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PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K)

Identity

Alias_namesprotein phosphatase 1K (PP2C domain containing)
protein phosphatase, Mg2?? dependent, 1K
Alias_symbol (synonym)DKFZp761G058
PP2Ckappa
hPTMP
PP2Cm
BDP
Other aliasMSUDMV
PTMP
UG0882E07
HGNC (Hugo) PPM1K
LocusID (NCBI) 152926
Atlas_Id 40324
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 88257609 and ends at 88284831 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPM1K (4q22.1) / IDS (Xq28)PPM1K (4q22.1) / LRPPRC (2p21)PPM1K (4q22.1) / PFN3 (5q35.3)
SQSTM1 (5q35.3) / PPM1K (4q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPM1K   25415
Cards
Entrez_Gene (NCBI)PPM1K  152926  protein phosphatase, Mg2+/Mn2+ dependent 1K
AliasesBDP; MSUDMV; PP2Ckappa; PP2Cm; 
PTMP; UG0882E07
GeneCards (Weizmann)PPM1K
Ensembl hg19 (Hinxton)ENSG00000163644 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163644 [Gene_View]  chr4:88257609-88284831 [Contig_View]  PPM1K [Vega]
ICGC DataPortalENSG00000163644
TCGA cBioPortalPPM1K
AceView (NCBI)PPM1K
Genatlas (Paris)PPM1K
WikiGenes152926
SOURCE (Princeton)PPM1K
Genetics Home Reference (NIH)PPM1K
Genomic and cartography
GoldenPath hg38 (UCSC)PPM1K  -     chr4:88257609-88284831 -  4q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPM1K  -     4q22.1   [Description]    (hg19-Feb_2009)
EnsemblPPM1K - 4q22.1 [CytoView hg19]  PPM1K - 4q22.1 [CytoView hg38]
Mapping of homologs : NCBIPPM1K [Mapview hg19]  PPM1K [Mapview hg38]
OMIM611065   615135   
Gene and transcription
Genbank (Entrez)AF351614 AK054678 AK092450 AK314417 AL834167
RefSeq transcript (Entrez)NM_152542
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPM1K
Cluster EST : UnigeneHs.43744 [ NCBI ]
CGAP (NCI)Hs.43744
Alternative Splicing GalleryENSG00000163644
Gene ExpressionPPM1K [ NCBI-GEO ]   PPM1K [ EBI - ARRAY_EXPRESS ]   PPM1K [ SEEK ]   PPM1K [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1K [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)152926
GTEX Portal (Tissue expression)PPM1K
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N3J5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N3J5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N3J5
Splice isoforms : SwissVarQ8N3J5
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusQ8N3J5
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2C_SIG (SM00331)  PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1K
DMDM Disease mutations152926
Blocks (Seattle)PPM1K
PDB (SRS)2IQ1    4DA1   
PDB (PDBSum)2IQ1    4DA1   
PDB (IMB)2IQ1    4DA1   
PDB (RSDB)2IQ1    4DA1   
Structural Biology KnowledgeBase2IQ1    4DA1   
SCOP (Structural Classification of Proteins)2IQ1    4DA1   
CATH (Classification of proteins structures)2IQ1    4DA1   
SuperfamilyQ8N3J5
Human Protein AtlasENSG00000163644
Peptide AtlasQ8N3J5
HPRD15167
IPIIPI00292799   IPI00217525   IPI00827632   
Protein Interaction databases
DIP (DOE-UCLA)Q8N3J5
IntAct (EBI)Q8N3J5
FunCoupENSG00000163644
BioGRIDPPM1K
STRING (EMBL)PPM1K
ZODIACPPM1K
Ontologies - Pathways
QuickGOQ8N3J5
Ontology : AmiGOprotein serine/threonine phosphatase activity  protein binding  mitochondrion  mitochondrial matrix  protein dephosphorylation  branched-chain amino acid catabolic process  metal ion binding  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  protein binding  mitochondrion  mitochondrial matrix  protein dephosphorylation  branched-chain amino acid catabolic process  metal ion binding  
NDEx NetworkPPM1K
Atlas of Cancer Signalling NetworkPPM1K
Wikipedia pathwaysPPM1K
Orthology - Evolution
OrthoDB152926
GeneTree (enSembl)ENSG00000163644
Phylogenetic Trees/Animal Genes : TreeFamPPM1K
HOVERGENQ8N3J5
HOGENOMQ8N3J5
Homologs : HomoloGenePPM1K
Homology/Alignments : Family Browser (UCSC)PPM1K
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1K [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPM1K
dbVarPPM1K
ClinVarPPM1K
1000_GenomesPPM1K 
Exome Variant ServerPPM1K
ExAC (Exome Aggregation Consortium)PPM1K (select the gene name)
Genetic variants : HAPMAP152926
Genomic Variants (DGV)PPM1K [DGVbeta]
DECIPHERPPM1K [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPM1K 
Mutations
ICGC Data PortalPPM1K 
TCGA Data PortalPPM1K 
Broad Tumor PortalPPM1K
OASIS PortalPPM1K [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1K  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPM1K
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PPM1K
DgiDB (Drug Gene Interaction Database)PPM1K
DoCM (Curated mutations)PPM1K (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPM1K (select a term)
intoGenPPM1K
Cancer3DPPM1K(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611065    615135   
Orphanet20169   
MedgenPPM1K
Genetic Testing Registry PPM1K
NextProtQ8N3J5 [Medical]
TSGene152926
GENETestsPPM1K
Target ValidationPPM1K
Huge Navigator PPM1K [HugePedia]
snp3D : Map Gene to Disease152926
BioCentury BCIQPPM1K
ClinGenPPM1K
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD152926
Chemical/Pharm GKB GenePA134912083
Clinical trialPPM1K
Miscellaneous
canSAR (ICR)PPM1K (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPM1K
EVEXPPM1K
GoPubMedPPM1K
iHOPPPM1K
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Jun 7 12:50:34 CEST 2017

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