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PPIL6 (peptidylprolyl isomerase like 6)

Identity

Alias_namespeptidylprolyl isomerase (cyclophilin)-like 6
Alias_symbol (synonym)bA425D10.6
MGC41939
dJ919F19.1
RSPH12
Other aliasPPIase
HGNC (Hugo) PPIL6
LocusID (NCBI) 285755
Atlas_Id 72135
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 109390215 and ends at 109441171 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZNF322 (6p22.2) / PPIL6 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p22;q21) ZNF322/PPIL6


External links

Nomenclature
HGNC (Hugo)PPIL6   21557
Cards
Entrez_Gene (NCBI)PPIL6  285755  peptidylprolyl isomerase like 6
AliasesPPIase; RSPH12; bA425D10.6; dJ919F19.1
GeneCards (Weizmann)PPIL6
Ensembl hg19 (Hinxton)ENSG00000185250 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185250 [Gene_View]  ENSG00000185250 [Sequence]  chr6:109390215-109441171 [Contig_View]  PPIL6 [Vega]
ICGC DataPortalENSG00000185250
TCGA cBioPortalPPIL6
AceView (NCBI)PPIL6
Genatlas (Paris)PPIL6
WikiGenes285755
SOURCE (Princeton)PPIL6
Genetics Home Reference (NIH)PPIL6
Genomic and cartography
GoldenPath hg38 (UCSC)PPIL6  -     chr6:109390215-109441171 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPIL6  -     6q21   [Description]    (hg19-Feb_2009)
EnsemblPPIL6 - 6q21 [CytoView hg19]  PPIL6 - 6q21 [CytoView hg38]
Mapping of homologs : NCBIPPIL6 [Mapview hg19]  PPIL6 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI052546 AK293674 AK315790 BC026359 BC026360
RefSeq transcript (Entrez)NM_001111298 NM_001286360 NM_001286361 NM_173672
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPIL6
Cluster EST : UnigeneHs.32234 [ NCBI ]
CGAP (NCI)Hs.32234
Alternative Splicing GalleryENSG00000185250
Gene ExpressionPPIL6 [ NCBI-GEO ]   PPIL6 [ EBI - ARRAY_EXPRESS ]   PPIL6 [ SEEK ]   PPIL6 [ MEM ]
Gene Expression Viewer (FireBrowse)PPIL6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)285755
GTEX Portal (Tissue expression)PPIL6
Human Protein AtlasENSG00000185250-PPIL6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXY8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXY8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXY8
Splice isoforms : SwissVarQ8IXY8
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusQ8IXY8
Domaine pattern : Prosite (Expaxy)CSA_PPIASE_2 (PS50072)   
Domains : Interpro (EBI)Cyclophilin-like_dom    Cyclophilin-type_PPIase    Cyclophilin-type_PPIase_dom   
Domain families : Pfam (Sanger)Pro_isomerase (PF00160)   
Domain families : Pfam (NCBI)pfam00160   
Conserved Domain (NCBI)PPIL6
DMDM Disease mutations285755
Blocks (Seattle)PPIL6
SuperfamilyQ8IXY8
Human Protein Atlas [tissue]ENSG00000185250-PPIL6 [tissue]
Peptide AtlasQ8IXY8
HPRD15165
IPIIPI00217696   IPI00973737   IPI00640570   IPI00910058   IPI00514884   IPI00942599   IPI00983605   
Protein Interaction databases
DIP (DOE-UCLA)Q8IXY8
IntAct (EBI)Q8IXY8
FunCoupENSG00000185250
BioGRIDPPIL6
STRING (EMBL)PPIL6
ZODIACPPIL6
Ontologies - Pathways
QuickGOQ8IXY8
Ontology : AmiGOprotein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein folding  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein folding  
NDEx NetworkPPIL6
Atlas of Cancer Signalling NetworkPPIL6
Wikipedia pathwaysPPIL6
Orthology - Evolution
OrthoDB285755
GeneTree (enSembl)ENSG00000185250
Phylogenetic Trees/Animal Genes : TreeFamPPIL6
HOVERGENQ8IXY8
HOGENOMQ8IXY8
Homologs : HomoloGenePPIL6
Homology/Alignments : Family Browser (UCSC)PPIL6
Gene fusions - Rearrangements
Fusion : QuiverPPIL6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPIL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPIL6
dbVarPPIL6
ClinVarPPIL6
1000_GenomesPPIL6 
Exome Variant ServerPPIL6
ExAC (Exome Aggregation Consortium)ENSG00000185250
GNOMAD BrowserENSG00000185250
Varsome BrowserPPIL6
Genetic variants : HAPMAP285755
Genomic Variants (DGV)PPIL6 [DGVbeta]
DECIPHERPPIL6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPIL6 
Mutations
ICGC Data PortalPPIL6 
TCGA Data PortalPPIL6 
Broad Tumor PortalPPIL6
OASIS PortalPPIL6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPIL6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPIL6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPIL6
DgiDB (Drug Gene Interaction Database)PPIL6
DoCM (Curated mutations)PPIL6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPIL6 (select a term)
intoGenPPIL6
Cancer3DPPIL6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPPIL6
MedgenPPIL6
Genetic Testing Registry PPIL6
NextProtQ8IXY8 [Medical]
TSGene285755
GENETestsPPIL6
Target ValidationPPIL6
Huge Navigator PPIL6 [HugePedia]
snp3D : Map Gene to Disease285755
BioCentury BCIQPPIL6
ClinGenPPIL6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD285755
Chemical/Pharm GKB GenePA134939571
Clinical trialPPIL6
Miscellaneous
canSAR (ICR)PPIL6 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPIL6
EVEXPPIL6
GoPubMedPPIL6
iHOPPPIL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:24:45 CEST 2018

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