Ensembl hg19 (Hinxton)ENSG00000166794 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166794 [Gene_View]  chr15:64155815-64163155 [Contig_View]  PPIB [Vega]
ICGC DataPortalENSG00000166794
TCGA cBioPortalPPIB
AceView (NCBI)PPIB
Genatlas (Paris)PPIB
WikiGenes5479
SOURCE (Princeton)PPIB
Genetics Home Reference (NIH)PPIB
Genomic and cartography
GoldenPath hg38 (UCSC)PPIB  -     chr15:64155815-64163155 -  15q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIB  -     15q22.31   [Description]    (hg19-Feb_2009)
EnsemblPPIB - 15q22.31 [CytoView hg19]  PPIB - 15q22.31 [CytoView hg38]
Mapping of homologs : NCBIPPIB [Mapview hg19]  PPIB [Mapview hg38]
OMIM123841   259440   
Gene and transcription
Genbank (Entrez)AK291149 AK311074 BC001125 BC008848 BC020800
RefSeq transcript (Entrez)NM_000942
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPIB
Cluster EST : UnigeneHs.434937 [ NCBI ]
CGAP (NCI)Hs.434937
Alternative Splicing GalleryENSG00000166794
Gene ExpressionPPIB [ NCBI-GEO ]   PPIB [ EBI - ARRAY_EXPRESS ]   PPIB [ SEEK ]   PPIB [ MEM ]
Gene Expression Viewer (FireBrowse)PPIB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5479
GTEX Portal (Tissue expression)PPIB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23284   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23284  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23284
Splice isoforms : SwissVarP23284
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusP23284
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)   
Domains : Interpro (EBI)Cyclophilin-like_dom    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)   
Domain families : Pfam (NCBI)pfam00160   
Conserved Domain (NCBI)PPIB
DMDM Disease mutations5479
Blocks (Seattle)PPIB
PDB (SRS)1CYN    3ICH    3ICI   
PDB (PDBSum)1CYN    3ICH    3ICI   
PDB (IMB)1CYN    3ICH    3ICI   
PDB (RSDB)1CYN    3ICH    3ICI   
Structural Biology KnowledgeBase1CYN    3ICH    3ICI   
SCOP (Structural Classification of Proteins)1CYN    3ICH    3ICI   
CATH (Classification of proteins structures)1CYN    3ICH    3ICI   
SuperfamilyP23284
Human Protein AtlasENSG00000166794
Peptide AtlasP23284
HPRD00458
IPIIPI00646304   
Protein Interaction databases
DIP (DOE-UCLA)P23284
IntAct (EBI)P23284
FunCoupENSG00000166794
BioGRIDPPIB
STRING (EMBL)PPIB
ZODIACPPIB
Ontologies - Pathways
QuickGOP23284
Ontology : AmiGOprotein peptidyl-prolyl isomerization  RNA binding  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  collagen binding  nucleus  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum lumen  smooth endoplasmic reticulum  focal adhesion  membrane  protein complex binding  macromolecular complex  endoplasmic reticulum chaperone complex  positive regulation of multicellular organism growth  melanosome  positive regulation by host of viral process  positive regulation by host of viral genome replication  perinuclear region of cytoplasm  protein stabilization  unfolded protein binding  bone development  chaperone-mediated protein folding  chaperone-mediated protein folding  extracellular exosome  RNA polymerase binding  regulation of post-translational protein modification  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  RNA binding  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  collagen binding  nucleus  endoplasmic reticulum  endoplasmic reticulum lumen  endoplasmic reticulum lumen  smooth endoplasmic reticulum  focal adhesion  membrane  protein complex binding  macromolecular complex  endoplasmic reticulum chaperone complex  positive regulation of multicellular organism growth  melanosome  positive regulation by host of viral process  positive regulation by host of viral genome replication  perinuclear region of cytoplasm  protein stabilization  unfolded protein binding  bone development  chaperone-mediated protein folding  chaperone-mediated protein folding  extracellular exosome  RNA polymerase binding  regulation of post-translational protein modification  
NDEx NetworkPPIB
Atlas of Cancer Signalling NetworkPPIB
Wikipedia pathwaysPPIB
Orthology - Evolution
OrthoDB5479
GeneTree (enSembl)ENSG00000166794
Phylogenetic Trees/Animal Genes : TreeFamPPIB
HOVERGENP23284
HOGENOMP23284
Homologs : HomoloGenePPIB
Homology/Alignments : Family Browser (UCSC)PPIB
Gene fusions - Rearrangements
Fusion Cancer (Beijing)SNX22 [15q22.31]  -  PPIB [15q22.31]  [FUSC002077]  [FUSC002077]  [FUSC002077]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIB
dbVarPPIB
ClinVarPPIB
1000_GenomesPPIB 
Exome Variant ServerPPIB
ExAC (Exome Aggregation Consortium)PPIB (select the gene name)
Genetic variants : HAPMAP5479
Genomic Variants (DGV)PPIB [DGVbeta]
DECIPHERPPIB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIB 
Mutations
ICGC Data PortalPPIB 
TCGA Data PortalPPIB 
Broad Tumor PortalPPIB
OASIS PortalPPIB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPIB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Osteogenesis Imperfecta Variant Database
BioMutasearch PPIB
DgiDB (Drug Gene Interaction Database)PPIB
DoCM (Curated mutations)PPIB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPIB (select a term)
intoGenPPIB
Cancer3DPPIB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123841    259440   
Orphanet18792    18793    18794   
MedgenPPIB
Genetic Testing Registry PPIB
NextProtP23284 [Medical]
TSGene5479
GENETestsPPIB
Huge Navigator PPIB [HugePedia]
snp3D : Map Gene to Disease5479
BioCentury BCIQPPIB
ClinGenPPIB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5479
Chemical/Pharm GKB GenePA33580
Clinical trialPPIB
Miscellaneous
canSAR (ICR)PPIB (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPIB
EVEXPPIB
GoPubMedPPIB
iHOPPPIB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:32:15 CEST 2017

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