Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PPIL1 (peptidylprolyl isomerase like 1)

Identity

Alias_namespeptidylprolyl isomerase (cyclophilin)-like 1
Alias_symbol (synonym)CYPL1
Other aliasCGI-124
PPIase
hCyPX
HGNC (Hugo) PPIL1
LocusID (NCBI) 51645
Atlas_Id 55956
Location 6p21.2  [Link to chromosome band 6p21]
Location_base_pair Starts at 36854830 and ends at 36875024 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPIL1 (6p21.2) / SMAP2 (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPIL1   9260
Cards
Entrez_Gene (NCBI)PPIL1  51645  peptidylprolyl isomerase like 1
AliasesCGI-124; CYPL1; PPIase; hCyPX
GeneCards (Weizmann)PPIL1
Ensembl hg19 (Hinxton)ENSG00000137168 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137168 [Gene_View]  ENSG00000137168 [Sequence]  chr6:36854830-36875024 [Contig_View]  PPIL1 [Vega]
ICGC DataPortalENSG00000137168
TCGA cBioPortalPPIL1
AceView (NCBI)PPIL1
Genatlas (Paris)PPIL1
WikiGenes51645
SOURCE (Princeton)PPIL1
Genetics Home Reference (NIH)PPIL1
Genomic and cartography
GoldenPath hg38 (UCSC)PPIL1  -     chr6:36854830-36875024 -  6p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIL1  -     6p21.2   [Description]    (hg19-Feb_2009)
EnsemblPPIL1 - 6p21.2 [CytoView hg19]  PPIL1 - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBIPPIL1 [Mapview hg19]  PPIL1 [Mapview hg38]
OMIM601301   
Gene and transcription
Genbank (Entrez)AF151882 AK026636 AY359032 BC003048 BU195579
RefSeq transcript (Entrez)NM_016059
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPIL1
Cluster EST : UnigeneHs.27693 [ NCBI ]
CGAP (NCI)Hs.27693
Alternative Splicing GalleryENSG00000137168
Gene ExpressionPPIL1 [ NCBI-GEO ]   PPIL1 [ EBI - ARRAY_EXPRESS ]   PPIL1 [ SEEK ]   PPIL1 [ MEM ]
Gene Expression Viewer (FireBrowse)PPIL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51645
GTEX Portal (Tissue expression)PPIL1
Human Protein AtlasENSG00000137168-PPIL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3C6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3C6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3C6
Splice isoforms : SwissVarQ9Y3C6
PhosPhoSitePlusQ9Y3C6
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)   
Domains : Interpro (EBI)Cyclophilin-like_dom_sf    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)   
Domain families : Pfam (NCBI)pfam00160   
Conserved Domain (NCBI)PPIL1
DMDM Disease mutations51645
Blocks (Seattle)PPIL1
PDB (SRS)1XWN    2K7N    2X7K    5MQF    5XJC   
PDB (PDBSum)1XWN    2K7N    2X7K    5MQF    5XJC   
PDB (IMB)1XWN    2K7N    2X7K    5MQF    5XJC   
PDB (RSDB)1XWN    2K7N    2X7K    5MQF    5XJC   
Structural Biology KnowledgeBase1XWN    2K7N    2X7K    5MQF    5XJC   
SCOP (Structural Classification of Proteins)1XWN    2K7N    2X7K    5MQF    5XJC   
CATH (Classification of proteins structures)1XWN    2K7N    2X7K    5MQF    5XJC   
SuperfamilyQ9Y3C6
Human Protein Atlas [tissue]ENSG00000137168-PPIL1 [tissue]
Peptide AtlasQ9Y3C6
HPRD03194
IPIIPI00007019   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3C6
IntAct (EBI)Q9Y3C6
FunCoupENSG00000137168
BioGRIDPPIL1
STRING (EMBL)PPIL1
ZODIACPPIL1
Ontologies - Pathways
QuickGOQ9Y3C6
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  protein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleus  nucleoplasm  protein folding  cyclosporin A binding  U2-type catalytic step 2 spliceosome  catalytic step 2 spliceosome  disordered domain specific binding  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  protein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleus  nucleoplasm  protein folding  cyclosporin A binding  U2-type catalytic step 2 spliceosome  catalytic step 2 spliceosome  disordered domain specific binding  
Pathways : KEGGSpliceosome   
NDEx NetworkPPIL1
Atlas of Cancer Signalling NetworkPPIL1
Wikipedia pathwaysPPIL1
Orthology - Evolution
OrthoDB51645
GeneTree (enSembl)ENSG00000137168
Phylogenetic Trees/Animal Genes : TreeFamPPIL1
HOVERGENQ9Y3C6
HOGENOMQ9Y3C6
Homologs : HomoloGenePPIL1
Homology/Alignments : Family Browser (UCSC)PPIL1
Gene fusions - Rearrangements
Fusion : QuiverPPIL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIL1
dbVarPPIL1
ClinVarPPIL1
1000_GenomesPPIL1 
Exome Variant ServerPPIL1
ExAC (Exome Aggregation Consortium)ENSG00000137168
GNOMAD BrowserENSG00000137168
Varsome BrowserPPIL1
Genetic variants : HAPMAP51645
Genomic Variants (DGV)PPIL1 [DGVbeta]
DECIPHERPPIL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIL1 
Mutations
ICGC Data PortalPPIL1 
TCGA Data PortalPPIL1 
Broad Tumor PortalPPIL1
OASIS PortalPPIL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPIL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPIL1
DgiDB (Drug Gene Interaction Database)PPIL1
DoCM (Curated mutations)PPIL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPIL1 (select a term)
intoGenPPIL1
Cancer3DPPIL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601301   
Orphanet
DisGeNETPPIL1
MedgenPPIL1
Genetic Testing Registry PPIL1
NextProtQ9Y3C6 [Medical]
TSGene51645
GENETestsPPIL1
Target ValidationPPIL1
Huge Navigator PPIL1 [HugePedia]
snp3D : Map Gene to Disease51645
BioCentury BCIQPPIL1
ClinGenPPIL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51645
Chemical/Pharm GKB GenePA33587
Clinical trialPPIL1
Miscellaneous
canSAR (ICR)PPIL1 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPIL1
EVEXPPIL1
GoPubMedPPIL1
iHOPPPIL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:31:34 CET 2018

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