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PPP1CC (protein phosphatase 1 catalytic subunit gamma)

Identity

Alias_namesprotein phosphatase 1, catalytic subunit, gamma isoform
protein phosphatase 1, catalytic subunit, gamma isozyme
Alias_symbol (synonym)PP1C
PP1gamma
Other aliasPP-1G
PPP1G
HGNC (Hugo) PPP1CC
LocusID (NCBI) 5501
Atlas_Id 41806
Location 12q24.11  [Link to chromosome band 12q24]
Location_base_pair Starts at 110719808 and ends at 110742978 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CADM2 (3p12.1) / PPP1CC (12q24.11)CDK14 (7q21.13) / PPP1CC (12q24.11)PPP1CC (12q24.11) / CENPF (1q41)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1CC   9283
Cards
Entrez_Gene (NCBI)PPP1CC  5501  protein phosphatase 1 catalytic subunit gamma
AliasesPP-1G; PP1C; PPP1G
GeneCards (Weizmann)PPP1CC
Ensembl hg19 (Hinxton)ENSG00000186298 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186298 [Gene_View]  chr12:110719808-110742978 [Contig_View]  PPP1CC [Vega]
ICGC DataPortalENSG00000186298
TCGA cBioPortalPPP1CC
AceView (NCBI)PPP1CC
Genatlas (Paris)PPP1CC
WikiGenes5501
SOURCE (Princeton)PPP1CC
Genetics Home Reference (NIH)PPP1CC
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1CC  -     chr12:110719808-110742978 -  12q24.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1CC  -     12q24.11   [Description]    (hg19-Feb_2009)
EnsemblPPP1CC - 12q24.11 [CytoView hg19]  PPP1CC - 12q24.11 [CytoView hg38]
Mapping of homologs : NCBIPPP1CC [Mapview hg19]  PPP1CC [Mapview hg38]
OMIM176914   
Gene and transcription
Genbank (Entrez)AA781342 AK091841 AK297882 AW575661 BC014073
RefSeq transcript (Entrez)NM_001244974 NM_002710
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1CC
Cluster EST : UnigeneHs.79081 [ NCBI ]
CGAP (NCI)Hs.79081
Alternative Splicing GalleryENSG00000186298
Gene ExpressionPPP1CC [ NCBI-GEO ]   PPP1CC [ EBI - ARRAY_EXPRESS ]   PPP1CC [ SEEK ]   PPP1CC [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1CC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5501
GTEX Portal (Tissue expression)PPP1CC
Human Protein AtlasENSG00000186298-PPP1CC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36873   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36873  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36873
Splice isoforms : SwissVarP36873
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP36873
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase    STPPase_N   
Domain families : Pfam (Sanger)Metallophos (PF00149)    STPPase_N (PF16891)   
Domain families : Pfam (NCBI)pfam00149    pfam16891   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP1CC
DMDM Disease mutations5501
Blocks (Seattle)PPP1CC
PDB (SRS)1IT6    1JK7    1U32    2BCD    2BDX    4UT2    4UT3    5INB    5J28   
PDB (PDBSum)1IT6    1JK7    1U32    2BCD    2BDX    4UT2    4UT3    5INB    5J28   
PDB (IMB)1IT6    1JK7    1U32    2BCD    2BDX    4UT2    4UT3    5INB    5J28   
PDB (RSDB)1IT6    1JK7    1U32    2BCD    2BDX    4UT2    4UT3    5INB    5J28   
Structural Biology KnowledgeBase1IT6    1JK7    1U32    2BCD    2BDX    4UT2    4UT3    5INB    5J28   
SCOP (Structural Classification of Proteins)1IT6    1JK7    1U32    2BCD    2BDX    4UT2    4UT3    5INB    5J28   
CATH (Classification of proteins structures)1IT6    1JK7    1U32    2BCD    2BDX    4UT2    4UT3    5INB    5J28   
SuperfamilyP36873
Human Protein Atlas [tissue]ENSG00000186298-PPP1CC [tissue]
Peptide AtlasP36873
HPRD08911
IPIIPI00005705   IPI00218187   IPI01022560   IPI01022713   IPI01022618   IPI01023066   IPI01022906   IPI01020909   
Protein Interaction databases
DIP (DOE-UCLA)P36873
IntAct (EBI)P36873
FunCoupENSG00000186298
BioGRIDPPP1CC
STRING (EMBL)PPP1CC
ZODIACPPP1CC
Ontologies - Pathways
QuickGOP36873
Ontology : AmiGOcondensed chromosome kinetochore  nuclear chromosome, telomeric region  RNA binding  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein binding  lamin binding  nucleus  nucleolus  cytoplasm  mitochondrion  mitochondrial outer membrane  cytosol  focal adhesion  glycogen metabolic process  protein dephosphorylation  protein dephosphorylation  sister chromatid cohesion  protein C-terminus binding  protein phosphatase 1 binding  nuclear speck  phosphatase activity  protein kinase binding  protein domain specific binding  neuron differentiation  midbody  cleavage furrow  protein complex binding  circadian regulation of gene expression  regulation of circadian rhythm  entrainment of circadian clock by photoperiod  dendritic spine  protein complex  regulation of nucleocytoplasmic transport  metal ion binding  protein N-terminus binding  cell division  PTW/PP1 phosphatase complex  
Ontology : EGO-EBIcondensed chromosome kinetochore  nuclear chromosome, telomeric region  RNA binding  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein binding  lamin binding  nucleus  nucleolus  cytoplasm  mitochondrion  mitochondrial outer membrane  cytosol  focal adhesion  glycogen metabolic process  protein dephosphorylation  protein dephosphorylation  sister chromatid cohesion  protein C-terminus binding  protein phosphatase 1 binding  nuclear speck  phosphatase activity  protein kinase binding  protein domain specific binding  neuron differentiation  midbody  cleavage furrow  protein complex binding  circadian regulation of gene expression  regulation of circadian rhythm  entrainment of circadian clock by photoperiod  dendritic spine  protein complex  regulation of nucleocytoplasmic transport  metal ion binding  protein N-terminus binding  cell division  PTW/PP1 phosphatase complex  
Pathways : KEGG   
NDEx NetworkPPP1CC
Atlas of Cancer Signalling NetworkPPP1CC
Wikipedia pathwaysPPP1CC
Orthology - Evolution
OrthoDB5501
GeneTree (enSembl)ENSG00000186298
Phylogenetic Trees/Animal Genes : TreeFamPPP1CC
HOVERGENP36873
HOGENOMP36873
Homologs : HomoloGenePPP1CC
Homology/Alignments : Family Browser (UCSC)PPP1CC
Gene fusions - Rearrangements
Fusion: Tumor Portal PPP1CC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1CC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1CC
dbVarPPP1CC
ClinVarPPP1CC
1000_GenomesPPP1CC 
Exome Variant ServerPPP1CC
ExAC (Exome Aggregation Consortium)ENSG00000186298
GNOMAD BrowserENSG00000186298
Genetic variants : HAPMAP5501
Genomic Variants (DGV)PPP1CC [DGVbeta]
DECIPHERPPP1CC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1CC 
Mutations
ICGC Data PortalPPP1CC 
TCGA Data PortalPPP1CC 
Broad Tumor PortalPPP1CC
OASIS PortalPPP1CC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1CC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1CC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1CC
DgiDB (Drug Gene Interaction Database)PPP1CC
DoCM (Curated mutations)PPP1CC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1CC (select a term)
intoGenPPP1CC
Cancer3DPPP1CC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176914   
Orphanet
MedgenPPP1CC
Genetic Testing Registry PPP1CC
NextProtP36873 [Medical]
TSGene5501
GENETestsPPP1CC
Target ValidationPPP1CC
Huge Navigator PPP1CC [HugePedia]
snp3D : Map Gene to Disease5501
BioCentury BCIQPPP1CC
ClinGenPPP1CC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5501
Chemical/Pharm GKB GenePA33611
Clinical trialPPP1CC
Miscellaneous
canSAR (ICR)PPP1CC (select the gene name)
Probes
Litterature
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1CC
EVEXPPP1CC
GoPubMedPPP1CC
iHOPPPP1CC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:06:11 CET 2017

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