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PPP1R42 (protein phosphatase 1 regulatory subunit 42)

Identity

Alias_namesLRRC67
leucine rich repeat containing 67
protein phosphatase 1, regulatory subunit 42
Alias_symbol (synonym)dtr
TLLR
Other alias
HGNC (Hugo) PPP1R42
LocusID (NCBI) 286187
Atlas_Id 72152
Location 8q13.1  [Link to chromosome band 8q13]
Location_base_pair Starts at 66987676 and ends at 67028551 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CSPP1 (8q13.1) / PPP1R42 (8q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP1R42   33732
Cards
Entrez_Gene (NCBI)PPP1R42  286187  protein phosphatase 1 regulatory subunit 42
AliasesLRRC67; TLLR; dtr
GeneCards (Weizmann)PPP1R42
Ensembl hg19 (Hinxton)ENSG00000178125 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178125 [Gene_View]  chr8:66987676-67028551 [Contig_View]  PPP1R42 [Vega]
ICGC DataPortalENSG00000178125
TCGA cBioPortalPPP1R42
AceView (NCBI)PPP1R42
Genatlas (Paris)PPP1R42
WikiGenes286187
SOURCE (Princeton)PPP1R42
Genetics Home Reference (NIH)PPP1R42
Genomic and cartography
GoldenPath hg38 (UCSC)PPP1R42  -     chr8:66987676-67028551 -  8q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP1R42  -     8q13.1   [Description]    (hg19-Feb_2009)
EnsemblPPP1R42 - 8q13.1 [CytoView hg19]  PPP1R42 - 8q13.1 [CytoView hg38]
Mapping of homologs : NCBIPPP1R42 [Mapview hg19]  PPP1R42 [Mapview hg38]
Gene and transcription
Genbank (Entrez)BC055413 BU678298 BX104552
RefSeq transcript (Entrez)NM_001013626 NM_001348563
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP1R42
Cluster EST : UnigeneHs.583933 [ NCBI ]
CGAP (NCI)Hs.583933
Alternative Splicing GalleryENSG00000178125
Gene ExpressionPPP1R42 [ NCBI-GEO ]   PPP1R42 [ EBI - ARRAY_EXPRESS ]   PPP1R42 [ SEEK ]   PPP1R42 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP1R42 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)286187
GTEX Portal (Tissue expression)PPP1R42
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z4L9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z4L9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z4L9
Splice isoforms : SwissVarQ7Z4L9
PhosPhoSitePlusQ7Z4L9
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)L_dom-like    Leu-rich_rpt    Leu-rich_rpt_4   
Domain families : Pfam (Sanger)LRR_4 (PF12799)   
Domain families : Pfam (NCBI)pfam12799   
Conserved Domain (NCBI)PPP1R42
DMDM Disease mutations286187
Blocks (Seattle)PPP1R42
SuperfamilyQ7Z4L9
Human Protein AtlasENSG00000178125
Peptide AtlasQ7Z4L9
HPRD14573
IPIIPI00887526   IPI00783171   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z4L9
IntAct (EBI)Q7Z4L9
FunCoupENSG00000178125
BioGRIDPPP1R42
STRING (EMBL)PPP1R42
ZODIACPPP1R42
Ontologies - Pathways
QuickGOQ7Z4L9
Ontology : AmiGOmanchette  actin binding  cytoplasm  centrosome  microtubule organizing center  cytoskeletal protein binding  regulation of phosphatase activity  microtubule cytoskeleton  microtubule cytoskeleton  tubulin binding  dynein complex binding  
Ontology : EGO-EBImanchette  actin binding  cytoplasm  centrosome  microtubule organizing center  cytoskeletal protein binding  regulation of phosphatase activity  microtubule cytoskeleton  microtubule cytoskeleton  tubulin binding  dynein complex binding  
NDEx NetworkPPP1R42
Atlas of Cancer Signalling NetworkPPP1R42
Wikipedia pathwaysPPP1R42
Orthology - Evolution
OrthoDB286187
GeneTree (enSembl)ENSG00000178125
Phylogenetic Trees/Animal Genes : TreeFamPPP1R42
HOVERGENQ7Z4L9
HOGENOMQ7Z4L9
Homologs : HomoloGenePPP1R42
Homology/Alignments : Family Browser (UCSC)PPP1R42
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP1R42 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP1R42
dbVarPPP1R42
ClinVarPPP1R42
1000_GenomesPPP1R42 
Exome Variant ServerPPP1R42
ExAC (Exome Aggregation Consortium)PPP1R42 (select the gene name)
Genetic variants : HAPMAP286187
Genomic Variants (DGV)PPP1R42 [DGVbeta]
DECIPHERPPP1R42 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP1R42 
Mutations
ICGC Data PortalPPP1R42 
TCGA Data PortalPPP1R42 
Broad Tumor PortalPPP1R42
OASIS PortalPPP1R42 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP1R42  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP1R42
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP1R42
DgiDB (Drug Gene Interaction Database)PPP1R42
DoCM (Curated mutations)PPP1R42 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP1R42 (select a term)
intoGenPPP1R42
Cancer3DPPP1R42(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPPP1R42
Genetic Testing Registry PPP1R42
NextProtQ7Z4L9 [Medical]
TSGene286187
GENETestsPPP1R42
Target ValidationPPP1R42
Huge Navigator PPP1R42 [HugePedia]
snp3D : Map Gene to Disease286187
BioCentury BCIQPPP1R42
ClinGenPPP1R42
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD286187
Chemical/Pharm GKB GenePA162394588
Clinical trialPPP1R42
Miscellaneous
canSAR (ICR)PPP1R42 (select the gene name)
Probes
Litterature
PubMed4 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP1R42
EVEXPPP1R42
GoPubMedPPP1R42
iHOPPPP1R42
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:37:08 CEST 2017

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