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PPP2CA (protein phosphatase 2 catalytic subunit alpha)

Identity

Alias (NCBI)NEDLBA
PP2Ac
PP2CA
PP2Calpha
RP-C
HGNC (Hugo) PPP2CA
HGNC Alias symbPP2Calpha
PP2AC
HGNC Alias nameprotein phosphatase 2A catalytic subunit, alpha isoform
HGNC Previous nameprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
 protein phosphatase 2, catalytic subunit, alpha isozyme
LocusID (NCBI) 5515
Atlas_Id 41813
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 134194332 and ends at 134226073 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP2CA (5q31.1) / CDH3 (16q22.1)PPP2CA (5q31.1) / CDKL3 (5q31.1)PPP2CA (5q31.1) / PIK3CA (3q26.32)
PPP2CA (5q31.1) / PPP2CA (5q31.1)PPP2CA (5q31.1) / SAMD12 (8q24.12)SAMD12 (8q24.12) / PPP2CA (5q31.1)
PPP2CA 5q31.1 / CDH3 16q22.1PPP2CA 5q31.1 / CDKL3 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP2CA   9299
Cards
Entrez_Gene (NCBI)PPP2CA    protein phosphatase 2 catalytic subunit alpha
AliasesNEDLBA; PP2Ac; PP2CA; PP2Calpha; 
RP-C
GeneCards (Weizmann)PPP2CA
Ensembl hg19 (Hinxton)ENSG00000113575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113575 [Gene_View]  ENSG00000113575 [Sequence]  chr5:134194332-134226073 [Contig_View]  PPP2CA [Vega]
ICGC DataPortalENSG00000113575
TCGA cBioPortalPPP2CA
AceView (NCBI)PPP2CA
Genatlas (Paris)PPP2CA
SOURCE (Princeton)PPP2CA
Genetics Home Reference (NIH)PPP2CA
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2CA  -     chr5:134194332-134226073 -  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2CA  -     5q31.1   [Description]    (hg19-Feb_2009)
GoldenPathPPP2CA - 5q31.1 [CytoView hg19]  PPP2CA - 5q31.1 [CytoView hg38]
ImmunoBaseENSG00000113575
Genome Data Viewer NCBIPPP2CA [Mapview hg19]  
OMIM176915   618354   
Gene and transcription
Genbank (Entrez)AB451240 AB451365 AK057424 AK097599 AV705728
RefSeq transcript (Entrez)NM_001355019 NM_002715
Consensus coding sequences : CCDS (NCBI)PPP2CA
Gene ExpressionPPP2CA [ NCBI-GEO ]   PPP2CA [ EBI - ARRAY_EXPRESS ]   PPP2CA [ SEEK ]   PPP2CA [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2CA [ Firebrowse - Broad ]
GenevisibleExpression of PPP2CA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5515
GTEX Portal (Tissue expression)PPP2CA
Human Protein AtlasENSG00000113575-PPP2CA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP67775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP67775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP67775
PhosPhoSitePlusP67775
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP2CA
PDB (RSDB)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC    5W0W    6NTS   
PDB Europe2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC    5W0W    6NTS   
PDB (PDBSum)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC    5W0W    6NTS   
PDB (IMB)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC    5W0W    6NTS   
Structural Biology KnowledgeBase2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC    5W0W    6NTS   
SCOP (Structural Classification of Proteins)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC    5W0W    6NTS   
CATH (Classification of proteins structures)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC    5W0W    6NTS   
SuperfamilyP67775
AlphaFold pdb e-kbP67775   
Human Protein Atlas [tissue]ENSG00000113575-PPP2CA [tissue]
HPRD08912
Protein Interaction databases
DIP (DOE-UCLA)P67775
IntAct (EBI)P67775
BioGRIDPPP2CA
STRING (EMBL)PPP2CA
ZODIACPPP2CA
Ontologies - Pathways
QuickGOP67775
Ontology : AmiGOprotein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  chromosome, centromeric region  spindle pole  regulation of protein phosphorylation  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  plasma membrane  regulation of DNA replication  regulation of transcription, DNA-templated  protein dephosphorylation  protein dephosphorylation  ceramide metabolic process  apoptotic process  mitotic nuclear membrane reassembly  mesoderm development  protein C-terminus binding  RNA splicing  response to organic substance  response to lead ion  response to lead ion  negative regulation of epithelial to mesenchymal transition  microtubule cytoskeleton  membrane  second-messenger-mediated signaling  regulation of Wnt signaling pathway  regulation of cell adhesion  negative regulation of cell growth  peptidyl-threonine dephosphorylation  peptidyl-threonine dephosphorylation  regulation of growth  negative regulation of tyrosine phosphorylation of STAT protein  membrane raft  synapse  regulation of cell differentiation  metal ion binding  protein heterodimerization activity  tau protein binding  GABA receptor binding  meiotic cell cycle  extracellular exosome  peptidyl-serine dephosphorylation  positive regulation of protein serine/threonine kinase activity  protein serine phosphatase activity  protein threonine phosphatase activity  regulation of microtubule binding  positive regulation of microtubule binding  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  chromosome, centromeric region  spindle pole  regulation of protein phosphorylation  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  plasma membrane  regulation of DNA replication  regulation of transcription, DNA-templated  protein dephosphorylation  protein dephosphorylation  ceramide metabolic process  apoptotic process  mitotic nuclear membrane reassembly  mesoderm development  protein C-terminus binding  RNA splicing  response to organic substance  response to lead ion  response to lead ion  negative regulation of epithelial to mesenchymal transition  microtubule cytoskeleton  membrane  second-messenger-mediated signaling  regulation of Wnt signaling pathway  regulation of cell adhesion  negative regulation of cell growth  peptidyl-threonine dephosphorylation  peptidyl-threonine dephosphorylation  regulation of growth  negative regulation of tyrosine phosphorylation of STAT protein  membrane raft  synapse  regulation of cell differentiation  metal ion binding  protein heterodimerization activity  tau protein binding  GABA receptor binding  meiotic cell cycle  extracellular exosome  peptidyl-serine dephosphorylation  positive regulation of protein serine/threonine kinase activity  protein serine phosphatase activity  protein threonine phosphatase activity  regulation of microtubule binding  positive regulation of microtubule binding  
Pathways : BIOCARTAAKT Signaling Pathway [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]    AKAP95 role in mitosis and chromosome dynamics [Genes]    mTOR Signaling Pathway [Genes]    Telomeres, Telomerase, Cellular Aging, and Immortality [Genes]    WNT Signaling Pathway [Genes]    ChREBP regulation by carbohydrates and cAMP [Genes]    CTCF: First Multivalent Nuclear Factor [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    Deregulation of CDK5 in Alzheimers Disease [Genes]    Protein Kinase A at the Centrosome [Genes]    Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway [Genes]    Keratinocyte Differentiation [Genes]   
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    TGF-beta signaling pathway    Hippo signaling pathway    Tight junction    Dopaminergic synapse    Long-term depression    Chagas disease (American trypanosomiasis)    Hepatitis C   
NDEx NetworkPPP2CA
Atlas of Cancer Signalling NetworkPPP2CA
Wikipedia pathwaysPPP2CA
Orthology - Evolution
OrthoDB5515
GeneTree (enSembl)ENSG00000113575
Phylogenetic Trees/Animal Genes : TreeFamPPP2CA
Homologs : HomoloGenePPP2CA
Homology/Alignments : Family Browser (UCSC)PPP2CA
Gene fusions - Rearrangements
Fusion : MitelmanPPP2CA/CDH3 [5q31.1/16q22.1]  
Fusion : MitelmanPPP2CA/CDKL3 [5q31.1/5q31.1]  
Fusion : QuiverPPP2CA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2CA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2CA
dbVarPPP2CA
ClinVarPPP2CA
MonarchPPP2CA
1000_GenomesPPP2CA 
Exome Variant ServerPPP2CA
GNOMAD BrowserENSG00000113575
Varsome BrowserPPP2CA
ACMGPPP2CA variants
VarityP67775
Genomic Variants (DGV)PPP2CA [DGVbeta]
DECIPHERPPP2CA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2CA 
Mutations
ICGC Data PortalPPP2CA 
TCGA Data PortalPPP2CA 
Broad Tumor PortalPPP2CA
OASIS PortalPPP2CA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2CA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP2CA
Mutations and Diseases : HGMDPPP2CA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP2CA
DgiDB (Drug Gene Interaction Database)PPP2CA
DoCM (Curated mutations)PPP2CA
CIViC (Clinical Interpretations of Variants in Cancer)PPP2CA
Cancer3DPPP2CA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176915    618354   
Orphanet
DisGeNETPPP2CA
MedgenPPP2CA
Genetic Testing Registry PPP2CA
NextProtP67775 [Medical]
GENETestsPPP2CA
Target ValidationPPP2CA
Huge Navigator PPP2CA [HugePedia]
ClinGenPPP2CA
Clinical trials, drugs, therapy
MyCancerGenomePPP2CA
Protein Interactions : CTDPPP2CA
Pharm GKB GenePA33663
Pharm GKB PathwaysPA165984799   
PharosP67775
Clinical trialPPP2CA
Miscellaneous
canSAR (ICR)PPP2CA
HarmonizomePPP2CA
DataMed IndexPPP2CA
Probes
Litterature
PubMed421 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP2CA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:30 CEST 2021

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