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PPP1R13B (protein phosphatase 1 regulatory subunit 13B)

Identity

Alias_namesprotein phosphatase 1, regulatory (inhibitor) subunit 13B
protein phosphatase 1, regulatory subunit 13B
Alias_symbol (synonym)p53BP2-like
KIAA0771
p85
ASPP1
Other alias
HGNC (Hugo) PPP1R13B
LocusID (NCBI) 23368
Atlas_Id 41807
Location 14q32.33  [Link to chromosome band 14q32]
Location_base_pair Starts at 103733751 and ends at 103847590 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP1R13B (14q32.33) / C14orf2 (14q32.33)PPP1R13B (14q32.33) / CCDC88C (14q32.11)VWA7 (6p21.33) / PPP1R13B (14q32.33)
PPP1R13B 14q32.33 / C14orf2 14q32.33PPP1R13B 14q32.33 / CCDC88C 14q32.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1R13B   14950
Cards
Entrez_Gene (NCBI)PPP1R13B  23368  protein phosphatase 1 regulatory subunit 13B
AliasesASPP1; p53BP2-like; p85
GeneCards (Weizmann)PPP1R13B
Ensembl hg19 (Hinxton)ENSG00000088808 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088808 [Gene_View]  chr14:103733751-103847590 [Contig_View]  PPP1R13B [Vega]
ICGC DataPortalENSG00000088808
TCGA cBioPortalPPP1R13B
AceView (NCBI)PPP1R13B
Genatlas (Paris)PPP1R13B
WikiGenes23368
SOURCE (Princeton)PPP1R13B
Genetics Home Reference (NIH)PPP1R13B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R13B  -     chr14:103733751-103847590 -  14q32.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R13B  -     14q32.33   [Description]    (hg19-Feb_2009)
EnsemblPPP1R13B - 14q32.33 [CytoView hg19]  PPP1R13B - 14q32.33 [CytoView hg38]
Mapping of homologs : NCBIPPP1R13B [Mapview hg19]  PPP1R13B [Mapview hg38]
OMIM606455   
Gene and transcription
Genbank (Entrez)AB018314 AJ318887 AK021580 AK023188 AK125374
RefSeq transcript (Entrez)NM_015316
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R13B
Cluster EST : UnigeneHs.709297 [ NCBI ]
CGAP (NCI)Hs.709297
Alternative Splicing GalleryENSG00000088808
Gene ExpressionPPP1R13B [ NCBI-GEO ]   PPP1R13B [ EBI - ARRAY_EXPRESS ]   PPP1R13B [ SEEK ]   PPP1R13B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R13B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23368
GTEX Portal (Tissue expression)PPP1R13B
Human Protein AtlasENSG00000088808-PPP1R13B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96KQ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96KQ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96KQ4
Splice isoforms : SwissVarQ96KQ4
PhosPhoSitePlusQ96KQ4
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    SH3 (PS50002)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    ASPP_1    SH3_domain    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam12796    pfam00018   
Domain families : Smart (EMBL)ANK (SM00248)  SH3 (SM00326)  
Conserved Domain (NCBI)PPP1R13B
DMDM Disease mutations23368
Blocks (Seattle)PPP1R13B
SuperfamilyQ96KQ4
Human Protein Atlas [tissue]ENSG00000088808-PPP1R13B [tissue]
Peptide AtlasQ96KQ4
HPRD07345
IPIIPI00306903   IPI00902966   IPI00445412   IPI01025916   IPI01026255   IPI01026183   IPI01026529   IPI01026387   
Protein Interaction databases
DIP (DOE-UCLA)Q96KQ4
IntAct (EBI)Q96KQ4
FunCoupENSG00000088808
BioGRIDPPP1R13B
STRING (EMBL)PPP1R13B
ZODIACPPP1R13B
Ontologies - Pathways
QuickGOQ96KQ4
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  plasma membrane  transcription factor binding  regulation of apoptotic process  negative regulation of cell cycle  perinuclear region of cytoplasm  intrinsic apoptotic signaling pathway by p53 class mediator  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  positive regulation of neuron death  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  plasma membrane  transcription factor binding  regulation of apoptotic process  negative regulation of cell cycle  perinuclear region of cytoplasm  intrinsic apoptotic signaling pathway by p53 class mediator  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  positive regulation of neuron death  regulation of signal transduction by p53 class mediator  
NDEx NetworkPPP1R13B
Atlas of Cancer Signalling NetworkPPP1R13B
Wikipedia pathwaysPPP1R13B
Orthology - Evolution
OrthoDB23368
GeneTree (enSembl)ENSG00000088808
Phylogenetic Trees/Animal Genes : TreeFamPPP1R13B
HOVERGENQ96KQ4
HOGENOMQ96KQ4
Homologs : HomoloGenePPP1R13B
Homology/Alignments : Family Browser (UCSC)PPP1R13B
Gene fusions - Rearrangements
Fusion : MitelmanPPP1R13B/C14orf2 [14q32.33/14q32.33]  
Fusion : MitelmanPPP1R13B/CCDC88C [14q32.33/14q32.11]  [t(14;14)(q32;q32)]  
Fusion: TCGAPPP1R13B 14q32.33 C14orf2 14q32.33 BRCA
Fusion: TCGAPPP1R13B 14q32.33 CCDC88C 14q32.11 BRCA
Fusion: Tumor Portal PPP1R13B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R13B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R13B
dbVarPPP1R13B
ClinVarPPP1R13B
1000_GenomesPPP1R13B 
Exome Variant ServerPPP1R13B
ExAC (Exome Aggregation Consortium)ENSG00000088808
GNOMAD BrowserENSG00000088808
Genetic variants : HAPMAP23368
Genomic Variants (DGV)PPP1R13B [DGVbeta]
DECIPHERPPP1R13B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R13B 
Mutations
ICGC Data PortalPPP1R13B 
TCGA Data PortalPPP1R13B 
Broad Tumor PortalPPP1R13B
OASIS PortalPPP1R13B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R13B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R13B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R13B
DgiDB (Drug Gene Interaction Database)PPP1R13B
DoCM (Curated mutations)PPP1R13B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R13B (select a term)
intoGenPPP1R13B
Cancer3DPPP1R13B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606455   
Orphanet
MedgenPPP1R13B
Genetic Testing Registry PPP1R13B
NextProtQ96KQ4 [Medical]
TSGene23368
GENETestsPPP1R13B
Target ValidationPPP1R13B
Huge Navigator PPP1R13B [HugePedia]
snp3D : Map Gene to Disease23368
BioCentury BCIQPPP1R13B
ClinGenPPP1R13B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23368
Chemical/Pharm GKB GenePA33622
Clinical trialPPP1R13B
Miscellaneous
canSAR (ICR)PPP1R13B (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R13B
EVEXPPP1R13B
GoPubMedPPP1R13B
iHOPPPP1R13B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:06:12 CET 2017

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