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PPIH (peptidylprolyl isomerase H)

Identity

Alias_namespeptidyl prolyl isomerase H (cyclophilin H)
Alias_symbol (synonym)USA-CYP
CYP-20
SnuCyp-20
CYPH
MGC5016
Other alias
HGNC (Hugo) PPIH
LocusID (NCBI) 10465
Atlas_Id 72132
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 42658377 and ends at 42676758 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHKA (11q13.2) / PPIH (1p34.2)PPIH (1p34.2) / MTSS1L (16q22.1)USP40 (2q37.1) / PPIH (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPIH   14651
Cards
Entrez_Gene (NCBI)PPIH  10465  peptidylprolyl isomerase H
AliasesCYP-20; CYPH; SnuCyp-20; USA-CYP
GeneCards (Weizmann)PPIH
Ensembl hg19 (Hinxton)ENSG00000171960 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171960 [Gene_View]  chr1:42658377-42676758 [Contig_View]  PPIH [Vega]
ICGC DataPortalENSG00000171960
TCGA cBioPortalPPIH
AceView (NCBI)PPIH
Genatlas (Paris)PPIH
WikiGenes10465
SOURCE (Princeton)PPIH
Genetics Home Reference (NIH)PPIH
Genomic and cartography
GoldenPath hg38 (UCSC)PPIH  -     chr1:42658377-42676758 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIH  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblPPIH - 1p34.2 [CytoView hg19]  PPIH - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIPPIH [Mapview hg19]  PPIH [Mapview hg38]
OMIM606095   
Gene and transcription
Genbank (Entrez)AF016371 AF036331 AF086102 AK294288 AK309438
RefSeq transcript (Entrez)NM_001330510 NM_006347
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPIH
Cluster EST : UnigeneHs.729213 [ NCBI ]
CGAP (NCI)Hs.729213
Alternative Splicing GalleryENSG00000171960
Gene ExpressionPPIH [ NCBI-GEO ]   PPIH [ EBI - ARRAY_EXPRESS ]   PPIH [ SEEK ]   PPIH [ MEM ]
Gene Expression Viewer (FireBrowse)PPIH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10465
GTEX Portal (Tissue expression)PPIH
Human Protein AtlasENSG00000171960-PPIH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43447   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43447  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43447
Splice isoforms : SwissVarO43447
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusO43447
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)   
Domains : Interpro (EBI)Cyclophilin-like_dom    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)   
Domain families : Pfam (NCBI)pfam00160   
Conserved Domain (NCBI)PPIH
DMDM Disease mutations10465
Blocks (Seattle)PPIH
PDB (SRS)1MZW    1QOI   
PDB (PDBSum)1MZW    1QOI   
PDB (IMB)1MZW    1QOI   
PDB (RSDB)1MZW    1QOI   
Structural Biology KnowledgeBase1MZW    1QOI   
SCOP (Structural Classification of Proteins)1MZW    1QOI   
CATH (Classification of proteins structures)1MZW    1QOI   
SuperfamilyO43447
Human Protein Atlas [tissue]ENSG00000171960-PPIH [tissue]
Peptide AtlasO43447
HPRD12084
IPIIPI00007346   IPI00643915   IPI00644363   IPI00645020   IPI00645494   IPI00981725   
Protein Interaction databases
DIP (DOE-UCLA)O43447
IntAct (EBI)O43447
FunCoupENSG00000171960
BioGRIDPPIH
STRING (EMBL)PPIH
ZODIACPPIH
Ontologies - Pathways
QuickGOO43447
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA splicing, via spliceosome  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleoplasm  spliceosomal complex  cytoplasm  protein folding  protein complex assembly  cyclosporin A binding  nuclear speck  ribonucleoprotein complex binding  positive regulation of viral genome replication  U4/U6 x U5 tri-snRNP complex  U4/U6 snRNP  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA splicing, via spliceosome  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleoplasm  spliceosomal complex  cytoplasm  protein folding  protein complex assembly  cyclosporin A binding  nuclear speck  ribonucleoprotein complex binding  positive regulation of viral genome replication  U4/U6 x U5 tri-snRNP complex  U4/U6 snRNP  
Pathways : KEGGSpliceosome   
NDEx NetworkPPIH
Atlas of Cancer Signalling NetworkPPIH
Wikipedia pathwaysPPIH
Orthology - Evolution
OrthoDB10465
GeneTree (enSembl)ENSG00000171960
Phylogenetic Trees/Animal Genes : TreeFamPPIH
HOVERGENO43447
HOGENOMO43447
Homologs : HomoloGenePPIH
Homology/Alignments : Family Browser (UCSC)PPIH
Gene fusions - Rearrangements
Fusion: Tumor Portal PPIH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIH
dbVarPPIH
ClinVarPPIH
1000_GenomesPPIH 
Exome Variant ServerPPIH
ExAC (Exome Aggregation Consortium)ENSG00000171960
GNOMAD BrowserENSG00000171960
Genetic variants : HAPMAP10465
Genomic Variants (DGV)PPIH [DGVbeta]
DECIPHERPPIH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIH 
Mutations
ICGC Data PortalPPIH 
TCGA Data PortalPPIH 
Broad Tumor PortalPPIH
OASIS PortalPPIH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPIH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPIH
DgiDB (Drug Gene Interaction Database)PPIH
DoCM (Curated mutations)PPIH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPIH (select a term)
intoGenPPIH
Cancer3DPPIH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606095   
Orphanet
MedgenPPIH
Genetic Testing Registry PPIH
NextProtO43447 [Medical]
TSGene10465
GENETestsPPIH
Target ValidationPPIH
Huge Navigator PPIH [HugePedia]
snp3D : Map Gene to Disease10465
BioCentury BCIQPPIH
ClinGenPPIH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10465
Chemical/Pharm GKB GenePA33586
Clinical trialPPIH
Miscellaneous
canSAR (ICR)PPIH (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPIH
EVEXPPIH
GoPubMedPPIH
iHOPPPIH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:23:17 CET 2017

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