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PPIF (peptidylprolyl isomerase F)

Identity

Alias (NCBI)CYP3
CyP-M
Cyp-D
CypD
HGNC (Hugo) PPIF
HGNC Alias symbhCyP3
Cyp-D
HGNC Alias namecyclophilin D
HGNC Previous namepeptidylprolyl isomerase F (cyclophilin F)
LocusID (NCBI) 10105
Atlas_Id 57966
Location 10q22.3  [Link to chromosome band 10q22]
Location_base_pair Starts at 79347469 and ends at 79355333 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMOTL1 (11q21) / PPIF (10q22.3)PPIF (10q22.3) / FAM57A (17p13.3)PPIF (10q22.3) / REEP3 (10q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPIF   9259
Cards
Entrez_Gene (NCBI)PPIF    peptidylprolyl isomerase F
AliasesCYP3; CyP-M; Cyp-D; CypD
GeneCards (Weizmann)PPIF
Ensembl hg19 (Hinxton)ENSG00000108179 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108179 [Gene_View]  ENSG00000108179 [Sequence]  chr10:79347469-79355333 [Contig_View]  PPIF [Vega]
ICGC DataPortalENSG00000108179
TCGA cBioPortalPPIF
AceView (NCBI)PPIF
Genatlas (Paris)PPIF
SOURCE (Princeton)PPIF
Genetics Home Reference (NIH)PPIF
Genomic and cartography
GoldenPath hg38 (UCSC)PPIF  -     chr10:79347469-79355333 +  10q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIF  -     10q22.3   [Description]    (hg19-Feb_2009)
GoldenPathPPIF - 10q22.3 [CytoView hg19]  PPIF - 10q22.3 [CytoView hg38]
ImmunoBaseENSG00000108179
Genome Data Viewer NCBIPPIF [Mapview hg19]  
OMIM604486   
Gene and transcription
Genbank (Entrez)AK296669 AK312757 AL832720 AY358854 BC005020
RefSeq transcript (Entrez)NM_005729
Consensus coding sequences : CCDS (NCBI)PPIF
Gene ExpressionPPIF [ NCBI-GEO ]   PPIF [ EBI - ARRAY_EXPRESS ]   PPIF [ SEEK ]   PPIF [ MEM ]
Gene Expression Viewer (FireBrowse)PPIF [ Firebrowse - Broad ]
GenevisibleExpression of PPIF in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10105
GTEX Portal (Tissue expression)PPIF
Human Protein AtlasENSG00000108179-PPIF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30405   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30405  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30405
PhosPhoSitePlusP30405
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)   
Domains : Interpro (EBI)Cyclophilin-like_dom_sf    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)   
Domain families : Pfam (NCBI)pfam00160   
Conserved Domain (NCBI)PPIF
PDB (RSDB)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS    6R8L    6R8O    6R8W    6R9S    6R9U    6R9X    6RA1    6Y3E    6YBM   
PDB Europe2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS    6R8L    6R8O    6R8W    6R9S    6R9U    6R9X    6RA1    6Y3E    6YBM   
PDB (PDBSum)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS    6R8L    6R8O    6R8W    6R9S    6R9U    6R9X    6RA1    6Y3E    6YBM   
PDB (IMB)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS    6R8L    6R8O    6R8W    6R9S    6R9U    6R9X    6RA1    6Y3E    6YBM   
Structural Biology KnowledgeBase2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS    6R8L    6R8O    6R8W    6R9S    6R9U    6R9X    6RA1    6Y3E    6YBM   
SCOP (Structural Classification of Proteins)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS    6R8L    6R8O    6R8W    6R9S    6R9U    6R9X    6RA1    6Y3E    6YBM   
CATH (Classification of proteins structures)2BIT    2BIU    2Z6W    3QYU    3R49    3R4G    3R54    3R56    3R57    3R59    3RCF    3RCG    3RCI    3RCK    3RCL    3RD9    3RDA    3RDB    3RDC    4J58    4J59    4J5A    4J5B    4J5C    4J5D    4J5E    4O8H    4O8I    4XNC    4ZSC    4ZSD    5A0E    5CBT    5CBU    5CBV    5CBW    5CCN    5CCQ    5CCR    5CCS    6R8L    6R8O    6R8W    6R9S    6R9U    6R9X    6RA1    6Y3E    6YBM   
SuperfamilyP30405
AlphaFold pdb e-kbP30405   
Human Protein Atlas [tissue]ENSG00000108179-PPIF [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P30405
IntAct (EBI)P30405
BioGRIDPPIF
STRING (EMBL)PPIF
ZODIACPPIF
Ontologies - Pathways
QuickGOP30405
Ontology : AmiGOprotein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  response to ischemia  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  cytoplasm  mitochondrion  mitochondrion  mitochondrial permeability transition pore complex  mitochondrial matrix  protein folding  apoptotic mitochondrial changes  regulation of proton-transporting ATPase activity, rotational mechanism  regulation of necrotic cell death  cyclosporin A binding  cyclosporin A binding  membrane  negative regulation of ATPase activity  negative regulation of apoptotic process  intracellular membrane-bounded organelle  regulation of mitochondrial membrane permeability  regulation of mitochondrial membrane permeability  necroptotic process  cellular response to hydrogen peroxide  cellular response to hydrogen peroxide  cellular response to arsenic-containing substance  cellular response to calcium ion  positive regulation of release of cytochrome c from mitochondria  negative regulation of release of cytochrome c from mitochondria  negative regulation of oxidative phosphorylation  regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  mitochondrial outer membrane permeabilization involved in programmed cell death  negative regulation of oxidative phosphorylation uncoupler activity  negative regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  response to ischemia  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  cytoplasm  mitochondrion  mitochondrion  mitochondrial permeability transition pore complex  mitochondrial matrix  protein folding  apoptotic mitochondrial changes  regulation of proton-transporting ATPase activity, rotational mechanism  regulation of necrotic cell death  cyclosporin A binding  cyclosporin A binding  membrane  negative regulation of ATPase activity  negative regulation of apoptotic process  intracellular membrane-bounded organelle  regulation of mitochondrial membrane permeability  regulation of mitochondrial membrane permeability  necroptotic process  cellular response to hydrogen peroxide  cellular response to hydrogen peroxide  cellular response to arsenic-containing substance  cellular response to calcium ion  positive regulation of release of cytochrome c from mitochondria  negative regulation of release of cytochrome c from mitochondria  negative regulation of oxidative phosphorylation  regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  mitochondrial outer membrane permeabilization involved in programmed cell death  negative regulation of oxidative phosphorylation uncoupler activity  negative regulation of intrinsic apoptotic signaling pathway  
Pathways : KEGGCalcium signaling pathway    Parkinson's disease    Huntington's disease    Toxoplasmosis   
NDEx NetworkPPIF
Atlas of Cancer Signalling NetworkPPIF
Wikipedia pathwaysPPIF
Orthology - Evolution
OrthoDB10105
GeneTree (enSembl)ENSG00000108179
Phylogenetic Trees/Animal Genes : TreeFamPPIF
Homologs : HomoloGenePPIF
Homology/Alignments : Family Browser (UCSC)PPIF
Gene fusions - Rearrangements
Fusion : QuiverPPIF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIF
dbVarPPIF
ClinVarPPIF
MonarchPPIF
1000_GenomesPPIF 
Exome Variant ServerPPIF
GNOMAD BrowserENSG00000108179
Varsome BrowserPPIF
ACMGPPIF variants
VarityP30405
Genomic Variants (DGV)PPIF [DGVbeta]
DECIPHERPPIF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIF 
Mutations
ICGC Data PortalPPIF 
TCGA Data PortalPPIF 
Broad Tumor PortalPPIF
OASIS PortalPPIF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIF  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPIF
Mutations and Diseases : HGMDPPIF
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPIF
DgiDB (Drug Gene Interaction Database)PPIF
DoCM (Curated mutations)PPIF
CIViC (Clinical Interpretations of Variants in Cancer)PPIF
Cancer3DPPIF
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604486   
Orphanet
DisGeNETPPIF
MedgenPPIF
Genetic Testing Registry PPIF
NextProtP30405 [Medical]
GENETestsPPIF
Target ValidationPPIF
Huge Navigator PPIF [HugePedia]
ClinGenPPIF
Clinical trials, drugs, therapy
MyCancerGenomePPIF
Protein Interactions : CTDPPIF
Pharm GKB GenePA33584
PharosP30405
Clinical trialPPIF
Miscellaneous
canSAR (ICR)PPIF
HarmonizomePPIF
DataMed IndexPPIF
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPIF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:21 CEST 2021

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