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PPP1R10 (protein phosphatase 1 regulatory subunit 10)

Identity

Alias_namesprotein phosphatase 1, regulatory (inhibitor) subunit 10
protein phosphatase 1, regulatory subunit 10
Alias_symbol (synonym)PNUTS
FB19
CAT53
p99
Other aliasPP1R10
R111
HGNC (Hugo) PPP1R10
LocusID (NCBI) 5514
Atlas_Id 47145
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 30600400 and ends at 30617307 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
JARID2 (6p22.3) / PPP1R10 (6p21.33)PPP1R10 (6p21.33) / PPP1R10 (6p21.33)PPP1R10 (6p21.33) / VCL (10q22.2)
JARID2 6p22.3 / PPP1R10 6p21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p22) JARID2/PPP1R10


External links

Nomenclature
HGNC (Hugo)PPP1R10   9284
Cards
Entrez_Gene (NCBI)PPP1R10  5514  protein phosphatase 1 regulatory subunit 10
AliasesCAT53; FB19; PNUTS; PP1R10; 
R111; p99
GeneCards (Weizmann)PPP1R10
Ensembl hg19 (Hinxton)ENSG00000204569 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204569 [Gene_View]  ENSG00000204569 [Sequence]  chr6:30600400-30617307 [Contig_View]  PPP1R10 [Vega]
ICGC DataPortalENSG00000204569
TCGA cBioPortalPPP1R10
AceView (NCBI)PPP1R10
Genatlas (Paris)PPP1R10
WikiGenes5514
SOURCE (Princeton)PPP1R10
Genetics Home Reference (NIH)PPP1R10
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R10  -     chr6:30600400-30617307 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R10  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblPPP1R10 - 6p21.33 [CytoView hg19]  PPP1R10 - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIPPP1R10 [Mapview hg19]  PPP1R10 [Mapview hg38]
OMIM603771   
Gene and transcription
Genbank (Entrez)AJ544537 AK307406 BC005267 BC136294 BC150310
RefSeq transcript (Entrez)NM_002714
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)PPP1R10
Cluster EST : UnigeneHs.106019 [ NCBI ]
CGAP (NCI)Hs.106019
Alternative Splicing GalleryENSG00000204569
Gene ExpressionPPP1R10 [ NCBI-GEO ]   PPP1R10 [ EBI - ARRAY_EXPRESS ]   PPP1R10 [ SEEK ]   PPP1R10 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5514
GTEX Portal (Tissue expression)PPP1R10
Human Protein AtlasENSG00000204569-PPP1R10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96QC0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96QC0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96QC0
Splice isoforms : SwissVarQ96QC0
PhosPhoSitePlusQ96QC0
Domaine pattern : Prosite (Expaxy)TFIIS_N (PS51319)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)TFIIS/CRSP70_N_sub    TFIIS/LEDGF_dom_sf    TFIIS_N    Znf_CCCH    Znf_CCCH_sf   
Domain families : Pfam (Sanger)Med26 (PF08711)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam08711    pfam00642   
Domain families : Smart (EMBL)TFS2N (SM00509)  ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)PPP1R10
DMDM Disease mutations5514
Blocks (Seattle)PPP1R10
SuperfamilyQ96QC0
Human Protein Atlas [tissue]ENSG00000204569-PPP1R10 [tissue]
Peptide AtlasQ96QC0
HPRD04797
IPIIPI00298731   IPI01014304   
Protein Interaction databases
DIP (DOE-UCLA)Q96QC0
IntAct (EBI)Q96QC0
FunCoupENSG00000204569
BioGRIDPPP1R10
STRING (EMBL)PPP1R10
ZODIACPPP1R10
Ontologies - Pathways
QuickGOQ96QC0
Ontology : AmiGOnuclear chromosome, telomeric region  chromatin  DNA binding  RNA binding  protein phosphatase inhibitor activity  protein binding  nucleus  nucleoplasm  protein import into nucleus  negative regulation of cardiac muscle cell apoptotic process  nuclear body  positive regulation of telomere maintenance  negative regulation of phosphoprotein phosphatase activity  metal ion binding  PTW/PP1 phosphatase complex  negative regulation of mitotic DNA damage checkpoint  
Ontology : EGO-EBInuclear chromosome, telomeric region  chromatin  DNA binding  RNA binding  protein phosphatase inhibitor activity  protein binding  nucleus  nucleoplasm  protein import into nucleus  negative regulation of cardiac muscle cell apoptotic process  nuclear body  positive regulation of telomere maintenance  negative regulation of phosphoprotein phosphatase activity  metal ion binding  PTW/PP1 phosphatase complex  negative regulation of mitotic DNA damage checkpoint  
NDEx NetworkPPP1R10
Atlas of Cancer Signalling NetworkPPP1R10
Wikipedia pathwaysPPP1R10
Orthology - Evolution
OrthoDB5514
GeneTree (enSembl)ENSG00000204569
Phylogenetic Trees/Animal Genes : TreeFamPPP1R10
HOVERGENQ96QC0
HOGENOMQ96QC0
Homologs : HomoloGenePPP1R10
Homology/Alignments : Family Browser (UCSC)PPP1R10
Gene fusions - Rearrangements
Fusion : MitelmanJARID2/PPP1R10 [6p22.3/6p21.33]  [t(6;6)(p21;p22)]  
Fusion PortalJARID2 6p22.3 PPP1R10 6p21.33 BLCA
Fusion : QuiverPPP1R10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R10
dbVarPPP1R10
ClinVarPPP1R10
1000_GenomesPPP1R10 
Exome Variant ServerPPP1R10
ExAC (Exome Aggregation Consortium)ENSG00000204569
GNOMAD BrowserENSG00000204569
Varsome BrowserPPP1R10
Genetic variants : HAPMAP5514
Genomic Variants (DGV)PPP1R10 [DGVbeta]
DECIPHERPPP1R10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R10 
Mutations
ICGC Data PortalPPP1R10 
TCGA Data PortalPPP1R10 
Broad Tumor PortalPPP1R10
OASIS PortalPPP1R10 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPPP1R10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R10
DgiDB (Drug Gene Interaction Database)PPP1R10
DoCM (Curated mutations)PPP1R10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R10 (select a term)
intoGenPPP1R10
Cancer3DPPP1R10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603771   
Orphanet
DisGeNETPPP1R10
MedgenPPP1R10
Genetic Testing Registry PPP1R10
NextProtQ96QC0 [Medical]
TSGene5514
GENETestsPPP1R10
Target ValidationPPP1R10
Huge Navigator PPP1R10 [HugePedia]
snp3D : Map Gene to Disease5514
BioCentury BCIQPPP1R10
ClinGenPPP1R10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5514
Chemical/Pharm GKB GenePA33612
Clinical trialPPP1R10
Miscellaneous
canSAR (ICR)PPP1R10 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R10
EVEXPPP1R10
GoPubMedPPP1R10
iHOPPPP1R10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:31:39 CET 2018

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