PPME1 (protein phosphatase methylesterase 1)

2009-06-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
ABDH19,PME-1
FUSION GENES

Other Information

Locus ID:

NCBI: 51400
MIM: 611117
HGNC: 30178
Ensembl: ENSG00000214517

Variants:

dbSNP: 51400
ClinVar: 51400
TCGA: ENSG00000214517
COSMIC: PPME1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000214517ENST00000328257Q9Y570
ENSG00000214517ENST00000328257A0A140VK39
ENSG00000214517ENST00000398427Q9Y570

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224436832013The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.64
213985892011Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.47
192931872009PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.37
178039902008Spatial control of protein phosphatase 2A (de)methylation.21
278109032017NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability.17
279136782016Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.14
227325522012Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.9
242533822014Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target.7
258396652015A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.5
248411982014Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.4

Citation

Dessen P

PPME1 (protein phosphatase methylesterase 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50942/ppme1