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PPP1R12B (protein phosphatase 1 regulatory subunit 12B)

Identity

Alias_namesMYPT2
protein phosphatase 1, regulatory (inhibitor) subunit 12B
protein phosphatase 1, regulatory subunit 12B
Alias_symbol (synonym)MGC87886
MGC131980
PP1bp55
Other alias
HGNC (Hugo) PPP1R12B
LocusID (NCBI) 4660
Atlas_Id 46968
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 202348702 and ends at 202438242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BGN (Xq28) / PPP1R12B (1q32.1)BZW2 (7p21.1) / PPP1R12B (1q32.1)DOCK7 (1p31.3) / PPP1R12B (1q32.1)
NFASC (1q32.1) / PPP1R12B (1q32.1)PPP1R12B (1q32.1) / HLA-DRB1 (6p21.32)PPP1R12B (1q32.1) / LGR6 (1q32.1)
PPP1R12B (1q32.1) / MCL1 (1q21.3)PPP1R12B (1q32.1) / MPDU1 (17p13.1)PPP1R12B (1q32.1) / PPP1R12B (1q32.1)
PPP1R12B (1q32.1) / SNX27 (1q21.3)DOCK7 1p31.3 / PPP1R12B 1q32.1NFASC 1q32.1 / PPP1R12B 1q32.1
PPP1R12B 1q32.1 / LGR6 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1R12B   7619
Cards
Entrez_Gene (NCBI)PPP1R12B  4660  protein phosphatase 1 regulatory subunit 12B
AliasesMYPT2; PP1bp55
GeneCards (Weizmann)PPP1R12B
Ensembl hg19 (Hinxton)ENSG00000077157 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077157 [Gene_View]  chr1:202348702-202438242 [Contig_View]  PPP1R12B [Vega]
ICGC DataPortalENSG00000077157
TCGA cBioPortalPPP1R12B
AceView (NCBI)PPP1R12B
Genatlas (Paris)PPP1R12B
WikiGenes4660
SOURCE (Princeton)PPP1R12B
Genetics Home Reference (NIH)PPP1R12B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R12B  -     chr1:202348702-202438242 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R12B  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblPPP1R12B - 1q32.1 [CytoView hg19]  PPP1R12B - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIPPP1R12B [Mapview hg19]  PPP1R12B [Mapview hg38]
OMIM603768   
Gene and transcription
Genbank (Entrez)AB003062 AB007972 AB050641 AB050642 AB588820
RefSeq transcript (Entrez)NM_001167857 NM_001167858 NM_001197131 NM_001331029 NM_002481 NM_032103 NM_032104 NM_032105
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R12B
Cluster EST : UnigeneHs.677346 [ NCBI ]
CGAP (NCI)Hs.677346
Alternative Splicing GalleryENSG00000077157
Gene ExpressionPPP1R12B [ NCBI-GEO ]   PPP1R12B [ EBI - ARRAY_EXPRESS ]   PPP1R12B [ SEEK ]   PPP1R12B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R12B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4660
GTEX Portal (Tissue expression)PPP1R12B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60237   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60237  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60237
Splice isoforms : SwissVarO60237
PhosPhoSitePlusO60237
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    MYPT1/MYPT2_chordates    PRKG1_interact   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    PRKG1_interact (PF15898)   
Domain families : Pfam (NCBI)pfam12796    pfam15898   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)PPP1R12B
DMDM Disease mutations4660
Blocks (Seattle)PPP1R12B
SuperfamilyO60237
Human Protein AtlasENSG00000077157
Peptide AtlasO60237
HPRD04794
IPIIPI00329075   IPI00903050   IPI00028643   IPI00028641   IPI00028645   IPI00644432   IPI00944994   IPI00945134   IPI00945355   
Protein Interaction databases
DIP (DOE-UCLA)O60237
IntAct (EBI)O60237
FunCoupENSG00000077157
BioGRIDPPP1R12B
STRING (EMBL)PPP1R12B
ZODIACPPP1R12B
Ontologies - Pathways
QuickGOO60237
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein binding  nucleoplasm  cytosol  regulation of muscle contraction  signal transduction  enzyme activator activity  phosphatase regulator activity  protein kinase binding  Z disc  A band  positive regulation of catalytic activity  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein binding  nucleoplasm  cytosol  regulation of muscle contraction  signal transduction  enzyme activator activity  phosphatase regulator activity  protein kinase binding  Z disc  A band  positive regulation of catalytic activity  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGVascular smooth muscle contraction    Focal adhesion    Regulation of actin cytoskeleton    Proteoglycans in cancer   
NDEx NetworkPPP1R12B
Atlas of Cancer Signalling NetworkPPP1R12B
Wikipedia pathwaysPPP1R12B
Orthology - Evolution
OrthoDB4660
GeneTree (enSembl)ENSG00000077157
Phylogenetic Trees/Animal Genes : TreeFamPPP1R12B
HOVERGENO60237
HOGENOMO60237
Homologs : HomoloGenePPP1R12B
Homology/Alignments : Family Browser (UCSC)PPP1R12B
Gene fusions - Rearrangements
Fusion : MitelmanDOCK7/PPP1R12B [1p31.3/1q32.1]  [t(1;1)(p31;q32)]  
Fusion : MitelmanNFASC/PPP1R12B [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Fusion : MitelmanPPP1R12B/LGR6 [1q32.1/1q32.1]  [t(1;1)(q32;q32)]  
Fusion : MitelmanPPP1R12B/SNX27 [1q32.1/1q21.3]  [t(1;1)(q21;q32)]  
Fusion: TCGADOCK7 1p31.3 PPP1R12B 1q32.1 BRCA
Fusion: TCGANFASC 1q32.1 PPP1R12B 1q32.1 LGG
Fusion: TCGAPPP1R12B 1q32.1 LGR6 1q32.1 LUSC
Fusion Cancer (Beijing)PPP1R12B [1q32.1]  -  HLA-DRB1 [6p21.32]  [FUSC002519]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R12B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R12B
dbVarPPP1R12B
ClinVarPPP1R12B
1000_GenomesPPP1R12B 
Exome Variant ServerPPP1R12B
ExAC (Exome Aggregation Consortium)PPP1R12B (select the gene name)
Genetic variants : HAPMAP4660
Genomic Variants (DGV)PPP1R12B [DGVbeta]
DECIPHERPPP1R12B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R12B 
Mutations
ICGC Data PortalPPP1R12B 
TCGA Data PortalPPP1R12B 
Broad Tumor PortalPPP1R12B
OASIS PortalPPP1R12B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R12B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R12B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R12B
DgiDB (Drug Gene Interaction Database)PPP1R12B
DoCM (Curated mutations)PPP1R12B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R12B (select a term)
intoGenPPP1R12B
Cancer3DPPP1R12B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603768   
Orphanet
MedgenPPP1R12B
Genetic Testing Registry PPP1R12B
NextProtO60237 [Medical]
TSGene4660
GENETestsPPP1R12B
Huge Navigator PPP1R12B [HugePedia]
snp3D : Map Gene to Disease4660
BioCentury BCIQPPP1R12B
ClinGenPPP1R12B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4660
Chemical/Pharm GKB GenePA33618
Clinical trialPPP1R12B
Miscellaneous
canSAR (ICR)PPP1R12B (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R12B
EVEXPPP1R12B
GoPubMedPPP1R12B
iHOPPPP1R12B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:32:20 CEST 2017

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