Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F)

Identity

Alias_namesprotein phosphatase 1F (PP2C domain containing)
protein phosphatase, Mg2?? dependent, 1F
Alias_symbol (synonym)FEM-2
KIAA0015
POPX2
CaMKPase
CAMKP
Other aliashFEM-2
HGNC (Hugo) PPM1F
LocusID (NCBI) 9647
Atlas_Id 43425
Location 22q11.22  [Link to chromosome band 22q11]
Location_base_pair Starts at 21919419 and ends at 21952878 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPM1F (22q11.22) / HDAC4 (2q37.3)PPM1F (22q11.22) / POLR3A (10q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPM1F   19388
Cards
Entrez_Gene (NCBI)PPM1F  9647  protein phosphatase, Mg2+/Mn2+ dependent 1F
AliasesCAMKP; CaMKPase; FEM-2; POPX2; 
hFEM-2
GeneCards (Weizmann)PPM1F
Ensembl hg19 (Hinxton)ENSG00000100034 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100034 [Gene_View]  chr22:21919419-21952878 [Contig_View]  PPM1F [Vega]
ICGC DataPortalENSG00000100034
TCGA cBioPortalPPM1F
AceView (NCBI)PPM1F
Genatlas (Paris)PPM1F
WikiGenes9647
SOURCE (Princeton)PPM1F
Genetics Home Reference (NIH)PPM1F
Genomic and cartography
GoldenPath hg38 (UCSC)PPM1F  -     chr22:21919419-21952878 -  22q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPM1F  -     22q11.22   [Description]    (hg19-Feb_2009)
EnsemblPPM1F - 22q11.22 [CytoView hg19]  PPM1F - 22q11.22 [CytoView hg38]
Mapping of homologs : NCBIPPM1F [Mapview hg19]  PPM1F [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF305840 AF520615 AK126377 AK291628 AK294557
RefSeq transcript (Entrez)NM_014634
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPM1F
Cluster EST : UnigeneHs.112728 [ NCBI ]
CGAP (NCI)Hs.112728
Alternative Splicing GalleryENSG00000100034
Gene ExpressionPPM1F [ NCBI-GEO ]   PPM1F [ EBI - ARRAY_EXPRESS ]   PPM1F [ SEEK ]   PPM1F [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1F [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9647
GTEX Portal (Tissue expression)PPM1F
Human Protein AtlasENSG00000100034-PPM1F [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49593   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49593  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49593
Splice isoforms : SwissVarP49593
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP49593
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2C_SIG (SM00331)  PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1F
DMDM Disease mutations9647
Blocks (Seattle)PPM1F
SuperfamilyP49593
Human Protein Atlas [tissue]ENSG00000100034-PPM1F [tissue]
Peptide AtlasP49593
HPRD10163
IPIIPI00291412   IPI00878280   IPI00878160   IPI00877996   IPI00878193   
Protein Interaction databases
DIP (DOE-UCLA)P49593
IntAct (EBI)P49593
FunCoupENSG00000100034
BioGRIDPPM1F
STRING (EMBL)PPM1F
ZODIACPPM1F
Ontologies - Pathways
QuickGOP49593
Ontology : AmiGOprotein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  cytosol  negative regulation of protein kinase activity  positive regulation of gene expression  positive regulation of epithelial cell migration  positive regulation of cell-substrate adhesion  histone dephosphorylation  negative regulation of peptidyl-serine phosphorylation  calmodulin-dependent protein phosphatase activity  cellular response to drug  peptidyl-threonine dephosphorylation  protein complex  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of transcription, DNA-templated  positive regulation of growth  metal ion binding  perinuclear region of cytoplasm  positive regulation of chemotaxis  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  positive regulation of focal adhesion assembly  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  cytosol  negative regulation of protein kinase activity  positive regulation of gene expression  positive regulation of epithelial cell migration  positive regulation of cell-substrate adhesion  histone dephosphorylation  negative regulation of peptidyl-serine phosphorylation  calmodulin-dependent protein phosphatase activity  cellular response to drug  peptidyl-threonine dephosphorylation  protein complex  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of transcription, DNA-templated  positive regulation of growth  metal ion binding  perinuclear region of cytoplasm  positive regulation of chemotaxis  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  positive regulation of focal adhesion assembly  intrinsic apoptotic signaling pathway  
NDEx NetworkPPM1F
Atlas of Cancer Signalling NetworkPPM1F
Wikipedia pathwaysPPM1F
Orthology - Evolution
OrthoDB9647
GeneTree (enSembl)ENSG00000100034
Phylogenetic Trees/Animal Genes : TreeFamPPM1F
HOVERGENP49593
HOGENOMP49593
Homologs : HomoloGenePPM1F
Homology/Alignments : Family Browser (UCSC)PPM1F
Gene fusions - Rearrangements
Fusion : QuiverPPM1F
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1F [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPM1F
dbVarPPM1F
ClinVarPPM1F
1000_GenomesPPM1F 
Exome Variant ServerPPM1F
ExAC (Exome Aggregation Consortium)ENSG00000100034
GNOMAD BrowserENSG00000100034
Genetic variants : HAPMAP9647
Genomic Variants (DGV)PPM1F [DGVbeta]
DECIPHERPPM1F [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPM1F 
Mutations
ICGC Data PortalPPM1F 
TCGA Data PortalPPM1F 
Broad Tumor PortalPPM1F
OASIS PortalPPM1F [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1F  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPM1F
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPM1F
DgiDB (Drug Gene Interaction Database)PPM1F
DoCM (Curated mutations)PPM1F (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPM1F (select a term)
intoGenPPM1F
Cancer3DPPM1F(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPPM1F
MedgenPPM1F
Genetic Testing Registry PPM1F
NextProtP49593 [Medical]
TSGene9647
GENETestsPPM1F
Target ValidationPPM1F
Huge Navigator PPM1F [HugePedia]
snp3D : Map Gene to Disease9647
BioCentury BCIQPPM1F
ClinGenPPM1F
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9647
Chemical/Pharm GKB GenePA134935566
Clinical trialPPM1F
Miscellaneous
canSAR (ICR)PPM1F (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPM1F
EVEXPPM1F
GoPubMedPPM1F
iHOPPPM1F
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:31:53 CET 2018
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