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PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)

Identity

Alias_namesprotein phosphatase 1 (formerly 2C)-like
protein phosphatase, Mg2?? dependent, 1L
Alias_symbol (synonym)PP2CE
Other aliasPP2C-epsilon
PPM1-LIKE
HGNC (Hugo) PPM1L
LocusID (NCBI) 151742
Atlas_Id 46827
Location 3q25.33  [Link to chromosome band 3q25]
Location_base_pair Starts at 160560001 and ends at 160796695 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PPM1L (3q25.33) / MCF2L2 (3q27.1)RNF213 (17q25.3) / PPM1L (3q25.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PPM1L   16381
Cards
Entrez_Gene (NCBI)PPM1L  151742  protein phosphatase, Mg2+/Mn2+ dependent 1L
AliasesPP2C-epsilon; PP2CE; PPM1-LIKE
GeneCards (Weizmann)PPM1L
Ensembl hg19 (Hinxton)ENSG00000163590 [Gene_View]  chr3:160560001-160796695 [Contig_View]  PPM1L [Vega]
Ensembl hg38 (Hinxton)ENSG00000163590 [Gene_View]  chr3:160560001-160796695 [Contig_View]  PPM1L [Vega]
ICGC DataPortalENSG00000163590
TCGA cBioPortalPPM1L
AceView (NCBI)PPM1L
Genatlas (Paris)PPM1L
WikiGenes151742
SOURCE (Princeton)PPM1L
Genetics Home Reference (NIH)PPM1L
Genomic and cartography
GoldenPath hg19 (UCSC)PPM1L  -     chr3:160560001-160796695 +  3q25.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPM1L  -     3q25.33   [Description]    (hg38-Dec_2013)
EnsemblPPM1L - 3q25.33 [CytoView hg19]  PPM1L - 3q25.33 [CytoView hg38]
Mapping of homologs : NCBIPPM1L [Mapview hg19]  PPM1L [Mapview hg38]
OMIM611931   
Gene and transcription
Genbank (Entrez)AK055115 AK055323 AK055510 AK092378 AW274846
RefSeq transcript (Entrez)NM_001317911 NM_001317912 NM_139245
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)PPM1L
Cluster EST : UnigeneHs.701353 [ NCBI ]
CGAP (NCI)Hs.701353
Alternative Splicing GalleryENSG00000163590
Gene ExpressionPPM1L [ NCBI-GEO ]   PPM1L [ EBI - ARRAY_EXPRESS ]   PPM1L [ SEEK ]   PPM1L [ MEM ]
Gene Expression Viewer (FireBrowse)PPM1L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)151742
GTEX Portal (Tissue expression)PPM1L
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5SGD2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5SGD2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5SGD2
Splice isoforms : SwissVarQ5SGD2
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusQ5SGD2
Domaine pattern : Prosite (Expaxy)PPM_1 (PS01032)    PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PP2C_BS    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2C_SIG (SM00331)  PP2Cc (SM00332)  
Conserved Domain (NCBI)PPM1L
DMDM Disease mutations151742
Blocks (Seattle)PPM1L
SuperfamilyQ5SGD2
Human Protein AtlasENSG00000163590
Peptide AtlasQ5SGD2
HPRD17889
IPIIPI00186145   IPI00657835   IPI00938040   IPI00938269   
Protein Interaction databases
DIP (DOE-UCLA)Q5SGD2
IntAct (EBI)Q5SGD2
FunCoupENSG00000163590
BioGRIDPPM1L
STRING (EMBL)PPM1L
ZODIACPPM1L
Ontologies - Pathways
QuickGOQ5SGD2
Ontology : AmiGOMAPK cascade  protein serine/threonine phosphatase activity  endoplasmic reticulum membrane  protein dephosphorylation  transmembrane receptor protein serine/threonine kinase signaling pathway  integral component of membrane  sphingolipid biosynthetic process  metal ion binding  extracellular exosome  
Ontology : EGO-EBIMAPK cascade  protein serine/threonine phosphatase activity  endoplasmic reticulum membrane  protein dephosphorylation  transmembrane receptor protein serine/threonine kinase signaling pathway  integral component of membrane  sphingolipid biosynthetic process  metal ion binding  extracellular exosome  
NDEx NetworkPPM1L
Atlas of Cancer Signalling NetworkPPM1L
Wikipedia pathwaysPPM1L
Orthology - Evolution
OrthoDB151742
GeneTree (enSembl)ENSG00000163590
Phylogenetic Trees/Animal Genes : TreeFamPPM1L
HOVERGENQ5SGD2
HOGENOMQ5SGD2
Homologs : HomoloGenePPM1L
Homology/Alignments : Family Browser (UCSC)PPM1L
Gene fusions - Rearrangements
Fusion : MitelmanPPM1L/MCF2L2 [3q25.33/3q27.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPM1L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPM1L
dbVarPPM1L
ClinVarPPM1L
1000_GenomesPPM1L 
Exome Variant ServerPPM1L
ExAC (Exome Aggregation Consortium)PPM1L (select the gene name)
Genetic variants : HAPMAP151742
Genomic Variants (DGV)PPM1L [DGVbeta]
DECIPHER (Syndromes)3:160560001-160796695  ENSG00000163590
CONAN: Copy Number AnalysisPPM1L 
Mutations
ICGC Data PortalPPM1L 
TCGA Data PortalPPM1L 
Broad Tumor PortalPPM1L
OASIS PortalPPM1L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPM1L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPM1L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPM1L
DgiDB (Drug Gene Interaction Database)PPM1L
DoCM (Curated mutations)PPM1L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPM1L (select a term)
intoGenPPM1L
Cancer3DPPM1L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611931   
Orphanet
MedgenPPM1L
Genetic Testing Registry PPM1L
NextProtQ5SGD2 [Medical]
TSGene151742
GENETestsPPM1L
Huge Navigator PPM1L [HugePedia]
snp3D : Map Gene to Disease151742
BioCentury BCIQPPM1L
ClinGenPPM1L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD151742
Chemical/Pharm GKB GenePA134871016
Clinical trialPPM1L
Miscellaneous
canSAR (ICR)PPM1L (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPM1L
EVEXPPM1L
GoPubMedPPM1L
iHOPPPM1L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:22:27 CET 2017

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