PPP1R12B (protein phosphatase 1 regulatory subunit 12B)

2007-04-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
MYPT2,PP1bp55
FUSION GENES

Other Information

Locus ID:

NCBI: 4660
MIM: 603768
HGNC: 7619
Ensembl: ENSG00000077157

Variants:

dbSNP: 4660
ClinVar: 4660
TCGA: ENSG00000077157
COSMIC: PPP1R12B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077157ENST00000290419O60237
ENSG00000077157ENST00000356764O60237
ENSG00000077157ENST00000391959O60237
ENSG00000077157ENST00000434615A0A0U1RQI8
ENSG00000077157ENST00000466273A0A0U1RQP2
ENSG00000077157ENST00000466968H7C4R6
ENSG00000077157ENST00000476364Q6GQY8
ENSG00000077157ENST00000480184O60237
ENSG00000077157ENST00000491336O60237
ENSG00000077157ENST00000608999O60237
ENSG00000077157ENST00000634903E1CKY7

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
Regulation of actin cytoskeletonKEGGhsa04810
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ROCKsREACTOMER-HSA-5627117
RHO GTPases activate PAKsREACTOMER-HSA-5627123
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
164310802006Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart.26
187827762008Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase.23
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3
304721862019The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer.2
236404102013Validation of PPP1R12B as a candidate gene for childhood asthma in Russians.0

Citation

Dessen P

PPP1R12B (protein phosphatase 1 regulatory subunit 12B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46968/ppp1r12b