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PPP1R42 (protein phosphatase 1 regulatory subunit 42)

Identity

Alias (NCBI)LRRC67
TLLR
TLRR
dtr
HGNC (Hugo) PPP1R42
HGNC Alias symbdtr
TLLR
HGNC Alias nametestis leucine-rich repeat
HGNC Previous nameLRRC67
HGNC Previous nameleucine rich repeat containing 67
 protein phosphatase 1, regulatory subunit 42
LocusID (NCBI) 286187
Atlas_Id 72152
Location 8q13.1  [Link to chromosome band 8q13]
Location_base_pair Starts at 66964103 and ends at 67028554 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSPP1 (8q13.1) / PPP1R42 (8q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP1R42   33732
Cards
Entrez_Gene (NCBI)PPP1R42    protein phosphatase 1 regulatory subunit 42
AliasesLRRC67; TLLR; TLRR; dtr
GeneCards (Weizmann)PPP1R42
Ensembl hg19 (Hinxton)ENSG00000178125 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178125 [Gene_View]  ENSG00000178125 [Sequence]  chr8:66964103-67028554 [Contig_View]  PPP1R42 [Vega]
ICGC DataPortalENSG00000178125
TCGA cBioPortalPPP1R42
AceView (NCBI)PPP1R42
Genatlas (Paris)PPP1R42
SOURCE (Princeton)PPP1R42
Genetics Home Reference (NIH)PPP1R42
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R42  -     chr8:66964103-67028554 -  8q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R42  -     8q13.1   [Description]    (hg19-Feb_2009)
GoldenPathPPP1R42 - 8q13.1 [CytoView hg19]  PPP1R42 - 8q13.1 [CytoView hg38]
ImmunoBaseENSG00000178125
Genome Data Viewer NCBIPPP1R42 [Mapview hg19]  
OMIM617720   
Gene and transcription
Genbank (Entrez)BC055413 BU678298 BX104552
RefSeq transcript (Entrez)NM_001013626 NM_001348563 NM_001364910 NM_001364911 NM_001364912
Consensus coding sequences : CCDS (NCBI)PPP1R42
Gene ExpressionPPP1R42 [ NCBI-GEO ]   PPP1R42 [ EBI - ARRAY_EXPRESS ]   PPP1R42 [ SEEK ]   PPP1R42 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R42 [ Firebrowse - Broad ]
GenevisibleExpression of PPP1R42 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)286187
GTEX Portal (Tissue expression)PPP1R42
Human Protein AtlasENSG00000178125-PPP1R42 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z4L9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z4L9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z4L9
PhosPhoSitePlusQ7Z4L9
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Leu-rich_rpt    Leu-rich_rpt_4    LRR_dom_sf   
Domain families : Pfam (Sanger)LRR_4 (PF12799)   
Domain families : Pfam (NCBI)pfam12799   
Conserved Domain (NCBI)PPP1R42
SuperfamilyQ7Z4L9
AlphaFold pdb e-kbQ7Z4L9   
Human Protein Atlas [tissue]ENSG00000178125-PPP1R42 [tissue]
HPRD14573
Protein Interaction databases
DIP (DOE-UCLA)Q7Z4L9
IntAct (EBI)Q7Z4L9
BioGRIDPPP1R42
STRING (EMBL)PPP1R42
ZODIACPPP1R42
Ontologies - Pathways
QuickGOQ7Z4L9
Ontology : AmiGOmanchette  actin binding  cytoplasm  centrosome  microtubule organizing center  regulation of phosphatase activity  microtubule cytoskeleton  tubulin binding  dynein complex binding  
Ontology : EGO-EBImanchette  actin binding  cytoplasm  centrosome  microtubule organizing center  regulation of phosphatase activity  microtubule cytoskeleton  tubulin binding  dynein complex binding  
NDEx NetworkPPP1R42
Atlas of Cancer Signalling NetworkPPP1R42
Wikipedia pathwaysPPP1R42
Orthology - Evolution
OrthoDB286187
GeneTree (enSembl)ENSG00000178125
Phylogenetic Trees/Animal Genes : TreeFamPPP1R42
Homologs : HomoloGenePPP1R42
Homology/Alignments : Family Browser (UCSC)PPP1R42
Gene fusions - Rearrangements
Fusion : QuiverPPP1R42
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R42 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R42
dbVarPPP1R42
ClinVarPPP1R42
MonarchPPP1R42
1000_GenomesPPP1R42 
Exome Variant ServerPPP1R42
GNOMAD BrowserENSG00000178125
Varsome BrowserPPP1R42
ACMGPPP1R42 variants
VarityQ7Z4L9
Genomic Variants (DGV)PPP1R42 [DGVbeta]
DECIPHERPPP1R42 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R42 
Mutations
ICGC Data PortalPPP1R42 
TCGA Data PortalPPP1R42 
Broad Tumor PortalPPP1R42
OASIS PortalPPP1R42 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R42  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP1R42
Mutations and Diseases : HGMDPPP1R42
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP1R42
DgiDB (Drug Gene Interaction Database)PPP1R42
DoCM (Curated mutations)PPP1R42
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R42
Cancer3DPPP1R42
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617720   
Orphanet
DisGeNETPPP1R42
MedgenPPP1R42
Genetic Testing Registry PPP1R42
NextProtQ7Z4L9 [Medical]
GENETestsPPP1R42
Target ValidationPPP1R42
Huge Navigator PPP1R42 [HugePedia]
ClinGenPPP1R42
Clinical trials, drugs, therapy
MyCancerGenomePPP1R42
Protein Interactions : CTDPPP1R42
Pharm GKB GenePA162394588
PharosQ7Z4L9
Clinical trialPPP1R42
Miscellaneous
canSAR (ICR)PPP1R42
HarmonizomePPP1R42
DataMed IndexPPP1R42
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP1R42
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:16:59 CEST 2021

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