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PPP1R37 (protein phosphatase 1 regulatory subunit 37)

Identity

Alias_namesLRRC68
leucine rich repeat containing 68
protein phosphatase 1, regulatory subunit 37
Other alias
HGNC (Hugo) PPP1R37
LocusID (NCBI) 284352
Atlas_Id 54549
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 45093173 and ends at 45147285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EHMT1 (9q34.3) / PPP1R37 (19q13.32)PPP1R37 (19q13.32) / CACNG1 (17q24.2)PPP1R37 (19q13.32) / IGSF23 (19q13.31)
PPP1R37 (19q13.32) / KLC3 (19q13.32)PPP1R37 (19q13.32) / PAFAH1B3 (19q13.2)PPP1R37 (19q13.32) / RHPN2 (19q13.11)
PPP1R37 (19q13.32) / ZNF224 (19q13.31)PPP1R37 (19q13.32) / ZNF225 (19q13.31)PRR19 (19q13.2) / PPP1R37 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PPP1R37   27607
Cards
Entrez_Gene (NCBI)PPP1R37  284352  protein phosphatase 1 regulatory subunit 37
AliasesLRRC68
GeneCards (Weizmann)PPP1R37
Ensembl hg19 (Hinxton)ENSG00000104866 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104866 [Gene_View]  chr19:45093173-45147285 [Contig_View]  PPP1R37 [Vega]
ICGC DataPortalENSG00000104866
TCGA cBioPortalPPP1R37
AceView (NCBI)PPP1R37
Genatlas (Paris)PPP1R37
WikiGenes284352
SOURCE (Princeton)PPP1R37
Genetics Home Reference (NIH)PPP1R37
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R37  -     chr19:45093173-45147285 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R37  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblPPP1R37 - 19q13.32 [CytoView hg19]  PPP1R37 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIPPP1R37 [Mapview hg19]  PPP1R37 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB075866 BC035704 BC039061
RefSeq transcript (Entrez)NM_019121
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R37
Cluster EST : UnigeneHs.285363 [ NCBI ]
CGAP (NCI)Hs.285363
Alternative Splicing GalleryENSG00000104866
Gene ExpressionPPP1R37 [ NCBI-GEO ]   PPP1R37 [ EBI - ARRAY_EXPRESS ]   PPP1R37 [ SEEK ]   PPP1R37 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R37 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284352
GTEX Portal (Tissue expression)PPP1R37
Human Protein AtlasENSG00000104866-PPP1R37 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75864   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75864  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75864
Splice isoforms : SwissVarO75864
PhosPhoSitePlusO75864
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt   
Domain families : Pfam (Sanger)LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam13516   
Conserved Domain (NCBI)PPP1R37
DMDM Disease mutations284352
Blocks (Seattle)PPP1R37
SuperfamilyO75864
Human Protein Atlas [tissue]ENSG00000104866-PPP1R37 [tissue]
Peptide AtlasO75864
IPIIPI00290511   IPI00885097   IPI00977264   IPI01012868   
Protein Interaction databases
DIP (DOE-UCLA)O75864
IntAct (EBI)O75864
FunCoupENSG00000104866
BioGRIDPPP1R37
STRING (EMBL)PPP1R37
ZODIACPPP1R37
Ontologies - Pathways
QuickGOO75864
Ontology : AmiGOprotein phosphatase inhibitor activity  protein binding  negative regulation of phosphatase activity  phosphatase binding  
Ontology : EGO-EBIprotein phosphatase inhibitor activity  protein binding  negative regulation of phosphatase activity  phosphatase binding  
NDEx NetworkPPP1R37
Atlas of Cancer Signalling NetworkPPP1R37
Wikipedia pathwaysPPP1R37
Orthology - Evolution
OrthoDB284352
GeneTree (enSembl)ENSG00000104866
Phylogenetic Trees/Animal Genes : TreeFamPPP1R37
HOVERGENO75864
HOGENOMO75864
Homologs : HomoloGenePPP1R37
Homology/Alignments : Family Browser (UCSC)PPP1R37
Gene fusions - Rearrangements
Fusion : MitelmanEHMT1/PPP1R37 [9q34.3/19q13.32]  [t(9;19)(q34;q13)]  
Fusion : MitelmanPPP1R37/CACNG1 [19q13.32/17q24.2]  [t(17;19)(q24;q13)]  
Fusion : MitelmanPPP1R37/IGSF23 [19q13.32/19q13.31]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPPP1R37/KLC3 [19q13.32/19q13.32]  [del(19)(q13q13)]  
Fusion : MitelmanPPP1R37/PAFAH1B3 [19q13.32/19q13.2]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPPP1R37/RHPN2 [19q13.32/19q13.11]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPPP1R37/ZNF224 [19q13.32/19q13.31]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPPP1R37/ZNF225 [19q13.32/19q13.31]  [t(19;19)(q13;q13)]  
Fusion : MitelmanPRR19/PPP1R37 [19q13.2/19q13.32]  [t(19;19)(q13;q13)]  
Fusion: Tumor Portal PPP1R37
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R37 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R37
dbVarPPP1R37
ClinVarPPP1R37
1000_GenomesPPP1R37 
Exome Variant ServerPPP1R37
ExAC (Exome Aggregation Consortium)ENSG00000104866
GNOMAD BrowserENSG00000104866
Genetic variants : HAPMAP284352
Genomic Variants (DGV)PPP1R37 [DGVbeta]
DECIPHERPPP1R37 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R37 
Mutations
ICGC Data PortalPPP1R37 
TCGA Data PortalPPP1R37 
Broad Tumor PortalPPP1R37
OASIS PortalPPP1R37 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R37  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R37
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R37
DgiDB (Drug Gene Interaction Database)PPP1R37
DoCM (Curated mutations)PPP1R37 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R37 (select a term)
intoGenPPP1R37
Cancer3DPPP1R37(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPPP1R37
Genetic Testing Registry PPP1R37
NextProtO75864 [Medical]
TSGene284352
GENETestsPPP1R37
Target ValidationPPP1R37
Huge Navigator PPP1R37 [HugePedia]
snp3D : Map Gene to Disease284352
BioCentury BCIQPPP1R37
ClinGenPPP1R37
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD284352
Chemical/Pharm GKB GenePA162394589
Clinical trialPPP1R37
Miscellaneous
canSAR (ICR)PPP1R37 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R37
EVEXPPP1R37
GoPubMedPPP1R37
iHOPPPP1R37
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:06:15 CET 2017

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