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PPP1R15A (protein phosphatase 1 regulatory subunit 15A)

Identity

Alias (NCBI)GADD34
HGNC (Hugo) PPP1R15A
HGNC Alias symbGADD34
HGNC Alias namegrowth arrest and DNA-damage-inducible 34
HGNC Previous nameprotein phosphatase 1, regulatory (inhibitor) subunit 15A
 protein phosphatase 1, regulatory subunit 15A
LocusID (NCBI) 23645
Atlas_Id 41808
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 48872392 and ends at 48876062 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PITX2 (4q25) / PPP1R15A (19q13.33)PPP1R15A (19q13.33) / ATP1A1 (1p13.1)PPP1R15A (19q13.33) / EGLN1 (1q42.2)
PPP1R15A (19q13.33) / HSPA1A (6p21.33)PPP1R15A (19q13.33) / PPP1R15A (19q13.33)TAGLN2 (1q23.2) / PPP1R15A (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;19)(q32;q13) IGH/Various Partners

External links

Nomenclature
HGNC (Hugo)PPP1R15A   14375
Cards
Entrez_Gene (NCBI)PPP1R15A    protein phosphatase 1 regulatory subunit 15A
AliasesGADD34
GeneCards (Weizmann)PPP1R15A
Ensembl hg19 (Hinxton)ENSG00000087074 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087074 [Gene_View]  ENSG00000087074 [Sequence]  chr19:48872392-48876062 [Contig_View]  PPP1R15A [Vega]
ICGC DataPortalENSG00000087074
TCGA cBioPortalPPP1R15A
AceView (NCBI)PPP1R15A
Genatlas (Paris)PPP1R15A
SOURCE (Princeton)PPP1R15A
Genetics Home Reference (NIH)PPP1R15A
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R15A  -     chr19:48872392-48876062 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R15A  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathPPP1R15A - 19q13.33 [CytoView hg19]  PPP1R15A - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000087074
genome Data Viewer NCBIPPP1R15A [Mapview hg19]  
OMIM611048   
Gene and transcription
Genbank (Entrez)AK001361 AK225632 AK296668 AK297615 AK298765
RefSeq transcript (Entrez)NM_014330
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R15A
Alternative Splicing GalleryENSG00000087074
Gene ExpressionPPP1R15A [ NCBI-GEO ]   PPP1R15A [ EBI - ARRAY_EXPRESS ]   PPP1R15A [ SEEK ]   PPP1R15A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R15A [ Firebrowse - Broad ]
GenevisibleExpression of PPP1R15A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23645
GTEX Portal (Tissue expression)PPP1R15A
Human Protein AtlasENSG00000087074-PPP1R15A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75807   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75807  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75807
Splice isoforms : SwissVarO75807
PhosPhoSitePlusO75807
Domains : Interpro (EBI)Prot_Pase1_reg-su15A/B_C   
Domain families : Pfam (Sanger)PP1c_bdg (PF10488)   
Domain families : Pfam (NCBI)pfam10488   
Conserved Domain (NCBI)PPP1R15A
Blocks (Seattle)PPP1R15A
PDB (RSDB)4XPN   
PDB Europe4XPN   
PDB (PDBSum)4XPN   
PDB (IMB)4XPN   
Structural Biology KnowledgeBase4XPN   
SCOP (Structural Classification of Proteins)4XPN   
CATH (Classification of proteins structures)4XPN   
SuperfamilyO75807
Human Protein Atlas [tissue]ENSG00000087074-PPP1R15A [tissue]
Peptide AtlasO75807
HPRD06572
IPIIPI00290444   IPI00978874   IPI01011935   
Protein Interaction databases
DIP (DOE-UCLA)O75807
IntAct (EBI)O75807
BioGRIDPPP1R15A
STRING (EMBL)PPP1R15A
ZODIACPPP1R15A
Ontologies - Pathways
QuickGOO75807
Ontology : AmiGOprotein phosphatase type 1 complex  protein phosphatase type 1 complex  protein binding  cytoplasm  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  cytosol  apoptotic process  cellular response to DNA damage stimulus  cell cycle arrest  protein phosphatase 1 binding  protein phosphatase 1 binding  membrane  protein phosphatase regulator activity  protein phosphatase regulator activity  protein kinase binding  positive regulation of translational initiation in response to stress  negative regulation of phosphoprotein phosphatase activity  positive regulation of phosphoprotein phosphatase activity  positive regulation of phosphoprotein phosphatase activity  response to endoplasmic reticulum stress  response to endoplasmic reticulum stress  negative regulation of protein dephosphorylation  regulation of translational initiation by eIF2 alpha dephosphorylation  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  protein localization to endoplasmic reticulum  protein phosphatase activator activity  positive regulation of peptidyl-serine dephosphorylation  negative regulation of PERK-mediated unfolded protein response  positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  
Ontology : EGO-EBIprotein phosphatase type 1 complex  protein phosphatase type 1 complex  protein binding  cytoplasm  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  cytosol  apoptotic process  cellular response to DNA damage stimulus  cell cycle arrest  protein phosphatase 1 binding  protein phosphatase 1 binding  membrane  protein phosphatase regulator activity  protein phosphatase regulator activity  protein kinase binding  positive regulation of translational initiation in response to stress  negative regulation of phosphoprotein phosphatase activity  positive regulation of phosphoprotein phosphatase activity  positive regulation of phosphoprotein phosphatase activity  response to endoplasmic reticulum stress  response to endoplasmic reticulum stress  negative regulation of protein dephosphorylation  regulation of translational initiation by eIF2 alpha dephosphorylation  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  protein localization to endoplasmic reticulum  protein phosphatase activator activity  positive regulation of peptidyl-serine dephosphorylation  negative regulation of PERK-mediated unfolded protein response  positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkPPP1R15A
Atlas of Cancer Signalling NetworkPPP1R15A
Wikipedia pathwaysPPP1R15A
Orthology - Evolution
OrthoDB23645
GeneTree (enSembl)ENSG00000087074
Phylogenetic Trees/Animal Genes : TreeFamPPP1R15A
HOGENOMO75807
Homologs : HomoloGenePPP1R15A
Homology/Alignments : Family Browser (UCSC)PPP1R15A
Gene fusions - Rearrangements
Fusion : QuiverPPP1R15A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R15A [hg38]
dbVarPPP1R15A
ClinVarPPP1R15A
MonarchPPP1R15A
1000_GenomesPPP1R15A 
Exome Variant ServerPPP1R15A
GNOMAD BrowserENSG00000087074
Varsome BrowserPPP1R15A
Genomic Variants (DGV)PPP1R15A [DGVbeta]
DECIPHERPPP1R15A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R15A 
Mutations
ICGC Data PortalPPP1R15A 
TCGA Data PortalPPP1R15A 
Broad Tumor PortalPPP1R15A
OASIS PortalPPP1R15A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R15A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP1R15A
Mutations and Diseases : HGMDPPP1R15A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R15A
DgiDB (Drug Gene Interaction Database)PPP1R15A
DoCM (Curated mutations)PPP1R15A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R15A (select a term)
intoGenPPP1R15A
Cancer3DPPP1R15A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611048   
Orphanet
DisGeNETPPP1R15A
MedgenPPP1R15A
Genetic Testing Registry PPP1R15A
NextProtO75807 [Medical]
GENETestsPPP1R15A
Target ValidationPPP1R15A
Huge Navigator PPP1R15A [HugePedia]
ClinGenPPP1R15A
Clinical trials, drugs, therapy
MyCancerGenomePPP1R15A
Protein Interactions : CTD
Pharm GKB GenePA33632
PharosO75807
Clinical trialPPP1R15A
Miscellaneous
canSAR (ICR)PPP1R15A (select the gene name)
HarmonizomePPP1R15A
DataMed IndexPPP1R15A
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP1R15A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:40:36 CET 2021
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