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PPIE (peptidylprolyl isomerase E)

Identity

Alias_symbol (synonym)CyP-33
MGC3736
MGC111222
Other aliasCYP-33
CYP33
HGNC (Hugo) PPIE
LocusID (NCBI) 10450
Atlas_Id 41799
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 39738845 and ends at 39763914 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKIRIN1 (1p34.3) / PPIE (1p34.2)EIF3M (11p13) / PPIE (1p34.2)PPIE (1p34.2) / MYCL (1p34.2)
PPIE (1p34.2) / PPIE (1p34.2)PPIE (1p34.2) / UBR4 (1p36.13)PTMA (2q37.1) / PPIE (1p34.2)
RLF (1p34.2) / PPIE (1p34.2)TRIT1 (1p34.2) / PPIE (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;11)(q27;q23) KMT2A/AFDN


External links

Nomenclature
HGNC (Hugo)PPIE   9258
LRG (Locus Reference Genomic)LRG_1053
Cards
Entrez_Gene (NCBI)PPIE  10450  peptidylprolyl isomerase E
AliasesCYP-33; CYP33
GeneCards (Weizmann)PPIE
Ensembl hg19 (Hinxton)ENSG00000084072 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000084072 [Gene_View]  chr1:39738845-39763914 [Contig_View]  PPIE [Vega]
ICGC DataPortalENSG00000084072
TCGA cBioPortalPPIE
AceView (NCBI)PPIE
Genatlas (Paris)PPIE
WikiGenes10450
SOURCE (Princeton)PPIE
Genetics Home Reference (NIH)PPIE
Genomic and cartography
GoldenPath hg38 (UCSC)PPIE  -     chr1:39738845-39763914 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIE  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblPPIE - 1p34.2 [CytoView hg19]  PPIE - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIPPIE [Mapview hg19]  PPIE [Mapview hg38]
OMIM602435   
Gene and transcription
Genbank (Entrez)AF042385 AF042386 AF104012 AF104013 AI079772
RefSeq transcript (Entrez)NM_001195007 NM_001319293 NM_006112 NM_203456 NM_203457
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPIE
Cluster EST : UnigeneHs.524690 [ NCBI ]
CGAP (NCI)Hs.524690
Alternative Splicing GalleryENSG00000084072
Gene ExpressionPPIE [ NCBI-GEO ]   PPIE [ EBI - ARRAY_EXPRESS ]   PPIE [ SEEK ]   PPIE [ MEM ]
Gene Expression Viewer (FireBrowse)PPIE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10450
GTEX Portal (Tissue expression)PPIE
Human Protein AtlasENSG00000084072-PPIE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNP9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNP9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNP9
Splice isoforms : SwissVarQ9UNP9
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusQ9UNP9
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)    RRM (PS50102)   
Domains : Interpro (EBI)Cyclophilin-like_dom    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom    Nucleotide-bd_a/b_plait    PPIE    PPIE_RRM    RRM_dom   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00160    pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)PPIE
DMDM Disease mutations10450
Blocks (Seattle)PPIE
PDB (SRS)1ZMF    2CQB    2KU7    2KYX    2R99    3LPY    3MDF    3UCH   
PDB (PDBSum)1ZMF    2CQB    2KU7    2KYX    2R99    3LPY    3MDF    3UCH   
PDB (IMB)1ZMF    2CQB    2KU7    2KYX    2R99    3LPY    3MDF    3UCH   
PDB (RSDB)1ZMF    2CQB    2KU7    2KYX    2R99    3LPY    3MDF    3UCH   
Structural Biology KnowledgeBase1ZMF    2CQB    2KU7    2KYX    2R99    3LPY    3MDF    3UCH   
SCOP (Structural Classification of Proteins)1ZMF    2CQB    2KU7    2KYX    2R99    3LPY    3MDF    3UCH   
CATH (Classification of proteins structures)1ZMF    2CQB    2KU7    2KYX    2R99    3LPY    3MDF    3UCH   
SuperfamilyQ9UNP9
Human Protein Atlas [tissue]ENSG00000084072-PPIE [tissue]
Peptide AtlasQ9UNP9
HPRD03893
IPIIPI00009316   IPI00220188   IPI00514173   IPI00514708   IPI00983184   IPI00978978   IPI00977574   IPI00985437   IPI00975753   IPI00977062   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNP9
IntAct (EBI)Q9UNP9
FunCoupENSG00000084072
BioGRIDPPIE
STRING (EMBL)PPIE
ZODIACPPIE
Ontologies - Pathways
QuickGOQ9UNP9
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA splicing, via spliceosome  protein peptidyl-prolyl isomerization  RNA binding  RNA binding  peptidyl-prolyl cis-trans isomerase activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  transcription-coupled nucleotide-excision repair  regulation of transcription, DNA-templated  protein folding  cyclosporin A binding  nuclear speck  secretory granule lumen  neutrophil degranulation  positive regulation of viral genome replication  catalytic step 2 spliceosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA splicing, via spliceosome  protein peptidyl-prolyl isomerization  RNA binding  RNA binding  peptidyl-prolyl cis-trans isomerase activity  protein binding  extracellular region  nucleus  nucleoplasm  cytosol  transcription-coupled nucleotide-excision repair  regulation of transcription, DNA-templated  protein folding  cyclosporin A binding  nuclear speck  secretory granule lumen  neutrophil degranulation  positive regulation of viral genome replication  catalytic step 2 spliceosome  ficolin-1-rich granule lumen  
Pathways : KEGGSpliceosome   
NDEx NetworkPPIE
Atlas of Cancer Signalling NetworkPPIE
Wikipedia pathwaysPPIE
Orthology - Evolution
OrthoDB10450
GeneTree (enSembl)ENSG00000084072
Phylogenetic Trees/Animal Genes : TreeFamPPIE
HOVERGENQ9UNP9
HOGENOMQ9UNP9
Homologs : HomoloGenePPIE
Homology/Alignments : Family Browser (UCSC)PPIE
Gene fusions - Rearrangements
Tumor Fusion PortalPPIE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIE
dbVarPPIE
ClinVarPPIE
1000_GenomesPPIE 
Exome Variant ServerPPIE
ExAC (Exome Aggregation Consortium)ENSG00000084072
GNOMAD BrowserENSG00000084072
Genetic variants : HAPMAP10450
Genomic Variants (DGV)PPIE [DGVbeta]
DECIPHERPPIE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIE 
Mutations
ICGC Data PortalPPIE 
TCGA Data PortalPPIE 
Broad Tumor PortalPPIE
OASIS PortalPPIE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPIE
BioMutasearch PPIE
DgiDB (Drug Gene Interaction Database)PPIE
DoCM (Curated mutations)PPIE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPIE (select a term)
intoGenPPIE
Cancer3DPPIE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602435   
Orphanet
DisGeNETPPIE
MedgenPPIE
Genetic Testing Registry PPIE
NextProtQ9UNP9 [Medical]
TSGene10450
GENETestsPPIE
Target ValidationPPIE
Huge Navigator PPIE [HugePedia]
snp3D : Map Gene to Disease10450
BioCentury BCIQPPIE
ClinGenPPIE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10450
Chemical/Pharm GKB GenePA33583
Clinical trialPPIE
Miscellaneous
canSAR (ICR)PPIE (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPIE
EVEXPPIE
GoPubMedPPIE
iHOPPPIE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:29:49 CET 2017

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