Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PPIL2 (peptidylprolyl isomerase like 2)

Identity

Alias_namespeptidylprolyl isomerase (cyclophilin)-like 2
Alias_symbol (synonym)UBOX7
CYC4
Cyp-60
Other aliasCYP60
hCyP-60
HGNC (Hugo) PPIL2
LocusID (NCBI) 23759
Atlas_Id 41800
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 21665984 and ends at 21697913 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPIL2 (22q11.21) / KIAA1671 (22q11.23)PPIL2 (22q11.21) / UBE2L3 (22q11.21)PTMA (2q37.1) / PPIL2 (22q11.21)
STYXL1 (7q11.23) / PPIL2 (22q11.21)PPIL2 22q11.21 / KIAA1671 22q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPIL2   9261
Cards
Entrez_Gene (NCBI)PPIL2  23759  peptidylprolyl isomerase like 2
AliasesCYC4; CYP60; Cyp-60; UBOX7; 
hCyP-60
GeneCards (Weizmann)PPIL2
Ensembl hg19 (Hinxton)ENSG00000100023 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100023 [Gene_View]  chr22:21665984-21697913 [Contig_View]  PPIL2 [Vega]
ICGC DataPortalENSG00000100023
TCGA cBioPortalPPIL2
AceView (NCBI)PPIL2
Genatlas (Paris)PPIL2
WikiGenes23759
SOURCE (Princeton)PPIL2
Genetics Home Reference (NIH)PPIL2
Genomic and cartography
GoldenPath hg38 (UCSC)PPIL2  -     chr22:21665984-21697913 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIL2  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblPPIL2 - 22q11.21 [CytoView hg19]  PPIL2 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIPPIL2 [Mapview hg19]  PPIL2 [Mapview hg38]
OMIM607588   
Gene and transcription
Genbank (Entrez)AA743164 AF320072 AK097249 AK127259 AK289545
RefSeq transcript (Entrez)NM_001317996 NM_014337 NM_148175 NM_148176
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPIL2
Cluster EST : UnigeneHs.438587 [ NCBI ]
CGAP (NCI)Hs.438587
Alternative Splicing GalleryENSG00000100023
Gene ExpressionPPIL2 [ NCBI-GEO ]   PPIL2 [ EBI - ARRAY_EXPRESS ]   PPIL2 [ SEEK ]   PPIL2 [ MEM ]
Gene Expression Viewer (FireBrowse)PPIL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23759
GTEX Portal (Tissue expression)PPIL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13356   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13356  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13356
Splice isoforms : SwissVarQ13356
PhosPhoSitePlusQ13356
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_1 (PS00170)    CSA_PPIASE_2 (PS50072)    U_BOX (PS51698)   
Domains : Interpro (EBI)Cyclophilin-like_dom    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_CS    Cyclophilin-type_PPIase_dom    Ubox_domain    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)   
Domain families : Pfam (NCBI)pfam00160   
Domain families : Smart (EMBL)Ubox (SM00504)  
Conserved Domain (NCBI)PPIL2
DMDM Disease mutations23759
Blocks (Seattle)PPIL2
PDB (SRS)1ZKC   
PDB (PDBSum)1ZKC   
PDB (IMB)1ZKC   
PDB (RSDB)1ZKC   
Structural Biology KnowledgeBase1ZKC   
SCOP (Structural Classification of Proteins)1ZKC   
CATH (Classification of proteins structures)1ZKC   
SuperfamilyQ13356
Human Protein AtlasENSG00000100023
Peptide AtlasQ13356
HPRD08472
IPIIPI00003824   IPI00217324   IPI00910138   IPI00964071   IPI00879711   IPI00878225   IPI00877682   
Protein Interaction databases
DIP (DOE-UCLA)Q13356
IntAct (EBI)Q13356
FunCoupENSG00000100023
BioGRIDPPIL2
STRING (EMBL)PPIL2
ZODIACPPIL2
Ontologies - Pathways
QuickGOQ13356
Ontology : AmiGOprotein polyubiquitination  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  Golgi lumen  plasma membrane  protein folding  ubiquitin-ubiquitin ligase activity  leukocyte migration  ubiquitin protein ligase activity  protein localization to plasma membrane  
Ontology : EGO-EBIprotein polyubiquitination  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  Golgi lumen  plasma membrane  protein folding  ubiquitin-ubiquitin ligase activity  leukocyte migration  ubiquitin protein ligase activity  protein localization to plasma membrane  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkPPIL2
Atlas of Cancer Signalling NetworkPPIL2
Wikipedia pathwaysPPIL2
Orthology - Evolution
OrthoDB23759
GeneTree (enSembl)ENSG00000100023
Phylogenetic Trees/Animal Genes : TreeFamPPIL2
HOVERGENQ13356
HOGENOMQ13356
Homologs : HomoloGenePPIL2
Homology/Alignments : Family Browser (UCSC)PPIL2
Gene fusions - Rearrangements
Fusion : MitelmanPPIL2/KIAA1671 [22q11.21/22q11.23]  
Fusion: TCGAPPIL2 22q11.21 KIAA1671 22q11.23 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIL2
dbVarPPIL2
ClinVarPPIL2
1000_GenomesPPIL2 
Exome Variant ServerPPIL2
ExAC (Exome Aggregation Consortium)PPIL2 (select the gene name)
Genetic variants : HAPMAP23759
Genomic Variants (DGV)PPIL2 [DGVbeta]
DECIPHERPPIL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIL2 
Mutations
ICGC Data PortalPPIL2 
TCGA Data PortalPPIL2 
Broad Tumor PortalPPIL2
OASIS PortalPPIL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPIL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPIL2
DgiDB (Drug Gene Interaction Database)PPIL2
DoCM (Curated mutations)PPIL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPIL2 (select a term)
intoGenPPIL2
Cancer3DPPIL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607588   
Orphanet
MedgenPPIL2
Genetic Testing Registry PPIL2
NextProtQ13356 [Medical]
TSGene23759
GENETestsPPIL2
Target ValidationPPIL2
Huge Navigator PPIL2 [HugePedia]
snp3D : Map Gene to Disease23759
BioCentury BCIQPPIL2
ClinGenPPIL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23759
Chemical/Pharm GKB GenePA33588
Clinical trialPPIL2
Miscellaneous
canSAR (ICR)PPIL2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPIL2
EVEXPPIL2
GoPubMedPPIL2
iHOPPPIL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:32 CEST 2017

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