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PPP2CB (protein phosphatase 2 catalytic subunit beta)

Identity

Alias_namesbeta isoform
Alias_symbol (synonym)PP2Abeta
Other aliasPP2CB
HGNC (Hugo) PPP2CB
LocusID (NCBI) 5516
Atlas_Id 47185
Location 8p12  [Link to chromosome band 8p12]
Location_base_pair Starts at 30785610 and ends at 30812836 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP2CB (8p12) / COL1A2 (7q21.3)PPP2CB (8p12) / PURG (8p12)PPP2CB 8p12 / PURG 8p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP2CB   9300
Cards
Entrez_Gene (NCBI)PPP2CB  5516  protein phosphatase 2 catalytic subunit beta
AliasesPP2Abeta; PP2CB
GeneCards (Weizmann)PPP2CB
Ensembl hg19 (Hinxton)ENSG00000104695 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104695 [Gene_View]  chr8:30785610-30812836 [Contig_View]  PPP2CB [Vega]
ICGC DataPortalENSG00000104695
TCGA cBioPortalPPP2CB
AceView (NCBI)PPP2CB
Genatlas (Paris)PPP2CB
WikiGenes5516
SOURCE (Princeton)PPP2CB
Genetics Home Reference (NIH)PPP2CB
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2CB  -     chr8:30785610-30812836 -  8p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2CB  -     8p12   [Description]    (hg19-Feb_2009)
EnsemblPPP2CB - 8p12 [CytoView hg19]  PPP2CB - 8p12 [CytoView hg38]
Mapping of homologs : NCBIPPP2CB [Mapview hg19]  PPP2CB [Mapview hg38]
OMIM176916   
Gene and transcription
Genbank (Entrez)AF444006 AK091875 BC012022 BG716837 BT019526
RefSeq transcript (Entrez)NM_001009552 NM_004156
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2CB
Cluster EST : UnigeneHs.491440 [ NCBI ]
CGAP (NCI)Hs.491440
Alternative Splicing GalleryENSG00000104695
Gene ExpressionPPP2CB [ NCBI-GEO ]   PPP2CB [ EBI - ARRAY_EXPRESS ]   PPP2CB [ SEEK ]   PPP2CB [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2CB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5516
GTEX Portal (Tissue expression)PPP2CB
Human Protein AtlasENSG00000104695-PPP2CB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62714   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62714  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62714
Splice isoforms : SwissVarP62714
PhosPhoSitePlusP62714
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP2CB
DMDM Disease mutations5516
Blocks (Seattle)PPP2CB
SuperfamilyP62714
Human Protein Atlas [tissue]ENSG00000104695-PPP2CB [tissue]
Peptide AtlasP62714
HPRD01487
IPIIPI00429689   IPI00796774   IPI00983167   IPI00983774   IPI00974178   IPI00985356   
Protein Interaction databases
DIP (DOE-UCLA)P62714
IntAct (EBI)P62714
FunCoupENSG00000104695
BioGRIDPPP2CB
STRING (EMBL)PPP2CB
ZODIACPPP2CB
Ontologies - Pathways
QuickGOP62714
Ontology : AmiGOprotein phosphatase type 2A complex  chromosome, centromeric region  spindle pole  protein serine/threonine phosphatase activity  protein binding  nucleus  cytosol  protein dephosphorylation  protein C-terminus binding  apoptotic mitochondrial changes  regulation of gene expression  response to endoplasmic reticulum stress  response to hydrogen peroxide  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of Ras protein signal transduction  response to antibiotic  metal ion binding  extracellular exosome  
Ontology : EGO-EBIprotein phosphatase type 2A complex  chromosome, centromeric region  spindle pole  protein serine/threonine phosphatase activity  protein binding  nucleus  cytosol  protein dephosphorylation  protein C-terminus binding  apoptotic mitochondrial changes  regulation of gene expression  response to endoplasmic reticulum stress  response to hydrogen peroxide  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of Ras protein signal transduction  response to antibiotic  metal ion binding  extracellular exosome  
Pathways : KEGG   
NDEx NetworkPPP2CB
Atlas of Cancer Signalling NetworkPPP2CB
Wikipedia pathwaysPPP2CB
Orthology - Evolution
OrthoDB5516
GeneTree (enSembl)ENSG00000104695
Phylogenetic Trees/Animal Genes : TreeFamPPP2CB
HOVERGENP62714
HOGENOMP62714
Homologs : HomoloGenePPP2CB
Homology/Alignments : Family Browser (UCSC)PPP2CB
Gene fusions - Rearrangements
Fusion: TCGA_MDACCPPP2CB 8p12 PURG 8p12 BRCA OV
Tumor Fusion PortalPPP2CB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2CB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2CB
dbVarPPP2CB
ClinVarPPP2CB
1000_GenomesPPP2CB 
Exome Variant ServerPPP2CB
ExAC (Exome Aggregation Consortium)ENSG00000104695
GNOMAD BrowserENSG00000104695
Genetic variants : HAPMAP5516
Genomic Variants (DGV)PPP2CB [DGVbeta]
DECIPHERPPP2CB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2CB 
Mutations
ICGC Data PortalPPP2CB 
TCGA Data PortalPPP2CB 
Broad Tumor PortalPPP2CB
OASIS PortalPPP2CB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2CB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2CB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2CB
DgiDB (Drug Gene Interaction Database)PPP2CB
DoCM (Curated mutations)PPP2CB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2CB (select a term)
intoGenPPP2CB
Cancer3DPPP2CB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176916   
Orphanet
DisGeNETPPP2CB
MedgenPPP2CB
Genetic Testing Registry PPP2CB
NextProtP62714 [Medical]
TSGene5516
GENETestsPPP2CB
Target ValidationPPP2CB
Huge Navigator PPP2CB [HugePedia]
snp3D : Map Gene to Disease5516
BioCentury BCIQPPP2CB
ClinGenPPP2CB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5516
Chemical/Pharm GKB GenePA33664
Clinical trialPPP2CB
Miscellaneous
canSAR (ICR)PPP2CB (select the gene name)
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2CB
EVEXPPP2CB
GoPubMedPPP2CB
iHOPPPP2CB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:29:58 CET 2017

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