PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)

2007-04-01  

Identity

HGNC
LOCATION
3q25.33
LOCUSID
ALIAS
PP2C-epsilon,PP2CE,PPM1-LIKE
FUSION GENES

Other Information

Locus ID:

NCBI: 151742
MIM: 611931
HGNC: 16381
Ensembl: ENSG00000163590

Variants:

dbSNP: 151742
ClinVar: 151742
TCGA: ENSG00000163590
COSMIC: PPM1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163590ENST00000295839Q5SGD2
ENSG00000163590ENST00000464260Q5SGD2
ENSG00000163590ENST00000497343Q5SGD2
ENSG00000163590ENST00000498165Q5SGD2

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
181652322008Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.28
174560472007Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.17
198478902010Genome-wide scan identifies a copy number variable region at 3q26 that regulates PPM1L in APC mutation-negative familial colorectal cancer patients.17
227961122012Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites.10
155603752004Molecular cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon*).1

Citation

Dessen P

PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46827/ppm1l