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PPP1R14B (protein phosphatase 1 regulatory inhibitor subunit 14B)

Identity

Alias (NCBI)PHI-1
PLCB3N
PNG
SOM172
HGNC (Hugo) PPP1R14B
HGNC Alias symbSOM172
PNG
PHI-1
HGNC Previous namePLCB3N
HGNC Previous nameprotein phosphatase 1, regulatory (inhibitor) subunit 14B
LocusID (NCBI) 26472
Atlas_Id 46899
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64244479 and ends at 64246943 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPP1R14B   9057
Cards
Entrez_Gene (NCBI)PPP1R14B  26472  protein phosphatase 1 regulatory inhibitor subunit 14B
AliasesPHI-1; PLCB3N; PNG; SOM172
GeneCards (Weizmann)PPP1R14B
Ensembl hg19 (Hinxton)ENSG00000173457 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173457 [Gene_View]  ENSG00000173457 [Sequence]  chr11:64244479-64246943 [Contig_View]  PPP1R14B [Vega]
ICGC DataPortalENSG00000173457
TCGA cBioPortalPPP1R14B
AceView (NCBI)PPP1R14B
Genatlas (Paris)PPP1R14B
WikiGenes26472
SOURCE (Princeton)PPP1R14B
Genetics Home Reference (NIH)PPP1R14B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R14B  -     chr11:64244479-64246943 -  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R14B  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathPPP1R14B - 11q13.1 [CytoView hg19]  PPP1R14B - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000173457
genome Data Viewer NCBIPPP1R14B [Mapview hg19]  
OMIM601140   
Gene and transcription
Genbank (Entrez)AF318364 BC014522 BC071884 BC094817 BF155230
RefSeq transcript (Entrez)NM_138689
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R14B
Alternative Splicing GalleryENSG00000173457
Gene ExpressionPPP1R14B [ NCBI-GEO ]   PPP1R14B [ EBI - ARRAY_EXPRESS ]   PPP1R14B [ SEEK ]   PPP1R14B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R14B [ Firebrowse - Broad ]
GenevisibleExpression of PPP1R14B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26472
GTEX Portal (Tissue expression)PPP1R14B
Human Protein AtlasENSG00000173457-PPP1R14B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96C90   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96C90  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96C90
Splice isoforms : SwissVarQ96C90
PhosPhoSitePlusQ96C90
Domains : Interpro (EBI)CPI-17    CPI-17_sf   
Domain families : Pfam (Sanger)PP1_inhibitor (PF05361)   
Domain families : Pfam (NCBI)pfam05361   
Conserved Domain (NCBI)PPP1R14B
DMDM Disease mutations26472
Blocks (Seattle)PPP1R14B
SuperfamilyQ96C90
Human Protein Atlas [tissue]ENSG00000173457-PPP1R14B [tissue]
Peptide AtlasQ96C90
HPRD18513
IPIIPI00103814   IPI00398922   IPI01012313   IPI01010710   
Protein Interaction databases
DIP (DOE-UCLA)Q96C90
IntAct (EBI)Q96C90
FunCoupENSG00000173457
BioGRIDPPP1R14B
STRING (EMBL)PPP1R14B
ZODIACPPP1R14B
Ontologies - Pathways
QuickGOQ96C90
Ontology : AmiGOprotein serine/threonine phosphatase inhibitor activity  cytoplasm  negative regulation of phosphoprotein phosphatase activity  regulation of phosphorylation  innate immune response  
Ontology : EGO-EBIprotein serine/threonine phosphatase inhibitor activity  cytoplasm  negative regulation of phosphoprotein phosphatase activity  regulation of phosphorylation  innate immune response  
NDEx NetworkPPP1R14B
Atlas of Cancer Signalling NetworkPPP1R14B
Wikipedia pathwaysPPP1R14B
Orthology - Evolution
OrthoDB26472
GeneTree (enSembl)ENSG00000173457
Phylogenetic Trees/Animal Genes : TreeFamPPP1R14B
HOGENOMQ96C90
Homologs : HomoloGenePPP1R14B
Homology/Alignments : Family Browser (UCSC)PPP1R14B
Gene fusions - Rearrangements
Fusion : QuiverPPP1R14B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R14B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R14B
dbVarPPP1R14B
ClinVarPPP1R14B
1000_GenomesPPP1R14B 
Exome Variant ServerPPP1R14B
GNOMAD BrowserENSG00000173457
Varsome BrowserPPP1R14B
Genetic variants : HAPMAP26472
Genomic Variants (DGV)PPP1R14B [DGVbeta]
DECIPHERPPP1R14B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R14B 
Mutations
ICGC Data PortalPPP1R14B 
TCGA Data PortalPPP1R14B 
Broad Tumor PortalPPP1R14B
OASIS PortalPPP1R14B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R14B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP1R14B
Mutations and Diseases : HGMDPPP1R14B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R14B
DgiDB (Drug Gene Interaction Database)PPP1R14B
DoCM (Curated mutations)PPP1R14B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R14B (select a term)
intoGenPPP1R14B
Cancer3DPPP1R14B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601140   
Orphanet
DisGeNETPPP1R14B
MedgenPPP1R14B
Genetic Testing Registry PPP1R14B
NextProtQ96C90 [Medical]
TSGene26472
GENETestsPPP1R14B
Target ValidationPPP1R14B
Huge Navigator PPP1R14B [HugePedia]
snp3D : Map Gene to Disease26472
BioCentury BCIQPPP1R14B
ClinGenPPP1R14B
Clinical trials, drugs, therapy
Protein Interactions : CTD26472
Pharm GKB GenePA33624
Clinical trialPPP1R14B
Miscellaneous
canSAR (ICR)PPP1R14B (select the gene name)
HarmonizomePPP1R14B
DataMed IndexPPP1R14B
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R14B
EVEXPPP1R14B
GoPubMedPPP1R14B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:30:56 CEST 2020
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