Identity
HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
BDP,MSUDMV,PP2Ckappa,PP2Cm,PTMP,UG0882E07
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 152926
MIM: 611065
HGNC: 25415
Ensembl: ENSG00000163644
Variants:
dbSNP: 152926
ClinVar: 152926
TCGA: ENSG00000163644
COSMIC: PPM1K
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of amino acids and derivatives | REACTOME | R-HSA-71291 |
| Branched-chain amino acid catabolism | REACTOME | R-HSA-70895 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36863088 | 2023 | PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome. | 4 |
| 36863088 | 2023 | PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome. | 4 |
| 33964402 | 2021 | The role of PP5 and PP2C in cardiac health and disease. | 8 |
| 34382495 | 2021 | Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease. | 5 |
| 33964402 | 2021 | The role of PP5 and PP2C in cardiac health and disease. | 8 |
| 34382495 | 2021 | Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease. | 5 |
| 30451284 | 2019 | Crystal structure and catalytic activity of the PPM1K N94K mutant. | 4 |
| 30451284 | 2019 | Crystal structure and catalytic activity of the PPM1K N94K mutant. | 4 |
| 29855804 | 2018 | Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese. | 9 |
| 29855804 | 2018 | Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese. | 9 |
| 28768654 | 2017 | Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial. | 17 |
| 28768654 | 2017 | Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial. | 17 |
| 26592513 | 2015 | Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells. | 5 |
| 26592513 | 2015 | Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells. | 5 |
| 23446828 | 2013 | Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. | 36 |
Citation
Dessen P
PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/40324/ppm1k
