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PPM1J (protein phosphatase, Mg2+/Mn2+ dependent 1J)

Identity

Alias (NCBI)PP2CZ
PP2Czeta
PPP2CZ
HGNC (Hugo) PPM1J
HGNC Alias symbFLJ35951
MGC19531
DKFZp434P1514
PP2Czeta
PPP2CZ
HGNC Alias nameprotein phosphatase 2C zeta
HGNC Previous nameprotein phosphatase 1J (PP2C domain containing)
 protein phosphatase, Mg2+/Mn2+ dependent, 1J
LocusID (NCBI) 333926
Atlas_Id 72138
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 112709994 and ends at 112715328 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPM1J   20785
Cards
Entrez_Gene (NCBI)PPM1J    protein phosphatase, Mg2+/Mn2+ dependent 1J
AliasesPP2CZ; PP2Czeta; PPP2CZ
GeneCards (Weizmann)PPM1J
Ensembl hg19 (Hinxton)ENSG00000155367 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155367 [Gene_View]  ENSG00000155367 [Sequence]  chr1:112709994-112715328 [Contig_View]  PPM1J [Vega]
ICGC DataPortalENSG00000155367
TCGA cBioPortalPPM1J
AceView (NCBI)PPM1J
Genatlas (Paris)PPM1J
SOURCE (Princeton)PPM1J
Genetics Home Reference (NIH)PPM1J
Genomic and cartography
GoldenPath hg38 (UCSC)PPM1J  -     chr1:112709994-112715328 -  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPM1J  -     1p13.2   [Description]    (hg19-Feb_2009)
GoldenPathPPM1J - 1p13.2 [CytoView hg19]  PPM1J - 1p13.2 [CytoView hg38]
ImmunoBaseENSG00000155367
genome Data Viewer NCBIPPM1J [Mapview hg19]  
OMIM609957   
Gene and transcription
Genbank (Entrez)AB451327 AB451471 AK093270 AL133644 AL545356
RefSeq transcript (Entrez)NM_005167
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPM1J
Alternative Splicing GalleryENSG00000155367
Gene ExpressionPPM1J [ NCBI-GEO ]   PPM1J [ EBI - ARRAY_EXPRESS ]   PPM1J [ SEEK ]   PPM1J [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1J [ Firebrowse - Broad ]
GenevisibleExpression of PPM1J in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)333926
GTEX Portal (Tissue expression)PPM1J
Human Protein AtlasENSG00000155367-PPM1J [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5JR12   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5JR12  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5JR12
Splice isoforms : SwissVarQ5JR12
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ5JR12
Domaine pattern : Prosite (Expaxy)PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PPM-type_dom_sf    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1J
Blocks (Seattle)PPM1J
SuperfamilyQ5JR12
Human Protein Atlas [tissue]ENSG00000155367-PPM1J [tissue]
Peptide AtlasQ5JR12
HPRD15171
IPIIPI00376886   IPI00844458   
Protein Interaction databases
DIP (DOE-UCLA)Q5JR12
IntAct (EBI)Q5JR12
BioGRIDPPM1J
STRING (EMBL)PPM1J
ZODIACPPM1J
Ontologies - Pathways
QuickGOQ5JR12
Ontology : AmiGOprotein serine/threonine phosphatase activity  magnesium-dependent protein serine/threonine phosphatase activity  [pyruvate dehydrogenase (lipoamide)] phosphatase activity  mitochondrion  protein dephosphorylation  positive regulation of pyruvate dehydrogenase activity  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  magnesium-dependent protein serine/threonine phosphatase activity  [pyruvate dehydrogenase (lipoamide)] phosphatase activity  mitochondrion  protein dephosphorylation  positive regulation of pyruvate dehydrogenase activity  
Pathways : KEGGTight junction   
NDEx NetworkPPM1J
Atlas of Cancer Signalling NetworkPPM1J
Wikipedia pathwaysPPM1J
Orthology - Evolution
OrthoDB333926
GeneTree (enSembl)ENSG00000155367
Phylogenetic Trees/Animal Genes : TreeFamPPM1J
HOGENOMQ5JR12
Homologs : HomoloGenePPM1J
Homology/Alignments : Family Browser (UCSC)PPM1J
Gene fusions - Rearrangements
Fusion : QuiverPPM1J
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1J [hg38]
dbVarPPM1J
ClinVarPPM1J
MonarchPPM1J
1000_GenomesPPM1J 
Exome Variant ServerPPM1J
GNOMAD BrowserENSG00000155367
Varsome BrowserPPM1J
Genomic Variants (DGV)PPM1J [DGVbeta]
DECIPHERPPM1J [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPM1J 
Mutations
ICGC Data PortalPPM1J 
TCGA Data PortalPPM1J 
Broad Tumor PortalPPM1J
OASIS PortalPPM1J [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1J  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPM1J
Mutations and Diseases : HGMDPPM1J
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPM1J
DgiDB (Drug Gene Interaction Database)PPM1J
DoCM (Curated mutations)PPM1J (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPM1J (select a term)
intoGenPPM1J
Cancer3DPPM1J(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609957   
Orphanet
DisGeNETPPM1J
MedgenPPM1J
Genetic Testing Registry PPM1J
NextProtQ5JR12 [Medical]
GENETestsPPM1J
Target ValidationPPM1J
Huge Navigator PPM1J [HugePedia]
ClinGenPPM1J
Clinical trials, drugs, therapy
MyCancerGenomePPM1J
Protein Interactions : CTD
Pharm GKB GenePA142671150
Clinical trialPPM1J
Miscellaneous
canSAR (ICR)PPM1J (select the gene name)
HarmonizomePPM1J
DataMed IndexPPM1J
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPM1J
EVEXPPM1J
GoPubMedPPM1J
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:23:15 CET 2020
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