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PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A)

Identity

Alias_namesprotein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
protein phosphatase, Mg2?? dependent, 1A
Alias_symbol (synonym)MGC9201
PP2Calpha
PP2CA
Other aliasPP2C-ALPHA
HGNC (Hugo) PPM1A
LocusID (NCBI) 5494
Atlas_Id 41802
Location 14q23.1  [Link to chromosome band 14q23]
Location_base_pair Starts at 60249248 and ends at 60299087 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDH26 (20q13.33) / PPM1A (14q23.1)MAP4K4 (2q11.2) / PPM1A (14q23.1)MYO9B (19p13.11) / PPM1A (14q23.1)
NEAT1 (11q13.1) / PPM1A (14q23.1)PPM1A (14q23.1) / ADCK4 (19q13.2)PPM1A 14q23.1 / ADCK4 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPM1A   9275
Cards
Entrez_Gene (NCBI)PPM1A  5494  protein phosphatase, Mg2+/Mn2+ dependent 1A
AliasesPP2C-ALPHA; PP2CA; PP2Calpha
GeneCards (Weizmann)PPM1A
Ensembl hg19 (Hinxton)ENSG00000100614 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100614 [Gene_View]  chr14:60249248-60299087 [Contig_View]  PPM1A [Vega]
ICGC DataPortalENSG00000100614
TCGA cBioPortalPPM1A
AceView (NCBI)PPM1A
Genatlas (Paris)PPM1A
WikiGenes5494
SOURCE (Princeton)PPM1A
Genetics Home Reference (NIH)PPM1A
Genomic and cartography
GoldenPath hg38 (UCSC)PPM1A  -     chr14:60249248-60299087 +  14q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPM1A  -     14q23.1   [Description]    (hg19-Feb_2009)
EnsemblPPM1A - 14q23.1 [CytoView hg19]  PPM1A - 14q23.1 [CytoView hg38]
Mapping of homologs : NCBIPPM1A [Mapview hg19]  PPM1A [Mapview hg38]
OMIM606108   
Gene and transcription
Genbank (Entrez)AB451247 AB451371 AF070670 AI076736 AK097843
RefSeq transcript (Entrez)NM_021003 NM_177951 NM_177952
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPM1A
Cluster EST : UnigeneHs.130036 [ NCBI ]
CGAP (NCI)Hs.130036
Alternative Splicing GalleryENSG00000100614
Gene ExpressionPPM1A [ NCBI-GEO ]   PPM1A [ EBI - ARRAY_EXPRESS ]   PPM1A [ SEEK ]   PPM1A [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5494
GTEX Portal (Tissue expression)PPM1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35813   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35813  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35813
Splice isoforms : SwissVarP35813
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP35813
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PP2C_C    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)    PP2C_C (PF07830)   
Domain families : Pfam (NCBI)pfam00481    pfam07830   
Domain families : Smart (EMBL)PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1A
DMDM Disease mutations5494
Blocks (Seattle)PPM1A
PDB (SRS)1A6Q    3FXJ    3FXK    3FXL    3FXM    3FXO    4RA2    4RAF    4RAG   
PDB (PDBSum)1A6Q    3FXJ    3FXK    3FXL    3FXM    3FXO    4RA2    4RAF    4RAG   
PDB (IMB)1A6Q    3FXJ    3FXK    3FXL    3FXM    3FXO    4RA2    4RAF    4RAG   
PDB (RSDB)1A6Q    3FXJ    3FXK    3FXL    3FXM    3FXO    4RA2    4RAF    4RAG   
Structural Biology KnowledgeBase1A6Q    3FXJ    3FXK    3FXL    3FXM    3FXO    4RA2    4RAF    4RAG   
SCOP (Structural Classification of Proteins)1A6Q    3FXJ    3FXK    3FXL    3FXM    3FXO    4RA2    4RAF    4RAG   
CATH (Classification of proteins structures)1A6Q    3FXJ    3FXK    3FXL    3FXM    3FXO    4RA2    4RAF    4RAG   
SuperfamilyP35813
Human Protein AtlasENSG00000100614
Peptide AtlasP35813
HPRD16199
IPIIPI00020950   IPI00216196   IPI00900291   IPI00982480   IPI00975663   IPI00976248   IPI00979580   IPI00981934   
Protein Interaction databases
DIP (DOE-UCLA)P35813
IntAct (EBI)P35813
FunCoupENSG00000100614
BioGRIDPPM1A
STRING (EMBL)PPM1A
ZODIACPPM1A
Ontologies - Pathways
QuickGOP35813
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  magnesium ion binding  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  signal transducer activity  protein binding  nucleus  nucleoplasm  cytosol  cytosol  cytosol  plasma membrane  protein dephosphorylation  N-terminal protein myristoylation  cell cycle arrest  negative regulation of SMAD protein complex assembly  membrane  Wnt signaling pathway  dephosphorylation  manganese ion binding  positive regulation of Wnt signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  calmodulin-dependent protein phosphatase activity  peptidyl-threonine dephosphorylation  negative regulation of NF-kappaB import into nucleus  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of transcription, DNA-templated  positive regulation of protein export from nucleus  R-SMAD binding  cellular response to transforming growth factor beta stimulus  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  magnesium ion binding  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  signal transducer activity  protein binding  nucleus  nucleoplasm  cytosol  cytosol  cytosol  plasma membrane  protein dephosphorylation  N-terminal protein myristoylation  cell cycle arrest  negative regulation of SMAD protein complex assembly  membrane  Wnt signaling pathway  dephosphorylation  manganese ion binding  positive regulation of Wnt signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  calmodulin-dependent protein phosphatase activity  peptidyl-threonine dephosphorylation  negative regulation of NF-kappaB import into nucleus  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of transcription, DNA-templated  positive regulation of protein export from nucleus  R-SMAD binding  cellular response to transforming growth factor beta stimulus  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkPPM1A
Atlas of Cancer Signalling NetworkPPM1A
Wikipedia pathwaysPPM1A
Orthology - Evolution
OrthoDB5494
GeneTree (enSembl)ENSG00000100614
Phylogenetic Trees/Animal Genes : TreeFamPPM1A
HOVERGENP35813
HOGENOMP35813
Homologs : HomoloGenePPM1A
Homology/Alignments : Family Browser (UCSC)PPM1A
Gene fusions - Rearrangements
Fusion : MitelmanPPM1A/ADCK4 [14q23.1/19q13.2]  
Fusion: TCGAPPM1A 14q23.1 ADCK4 19q13.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPM1A
dbVarPPM1A
ClinVarPPM1A
1000_GenomesPPM1A 
Exome Variant ServerPPM1A
ExAC (Exome Aggregation Consortium)PPM1A (select the gene name)
Genetic variants : HAPMAP5494
Genomic Variants (DGV)PPM1A [DGVbeta]
DECIPHERPPM1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPM1A 
Mutations
ICGC Data PortalPPM1A 
TCGA Data PortalPPM1A 
Broad Tumor PortalPPM1A
OASIS PortalPPM1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPM1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPM1A
DgiDB (Drug Gene Interaction Database)PPM1A
DoCM (Curated mutations)PPM1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPM1A (select a term)
intoGenPPM1A
Cancer3DPPM1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606108   
Orphanet
MedgenPPM1A
Genetic Testing Registry PPM1A
NextProtP35813 [Medical]
TSGene5494
GENETestsPPM1A
Huge Navigator PPM1A [HugePedia]
snp3D : Map Gene to Disease5494
BioCentury BCIQPPM1A
ClinGenPPM1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5494
Chemical/Pharm GKB GenePA33603
Clinical trialPPM1A
Miscellaneous
canSAR (ICR)PPM1A (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPM1A
EVEXPPM1A
GoPubMedPPM1A
iHOPPPM1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:32:16 CEST 2017

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