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PPM1F (protein phosphatase, Mg2+/Mn2+ dependent, 1F)

Identity

Other namesCAMKP
CaMKPase
FEM-2
POPX2
hFEM-2
HGNC (Hugo) PPM1F
LocusID (NCBI) 9647
Location 22q11.22
Location_base_pair Starts at 22273792 and ends at 22307250 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPM1F   19388
Entrez_Gene (NCBI)PPM1F  9647  protein phosphatase, Mg2+/Mn2+ dependent, 1F
Cards
GeneCards (Weizmann)PPM1F
Ensembl (Hinxton)ENSG00000100034 [Gene_View]  chr22:22273792-22307250 [Contig_View]  PPM1F [Vega]
AceView (NCBI)PPM1F
Genatlas (Paris)PPM1F
SOURCE (Stanford)NM_014634
Genomic and cartography
GoldenPath (UCSC)PPM1F  -  22q11.22   chr22:22273792-22307250 -  22q11.22   [Description]    (hg19-Feb_2009)
EnsemblPPM1F - 22q11.22 [CytoView]
Mapping of homologs : NCBIPPM1F [Mapview]
Gene and transcription
Genbank (Entrez)AF305840 AF520615 AK126377 AK291628 AK294557
RefSeq transcript (SRS)NM_014634
RefSeq transcript (Entrez)NM_014634
RefSeq genomic (SRS)AC_000154 NC_000022 NC_018933 NT_011520 NW_001838745 NW_004078112
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NT_011520 NW_001838745 NW_004078112
Consensus coding sequences : CCDS (NCBI)PPM1F
Cluster EST : UnigeneHs.112728 [ SRS ] Hs.112728 [ NCBI ]
CGAP (NCI)Hs.112728
Alternative Splicing : Fast-db (Paris)GSHG0020226
Alternative Splicing GalleryENSG00000100034
Gene ExpressionPPM1F [ NCBI-GEO ]   PPM1F [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49593 (SRS) P49593 (Uniprot)
NextProtP49593
With graphics : InterProP49593
Splice isoforms : SwissVarP49593(Swissvar)
Domaine pattern : Prosite (SRS)PP2C (PS01032)   
Domaine pattern : Prosite (Expaxy)PP2C (PS01032)   
Domains : Interpro (SRS)PP2C-like    PP2C_Mn2_Asp60_BS    Protein_Pase_2C   
Domains : Interpro (EBI)PP2C-like    PP2C_Mn2_Asp60_BS    Protein_Pase_2C   
Related proteins : CluSTrP49593
Domain families : Pfam (SRS)PP2C (PF00481)   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2C_SIG (SM00331)  PP2Cc (SM00332)  
DMDM9647
Blocks (Seattle)P49593
Human Protein AtlasENSG00000100034
HPRD10163
IPIIPI00291412   IPI00878280   IPI00878160   IPI00877996   IPI00878193   
Protein Interaction databases
DIP (DOE-UCLA)P49593
IntAct (EBI)P49593
FunCoupENSG00000100034
REACTOMEPPM1F
Protein Interaction Database9647
BioGRIDPPM1F
InParanoidP49593
Interologous Interaction database P49593
IntegromeDBPPM1F
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PPM1F
SNP (GeneSNP Utah)PPM1F
SNP : HGBasePPM1F
Genetic variants : HAPMAPPPM1F
Somatic Mutations in Cancer : COSMICPPM1F 
CONAN: Copy Number AnalysisPPM1F 
Mutations and Diseases : HGMDPPM1F
OMIM
GENETests
Disease Genetic AssociationPPM1F
Huge Navigator PPM1F [HugePedia]  PPM1F [HugeCancerGEM]
Genomic VariantsPPM1F  PPM1F [DGVbeta]
ClinVarPPM1F
snp3D : Map Gene to Disease9647
General knowledge
Homologs : HomoloGenePPM1F
Homology/Alignments : Family Browser (UCSC)PPM1F
Phylogenetic Trees/Animal Genes : TreeFamPPM1F
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.16 [ Enzyme-SRS ]   3.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
Chemical/Protein Interactions : CTD9647
Chemical/Pharm GKB GenePA134935566
Clinical trialPPM1F
Cancer Resource (Charite)ENSG00000100034
Ontology : AmiGOprotein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  cytosol  negative regulation of protein kinase activity  positive regulation of gene expression  positive regulation of epithelial cell migration  positive regulation of cell-substrate adhesion  phosphatase activity  negative regulation of peptidyl-serine phosphorylation  calmodulin-dependent protein phosphatase activity  cellular response to drug  peptidyl-threonine dephosphorylation  protein complex  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of transcription, DNA-dependent  positive regulation of growth  metal ion binding  perinuclear region of cytoplasm  positive regulation of chemotaxis  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  positive regulation of focal adhesion assembly  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  cytosol  negative regulation of protein kinase activity  positive regulation of gene expression  positive regulation of epithelial cell migration  positive regulation of cell-substrate adhesion  phosphatase activity  negative regulation of peptidyl-serine phosphorylation  calmodulin-dependent protein phosphatase activity  cellular response to drug  peptidyl-threonine dephosphorylation  protein complex  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of protein kinase activity by regulation of protein phosphorylation  negative regulation of transcription, DNA-dependent  positive regulation of growth  metal ion binding  perinuclear region of cytoplasm  positive regulation of chemotaxis  positive regulation of stress fiber assembly  positive regulation of stress fiber assembly  positive regulation of focal adhesion assembly  intrinsic apoptotic signaling pathway  
Other databases
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
PubGenePPM1F
iHOPPPM1F
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:56:59 CEST 2013
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