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PPP1R21 (protein phosphatase 1, regulatory subunit 21)

Identity

Alias_namesCCDC128
KLRAQ1
coiled-coil domain containing 128
KLRAQ motif containing 1
protein phosphatase 1, regulatory subunit 21
Alias_symbol (synonym)FLJ16566
Other alias
HGNC (Hugo) PPP1R21
LocusID (NCBI) 129285
Atlas_Id 72144
Location 2p16.3  [Link to chromosome band 2p16]
Location_base_pair Starts at 48667908 and ends at 48742531 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AKR1B1 (7q33) / PPP1R21 (2p16.3)PPP1R21 (2p16.3) / GNGT1 (7q21.3)PPP1R21 (2p16.3) / STON1 (2p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1R21   30595
Cards
Entrez_Gene (NCBI)PPP1R21  129285  protein phosphatase 1, regulatory subunit 21
AliasesCCDC128; KLRAQ1
GeneCards (Weizmann)PPP1R21
Ensembl hg19 (Hinxton)ENSG00000162869 [Gene_View]  chr2:48667908-48742531 [Contig_View]  PPP1R21 [Vega]
Ensembl hg38 (Hinxton)ENSG00000162869 [Gene_View]  chr2:48667908-48742531 [Contig_View]  PPP1R21 [Vega]
ICGC DataPortalENSG00000162869
TCGA cBioPortalPPP1R21
AceView (NCBI)PPP1R21
Genatlas (Paris)PPP1R21
WikiGenes129285
SOURCE (Princeton)PPP1R21
Genetics Home Reference (NIH)PPP1R21
Genomic and cartography
GoldenPath hg19 (UCSC)PPP1R21  -     chr2:48667908-48742531 +  2p16.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP1R21  -     2p16.3   [Description]    (hg38-Dec_2013)
EnsemblPPP1R21 - 2p16.3 [CytoView hg19]  PPP1R21 - 2p16.3 [CytoView hg38]
Mapping of homologs : NCBIPPP1R21 [Mapview hg19]  PPP1R21 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA449986 AK122900 AK172753 AK172762 AK307755
RefSeq transcript (Entrez)NM_001135629 NM_001135630 NM_001193475 NM_152994
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)PPP1R21
Cluster EST : UnigeneHs.654619 [ NCBI ]
CGAP (NCI)Hs.654619
Alternative Splicing GalleryENSG00000162869
Gene ExpressionPPP1R21 [ NCBI-GEO ]   PPP1R21 [ EBI - ARRAY_EXPRESS ]   PPP1R21 [ SEEK ]   PPP1R21 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)129285
GTEX Portal (Tissue expression)PPP1R21
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMI0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMI0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMI0
Splice isoforms : SwissVarQ6ZMI0
PhosPhoSitePlusQ6ZMI0
Domains : Interpro (EBI)KLRAQ/TTKRSYEDQ_C    Unchr_KLRAQ/TTKRSYEDQ_N   
Domain families : Pfam (Sanger)KLRAQ (PF10205)    TTKRSYEDQ (PF10212)   
Domain families : Pfam (NCBI)pfam10205    pfam10212   
Conserved Domain (NCBI)PPP1R21
DMDM Disease mutations129285
Blocks (Seattle)PPP1R21
SuperfamilyQ6ZMI0
Human Protein AtlasENSG00000162869
Peptide AtlasQ6ZMI0
HPRD17294
IPIIPI00396527   IPI00747521   IPI00845272   IPI00893568   IPI00845285   IPI00893016   IPI00893683   IPI00894254   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMI0
IntAct (EBI)Q6ZMI0
FunCoupENSG00000162869
BioGRIDPPP1R21
STRING (EMBL)PPP1R21
ZODIACPPP1R21
Ontologies - Pathways
QuickGOQ6ZMI0
Ontology : AmiGOmembrane  phosphatase binding  
Ontology : EGO-EBImembrane  phosphatase binding  
NDEx NetworkPPP1R21
Atlas of Cancer Signalling NetworkPPP1R21
Wikipedia pathwaysPPP1R21
Orthology - Evolution
OrthoDB129285
GeneTree (enSembl)ENSG00000162869
Phylogenetic Trees/Animal Genes : TreeFamPPP1R21
HOVERGENQ6ZMI0
HOGENOMQ6ZMI0
Homologs : HomoloGenePPP1R21
Homology/Alignments : Family Browser (UCSC)PPP1R21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R21
dbVarPPP1R21
ClinVarPPP1R21
1000_GenomesPPP1R21 
Exome Variant ServerPPP1R21
ExAC (Exome Aggregation Consortium)PPP1R21 (select the gene name)
Genetic variants : HAPMAP129285
Genomic Variants (DGV)PPP1R21 [DGVbeta]
DECIPHER (Syndromes)2:48667908-48742531  ENSG00000162869
CONAN: Copy Number AnalysisPPP1R21 
Mutations
ICGC Data PortalPPP1R21 
TCGA Data PortalPPP1R21 
Broad Tumor PortalPPP1R21
OASIS PortalPPP1R21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R21
DgiDB (Drug Gene Interaction Database)PPP1R21
DoCM (Curated mutations)PPP1R21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R21 (select a term)
intoGenPPP1R21
Cancer3DPPP1R21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPPP1R21
Genetic Testing Registry PPP1R21
NextProtQ6ZMI0 [Medical]
TSGene129285
GENETestsPPP1R21
Huge Navigator PPP1R21 [HugePedia]
snp3D : Map Gene to Disease129285
BioCentury BCIQPPP1R21
ClinGenPPP1R21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD129285
Chemical/Pharm GKB GenePA164722001
Clinical trialPPP1R21
Miscellaneous
canSAR (ICR)PPP1R21 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R21
EVEXPPP1R21
GoPubMedPPP1R21
iHOPPPP1R21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:39:25 CET 2017

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