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PPID (peptidylprolyl isomerase D)

Identity

Alias_namespeptidylprolyl isomerase D (cyclophilin D)
Alias_symbol (synonym)CYP-40
Other aliasCYPD
HGNC (Hugo) PPID
LocusID (NCBI) 5481
Atlas_Id 46110
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 158709127 and ends at 158723400 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MRPS10 (6p21.1) / PPID (4q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPID   9257
Cards
Entrez_Gene (NCBI)PPID  5481  peptidylprolyl isomerase D
AliasesCYP-40; CYPD
GeneCards (Weizmann)PPID
Ensembl hg19 (Hinxton)ENSG00000171497 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171497 [Gene_View]  chr4:158709127-158723400 [Contig_View]  PPID [Vega]
ICGC DataPortalENSG00000171497
TCGA cBioPortalPPID
AceView (NCBI)PPID
Genatlas (Paris)PPID
WikiGenes5481
SOURCE (Princeton)PPID
Genetics Home Reference (NIH)PPID
Genomic and cartography
GoldenPath hg38 (UCSC)PPID  -     chr4:158709127-158723400 -  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPID  -     4q32.1   [Description]    (hg19-Feb_2009)
EnsemblPPID - 4q32.1 [CytoView hg19]  PPID - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBIPPID [Mapview hg19]  PPID [Mapview hg38]
OMIM601753   
Gene and transcription
Genbank (Entrez)AK313929 BC014893 BC030707 BG699755 BU726810
RefSeq transcript (Entrez)NM_005038
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPID
Cluster EST : UnigeneHs.183958 [ NCBI ]
CGAP (NCI)Hs.183958
Alternative Splicing GalleryENSG00000171497
Gene ExpressionPPID [ NCBI-GEO ]   PPID [ EBI - ARRAY_EXPRESS ]   PPID [ SEEK ]   PPID [ MEM ]
Gene Expression Viewer (FireBrowse)PPID [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5481
GTEX Portal (Tissue expression)PPID
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08752   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08752  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08752
Splice isoforms : SwissVarQ08752
PhosPhoSitePlusQ08752
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Cyclophilin-like_dom    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)    TPR_7 (PF13176)   
Domain families : Pfam (NCBI)pfam00160    pfam13176   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)PPID
DMDM Disease mutations5481
Blocks (Seattle)PPID
SuperfamilyQ08752
Human Protein AtlasENSG00000171497
Peptide AtlasQ08752
HPRD11875
IPIIPI00003927   IPI00965404   IPI00967512   
Protein Interaction databases
DIP (DOE-UCLA)Q08752
IntAct (EBI)Q08752
FunCoupENSG00000171497
BioGRIDPPID
STRING (EMBL)PPID
ZODIACPPID
Ontologies - Pathways
QuickGOQ08752
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  protein folding  protein complex assembly  apoptotic process  transcription factor binding  protein transport  cyclosporin A binding  viral release from host cell  estrogen receptor binding  Hsp70 protein binding  heat shock protein binding  lipid particle organization  positive regulation of apoptotic process  positive regulation of viral genome replication  positive regulation of protein secretion  Hsp90 protein binding  chaperone-mediated protein folding  cellular response to UV-A  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  protein folding  protein complex assembly  apoptotic process  transcription factor binding  protein transport  cyclosporin A binding  viral release from host cell  estrogen receptor binding  Hsp70 protein binding  heat shock protein binding  lipid particle organization  positive regulation of apoptotic process  positive regulation of viral genome replication  positive regulation of protein secretion  Hsp90 protein binding  chaperone-mediated protein folding  cellular response to UV-A  
NDEx NetworkPPID
Atlas of Cancer Signalling NetworkPPID
Wikipedia pathwaysPPID
Orthology - Evolution
OrthoDB5481
GeneTree (enSembl)ENSG00000171497
Phylogenetic Trees/Animal Genes : TreeFamPPID
HOVERGENQ08752
HOGENOMQ08752
Homologs : HomoloGenePPID
Homology/Alignments : Family Browser (UCSC)PPID
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPID [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPID
dbVarPPID
ClinVarPPID
1000_GenomesPPID 
Exome Variant ServerPPID
ExAC (Exome Aggregation Consortium)PPID (select the gene name)
Genetic variants : HAPMAP5481
Genomic Variants (DGV)PPID [DGVbeta]
DECIPHERPPID [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPID 
Mutations
ICGC Data PortalPPID 
TCGA Data PortalPPID 
Broad Tumor PortalPPID
OASIS PortalPPID [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPID  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPID
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPID
DgiDB (Drug Gene Interaction Database)PPID
DoCM (Curated mutations)PPID (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPID (select a term)
intoGenPPID
Cancer3DPPID(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601753   
Orphanet
MedgenPPID
Genetic Testing Registry PPID
NextProtQ08752 [Medical]
TSGene5481
GENETestsPPID
Target ValidationPPID
Huge Navigator PPID [HugePedia]
snp3D : Map Gene to Disease5481
BioCentury BCIQPPID
ClinGenPPID
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5481
Chemical/Pharm GKB GenePA33582
Clinical trialPPID
Miscellaneous
canSAR (ICR)PPID (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPID
EVEXPPID
GoPubMedPPID
iHOPPPID
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:25:55 CEST 2017

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