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PPP2CB (protein phosphatase 2 catalytic subunit beta)

Identity

Alias (NCBI)PP2Abeta
PP2CB
HGNC (Hugo) PPP2CB
HGNC Alias symbPP2Abeta
HGNC Alias nameprotein phosphatase 2A catalytic subunit, beta isoform
HGNC Previous nameprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
 protein phosphatase 2, catalytic subunit, beta isozyme
LocusID (NCBI) 5516
Atlas_Id 47185
Location 8p12  [Link to chromosome band 8p12]
Location_base_pair Starts at 30785619 and ends at 30812818 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP2CB (8p12) / COL1A2 (7q21.3)PPP2CB (8p12) / PURG (8p12)PPP2CB 8p12 / PURG 8p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP2CB   9300
Cards
Entrez_Gene (NCBI)PPP2CB    protein phosphatase 2 catalytic subunit beta
AliasesPP2Abeta; PP2CB
GeneCards (Weizmann)PPP2CB
Ensembl hg19 (Hinxton)ENSG00000104695 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104695 [Gene_View]  ENSG00000104695 [Sequence]  chr8:30785619-30812818 [Contig_View]  PPP2CB [Vega]
ICGC DataPortalENSG00000104695
TCGA cBioPortalPPP2CB
AceView (NCBI)PPP2CB
Genatlas (Paris)PPP2CB
SOURCE (Princeton)PPP2CB
Genetics Home Reference (NIH)PPP2CB
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2CB  -     chr8:30785619-30812818 -  8p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2CB  -     8p12   [Description]    (hg19-Feb_2009)
GoldenPathPPP2CB - 8p12 [CytoView hg19]  PPP2CB - 8p12 [CytoView hg38]
ImmunoBaseENSG00000104695
Genome Data Viewer NCBIPPP2CB [Mapview hg19]  
OMIM176916   
Gene and transcription
Genbank (Entrez)AF444006 AK091875 BC012022 BG716837 BT019526
RefSeq transcript (Entrez)NM_001009552 NM_004156
Consensus coding sequences : CCDS (NCBI)PPP2CB
Gene ExpressionPPP2CB [ NCBI-GEO ]   PPP2CB [ EBI - ARRAY_EXPRESS ]   PPP2CB [ SEEK ]   PPP2CB [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2CB [ Firebrowse - Broad ]
GenevisibleExpression of PPP2CB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5516
GTEX Portal (Tissue expression)PPP2CB
Human Protein AtlasENSG00000104695-PPP2CB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62714   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62714  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62714
PhosPhoSitePlusP62714
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP2CB
SuperfamilyP62714
AlphaFold pdb e-kbP62714   
Human Protein Atlas [tissue]ENSG00000104695-PPP2CB [tissue]
HPRD01487
Protein Interaction databases
DIP (DOE-UCLA)P62714
IntAct (EBI)P62714
BioGRIDPPP2CB
STRING (EMBL)PPP2CB
ZODIACPPP2CB
Ontologies - Pathways
QuickGOP62714
Ontology : AmiGOprotein phosphatase type 2A complex  chromosome, centromeric region  spindle pole  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  cytosol  protein dephosphorylation  protein C-terminus binding  apoptotic mitochondrial changes  response to lead ion  regulation of gene expression  response to endoplasmic reticulum stress  peptidyl-threonine dephosphorylation  response to hydrogen peroxide  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of Ras protein signal transduction  response to antibiotic  metal ion binding  tau protein binding  peptidyl-serine dephosphorylation  protein serine phosphatase activity  protein threonine phosphatase activity  positive regulation of microtubule binding  
Ontology : EGO-EBIprotein phosphatase type 2A complex  chromosome, centromeric region  spindle pole  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  cytosol  protein dephosphorylation  protein C-terminus binding  apoptotic mitochondrial changes  response to lead ion  regulation of gene expression  response to endoplasmic reticulum stress  peptidyl-threonine dephosphorylation  response to hydrogen peroxide  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of Ras protein signal transduction  response to antibiotic  metal ion binding  tau protein binding  peptidyl-serine dephosphorylation  protein serine phosphatase activity  protein threonine phosphatase activity  positive regulation of microtubule binding  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    TGF-beta signaling pathway    Hippo signaling pathway    Tight junction    Dopaminergic synapse    Long-term depression    Chagas disease (American trypanosomiasis)    Hepatitis C   
NDEx NetworkPPP2CB
Atlas of Cancer Signalling NetworkPPP2CB
Wikipedia pathwaysPPP2CB
Orthology - Evolution
OrthoDB5516
GeneTree (enSembl)ENSG00000104695
Phylogenetic Trees/Animal Genes : TreeFamPPP2CB
Homologs : HomoloGenePPP2CB
Homology/Alignments : Family Browser (UCSC)PPP2CB
Gene fusions - Rearrangements
Fusion : QuiverPPP2CB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2CB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2CB
dbVarPPP2CB
ClinVarPPP2CB
MonarchPPP2CB
1000_GenomesPPP2CB 
Exome Variant ServerPPP2CB
GNOMAD BrowserENSG00000104695
Varsome BrowserPPP2CB
ACMGPPP2CB variants
VarityP62714
Genomic Variants (DGV)PPP2CB [DGVbeta]
DECIPHERPPP2CB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2CB 
Mutations
ICGC Data PortalPPP2CB 
TCGA Data PortalPPP2CB 
Broad Tumor PortalPPP2CB
OASIS PortalPPP2CB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2CB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP2CB
Mutations and Diseases : HGMDPPP2CB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP2CB
DgiDB (Drug Gene Interaction Database)PPP2CB
DoCM (Curated mutations)PPP2CB
CIViC (Clinical Interpretations of Variants in Cancer)PPP2CB
Cancer3DPPP2CB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176916   
Orphanet
DisGeNETPPP2CB
MedgenPPP2CB
Genetic Testing Registry PPP2CB
NextProtP62714 [Medical]
GENETestsPPP2CB
Target ValidationPPP2CB
Huge Navigator PPP2CB [HugePedia]
ClinGenPPP2CB
Clinical trials, drugs, therapy
MyCancerGenomePPP2CB
Protein Interactions : CTDPPP2CB
Pharm GKB GenePA33664
PharosP62714
Clinical trialPPP2CB
Miscellaneous
canSAR (ICR)PPP2CB
HarmonizomePPP2CB
DataMed IndexPPP2CB
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP2CB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:30 CEST 2021

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