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PPP1R12A (protein phosphatase 1, regulatory subunit 12A)

Identity

Other namesM130
MBS
MYPT1
HGNC (Hugo) PPP1R12A
LocusID (NCBI) 4659
Location 12q21.2
Location_base_pair Starts at 80167343 and ends at 80329235 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPP1R12A   7618
Cards
Entrez_Gene (NCBI)PPP1R12A  4659  protein phosphatase 1, regulatory subunit 12A
GeneCards (Weizmann)PPP1R12A
Ensembl (Hinxton)ENSG00000058272 [Gene_View]  chr12:80167343-80329235 [Contig_View]  PPP1R12A [Vega]
ICGC DataPortalENSG00000058272
AceView (NCBI)PPP1R12A
Genatlas (Paris)PPP1R12A
WikiGenes4659
SOURCE (Princeton)NM_001143885 NM_001143886 NM_001244990 NM_001244992 NM_002480
Genomic and cartography
GoldenPath (UCSC)PPP1R12A  -  12q21.2   chr12:80167343-80329235 -  12q21.2   [Description]    (hg19-Feb_2009)
EnsemblPPP1R12A - 12q21.2 [CytoView]
Mapping of homologs : NCBIPPP1R12A [Mapview]
OMIM602021   
Gene and transcription
Genbank (Entrez)AF086032 AF458589 AK057712 AK302692 AK314193
RefSeq transcript (Entrez)NM_001143885 NM_001143886 NM_001244990 NM_001244992 NM_002480
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NT_029419 NW_001838061 NW_004929384
Consensus coding sequences : CCDS (NCBI)PPP1R12A
Cluster EST : UnigeneHs.49582 [ NCBI ]
CGAP (NCI)Hs.49582
Alternative Splicing : Fast-db (Paris)GSHG0007649
Alternative Splicing GalleryENSG00000058272
Gene ExpressionPPP1R12A [ NCBI-GEO ]     PPP1R12A [ SEEK ]   PPP1R12A [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14974 (Uniprot)
NextProtO14974  [Medical]
With graphics : InterProO14974
Splice isoforms : SwissVarO14974 (Swissvar)
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Pase-1_reg_su_12A/B/C_euk   
Related proteins : CluSTrO14974
Domain families : Pfam (Sanger)Ank (PF00023)   
Domain families : Pfam (NCBI)pfam00023   
Domain families : Smart (EMBL)ANK (SM00248)  
DMDM Disease mutations4659
Blocks (Seattle)O14974
PDB (SRS)2KJY   
PDB (PDBSum)2KJY   
PDB (IMB)2KJY   
PDB (RSDB)2KJY   
Human Protein AtlasENSG00000058272
Peptide AtlasO14974
HPRD03606
IPIIPI00183002   IPI00397728   IPI00413191   IPI00397730   IPI01015009   IPI01021531   IPI01025264   IPI01015368   IPI00816559   IPI01022049   IPI01022374   IPI01022529   IPI01021639   IPI01021808   IPI01021963   IPI01020925   IPI01021077   IPI01021487   
Protein Interaction databases
DIP (DOE-UCLA)O14974
IntAct (EBI)O14974
FunCoupENSG00000058272
BioGRIDPPP1R12A
InParanoidO14974
Interologous Interaction database O14974
IntegromeDBPPP1R12A
STRING (EMBL)PPP1R12A
Ontologies - Pathways
Ontology : AmiGOG2/M transition of mitotic cell cycle  mitotic cell cycle  kinetochore  enzyme inhibitor activity  signal transducer activity  protein binding  nucleoplasm  cytoplasm  centrosome  protein dephosphorylation  mitotic nuclear division  signal transduction  actin cytoskeleton  phosphatase regulator activity  phosphatase regulator activity  protein kinase binding  regulation of cell adhesion  regulation of myosin-light-chain-phosphatase activity  negative regulation of catalytic activity  contractile fiber  positive regulation of transcription from RNA polymerase II promoter  regulation of nucleocytoplasmic transport  centrosome organization  14-3-3 protein binding  PTW/PP1 phosphatase complex  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  mitotic cell cycle  kinetochore  enzyme inhibitor activity  signal transducer activity  protein binding  nucleoplasm  cytoplasm  centrosome  protein dephosphorylation  mitotic nuclear division  signal transduction  actin cytoskeleton  phosphatase regulator activity  phosphatase regulator activity  protein kinase binding  regulation of cell adhesion  regulation of myosin-light-chain-phosphatase activity  negative regulation of catalytic activity  contractile fiber  positive regulation of transcription from RNA polymerase II promoter  regulation of nucleocytoplasmic transport  centrosome organization  14-3-3 protein binding  PTW/PP1 phosphatase complex  
Pathways : KEGGVascular smooth muscle contraction    Focal adhesion    Regulation of actin cytoskeleton    Proteoglycans in cancer   
Protein Interaction DatabasePPP1R12A
Wikipedia pathwaysPPP1R12A
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PPP1R12A
SNP (GeneSNP Utah)PPP1R12A
SNP : HGBasePPP1R12A
Genetic variants : HAPMAPPPP1R12A
1000_GenomesPPP1R12A 
ICGC programENSG00000058272 
CONAN: Copy Number AnalysisPPP1R12A 
Somatic Mutations in Cancer : COSMICPPP1R12A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDPPP1R12A
OMIM602021   
MedgenPPP1R12A
GENETestsPPP1R12A
Disease Genetic AssociationPPP1R12A
Huge Navigator PPP1R12A [HugePedia]  PPP1R12A [HugeCancerGEM]
Genomic VariantsPPP1R12A  PPP1R12A [DGVbeta]
Exome VariantPPP1R12A
dbVarPPP1R12A
ClinVarPPP1R12A
snp3D : Map Gene to Disease4659
General knowledge
Homologs : HomoloGenePPP1R12A
Homology/Alignments : Family Browser (UCSC)PPP1R12A
Phylogenetic Trees/Animal Genes : TreeFamPPP1R12A
Chemical/Protein Interactions : CTD4659
Chemical/Pharm GKB GenePA33617
Clinical trialPPP1R12A
Cancer Resource (Charite)ENSG00000058272
Other databases
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
CoreMinePPP1R12A
iHOPPPP1R12A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:09:45 CEST 2014

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