PPP1R12C (protein phosphatase 1 regulatory subunit 12C)

2007-04-01  

Identity

HGNC
PPP1R12C
LOCATION
19q13.42
LOCUSID
54776
ALIAS
AAVS1,LENG3,MBS85,p84,p85
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54776
MIM: 613245
HGNC: 14947
Ensembl: ENSG00000125503

Variants:

dbSNP: 54776
ClinVar: 54776
TCGA: ENSG00000125503
COSMIC: PPP1R12C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125503ENST00000263433Q9BZL4
ENSG00000125503ENST00000435544Q9BZL4
ENSG00000125503ENST00000591938K7ER83
ENSG00000125503ENST00000592993K7EL81

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
Regulation of actin cytoskeletonKEGGhsa04810
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
145062642003Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA.33
248293542014Adeno-associated virus Rep represses the human integration site promoter by two pathways that are similar to those required for the regulation of the viral p5 promoter.7

Citation

Dessen P

PPP1R12C (protein phosphatase 1 regulatory subunit 12C)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47114/ppp1r12c