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PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)

Identity

Alias_namesbeta isoform
Alias_symbol (synonym)PPC2BETAX
PP2CB
PP2CBETA
Other aliasPP2C-beta
PP2C-beta-X
HGNC (Hugo) PPM1B
LocusID (NCBI) 5495
Atlas_Id 46724
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 44168803 and ends at 44231473 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPM1B (2p21) / ABCG8 (2p21)PPM1B (2p21) / FAS (10q23.31)PRDM10 (11q24.3) / PPM1B (2p21)
PPM1B 2p21 / ABCG8 2p21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPM1B   9276
Cards
Entrez_Gene (NCBI)PPM1B  5495  protein phosphatase, Mg2+/Mn2+ dependent 1B
AliasesPP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; 
PPC2BETAX
GeneCards (Weizmann)PPM1B
Ensembl hg19 (Hinxton)ENSG00000138032 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138032 [Gene_View]  chr2:44168803-44231473 [Contig_View]  PPM1B [Vega]
ICGC DataPortalENSG00000138032
TCGA cBioPortalPPM1B
AceView (NCBI)PPM1B
Genatlas (Paris)PPM1B
WikiGenes5495
SOURCE (Princeton)PPM1B
Genetics Home Reference (NIH)PPM1B
Genomic and cartography
GoldenPath hg38 (UCSC)PPM1B  -     chr2:44168803-44231473 +  2p21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPM1B  -     2p21   [Description]    (hg19-Feb_2009)
EnsemblPPM1B - 2p21 [CytoView hg19]  PPM1B - 2p21 [CytoView hg38]
Mapping of homologs : NCBIPPM1B [Mapview hg19]  PPM1B [Mapview hg38]
OMIM603770   
Gene and transcription
Genbank (Entrez)AA742374 AA769851 AF136972 AF294792 AJ005801
RefSeq transcript (Entrez)NM_001033556 NM_001033557 NM_002706 NM_177968 NM_177969
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPM1B
Cluster EST : UnigeneHs.416769 [ NCBI ]
CGAP (NCI)Hs.416769
Alternative Splicing GalleryENSG00000138032
Gene ExpressionPPM1B [ NCBI-GEO ]   PPM1B [ EBI - ARRAY_EXPRESS ]   PPM1B [ SEEK ]   PPM1B [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5495
GTEX Portal (Tissue expression)PPM1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75688   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75688  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75688
Splice isoforms : SwissVarO75688
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusO75688
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PP2C_C    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)    PP2C_C (PF07830)   
Domain families : Pfam (NCBI)pfam00481    pfam07830   
Domain families : Smart (EMBL)PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1B
DMDM Disease mutations5495
Blocks (Seattle)PPM1B
PDB (SRS)2P8E   
PDB (PDBSum)2P8E   
PDB (IMB)2P8E   
PDB (RSDB)2P8E   
Structural Biology KnowledgeBase2P8E   
SCOP (Structural Classification of Proteins)2P8E   
CATH (Classification of proteins structures)2P8E   
SuperfamilyO75688
Human Protein AtlasENSG00000138032
Peptide AtlasO75688
HPRD04796
IPIIPI00026612   IPI00743802   IPI00219537   IPI01018123   IPI00651725   IPI00917979   IPI00916263   
Protein Interaction databases
DIP (DOE-UCLA)O75688
IntAct (EBI)O75688
FunCoupENSG00000138032
BioGRIDPPM1B
STRING (EMBL)PPM1B
ZODIACPPM1B
Ontologies - Pathways
QuickGOO75688
Ontology : AmiGOmagnesium ion binding  protein serine/threonine phosphatase activity  protein binding  nucleolus  cytosol  cytosol  cytosol  protein dephosphorylation  N-terminal protein myristoylation  membrane  manganese ion binding  negative regulation of interferon-beta production  peptidyl-threonine dephosphorylation  negative regulation of NF-kappaB import into nucleus  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of defense response to virus  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine phosphatase activity  protein binding  nucleolus  cytosol  cytosol  cytosol  protein dephosphorylation  N-terminal protein myristoylation  membrane  manganese ion binding  negative regulation of interferon-beta production  peptidyl-threonine dephosphorylation  negative regulation of NF-kappaB import into nucleus  negative regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of defense response to virus  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkPPM1B
Atlas of Cancer Signalling NetworkPPM1B
Wikipedia pathwaysPPM1B
Orthology - Evolution
OrthoDB5495
GeneTree (enSembl)ENSG00000138032
Phylogenetic Trees/Animal Genes : TreeFamPPM1B
HOVERGENO75688
HOGENOMO75688
Homologs : HomoloGenePPM1B
Homology/Alignments : Family Browser (UCSC)PPM1B
Gene fusions - Rearrangements
Fusion: TCGAPPM1B 2p21 ABCG8 2p21 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPM1B
dbVarPPM1B
ClinVarPPM1B
1000_GenomesPPM1B 
Exome Variant ServerPPM1B
ExAC (Exome Aggregation Consortium)PPM1B (select the gene name)
Genetic variants : HAPMAP5495
Genomic Variants (DGV)PPM1B [DGVbeta]
DECIPHERPPM1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPM1B 
Mutations
ICGC Data PortalPPM1B 
TCGA Data PortalPPM1B 
Broad Tumor PortalPPM1B
OASIS PortalPPM1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPM1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PPM1B
DgiDB (Drug Gene Interaction Database)PPM1B
DoCM (Curated mutations)PPM1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPM1B (select a term)
intoGenPPM1B
Cancer3DPPM1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603770   
Orphanet17525   
MedgenPPM1B
Genetic Testing Registry PPM1B
NextProtO75688 [Medical]
TSGene5495
GENETestsPPM1B
Target ValidationPPM1B
Huge Navigator PPM1B [HugePedia]
snp3D : Map Gene to Disease5495
BioCentury BCIQPPM1B
ClinGenPPM1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5495
Chemical/Pharm GKB GenePA33604
Clinical trialPPM1B
Miscellaneous
canSAR (ICR)PPM1B (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPM1B
EVEXPPM1B
GoPubMedPPM1B
iHOPPPM1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:25:56 CEST 2017

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