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PPP1R15B (protein phosphatase 1 regulatory subunit 15B)

Identity

Alias_namesprotein phosphatase 1, regulatory (inhibitor) subunit 15B
protein phosphatase 1, regulatory subunit 15B
Alias_symbol (synonym)FLJ14744
Other aliasCREP
MSSGM2
HGNC (Hugo) PPP1R15B
LocusID (NCBI) 84919
Atlas_Id 46951
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 204403364 and ends at 204411817 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GABPB1 (15q21.2) / PPP1R15B (1q32.1)PPP1R15B (1q32.1) / DISP1 (1q41)PPP1R15B (1q32.1) / PPP1R15B (1q32.1)
WDR55 (5q31.3) / PPP1R15B (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1R15B   14951
Cards
Entrez_Gene (NCBI)PPP1R15B  84919  protein phosphatase 1 regulatory subunit 15B
AliasesCREP; MSSGM2
GeneCards (Weizmann)PPP1R15B
Ensembl hg19 (Hinxton)ENSG00000158615 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158615 [Gene_View]  chr1:204403364-204411817 [Contig_View]  PPP1R15B [Vega]
ICGC DataPortalENSG00000158615
TCGA cBioPortalPPP1R15B
AceView (NCBI)PPP1R15B
Genatlas (Paris)PPP1R15B
WikiGenes84919
SOURCE (Princeton)PPP1R15B
Genetics Home Reference (NIH)PPP1R15B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R15B  -     chr1:204403364-204411817 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R15B  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblPPP1R15B - 1q32.1 [CytoView hg19]  PPP1R15B - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIPPP1R15B [Mapview hg19]  PPP1R15B [Mapview hg38]
OMIM613257   616817   
Gene and transcription
Genbank (Entrez)AI363360 AK023680 AK027650 AK222877 AK303535
RefSeq transcript (Entrez)NM_032833
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R15B
Cluster EST : UnigeneHs.304376 [ NCBI ]
CGAP (NCI)Hs.304376
Alternative Splicing GalleryENSG00000158615
Gene ExpressionPPP1R15B [ NCBI-GEO ]   PPP1R15B [ EBI - ARRAY_EXPRESS ]   PPP1R15B [ SEEK ]   PPP1R15B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R15B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84919
GTEX Portal (Tissue expression)PPP1R15B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5SWA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5SWA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5SWA1
Splice isoforms : SwissVarQ5SWA1
PhosPhoSitePlusQ5SWA1
Domains : Interpro (EBI)Prot_Pase1_reg-su15A/B_C    Prot_Pase1_reg-su15B_N   
Domain families : Pfam (Sanger)CReP_N (PF10472)    PP1c_bdg (PF10488)   
Domain families : Pfam (NCBI)pfam10472    pfam10488   
Conserved Domain (NCBI)PPP1R15B
DMDM Disease mutations84919
Blocks (Seattle)PPP1R15B
PDB (SRS)4V0U    4V0V    4V0W    4V0X   
PDB (PDBSum)4V0U    4V0V    4V0W    4V0X   
PDB (IMB)4V0U    4V0V    4V0W    4V0X   
PDB (RSDB)4V0U    4V0V    4V0W    4V0X   
Structural Biology KnowledgeBase4V0U    4V0V    4V0W    4V0X   
SCOP (Structural Classification of Proteins)4V0U    4V0V    4V0W    4V0X   
CATH (Classification of proteins structures)4V0U    4V0V    4V0W    4V0X   
SuperfamilyQ5SWA1
Human Protein AtlasENSG00000158615
Peptide AtlasQ5SWA1
HPRD17892
IPIIPI00045837   IPI01015720   
Protein Interaction databases
DIP (DOE-UCLA)Q5SWA1
IntAct (EBI)Q5SWA1
FunCoupENSG00000158615
BioGRIDPPP1R15B
STRING (EMBL)PPP1R15B
ZODIACPPP1R15B
Ontologies - Pathways
QuickGOQ5SWA1
Ontology : AmiGOprotein phosphatase type 1 complex  protein phosphatase type 1 complex  negative regulation of protein phosphorylation  protein binding  ER overload response  protein phosphatase regulator activity  response to hydrogen peroxide  regulation of catalytic activity  peptidyl-serine dephosphorylation  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  
Ontology : EGO-EBIprotein phosphatase type 1 complex  protein phosphatase type 1 complex  negative regulation of protein phosphorylation  protein binding  ER overload response  protein phosphatase regulator activity  response to hydrogen peroxide  regulation of catalytic activity  peptidyl-serine dephosphorylation  negative regulation of PERK-mediated unfolded protein response  negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  
NDEx NetworkPPP1R15B
Atlas of Cancer Signalling NetworkPPP1R15B
Wikipedia pathwaysPPP1R15B
Orthology - Evolution
OrthoDB84919
GeneTree (enSembl)ENSG00000158615
Phylogenetic Trees/Animal Genes : TreeFamPPP1R15B
HOVERGENQ5SWA1
HOGENOMQ5SWA1
Homologs : HomoloGenePPP1R15B
Homology/Alignments : Family Browser (UCSC)PPP1R15B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R15B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R15B
dbVarPPP1R15B
ClinVarPPP1R15B
1000_GenomesPPP1R15B 
Exome Variant ServerPPP1R15B
ExAC (Exome Aggregation Consortium)PPP1R15B (select the gene name)
Genetic variants : HAPMAP84919
Genomic Variants (DGV)PPP1R15B [DGVbeta]
DECIPHERPPP1R15B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R15B 
Mutations
ICGC Data PortalPPP1R15B 
TCGA Data PortalPPP1R15B 
Broad Tumor PortalPPP1R15B
OASIS PortalPPP1R15B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R15B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R15B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R15B
DgiDB (Drug Gene Interaction Database)PPP1R15B
DoCM (Curated mutations)PPP1R15B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R15B (select a term)
intoGenPPP1R15B
Cancer3DPPP1R15B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613257    616817   
Orphanet22619   
MedgenPPP1R15B
Genetic Testing Registry PPP1R15B
NextProtQ5SWA1 [Medical]
TSGene84919
GENETestsPPP1R15B
Target ValidationPPP1R15B
Huge Navigator PPP1R15B [HugePedia]
snp3D : Map Gene to Disease84919
BioCentury BCIQPPP1R15B
ClinGenPPP1R15B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84919
Chemical/Pharm GKB GenePA33633
Clinical trialPPP1R15B
Miscellaneous
canSAR (ICR)PPP1R15B (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R15B
EVEXPPP1R15B
GoPubMedPPP1R15B
iHOPPPP1R15B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:38 CEST 2017

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