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PPP1R15A (protein phosphatase 1 regulatory subunit 15A)

Identity

Alias_namesprotein phosphatase 1, regulatory (inhibitor) subunit 15A
protein phosphatase 1, regulatory subunit 15A
Alias_symbol (synonym)GADD34
Other alias
HGNC (Hugo) PPP1R15A
LocusID (NCBI) 23645
Atlas_Id 41808
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 48872392 and ends at 48876062 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PITX2 (4q25) / PPP1R15A (19q13.33)PPP1R15A (19q13.33) / ATP1A1 (1p13.1)PPP1R15A (19q13.33) / EGLN1 (1q42.2)
PPP1R15A (19q13.33) / HSPA1A (6p21.33)PPP1R15A (19q13.33) / PPP1R15A (19q13.33)TAGLN2 (1q23.2) / PPP1R15A (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1R15A   14375
Cards
Entrez_Gene (NCBI)PPP1R15A  23645  protein phosphatase 1 regulatory subunit 15A
AliasesGADD34
GeneCards (Weizmann)PPP1R15A
Ensembl hg19 (Hinxton)ENSG00000087074 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087074 [Gene_View]  chr19:48872392-48876062 [Contig_View]  PPP1R15A [Vega]
ICGC DataPortalENSG00000087074
TCGA cBioPortalPPP1R15A
AceView (NCBI)PPP1R15A
Genatlas (Paris)PPP1R15A
WikiGenes23645
SOURCE (Princeton)PPP1R15A
Genetics Home Reference (NIH)PPP1R15A
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R15A  -     chr19:48872392-48876062 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R15A  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblPPP1R15A - 19q13.33 [CytoView hg19]  PPP1R15A - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIPPP1R15A [Mapview hg19]  PPP1R15A [Mapview hg38]
OMIM611048   
Gene and transcription
Genbank (Entrez)AK001361 AK225632 AK296668 AK297615 AK298765
RefSeq transcript (Entrez)NM_014330
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R15A
Cluster EST : UnigeneHs.631593 [ NCBI ]
CGAP (NCI)Hs.631593
Alternative Splicing GalleryENSG00000087074
Gene ExpressionPPP1R15A [ NCBI-GEO ]   PPP1R15A [ EBI - ARRAY_EXPRESS ]   PPP1R15A [ SEEK ]   PPP1R15A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R15A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23645
GTEX Portal (Tissue expression)PPP1R15A
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75807   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75807  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75807
Splice isoforms : SwissVarO75807
PhosPhoSitePlusO75807
Domains : Interpro (EBI)Prot_Pase1_reg-su15A/B_C   
Domain families : Pfam (Sanger)PP1c_bdg (PF10488)   
Domain families : Pfam (NCBI)pfam10488   
Conserved Domain (NCBI)PPP1R15A
DMDM Disease mutations23645
Blocks (Seattle)PPP1R15A
PDB (SRS)4XPN   
PDB (PDBSum)4XPN   
PDB (IMB)4XPN   
PDB (RSDB)4XPN   
Structural Biology KnowledgeBase4XPN   
SCOP (Structural Classification of Proteins)4XPN   
CATH (Classification of proteins structures)4XPN   
SuperfamilyO75807
Human Protein AtlasENSG00000087074
Peptide AtlasO75807
HPRD06572
IPIIPI00290444   IPI00978874   IPI01011935   
Protein Interaction databases
DIP (DOE-UCLA)O75807
IntAct (EBI)O75807
FunCoupENSG00000087074
BioGRIDPPP1R15A
STRING (EMBL)PPP1R15A
ZODIACPPP1R15A
Ontologies - Pathways
QuickGOO75807
Ontology : AmiGOprotein phosphatase type 1 complex  protein binding  cytoplasm  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  cytosol  apoptotic process  cellular response to DNA damage stimulus  cell cycle arrest  protein phosphatase 1 binding  protein phosphatase 1 binding  membrane  protein phosphatase regulator activity  protein kinase binding  endoplasmic reticulum unfolded protein response  positive regulation of translational initiation in response to stress  negative regulation of phosphoprotein phosphatase activity  positive regulation of phosphoprotein phosphatase activity  positive regulation of peptidyl-serine phosphorylation  response to endoplasmic reticulum stress  negative regulation of protein dephosphorylation  regulation of translational initiation by eIF2 alpha dephosphorylation  positive regulation of transcription from RNA polymerase I promoter  regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  peptidyl-serine dephosphorylation  protein localization to endoplasmic reticulum  protein phosphatase activator activity  positive regulation of peptidyl-serine dephosphorylation  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Ontology : EGO-EBIprotein phosphatase type 1 complex  protein binding  cytoplasm  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  cytosol  apoptotic process  cellular response to DNA damage stimulus  cell cycle arrest  protein phosphatase 1 binding  protein phosphatase 1 binding  membrane  protein phosphatase regulator activity  protein kinase binding  endoplasmic reticulum unfolded protein response  positive regulation of translational initiation in response to stress  negative regulation of phosphoprotein phosphatase activity  positive regulation of phosphoprotein phosphatase activity  positive regulation of peptidyl-serine phosphorylation  response to endoplasmic reticulum stress  negative regulation of protein dephosphorylation  regulation of translational initiation by eIF2 alpha dephosphorylation  positive regulation of transcription from RNA polymerase I promoter  regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  peptidyl-serine dephosphorylation  protein localization to endoplasmic reticulum  protein phosphatase activator activity  positive regulation of peptidyl-serine dephosphorylation  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkPPP1R15A
Atlas of Cancer Signalling NetworkPPP1R15A
Wikipedia pathwaysPPP1R15A
Orthology - Evolution
OrthoDB23645
GeneTree (enSembl)ENSG00000087074
Phylogenetic Trees/Animal Genes : TreeFamPPP1R15A
HOVERGENO75807
HOGENOMO75807
Homologs : HomoloGenePPP1R15A
Homology/Alignments : Family Browser (UCSC)PPP1R15A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R15A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R15A
dbVarPPP1R15A
ClinVarPPP1R15A
1000_GenomesPPP1R15A 
Exome Variant ServerPPP1R15A
ExAC (Exome Aggregation Consortium)PPP1R15A (select the gene name)
Genetic variants : HAPMAP23645
Genomic Variants (DGV)PPP1R15A [DGVbeta]
DECIPHERPPP1R15A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R15A 
Mutations
ICGC Data PortalPPP1R15A 
TCGA Data PortalPPP1R15A 
Broad Tumor PortalPPP1R15A
OASIS PortalPPP1R15A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R15A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R15A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R15A
DgiDB (Drug Gene Interaction Database)PPP1R15A
DoCM (Curated mutations)PPP1R15A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R15A (select a term)
intoGenPPP1R15A
Cancer3DPPP1R15A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611048   
Orphanet
MedgenPPP1R15A
Genetic Testing Registry PPP1R15A
NextProtO75807 [Medical]
TSGene23645
GENETestsPPP1R15A
Target ValidationPPP1R15A
Huge Navigator PPP1R15A [HugePedia]
snp3D : Map Gene to Disease23645
BioCentury BCIQPPP1R15A
ClinGenPPP1R15A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23645
Chemical/Pharm GKB GenePA33632
Clinical trialPPP1R15A
Miscellaneous
canSAR (ICR)PPP1R15A (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R15A
EVEXPPP1R15A
GoPubMedPPP1R15A
iHOPPPP1R15A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 18 14:04:05 CEST 2017

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