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PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)

Identity

Alias (NCBI)CAMKPN
CaMKP-N
POPX1
PP2CH
caMKN
HGNC (Hugo) PPM1E
HGNC Alias symbPOPX1
KIAA1072
PP2CH
CaMKP-N
HGNC Alias namepartner of PIX 1
 nuclear calmodulin-dependent protein kinase phosphatase
HGNC Previous nameprotein phosphatase 1E (PP2C domain containing)
 protein phosphatase, Mg2+/Mn2+ dependent, 1E
LocusID (NCBI) 22843
Atlas_Id 43424
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58755854 and ends at 58985179 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KCND3 (1p13.2) / PPM1E (17q22)NCBP3 (17p13.2) / PPM1E (17q22)PPM1E (17q22) / PPM1E (17q22)
PPM1E (17q22) / SPAG5 (17q11.2)PPM1E (17q22) / VMP1 (17q23.1)PPP6C (9q33.3) / PPM1E (17q22)
RCOR1 (14q32.31) / PPM1E (17q22)PPM1E 17q22 / SPAG5 17q11.2PPM1E 17q22 / VMP1 17q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPM1E   19322
Cards
Entrez_Gene (NCBI)PPM1E    protein phosphatase, Mg2+/Mn2+ dependent 1E
AliasesCAMKPN; CaMKP-N; POPX1; PP2CH; 
caMKN
GeneCards (Weizmann)PPM1E
Ensembl hg19 (Hinxton)ENSG00000175175 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175175 [Gene_View]  ENSG00000175175 [Sequence]  chr17:58755854-58985179 [Contig_View]  PPM1E [Vega]
ICGC DataPortalENSG00000175175
TCGA cBioPortalPPM1E
AceView (NCBI)PPM1E
Genatlas (Paris)PPM1E
SOURCE (Princeton)PPM1E
Genetics Home Reference (NIH)PPM1E
Genomic and cartography
GoldenPath hg38 (UCSC)PPM1E  -     chr17:58755854-58985179 +  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPM1E  -     17q22   [Description]    (hg19-Feb_2009)
GoldenPathPPM1E - 17q22 [CytoView hg19]  PPM1E - 17q22 [CytoView hg38]
ImmunoBaseENSG00000175175
Genome Data Viewer NCBIPPM1E [Mapview hg19]  
OMIM619308   
Gene and transcription
Genbank (Entrez)AB028995 AF260269 AF520614 AK289966 BC136290
RefSeq transcript (Entrez)NM_014906
Consensus coding sequences : CCDS (NCBI)PPM1E
Gene ExpressionPPM1E [ NCBI-GEO ]   PPM1E [ EBI - ARRAY_EXPRESS ]   PPM1E [ SEEK ]   PPM1E [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1E [ Firebrowse - Broad ]
GenevisibleExpression of PPM1E in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22843
GTEX Portal (Tissue expression)PPM1E
Human Protein AtlasENSG00000175175-PPM1E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WY54   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WY54  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WY54
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8WY54
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PPM-type_dom_sf    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1E
SuperfamilyQ8WY54
AlphaFold pdb e-kbQ8WY54   
Human Protein Atlas [tissue]ENSG00000175175-PPM1E [tissue]
HPRD17888
Protein Interaction databases
DIP (DOE-UCLA)Q8WY54
IntAct (EBI)Q8WY54
BioGRIDPPM1E
STRING (EMBL)PPM1E
ZODIACPPM1E
Ontologies - Pathways
QuickGOQ8WY54
Ontology : AmiGOprotein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  nucleoplasm  nucleolus  mitochondrion  negative regulation of protein kinase activity  negative regulation of protein kinase activity  protein dephosphorylation  protein-containing complex  cellular response to drug  peptidyl-threonine dephosphorylation  metal ion binding  positive regulation of stress fiber assembly  protein serine phosphatase activity  protein threonine phosphatase activity  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  nucleoplasm  nucleolus  mitochondrion  negative regulation of protein kinase activity  negative regulation of protein kinase activity  protein dephosphorylation  protein-containing complex  cellular response to drug  peptidyl-threonine dephosphorylation  metal ion binding  positive regulation of stress fiber assembly  protein serine phosphatase activity  protein threonine phosphatase activity  
NDEx NetworkPPM1E
Atlas of Cancer Signalling NetworkPPM1E
Wikipedia pathwaysPPM1E
Orthology - Evolution
OrthoDB22843
GeneTree (enSembl)ENSG00000175175
Phylogenetic Trees/Animal Genes : TreeFamPPM1E
Homologs : HomoloGenePPM1E
Homology/Alignments : Family Browser (UCSC)PPM1E
Gene fusions - Rearrangements
Fusion : MitelmanKCND3/PPM1E [1p13.2/17q22]  
Fusion : MitelmanPPM1E/SPAG5 [17q22/17q11.2]  
Fusion : MitelmanPPM1E/VMP1 [17q22/17q23.1]  
Fusion : QuiverPPM1E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPM1E
dbVarPPM1E
ClinVarPPM1E
MonarchPPM1E
1000_GenomesPPM1E 
Exome Variant ServerPPM1E
GNOMAD BrowserENSG00000175175
Varsome BrowserPPM1E
ACMGPPM1E variants
VarityQ8WY54
Genomic Variants (DGV)PPM1E [DGVbeta]
DECIPHERPPM1E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPM1E 
Mutations
ICGC Data PortalPPM1E 
TCGA Data PortalPPM1E 
Broad Tumor PortalPPM1E
OASIS PortalPPM1E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1E  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPM1E
Mutations and Diseases : HGMDPPM1E
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPM1E
DgiDB (Drug Gene Interaction Database)PPM1E
DoCM (Curated mutations)PPM1E
CIViC (Clinical Interpretations of Variants in Cancer)PPM1E
Cancer3DPPM1E
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619308   
Orphanet
DisGeNETPPM1E
MedgenPPM1E
Genetic Testing Registry PPM1E
NextProtQ8WY54 [Medical]
GENETestsPPM1E
Target ValidationPPM1E
Huge Navigator PPM1E [HugePedia]
ClinGenPPM1E
Clinical trials, drugs, therapy
MyCancerGenomePPM1E
Protein Interactions : CTDPPM1E
Pharm GKB GenePA134943567
PharosQ8WY54
Clinical trialPPM1E
Miscellaneous
canSAR (ICR)PPM1E
HarmonizomePPM1E
DataMed IndexPPM1E
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPM1E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:22 CEST 2021

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