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PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G)

Identity

Alias_namesprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
protein phosphatase, Mg2?? dependent, 1G
Alias_symbol (synonym)PP2CG
PP2Cgamma
Other aliasPP2CGAMMA
PPP2CG
HGNC (Hugo) PPM1G
LocusID (NCBI) 5496
Atlas_Id 46927
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 27381199 and ends at 27409683 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APLP2 (11q24.3) / PPM1G (2p23.3)HSPA5 (9q33.3) / PPM1G (2p23.3)IQCE (7p22.3) / PPM1G (2p23.3)
MEG3 (14q32.2) / PPM1G (2p23.3)PCNX3 (11q13.1) / PPM1G (2p23.3)PPM1G (2p23.3) / DDX25 (11q24.2)
PPM1G (2p23.3) / FOXO3 (6q21)PPM1G (2p23.3) / MPPE1 (18p11.21)PPM1G (2p23.3) / PPM1G (2p23.3)
RASAL2 (1q25.2) / PPM1G (2p23.3)TLK2 (17q23.2) / PPM1G (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPM1G   9278
Cards
Entrez_Gene (NCBI)PPM1G  5496  protein phosphatase, Mg2+/Mn2+ dependent 1G
AliasesPP2CG; PP2CGAMMA; PPP2CG
GeneCards (Weizmann)PPM1G
Ensembl hg19 (Hinxton)ENSG00000115241 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115241 [Gene_View]  chr2:27381199-27409683 [Contig_View]  PPM1G [Vega]
ICGC DataPortalENSG00000115241
TCGA cBioPortalPPM1G
AceView (NCBI)PPM1G
Genatlas (Paris)PPM1G
WikiGenes5496
SOURCE (Princeton)PPM1G
Genetics Home Reference (NIH)PPM1G
Genomic and cartography
GoldenPath hg38 (UCSC)PPM1G  -     chr2:27381199-27409683 -  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPM1G  -     2p23.3   [Description]    (hg19-Feb_2009)
EnsemblPPM1G - 2p23.3 [CytoView hg19]  PPM1G - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIPPM1G [Mapview hg19]  PPM1G [Mapview hg38]
OMIM605119   
Gene and transcription
Genbank (Entrez)AB209197 AI623188 AI879284 AK127593 AK293141
RefSeq transcript (Entrez)NM_177983
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPM1G
Cluster EST : UnigeneHs.643951 [ NCBI ]
CGAP (NCI)Hs.643951
Alternative Splicing GalleryENSG00000115241
Gene ExpressionPPM1G [ NCBI-GEO ]   PPM1G [ EBI - ARRAY_EXPRESS ]   PPM1G [ SEEK ]   PPM1G [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1G [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5496
GTEX Portal (Tissue expression)PPM1G
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15355   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15355  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15355
Splice isoforms : SwissVarO15355
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusO15355
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1G
DMDM Disease mutations5496
Blocks (Seattle)PPM1G
SuperfamilyO15355
Human Protein AtlasENSG00000115241
Peptide AtlasO15355
HPRD09237
IPIIPI00006167   IPI01015454   IPI00746326   IPI00449038   
Protein Interaction databases
DIP (DOE-UCLA)O15355
IntAct (EBI)O15355
FunCoupENSG00000115241
BioGRIDPPM1G
STRING (EMBL)PPM1G
ZODIACPPM1G
Ontologies - Pathways
QuickGOO15355
Ontology : AmiGOprotein serine/threonine phosphatase activity  protein binding  nucleus  nucleoplasm  cytoplasm  protein dephosphorylation  cell cycle arrest  membrane  peptidyl-threonine dephosphorylation  metal ion binding  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  protein binding  nucleus  nucleoplasm  cytoplasm  protein dephosphorylation  cell cycle arrest  membrane  peptidyl-threonine dephosphorylation  metal ion binding  
NDEx NetworkPPM1G
Atlas of Cancer Signalling NetworkPPM1G
Wikipedia pathwaysPPM1G
Orthology - Evolution
OrthoDB5496
GeneTree (enSembl)ENSG00000115241
Phylogenetic Trees/Animal Genes : TreeFamPPM1G
HOVERGENO15355
HOGENOMO15355
Homologs : HomoloGenePPM1G
Homology/Alignments : Family Browser (UCSC)PPM1G
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1G [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPM1G
dbVarPPM1G
ClinVarPPM1G
1000_GenomesPPM1G 
Exome Variant ServerPPM1G
ExAC (Exome Aggregation Consortium)PPM1G (select the gene name)
Genetic variants : HAPMAP5496
Genomic Variants (DGV)PPM1G [DGVbeta]
DECIPHERPPM1G [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPM1G 
Mutations
ICGC Data PortalPPM1G 
TCGA Data PortalPPM1G 
Broad Tumor PortalPPM1G
OASIS PortalPPM1G [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1G  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPM1G
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPM1G
DgiDB (Drug Gene Interaction Database)PPM1G
DoCM (Curated mutations)PPM1G (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPM1G (select a term)
intoGenPPM1G
Cancer3DPPM1G(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605119   
Orphanet
MedgenPPM1G
Genetic Testing Registry PPM1G
NextProtO15355 [Medical]
TSGene5496
GENETestsPPM1G
Target ValidationPPM1G
Huge Navigator PPM1G [HugePedia]
snp3D : Map Gene to Disease5496
BioCentury BCIQPPM1G
ClinGenPPM1G
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5496
Chemical/Pharm GKB GenePA33606
Clinical trialPPM1G
Miscellaneous
canSAR (ICR)PPM1G (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPM1G
EVEXPPM1G
GoPubMedPPM1G
iHOPPPM1G
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:34 CEST 2017

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