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PPIF (peptidylprolyl isomerase F)

Identity

Alias_namespeptidylprolyl isomerase F (cyclophilin F)
Alias_symbol (synonym)hCyP3
Cyp-D
Other aliasCYP3
CyP-M
CypD
HGNC (Hugo) PPIF
LocusID (NCBI) 10105
Atlas_Id 72130
Location 10q22.3  [Link to chromosome band 10q22]
Location_base_pair Starts at 79347464 and ends at 79355333 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AMOTL1 (11q21) / PPIF (10q22.3)PPIF (10q22.3) / FAM57A (17p13.3)PPIF (10q22.3) / REEP3 (10q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPIF   9259
Cards
Entrez_Gene (NCBI)PPIF  10105  peptidylprolyl isomerase F
AliasesCYP3; CyP-M; Cyp-D; CypD
GeneCards (Weizmann)PPIF
Ensembl hg19 (Hinxton)ENSG00000108179 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108179 [Gene_View]  chr10:79347464-79355333 [Contig_View]  PPIF [Vega]
ICGC DataPortalENSG00000108179
TCGA cBioPortalPPIF
AceView (NCBI)PPIF
Genatlas (Paris)PPIF
WikiGenes10105
SOURCE (Princeton)PPIF
Genetics Home Reference (NIH)PPIF
Genomic and cartography
GoldenPath hg38 (UCSC)PPIF  -     chr10:79347464-79355333 +  10q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIF  -     10q22.3   [Description]    (hg19-Feb_2009)
EnsemblPPIF - 10q22.3 [CytoView hg19]  PPIF - 10q22.3 [CytoView hg38]
Mapping of homologs : NCBIPPIF [Mapview hg19]  PPIF [Mapview hg38]
OMIM604486   
Gene and transcription
Genbank (Entrez)AK296669 AK312757 AL832720 AY358854 BC005020
RefSeq transcript (Entrez)NM_005729
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPIF
Cluster EST : UnigeneHs.381072 [ NCBI ]
CGAP (NCI)Hs.381072
Alternative Splicing GalleryENSG00000108179
Gene ExpressionPPIF [ NCBI-GEO ]   PPIF [ EBI - ARRAY_EXPRESS ]   PPIF [ SEEK ]   PPIF [ MEM ]
Gene Expression Viewer (FireBrowse)PPIF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10105
GTEX Portal (Tissue expression)PPIF
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30405   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30405  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30405
Splice isoforms : SwissVarP30405
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusP30405
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)   
Domains : Interpro (EBI)Cyclophilin-like_dom    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)   
Domain families : Pfam (NCBI)pfam00160   
Conserved Domain (NCBI)PPIF
DMDM Disease mutations10105
Blocks (Seattle)PPIF
PDB (SRS)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS   
PDB (PDBSum)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS   
PDB (IMB)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS   
PDB (RSDB)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS   
Structural Biology KnowledgeBase2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS   
SCOP (Structural Classification of Proteins)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS   
CATH (Classification of proteins structures)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS   
SuperfamilyP30405
Human Protein AtlasENSG00000108179
Peptide AtlasP30405
HPRD06839
IPIIPI00026519   IPI00657779   IPI00432130   IPI00552916   
Protein Interaction databases
DIP (DOE-UCLA)P30405
IntAct (EBI)P30405
FunCoupENSG00000108179
BioGRIDPPIF
STRING (EMBL)PPIF
ZODIACPPIF
Ontologies - Pathways
QuickGOP30405
Ontology : AmiGOprotein peptidyl-prolyl isomerization  response to ischemia  peptidyl-prolyl cis-trans isomerase activity  protein binding  mitochondrion  mitochondrial proton-transporting ATP synthase complex  mitochondrial matrix  protein folding  apoptotic mitochondrial changes  regulation of proton-transporting ATPase activity, rotational mechanism  regulation of necrotic cell death  cyclosporin A binding  membrane  negative regulation of ATPase activity  negative regulation of apoptotic process  regulation of mitochondrial membrane permeability  necroptotic process  cellular response to hydrogen peroxide  cellular response to arsenic-containing substance  cellular response to calcium ion  positive regulation of release of cytochrome c from mitochondria  negative regulation of release of cytochrome c from mitochondria  negative regulation of oxidative phosphorylation  regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  negative regulation of oxidative phosphorylation uncoupler activity  negative regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  response to ischemia  peptidyl-prolyl cis-trans isomerase activity  protein binding  mitochondrion  mitochondrial proton-transporting ATP synthase complex  mitochondrial matrix  protein folding  apoptotic mitochondrial changes  regulation of proton-transporting ATPase activity, rotational mechanism  regulation of necrotic cell death  cyclosporin A binding  membrane  negative regulation of ATPase activity  negative regulation of apoptotic process  regulation of mitochondrial membrane permeability  necroptotic process  cellular response to hydrogen peroxide  cellular response to arsenic-containing substance  cellular response to calcium ion  positive regulation of release of cytochrome c from mitochondria  negative regulation of release of cytochrome c from mitochondria  negative regulation of oxidative phosphorylation  regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  negative regulation of oxidative phosphorylation uncoupler activity  negative regulation of intrinsic apoptotic signaling pathway  
Pathways : KEGGCalcium signaling pathway    Parkinson's disease    Huntington's disease    Toxoplasmosis   
NDEx NetworkPPIF
Atlas of Cancer Signalling NetworkPPIF
Wikipedia pathwaysPPIF
Orthology - Evolution
OrthoDB10105
GeneTree (enSembl)ENSG00000108179
Phylogenetic Trees/Animal Genes : TreeFamPPIF
HOVERGENP30405
HOGENOMP30405
Homologs : HomoloGenePPIF
Homology/Alignments : Family Browser (UCSC)PPIF
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIF
dbVarPPIF
ClinVarPPIF
1000_GenomesPPIF 
Exome Variant ServerPPIF
ExAC (Exome Aggregation Consortium)PPIF (select the gene name)
Genetic variants : HAPMAP10105
Genomic Variants (DGV)PPIF [DGVbeta]
DECIPHERPPIF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIF 
Mutations
ICGC Data PortalPPIF 
TCGA Data PortalPPIF 
Broad Tumor PortalPPIF
OASIS PortalPPIF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPIF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PPIF
DgiDB (Drug Gene Interaction Database)PPIF
DoCM (Curated mutations)PPIF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPIF (select a term)
intoGenPPIF
Cancer3DPPIF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604486   
Orphanet
MedgenPPIF
Genetic Testing Registry PPIF
NextProtP30405 [Medical]
TSGene10105
GENETestsPPIF
Target ValidationPPIF
Huge Navigator PPIF [HugePedia]
snp3D : Map Gene to Disease10105
BioCentury BCIQPPIF
ClinGenPPIF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10105
Chemical/Pharm GKB GenePA33584
Clinical trialPPIF
Miscellaneous
canSAR (ICR)PPIF (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPIF
EVEXPPIF
GoPubMedPPIF
iHOPPPIF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:36:21 CEST 2017

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