PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A)

2007-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CPI-17,CPI17,PPP1INL
FUSION GENES

Other Information

Locus ID:

NCBI: 94274
MIM: 608153
HGNC: 14871
Ensembl: ENSG00000167641

Variants:

dbSNP: 94274
ClinVar: 94274
TCGA: ENSG00000167641
COSMIC: PPP1R14A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167641ENST00000301242Q96A00
ENSG00000167641ENST00000347262Q96A00
ENSG00000167641ENST00000587515A0A0B4J2A3
ENSG00000167641ENST00000591291K7EMN0
ENSG00000167641ENST00000591585K7EJB8

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168859852006Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase.71
188356522009Functional inactivation of NF2/merlin in human mesothelioma.41
222753762012A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.21
202029762010cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17.19
152349082004Role of CPI-17 in the regulation of endothelial cytoskeleton.18
173012912007Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor.15
150035082004Association of CPI-17 with protein kinase C and casein kinase I.12
232754392013GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction.11
235415852013Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells.9
277930412016CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.7

Citation

Dessen P

PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43828/ppp1r14a