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PPP1R12C (protein phosphatase 1 regulatory subunit 12C)

Identity

Alias_namesLENG3
leukocyte receptor cluster (LRC) member 3
protein phosphatase 1, regulatory (inhibitor) subunit 12C
protein phosphatase 1, regulatory subunit 12C
Alias_symbol (synonym)DKFZP434D0412
p84
MBS85
p85
Other alias
HGNC (Hugo) PPP1R12C
LocusID (NCBI) 54776
Atlas_Id 47114
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 55090913 and ends at 55117600 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ACTG1 (17q25.3) / PPP1R12C (19q13.42)PPP1R12C (19q13.42) / KISS1 (1q32.1)PPP1R12C (19q13.42) / PPP6R1 (19q13.42)
PPP1R12C (19q13.42) / TLE3 (15q23)PPP1R12C (19q13.42) / ZNF233 (19q13.31)PPP1R12C (19q13.42) / ZNF460 (19q13.43)
ULK1 (12q24.33) / PPP1R12C (19q13.42)PPP1R12C 19q13.42 / KISS1 1q32.1PPP1R12C 19q13.42 / PPP6R1 19q13.42
PPP1R12C 19q13.42 / ZNF233 19q13.31PPP1R12C 19q13.42 / ZNF460 19q13.43ULK1 12q24.33 / PPP1R12C 19q13.42

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1R12C   14947
Cards
Entrez_Gene (NCBI)PPP1R12C  54776  protein phosphatase 1 regulatory subunit 12C
AliasesLENG3; MBS85; p84; p85
GeneCards (Weizmann)PPP1R12C
Ensembl hg19 (Hinxton)ENSG00000125503 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125503 [Gene_View]  chr19:55090913-55117600 [Contig_View]  PPP1R12C [Vega]
ICGC DataPortalENSG00000125503
TCGA cBioPortalPPP1R12C
AceView (NCBI)PPP1R12C
Genatlas (Paris)PPP1R12C
WikiGenes54776
SOURCE (Princeton)PPP1R12C
Genetics Home Reference (NIH)PPP1R12C
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R12C  -     chr19:55090913-55117600 -  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R12C  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblPPP1R12C - 19q13.42 [CytoView hg19]  PPP1R12C - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBIPPP1R12C [Mapview hg19]  PPP1R12C [Mapview hg38]
OMIM613245   
Gene and transcription
Genbank (Entrez)AA551617 AB209452 AF211968 AF312028 AK027086
RefSeq transcript (Entrez)NM_001271618 NM_017607
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R12C
Cluster EST : UnigeneHs.631579 [ NCBI ]
CGAP (NCI)Hs.631579
Alternative Splicing GalleryENSG00000125503
Gene ExpressionPPP1R12C [ NCBI-GEO ]   PPP1R12C [ EBI - ARRAY_EXPRESS ]   PPP1R12C [ SEEK ]   PPP1R12C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R12C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54776
GTEX Portal (Tissue expression)PPP1R12C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZL4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZL4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZL4
Splice isoforms : SwissVarQ9BZL4
PhosPhoSitePlusQ9BZL4
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    PPP1R12C    PRKG1_interact   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    PRKG1_interact (PF15898)   
Domain families : Pfam (NCBI)pfam12796    pfam15898   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)PPP1R12C
DMDM Disease mutations54776
Blocks (Seattle)PPP1R12C
SuperfamilyQ9BZL4
Human Protein AtlasENSG00000125503
Peptide AtlasQ9BZL4
HPRD11452
IPIIPI00014340   IPI00443045   IPI00879187   IPI00879023   IPI01013276   IPI00953027   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZL4
IntAct (EBI)Q9BZL4
FunCoupENSG00000125503
BioGRIDPPP1R12C
STRING (EMBL)PPP1R12C
ZODIACPPP1R12C
Ontologies - Pathways
QuickGOQ9BZL4
Ontology : AmiGOprotein binding  cytoplasm  protein kinase binding  
Ontology : EGO-EBIprotein binding  cytoplasm  protein kinase binding  
Pathways : KEGGVascular smooth muscle contraction    Focal adhesion    Regulation of actin cytoskeleton    Proteoglycans in cancer   
NDEx NetworkPPP1R12C
Atlas of Cancer Signalling NetworkPPP1R12C
Wikipedia pathwaysPPP1R12C
Orthology - Evolution
OrthoDB54776
GeneTree (enSembl)ENSG00000125503
Phylogenetic Trees/Animal Genes : TreeFamPPP1R12C
HOVERGENQ9BZL4
HOGENOMQ9BZL4
Homologs : HomoloGenePPP1R12C
Homology/Alignments : Family Browser (UCSC)PPP1R12C
Gene fusions - Rearrangements
Fusion : MitelmanACTG1/PPP1R12C [17q25.3/19q13.42]  [t(17;19)(q25;q13)]  
Fusion : MitelmanPPP1R12C/KISS1 [19q13.42/1q32.1]  [t(1;19)(q32;q13)]  
Fusion : MitelmanPPP1R12C/PPP6R1 [19q13.42/19q13.42]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPPP1R12C/ZNF233 [19q13.42/19q13.31]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPPP1R12C/ZNF460 [19q13.42/19q13.43]  [t(19;19)(q13;q13)]  
Fusion : MitelmanULK1/PPP1R12C [12q24.33/19q13.42]  [t(12;19)(q24;q13)]  
Fusion: TCGAPPP1R12C 19q13.42 KISS1 1q32.1 BRCA
Fusion: TCGAPPP1R12C 19q13.42 PPP6R1 19q13.42 LUAD
Fusion: TCGAPPP1R12C 19q13.42 ZNF233 19q13.31 BRCA
Fusion: TCGAPPP1R12C 19q13.42 ZNF460 19q13.43 BRCA
Fusion: TCGAULK1 12q24.33 PPP1R12C 19q13.42 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R12C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R12C
dbVarPPP1R12C
ClinVarPPP1R12C
1000_GenomesPPP1R12C 
Exome Variant ServerPPP1R12C
ExAC (Exome Aggregation Consortium)PPP1R12C (select the gene name)
Genetic variants : HAPMAP54776
Genomic Variants (DGV)PPP1R12C [DGVbeta]
DECIPHERPPP1R12C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R12C 
Mutations
ICGC Data PortalPPP1R12C 
TCGA Data PortalPPP1R12C 
Broad Tumor PortalPPP1R12C
OASIS PortalPPP1R12C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R12C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R12C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R12C
DgiDB (Drug Gene Interaction Database)PPP1R12C
DoCM (Curated mutations)PPP1R12C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R12C (select a term)
intoGenPPP1R12C
Cancer3DPPP1R12C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613245   
Orphanet
MedgenPPP1R12C
Genetic Testing Registry PPP1R12C
NextProtQ9BZL4 [Medical]
TSGene54776
GENETestsPPP1R12C
Target ValidationPPP1R12C
Huge Navigator PPP1R12C [HugePedia]
snp3D : Map Gene to Disease54776
BioCentury BCIQPPP1R12C
ClinGenPPP1R12C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54776
Chemical/Pharm GKB GenePA33619
Clinical trialPPP1R12C
Miscellaneous
canSAR (ICR)PPP1R12C (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R12C
EVEXPPP1R12C
GoPubMedPPP1R12C
iHOPPPP1R12C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:37 CEST 2017

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