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PPP1R37 (protein phosphatase 1 regulatory subunit 37)

Identity

Alias (NCBI)LRRC68
HGNC (Hugo) PPP1R37
HGNC Previous nameLRRC68
HGNC Previous nameleucine rich repeat containing 68
 protein phosphatase 1, regulatory subunit 37
LocusID (NCBI) 284352
Atlas_Id 54549
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 45093179 and ends at 45147285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EHMT1 (9q34.3) / PPP1R37 (19q13.32)PPP1R37 (19q13.32) / CACNG1 (17q24.2)PPP1R37 (19q13.32) / IGSF23 (19q13.31)
PPP1R37 (19q13.32) / KLC3 (19q13.32)PPP1R37 (19q13.32) / PAFAH1B3 (19q13.2)PPP1R37 (19q13.32) / RHPN2 (19q13.11)
PPP1R37 (19q13.32) / ZNF224 (19q13.31)PPP1R37 (19q13.32) / ZNF225 (19q13.31)PRR19 (19q13.2) / PPP1R37 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(19;19)(q13;q13) PPP1R37/PPP6R1


External links

 

Nomenclature
HGNC (Hugo)PPP1R37   27607
Cards
Entrez_Gene (NCBI)PPP1R37    protein phosphatase 1 regulatory subunit 37
AliasesLRRC68
GeneCards (Weizmann)PPP1R37
Ensembl hg19 (Hinxton)ENSG00000104866 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104866 [Gene_View]  ENSG00000104866 [Sequence]  chr19:45093179-45147285 [Contig_View]  PPP1R37 [Vega]
ICGC DataPortalENSG00000104866
TCGA cBioPortalPPP1R37
AceView (NCBI)PPP1R37
Genatlas (Paris)PPP1R37
SOURCE (Princeton)PPP1R37
Genetics Home Reference (NIH)PPP1R37
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R37  -     chr19:45093179-45147285 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R37  -     19q13.32   [Description]    (hg19-Feb_2009)
GoldenPathPPP1R37 - 19q13.32 [CytoView hg19]  PPP1R37 - 19q13.32 [CytoView hg38]
ImmunoBaseENSG00000104866
Genome Data Viewer NCBIPPP1R37 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB075866 BC035704 BC039061
RefSeq transcript (Entrez)NM_019121
Consensus coding sequences : CCDS (NCBI)PPP1R37
Gene ExpressionPPP1R37 [ NCBI-GEO ]   PPP1R37 [ EBI - ARRAY_EXPRESS ]   PPP1R37 [ SEEK ]   PPP1R37 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R37 [ Firebrowse - Broad ]
GenevisibleExpression of PPP1R37 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284352
GTEX Portal (Tissue expression)PPP1R37
Human Protein AtlasENSG00000104866-PPP1R37 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75864   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75864  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75864
PhosPhoSitePlusO75864
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Leu-rich_rpt    LRR_dom_sf   
Domain families : Pfam (Sanger)LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam13516   
Conserved Domain (NCBI)PPP1R37
SuperfamilyO75864
AlphaFold pdb e-kbO75864   
Human Protein Atlas [tissue]ENSG00000104866-PPP1R37 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)O75864
IntAct (EBI)O75864
BioGRIDPPP1R37
STRING (EMBL)PPP1R37
ZODIACPPP1R37
Ontologies - Pathways
QuickGOO75864
Ontology : AmiGOprotein phosphatase inhibitor activity  protein binding  negative regulation of phosphoprotein phosphatase activity  
Ontology : EGO-EBIprotein phosphatase inhibitor activity  protein binding  negative regulation of phosphoprotein phosphatase activity  
NDEx NetworkPPP1R37
Atlas of Cancer Signalling NetworkPPP1R37
Wikipedia pathwaysPPP1R37
Orthology - Evolution
OrthoDB284352
GeneTree (enSembl)ENSG00000104866
Phylogenetic Trees/Animal Genes : TreeFamPPP1R37
Homologs : HomoloGenePPP1R37
Homology/Alignments : Family Browser (UCSC)PPP1R37
Gene fusions - Rearrangements
Fusion : MitelmanEHMT1/PPP1R37 [9q34.3/19q13.32]  
Fusion : MitelmanPPP1R37/CACNG1 [19q13.32/17q24.2]  
Fusion : MitelmanPPP1R37/IGSF23 [19q13.32/19q13.31]  
Fusion : MitelmanPPP1R37/KLC3 [19q13.32/19q13.32]  
Fusion : MitelmanPPP1R37/PAFAH1B3 [19q13.32/19q13.2]  
Fusion : MitelmanPPP1R37/RHPN2 [19q13.32/19q13.11]  
Fusion : MitelmanPPP1R37/ZNF224 [19q13.32/19q13.31]  
Fusion : MitelmanPPP1R37/ZNF225 [19q13.32/19q13.31]  
Fusion : MitelmanPRR19/PPP1R37 [19q13.2/19q13.32]  
Fusion : QuiverPPP1R37
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R37 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R37
dbVarPPP1R37
ClinVarPPP1R37
MonarchPPP1R37
1000_GenomesPPP1R37 
Exome Variant ServerPPP1R37
GNOMAD BrowserENSG00000104866
Varsome BrowserPPP1R37
ACMGPPP1R37 variants
VarityO75864
Genomic Variants (DGV)PPP1R37 [DGVbeta]
DECIPHERPPP1R37 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R37 
Mutations
ICGC Data PortalPPP1R37 
TCGA Data PortalPPP1R37 
Broad Tumor PortalPPP1R37
OASIS PortalPPP1R37 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R37  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP1R37
Mutations and Diseases : HGMDPPP1R37
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP1R37
DgiDB (Drug Gene Interaction Database)PPP1R37
DoCM (Curated mutations)PPP1R37
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R37
Cancer3DPPP1R37
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPPP1R37
MedgenPPP1R37
Genetic Testing Registry PPP1R37
NextProtO75864 [Medical]
GENETestsPPP1R37
Target ValidationPPP1R37
Huge Navigator PPP1R37 [HugePedia]
ClinGenPPP1R37
Clinical trials, drugs, therapy
MyCancerGenomePPP1R37
Protein Interactions : CTDPPP1R37
Pharm GKB GenePA162394589
PharosO75864
Clinical trialPPP1R37
Miscellaneous
canSAR (ICR)PPP1R37
HarmonizomePPP1R37
DataMed IndexPPP1R37
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP1R37
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:28 CEST 2021

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