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PPID (peptidylprolyl isomerase D)

Identity

Alias (NCBI)CYP-40
CYPD
HGNC (Hugo) PPID
HGNC Alias symbCYP-40
HGNC Alias namecyclophilin 40
HGNC Previous namepeptidylprolyl isomerase D (cyclophilin D)
LocusID (NCBI) 5481
Atlas_Id 46110
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 158709127 and ends at 158723396 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MRPS10 (6p21.1)::PPID (4q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPID   9257
Cards
Entrez_Gene (NCBI)PPID    peptidylprolyl isomerase D
AliasesCYP-40; CYPD
GeneCards (Weizmann)PPID
Ensembl hg19 (Hinxton)ENSG00000171497 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171497 [Gene_View]  ENSG00000171497 [Sequence]  chr4:158709127-158723396 [Contig_View]  PPID [Vega]
ICGC DataPortalENSG00000171497
TCGA cBioPortalPPID
AceView (NCBI)PPID
Genatlas (Paris)PPID
SOURCE (Princeton)PPID
Genetics Home Reference (NIH)PPID
Genomic and cartography
GoldenPath hg38 (UCSC)PPID  -     chr4:158709127-158723396 -  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPID  -     4q32.1   [Description]    (hg19-Feb_2009)
GoldenPathPPID - 4q32.1 [CytoView hg19]  PPID - 4q32.1 [CytoView hg38]
ImmunoBaseENSG00000171497
Genome Data Viewer NCBIPPID [Mapview hg19]  
OMIM601753   
Gene and transcription
Genbank (Entrez)AK313929 BC014893 BC030707 BG699755 BU726810
RefSeq transcript (Entrez)NM_005038
Consensus coding sequences : CCDS (NCBI)PPID
Gene ExpressionPPID [ NCBI-GEO ]   PPID [ EBI - ARRAY_EXPRESS ]   PPID [ SEEK ]   PPID [ MEM ]
Gene Expression Viewer (FireBrowse)PPID [ Firebrowse - Broad ]
GenevisibleExpression of PPID in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5481
GTEX Portal (Tissue expression)PPID
Human Protein AtlasENSG00000171497-PPID [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08752   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08752  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08752
PhosPhoSitePlusQ08752
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Cyclophilin-like_dom_sf    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)    TPR_7 (PF13176)   
Domain families : Pfam (NCBI)pfam00160    pfam13176   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)PPID
SuperfamilyQ08752
AlphaFold pdb e-kbQ08752   
Human Protein Atlas [tissue]ENSG00000171497-PPID [tissue]
HPRD11875
Protein Interaction databases
DIP (DOE-UCLA)Q08752
IntAct (EBI)Q08752
BioGRIDPPID
STRING (EMBL)PPID
ZODIACPPID
Ontologies - Pathways
QuickGOQ08752
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  protein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytoplasm  cytosol  protein folding  protein folding  apoptotic process  transcription factor binding  protein transport  cyclosporin A binding  cyclosporin A binding  cyclosporin A binding  viral release from host cell  estrogen receptor binding  Hsp70 protein binding  heat shock protein binding  lipid droplet organization  positive regulation of apoptotic process  positive regulation of viral genome replication  positive regulation of protein secretion  Hsp90 protein binding  chaperone-mediated protein folding  protein-containing complex assembly  cellular response to UV-A  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  protein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytoplasm  cytosol  protein folding  protein folding  apoptotic process  transcription factor binding  protein transport  cyclosporin A binding  cyclosporin A binding  cyclosporin A binding  viral release from host cell  estrogen receptor binding  Hsp70 protein binding  heat shock protein binding  lipid droplet organization  positive regulation of apoptotic process  positive regulation of viral genome replication  positive regulation of protein secretion  Hsp90 protein binding  chaperone-mediated protein folding  protein-containing complex assembly  cellular response to UV-A  
Pathways : KEGGKEGG_CALCIUM_SIGNALING    KEGG_PARKINSONS_DISEASE    KEGG_HUNTINGTONS_DISEASE   
NDEx NetworkPPID
Atlas of Cancer Signalling NetworkPPID
Wikipedia pathwaysPPID
Orthology - Evolution
OrthoDB5481
GeneTree (enSembl)ENSG00000171497
Phylogenetic Trees/Animal Genes : TreeFamPPID
Homologs : HomoloGenePPID
Homology/Alignments : Family Browser (UCSC)PPID
Gene fusions - Rearrangements
Fusion : QuiverPPID
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPID [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPID
dbVarPPID
ClinVarPPID
MonarchPPID
1000_GenomesPPID 
Exome Variant ServerPPID
GNOMAD BrowserENSG00000171497
Varsome BrowserPPID
ACMGPPID variants
VarityQ08752
Genomic Variants (DGV)PPID [DGVbeta]
DECIPHERPPID [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPID 
Mutations
ICGC Data PortalPPID 
TCGA Data PortalPPID 
Broad Tumor PortalPPID
OASIS PortalPPID [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPID  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPID
Mutations and Diseases : HGMDPPID
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPID
DgiDB (Drug Gene Interaction Database)PPID
DoCM (Curated mutations)PPID
CIViC (Clinical Interpretations of Variants in Cancer)PPID
Cancer3DPPID
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601753   
Orphanet
DisGeNETPPID
MedgenPPID
Genetic Testing Registry PPID
NextProtQ08752 [Medical]
GENETestsPPID
Target ValidationPPID
Huge Navigator PPID [HugePedia]
ClinGenPPID
Clinical trials, drugs, therapy
MyCancerGenomePPID
Protein Interactions : CTDPPID
Pharm GKB GenePA33582
PharosQ08752
Clinical trialPPID
Miscellaneous
canSAR (ICR)PPID
HarmonizomePPID
ARCHS4PPID
DataMed IndexPPID
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPID
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:53:21 CET 2022

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