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PPP2CA (protein phosphatase 2 catalytic subunit alpha)

Identity

Alias_namesalpha isoform
Alias_symbol (synonym)PP2Calpha
Other aliasPP2Ac
PP2CA
RP-C
HGNC (Hugo) PPP2CA
LocusID (NCBI) 5515
Atlas_Id 41813
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 134196457 and ends at 134226259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPP2CA (5q31.1) / CDH3 (16q22.1)PPP2CA (5q31.1) / CDKL3 (5q31.1)PPP2CA (5q31.1) / PIK3CA (3q26.32)
PPP2CA (5q31.1) / PPP2CA (5q31.1)PPP2CA (5q31.1) / SAMD12 (8q24.12)SAMD12 (8q24.12) / PPP2CA (5q31.1)
PPP2CA 5q31.1 / CDH3 16q22.1PPP2CA 5q31.1 / CDKL3 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP2CA   9299
Cards
Entrez_Gene (NCBI)PPP2CA  5515  protein phosphatase 2 catalytic subunit alpha
AliasesPP2Ac; PP2CA; PP2Calpha; RP-C
GeneCards (Weizmann)PPP2CA
Ensembl hg19 (Hinxton)ENSG00000113575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113575 [Gene_View]  chr5:134196457-134226259 [Contig_View]  PPP2CA [Vega]
ICGC DataPortalENSG00000113575
TCGA cBioPortalPPP2CA
AceView (NCBI)PPP2CA
Genatlas (Paris)PPP2CA
WikiGenes5515
SOURCE (Princeton)PPP2CA
Genetics Home Reference (NIH)PPP2CA
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2CA  -     chr5:134196457-134226259 -  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2CA  -     5q31.1   [Description]    (hg19-Feb_2009)
EnsemblPPP2CA - 5q31.1 [CytoView hg19]  PPP2CA - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBIPPP2CA [Mapview hg19]  PPP2CA [Mapview hg38]
OMIM176915   
Gene and transcription
Genbank (Entrez)AB451240 AB451365 AK057424 AK097599 AV705728
RefSeq transcript (Entrez)NM_002715
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2CA
Cluster EST : UnigeneHs.105818 [ NCBI ]
CGAP (NCI)Hs.105818
Alternative Splicing GalleryENSG00000113575
Gene ExpressionPPP2CA [ NCBI-GEO ]   PPP2CA [ EBI - ARRAY_EXPRESS ]   PPP2CA [ SEEK ]   PPP2CA [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2CA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5515
GTEX Portal (Tissue expression)PPP2CA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP67775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP67775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP67775
Splice isoforms : SwissVarP67775
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP67775
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP2CA
DMDM Disease mutations5515
Blocks (Seattle)PPP2CA
PDB (SRS)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC   
PDB (PDBSum)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC   
PDB (IMB)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC   
PDB (RSDB)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC   
Structural Biology KnowledgeBase2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC   
SCOP (Structural Classification of Proteins)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC   
CATH (Classification of proteins structures)2IAE    2IE3    2IE4    2NPP    2NYL    2NYM    3C5W    3DW8    3FGA    3K7V    3K7W    3P71    4I5L    4I5N    4IYP    4LAC   
SuperfamilyP67775
Human Protein AtlasENSG00000113575
Peptide AtlasP67775
HPRD08912
IPIIPI00008380   IPI00930502   IPI00815784   IPI00976419   IPI00984991   
Protein Interaction databases
DIP (DOE-UCLA)P67775
IntAct (EBI)P67775
FunCoupENSG00000113575
BioGRIDPPP2CA
STRING (EMBL)PPP2CA
ZODIACPPP2CA
Ontologies - Pathways
QuickGOP67775
Ontology : AmiGOprotein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  chromosome, centromeric region  spindle pole  phosphoprotein phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  plasma membrane  regulation of DNA replication  regulation of transcription, DNA-templated  protein dephosphorylation  ceramide metabolic process  apoptotic process  mitotic nuclear envelope reassembly  mesoderm development  protein C-terminus binding  RNA splicing  response to organic substance  negative regulation of epithelial to mesenchymal transition  microtubule cytoskeleton  membrane  second-messenger-mediated signaling  regulation of Wnt signaling pathway  regulation of cell adhesion  negative regulation of cell growth  regulation of growth  regulation of cell differentiation  metal ion binding  GABA receptor binding  meiotic cell cycle  extracellular exosome  positive regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  chromosome, centromeric region  spindle pole  phosphoprotein phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  plasma membrane  regulation of DNA replication  regulation of transcription, DNA-templated  protein dephosphorylation  ceramide metabolic process  apoptotic process  mitotic nuclear envelope reassembly  mesoderm development  protein C-terminus binding  RNA splicing  response to organic substance  negative regulation of epithelial to mesenchymal transition  microtubule cytoskeleton  membrane  second-messenger-mediated signaling  regulation of Wnt signaling pathway  regulation of cell adhesion  negative regulation of cell growth  regulation of growth  regulation of cell differentiation  metal ion binding  GABA receptor binding  meiotic cell cycle  extracellular exosome  positive regulation of protein serine/threonine kinase activity  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkPPP2CA
Atlas of Cancer Signalling NetworkPPP2CA
Wikipedia pathwaysPPP2CA
Orthology - Evolution
OrthoDB5515
GeneTree (enSembl)ENSG00000113575
Phylogenetic Trees/Animal Genes : TreeFamPPP2CA
HOVERGENP67775
HOGENOMP67775
Homologs : HomoloGenePPP2CA
Homology/Alignments : Family Browser (UCSC)PPP2CA
Gene fusions - Rearrangements
Fusion : MitelmanPPP2CA/CDH3 [5q31.1/16q22.1]  
Fusion : MitelmanPPP2CA/CDKL3 [5q31.1/5q31.1]  [t(5;5)(q31;q31)]  
Fusion: TCGAPPP2CA 5q31.1 CDH3 16q22.1 LUAD
Fusion: TCGAPPP2CA 5q31.1 CDKL3 5q31.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2CA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2CA
dbVarPPP2CA
ClinVarPPP2CA
1000_GenomesPPP2CA 
Exome Variant ServerPPP2CA
ExAC (Exome Aggregation Consortium)PPP2CA (select the gene name)
Genetic variants : HAPMAP5515
Genomic Variants (DGV)PPP2CA [DGVbeta]
DECIPHERPPP2CA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2CA 
Mutations
ICGC Data PortalPPP2CA 
TCGA Data PortalPPP2CA 
Broad Tumor PortalPPP2CA
OASIS PortalPPP2CA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2CA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2CA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2CA
DgiDB (Drug Gene Interaction Database)PPP2CA
DoCM (Curated mutations)PPP2CA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2CA (select a term)
intoGenPPP2CA
Cancer3DPPP2CA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176915   
Orphanet
MedgenPPP2CA
Genetic Testing Registry PPP2CA
NextProtP67775 [Medical]
TSGene5515
GENETestsPPP2CA
Target ValidationPPP2CA
Huge Navigator PPP2CA [HugePedia]
snp3D : Map Gene to Disease5515
BioCentury BCIQPPP2CA
ClinGenPPP2CA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5515
Chemical/Pharm GKB GenePA33663
Clinical trialPPP2CA
Miscellaneous
canSAR (ICR)PPP2CA (select the gene name)
Probes
Litterature
PubMed315 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2CA
EVEXPPP2CA
GoPubMedPPP2CA
iHOPPPP2CA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:11:25 CEST 2017

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