Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)

Identity

Alias_namesprotein phosphatase 1E (PP2C domain containing)
protein phosphatase, Mg2?? dependent, 1E
Alias_symbol (synonym)POPX1
KIAA1072
PP2CH
CaMKP-N
Other aliascaMKN
HGNC (Hugo) PPM1E
LocusID (NCBI) 22843
Atlas_Id 43424
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58755869 and ends at 58985179 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KCND3 (1p13.2) / PPM1E (17q22)NCBP3 (17p13.2) / PPM1E (17q22)PPM1E (17q22) / PPM1E (17q22)
PPM1E (17q22) / SPAG5 (17q11.2)PPM1E (17q22) / VMP1 (17q23.1)PPP6C (9q33.3) / PPM1E (17q22)
RCOR1 (14q32.31) / PPM1E (17q22)PPM1E 17q22 / SPAG5 17q11.2PPM1E 17q22 / VMP1 17q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPM1E   19322
Cards
Entrez_Gene (NCBI)PPM1E  22843  protein phosphatase, Mg2+/Mn2+ dependent 1E
AliasesCaMKP-N; POPX1; PP2CH; caMKN
GeneCards (Weizmann)PPM1E
Ensembl hg19 (Hinxton)ENSG00000175175 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175175 [Gene_View]  chr17:58755869-58985179 [Contig_View]  PPM1E [Vega]
ICGC DataPortalENSG00000175175
TCGA cBioPortalPPM1E
AceView (NCBI)PPM1E
Genatlas (Paris)PPM1E
WikiGenes22843
SOURCE (Princeton)PPM1E
Genetics Home Reference (NIH)PPM1E
Genomic and cartography
GoldenPath hg38 (UCSC)PPM1E  -     chr17:58755869-58985179 +  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPM1E  -     17q22   [Description]    (hg19-Feb_2009)
EnsemblPPM1E - 17q22 [CytoView hg19]  PPM1E - 17q22 [CytoView hg38]
Mapping of homologs : NCBIPPM1E [Mapview hg19]  PPM1E [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB028995 AF260269 AF520614 AK289966 BC136290
RefSeq transcript (Entrez)NM_014906
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPM1E
Cluster EST : UnigeneHs.245044 [ NCBI ]
CGAP (NCI)Hs.245044
Alternative Splicing GalleryENSG00000175175
Gene ExpressionPPM1E [ NCBI-GEO ]   PPM1E [ EBI - ARRAY_EXPRESS ]   PPM1E [ SEEK ]   PPM1E [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22843
GTEX Portal (Tissue expression)PPM1E
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WY54   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WY54  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WY54
Splice isoforms : SwissVarQ8WY54
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusQ8WY54
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1E
DMDM Disease mutations22843
Blocks (Seattle)PPM1E
SuperfamilyQ8WY54
Human Protein AtlasENSG00000175175
Peptide AtlasQ8WY54
HPRD17888
IPIIPI00103630   IPI00845435   IPI00845240   
Protein Interaction databases
DIP (DOE-UCLA)Q8WY54
IntAct (EBI)Q8WY54
FunCoupENSG00000175175
BioGRIDPPM1E
STRING (EMBL)PPM1E
ZODIACPPM1E
Ontologies - Pathways
QuickGOQ8WY54
Ontology : AmiGOprotein serine/threonine phosphatase activity  protein binding  nucleus  nucleolus  mitochondrion  negative regulation of protein kinase activity  cellular response to drug  peptidyl-threonine dephosphorylation  protein complex  metal ion binding  positive regulation of stress fiber assembly  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  protein binding  nucleus  nucleolus  mitochondrion  negative regulation of protein kinase activity  cellular response to drug  peptidyl-threonine dephosphorylation  protein complex  metal ion binding  positive regulation of stress fiber assembly  
NDEx NetworkPPM1E
Atlas of Cancer Signalling NetworkPPM1E
Wikipedia pathwaysPPM1E
Orthology - Evolution
OrthoDB22843
GeneTree (enSembl)ENSG00000175175
Phylogenetic Trees/Animal Genes : TreeFamPPM1E
HOVERGENQ8WY54
HOGENOMQ8WY54
Homologs : HomoloGenePPM1E
Homology/Alignments : Family Browser (UCSC)PPM1E
Gene fusions - Rearrangements
Fusion : MitelmanKCND3/PPM1E [1p13.2/17q22]  [t(1;17)(p13;q22)]  
Fusion : MitelmanPPM1E/SPAG5 [17q22/17q11.2]  [t(17;17)(q11;q22)]  
Fusion : MitelmanPPM1E/VMP1 [17q22/17q23.1]  [t(17;17)(q22;q23)]  
Fusion: TCGAPPM1E 17q22 SPAG5 17q11.2 BRCA
Fusion: TCGAPPM1E 17q22 VMP1 17q23.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPM1E
dbVarPPM1E
ClinVarPPM1E
1000_GenomesPPM1E 
Exome Variant ServerPPM1E
ExAC (Exome Aggregation Consortium)PPM1E (select the gene name)
Genetic variants : HAPMAP22843
Genomic Variants (DGV)PPM1E [DGVbeta]
DECIPHERPPM1E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPM1E 
Mutations
ICGC Data PortalPPM1E 
TCGA Data PortalPPM1E 
Broad Tumor PortalPPM1E
OASIS PortalPPM1E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPM1E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPM1E
DgiDB (Drug Gene Interaction Database)PPM1E
DoCM (Curated mutations)PPM1E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPM1E (select a term)
intoGenPPM1E
Cancer3DPPM1E(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPPM1E
Genetic Testing Registry PPM1E
NextProtQ8WY54 [Medical]
TSGene22843
GENETestsPPM1E
Target ValidationPPM1E
Huge Navigator PPM1E [HugePedia]
snp3D : Map Gene to Disease22843
BioCentury BCIQPPM1E
ClinGenPPM1E
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22843
Chemical/Pharm GKB GenePA134943567
Clinical trialPPM1E
Miscellaneous
canSAR (ICR)PPM1E (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPM1E
EVEXPPM1E
GoPubMedPPM1E
iHOPPPM1E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:50:34 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.