Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPME1 (protein phosphatase methylesterase 1)

Identity

Alias_symbol (synonym)PME-1
Other alias
HGNC (Hugo) PPME1
LocusID (NCBI) 51400
Atlas_Id 50942
Location 3q25.33  [Link to chromosome band 3q25]
Location_base_pair Starts at 74171063 and ends at 74254703 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACER3 (11q13.5) / PPME1 (11q13.4)C11orf49 (11p11.2) / PPME1 (11q13.4)PPME1 (11q13.4) / FYCO1 (3p21.31)
PPME1 (11q13.4) / MRPL48 (11q13.4)PPME1 (11q13.4) / NARS2 (11q14.1)PPME1 (11q13.4) / PGM2L1 (11q13.4)
PPME1 (11q13.4) / UVRAG (11q13.5)ACER3 11q13.5 / PPME1 11q13.4C11orf49 11p11.2 / PPME1 11q13.4
PPME1 11q13.4 / NARS2 11q14.1PPME1 11q13.4 / UVRAG 11q13.5

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(3;11)(p21;q13) PPME1/FYCO1
t(11;11)(p11;q13) C11orf49/PPME1
ACER3/PPME1 (11q13)
PPME1/MRPL48 (11q13)
PPME1/UVRAG (11q13)
t(11;11)(q13;q14) PPME1/NARS2

External links

Nomenclature
HGNC (Hugo)PPME1   30178
Cards
Entrez_Gene (NCBI)PPME1  51400  protein phosphatase methylesterase 1
AliasesPME-1
GeneCards (Weizmann)PPME1
Ensembl hg19 (Hinxton)ENSG00000214517 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000214517 [Gene_View]  ENSG00000214517 [Sequence]  chr11:74171063-74254703 [Contig_View]  PPME1 [Vega]
ICGC DataPortalENSG00000214517
TCGA cBioPortalPPME1
AceView (NCBI)PPME1
Genatlas (Paris)PPME1
WikiGenes51400
SOURCE (Princeton)PPME1
Genetics Home Reference (NIH)PPME1
Genomic and cartography
GoldenPath hg38 (UCSC)PPME1  -     chr11:74171063-74254703 +  3q25.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPME1  -     3q25.33   [Description]    (hg19-Feb_2009)
EnsemblPPME1 - 3q25.33 [CytoView hg19]  PPME1 - 3q25.33 [CytoView hg38]
Mapping of homologs : NCBIPPME1 [Mapview hg19]  PPME1 [Mapview hg38]
OMIM611117   
Gene and transcription
Genbank (Entrez)AF111853 AF157028 AK001381 AK022725 AK025414
RefSeq transcript (Entrez)NM_001271593 NM_016147
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPME1
Cluster EST : UnigeneHs.503251 [ NCBI ]
CGAP (NCI)Hs.503251
Alternative Splicing GalleryENSG00000214517
Gene ExpressionPPME1 [ NCBI-GEO ]   PPME1 [ EBI - ARRAY_EXPRESS ]   PPME1 [ SEEK ]   PPME1 [ MEM ]
Gene Expression Viewer (FireBrowse)PPME1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51400
GTEX Portal (Tissue expression)PPME1
Human Protein AtlasENSG00000214517-PPME1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y570   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y570  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y570
Splice isoforms : SwissVarQ9Y570
PhosPhoSitePlusQ9Y570
Domaine pattern : Prosite (Expaxy)LIPASE_SER (PS00120)   
Domains : Interpro (EBI)AB_hydrolase    AB_hydrolase_1    PPase_methylesterase_euk   
Domain families : Pfam (Sanger)Abhydrolase_6 (PF12697)   
Domain families : Pfam (NCBI)pfam12697   
Conserved Domain (NCBI)PPME1
DMDM Disease mutations51400
Blocks (Seattle)PPME1
PDB (SRS)3C5V    3C5W   
PDB (PDBSum)3C5V    3C5W   
PDB (IMB)3C5V    3C5W   
PDB (RSDB)3C5V    3C5W   
Structural Biology KnowledgeBase3C5V    3C5W   
SCOP (Structural Classification of Proteins)3C5V    3C5W   
CATH (Classification of proteins structures)3C5V    3C5W   
SuperfamilyQ9Y570
Human Protein Atlas [tissue]ENSG00000214517-PPME1 [tissue]
Peptide AtlasQ9Y570
HPRD17864
IPIIPI00007694   IPI00412156   IPI00921280   IPI01013834   IPI01011085   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y570
IntAct (EBI)Q9Y570
FunCoupENSG00000214517
BioGRIDPPME1
STRING (EMBL)PPME1
ZODIACPPME1
Ontologies - Pathways
QuickGOQ9Y570
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein phosphatase inhibitor activity  nucleoplasm  protein demethylation  protein demethylation  protein phosphatase regulator activity  protein kinase binding  protein phosphatase binding  negative regulation of phosphoprotein phosphatase activity  cadherin binding  protein phosphatase 2A binding  protein C-terminal methylesterase activity  protein C-terminal methylesterase activity  protein methylesterase activity  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein phosphatase inhibitor activity  nucleoplasm  protein demethylation  protein demethylation  protein phosphatase regulator activity  protein kinase binding  protein phosphatase binding  negative regulation of phosphoprotein phosphatase activity  cadherin binding  protein phosphatase 2A binding  protein C-terminal methylesterase activity  protein C-terminal methylesterase activity  protein methylesterase activity  
NDEx NetworkPPME1
Atlas of Cancer Signalling NetworkPPME1
Wikipedia pathwaysPPME1
Orthology - Evolution
OrthoDB51400
GeneTree (enSembl)ENSG00000214517
Phylogenetic Trees/Animal Genes : TreeFamPPME1
HOVERGENQ9Y570
HOGENOMQ9Y570
Homologs : HomoloGenePPME1
Homology/Alignments : Family Browser (UCSC)PPME1
Gene fusions - Rearrangements
Fusion : MitelmanACER3/PPME1 [11q13.5/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanC11orf49/PPME1 [11p11.2/11q13.4]  [t(11;11)(p11;q13)]  
Fusion : MitelmanPPME1/MRPL48 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPPME1/NARS2 [11q13.4/11q14.1]  [t(11;11)(q13;q14)]  
Fusion : MitelmanPPME1/UVRAG [11q13.4/11q13.5]  [t(11;11)(q13;q13)]  
Fusion PortalACER3 11q13.5 PPME1 11q13.4 LUAD
Fusion PortalC11orf49 11p11.2 PPME1 11q13.4 BRCA
Fusion PortalPPME1 11q13.4 NARS2 11q14.1 BRCA
Fusion PortalPPME1 11q13.4 UVRAG 11q13.5 SKCM
Fusion : QuiverPPME1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPME1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPME1
dbVarPPME1
ClinVarPPME1
1000_GenomesPPME1 
Exome Variant ServerPPME1
ExAC (Exome Aggregation Consortium)ENSG00000214517
GNOMAD BrowserENSG00000214517
Varsome BrowserPPME1
Genetic variants : HAPMAP51400
Genomic Variants (DGV)PPME1 [DGVbeta]
DECIPHERPPME1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPME1 
Mutations
ICGC Data PortalPPME1 
TCGA Data PortalPPME1 
Broad Tumor PortalPPME1
OASIS PortalPPME1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPME1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPME1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPME1
DgiDB (Drug Gene Interaction Database)PPME1
DoCM (Curated mutations)PPME1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPME1 (select a term)
intoGenPPME1
Cancer3DPPME1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611117   
Orphanet
DisGeNETPPME1
MedgenPPME1
Genetic Testing Registry PPME1
NextProtQ9Y570 [Medical]
TSGene51400
GENETestsPPME1
Target ValidationPPME1
Huge Navigator PPME1 [HugePedia]
snp3D : Map Gene to Disease51400
BioCentury BCIQPPME1
ClinGenPPME1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51400
Chemical/Pharm GKB GenePA142671152
Clinical trialPPME1
Miscellaneous
canSAR (ICR)PPME1 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPME1
EVEXPPME1
GoPubMedPPME1
iHOPPPME1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 11:24:45 CEST 2018
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.