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PPP1R1C (protein phosphatase 1 regulatory inhibitor subunit 1C)

Identity

Alias_namesprotein phosphatase 1
Alias_symbol (synonym)Inhibitor-1-like
Other aliasIPP5
HGNC (Hugo) PPP1R1C
LocusID (NCBI) 151242
Atlas_Id 47023
Location 2q31.3  [Link to chromosome band 2q31]
Location_base_pair Starts at 182850551 and ends at 182982483 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PDE1A (2q32.1) / PPP1R1C (2q31.3)SSFA2 (2q31.3) / PPP1R1C (2q31.3)PDE1A 2q32.1 / PPP1R1C 2q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1R1C   14940
Cards
Entrez_Gene (NCBI)PPP1R1C  151242  protein phosphatase 1 regulatory inhibitor subunit 1C
AliasesIPP5
GeneCards (Weizmann)PPP1R1C
Ensembl hg19 (Hinxton)ENSG00000150722 [Gene_View]  chr2:182850551-182982483 [Contig_View]  PPP1R1C [Vega]
Ensembl hg38 (Hinxton)ENSG00000150722 [Gene_View]  chr2:182850551-182982483 [Contig_View]  PPP1R1C [Vega]
ICGC DataPortalENSG00000150722
TCGA cBioPortalPPP1R1C
AceView (NCBI)PPP1R1C
Genatlas (Paris)PPP1R1C
WikiGenes151242
SOURCE (Princeton)PPP1R1C
Genetics Home Reference (NIH)PPP1R1C
Genomic and cartography
GoldenPath hg19 (UCSC)PPP1R1C  -     chr2:182850551-182982483 +  2q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP1R1C  -     2q31.3   [Description]    (hg38-Dec_2013)
EnsemblPPP1R1C - 2q31.3 [CytoView hg19]  PPP1R1C - 2q31.3 [CytoView hg38]
Mapping of homologs : NCBIPPP1R1C [Mapview hg19]  PPP1R1C [Mapview hg38]
OMIM613240   
Gene and transcription
Genbank (Entrez)AA321774 AF494535 AK129898 AK311322 AK311571
RefSeq transcript (Entrez)NM_001080545 NM_001261424 NM_001261425
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)PPP1R1C
Cluster EST : UnigeneHs.10941 [ NCBI ]
CGAP (NCI)Hs.10941
Alternative Splicing GalleryENSG00000150722
Gene ExpressionPPP1R1C [ NCBI-GEO ]   PPP1R1C [ EBI - ARRAY_EXPRESS ]   PPP1R1C [ SEEK ]   PPP1R1C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R1C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)151242
GTEX Portal (Tissue expression)PPP1R1C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WVI7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WVI7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WVI7
Splice isoforms : SwissVarQ8WVI7
PhosPhoSitePlusQ8WVI7
Domains : Interpro (EBI)PPI_1DARPP-32   
Domain families : Pfam (Sanger)DARPP-32 (PF05395)   
Domain families : Pfam (NCBI)pfam05395   
Conserved Domain (NCBI)PPP1R1C
DMDM Disease mutations151242
Blocks (Seattle)PPP1R1C
SuperfamilyQ8WVI7
Human Protein AtlasENSG00000150722
Peptide AtlasQ8WVI7
IPIIPI00735289   IPI00154746   
Protein Interaction databases
DIP (DOE-UCLA)Q8WVI7
IntAct (EBI)Q8WVI7
FunCoupENSG00000150722
BioGRIDPPP1R1C
STRING (EMBL)PPP1R1C
ZODIACPPP1R1C
Ontologies - Pathways
QuickGOQ8WVI7
Ontology : AmiGOprotein phosphatase inhibitor activity  protein serine/threonine phosphatase inhibitor activity  cytoplasm  negative regulation of protein kinase activity  cell cycle  positive regulation of cell growth  intracellular signal transduction  cell division  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIprotein phosphatase inhibitor activity  protein serine/threonine phosphatase inhibitor activity  cytoplasm  negative regulation of protein kinase activity  cell cycle  positive regulation of cell growth  intracellular signal transduction  cell division  positive regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkPPP1R1C
Atlas of Cancer Signalling NetworkPPP1R1C
Wikipedia pathwaysPPP1R1C
Orthology - Evolution
OrthoDB151242
GeneTree (enSembl)ENSG00000150722
Phylogenetic Trees/Animal Genes : TreeFamPPP1R1C
HOVERGENQ8WVI7
HOGENOMQ8WVI7
Homologs : HomoloGenePPP1R1C
Homology/Alignments : Family Browser (UCSC)PPP1R1C
Gene fusions - Rearrangements
Fusion : MitelmanPDE1A/PPP1R1C [2q32.1/2q31.3]  [t(2;2)(q31;q32)]  
Fusion: TCGAPDE1A 2q32.1 PPP1R1C 2q31.3 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R1C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R1C
dbVarPPP1R1C
ClinVarPPP1R1C
1000_GenomesPPP1R1C 
Exome Variant ServerPPP1R1C
ExAC (Exome Aggregation Consortium)PPP1R1C (select the gene name)
Genetic variants : HAPMAP151242
Genomic Variants (DGV)PPP1R1C [DGVbeta]
DECIPHER (Syndromes)2:182850551-182982483  ENSG00000150722
CONAN: Copy Number AnalysisPPP1R1C 
Mutations
ICGC Data PortalPPP1R1C 
TCGA Data PortalPPP1R1C 
Broad Tumor PortalPPP1R1C
OASIS PortalPPP1R1C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R1C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R1C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R1C
DgiDB (Drug Gene Interaction Database)PPP1R1C
DoCM (Curated mutations)PPP1R1C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R1C (select a term)
intoGenPPP1R1C
Cancer3DPPP1R1C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613240   
Orphanet
MedgenPPP1R1C
Genetic Testing Registry PPP1R1C
NextProtQ8WVI7 [Medical]
TSGene151242
GENETestsPPP1R1C
Huge Navigator PPP1R1C [HugePedia]
snp3D : Map Gene to Disease151242
BioCentury BCIQPPP1R1C
ClinGenPPP1R1C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD151242
Chemical/Pharm GKB GenePA33640
Clinical trialPPP1R1C
Miscellaneous
canSAR (ICR)PPP1R1C (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R1C
EVEXPPP1R1C
GoPubMedPPP1R1C
iHOPPPP1R1C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:19 CEST 2017

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