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PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha)

Written2016-03Razia Sultana, Kentaro Nakayama, Kohei Nakamura, Satoru Kyo
Department of Gynecology/Obstetrics Shimane University Hospital kn88@med.shimane-u.ac.jp

Abstract Review on PPP2R1A, with data on DNA, on the protein encoded, and where the gene is implicated.

(Note : for Links provided by Atlas : click)

Identity

Other names2AAA
Medium tumor antigen-associated 61 kDa protein
MGC786
PP2A subunit A isoform PR65-alpha
PP2A subunit A isoform R1-alpha
PP2A-Aalpha
PP2AAALPHA
PR65A
protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
protein phosphatase 2, regulatory subunit A, alpha
serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
HGNC (Hugo) PPP2R1A
LocusID (NCBI) 5518
Atlas_Id 41814
Location 19q13.41  [Link to chromosome band 19q13]
Location_base_pair Starts at 52693055 and ends at 52729678 bp from pter ( according to hg19-Feb_2009)  [Mapping PPP2R1A.png]
Local_order Start at 52693055 and end at 52729678bp. (NCBI 37,August 2010), on the direct strand.
 
  PPP2R1A gene is located on the long (q) arm of chromosome 19 at position 13.41

DNA/RNA

 
Description PPP2R1A gene is encoded by 15 exons located on chromosome 19q13. The genomic size is 36624 bp.
Transcription mRNA size: 2509 bp; coding sequence from 296bp-1770 bp.

Protein

Note The PPP2R1A cDNA has 1767 bp open reading frame encoding a predicted polypeptide of 589 amino acids with a predicted molecular mass of 65KDa.
 
Description The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Interacts with PLA2G16; this interaction might decrease PP2A activity. Belongs to the phosphatase 2A regulatory subunit A family.
 
Expression PPP2R1A is highly expressed from brain (seen 50 times), skin , eye , lung , ovary , uterus , leiomyosarcoma and 129 other tissues.
 
  mRNA expression in normal human tissues for PPP2R1A Gene
Localisation PPP2R1A is located in the cytoplasm, chromosome and centromere in the cell.
Function PP2A is an important and ubiquitously expressed serine threonine phosphatase family, which plays a critical role in many fundamental cellular processes, such as cell proliferation, signal transduction, DNA repair, and apoptosis. The basis for its multifunctionality rests on the large number of subunits that determine its phosphatase activity, substrate specificity, and subcellular localization. PP2A is a heterotrimer composed of a scaffold subunit (A), a catalytic subunit (C), and one of many regulatory subunits (B). The dimeric form consisting of the scaffold and catalytic subunit also exists as the core-PP2A enzyme. Among these subunits, PP2A-A acts as a structural assembly base to escort the catalytic subunit and to facilitate interaction with the regulatory subunit and other substrates, which is essential for the activity of the holoenzyme. The PP2A scaffold subunit is encoded by two distinct genes, Ppp2r1a and Ppp2r1b, resulting in two isoforms, Aα and A β, which are 87% identical. However, in about 90% of the PP2A assemblies, the core and/or holoenzyme is composed of the A α scaffold subunit and is highly abundant in all tissues. The discovery that Aα is mutated in a variety of human malignancies, including cancer of the breast, lung, skin, and ovaries, provided evidence that PP2A-Aα plays a role in cancer, suggesting its role in tumor suppression. PP2A has been studied in vitro using an exogenous inhibitor, okadaic acid(OA), or RNA interference by others, suggesting its possible role in the regulation of meiosis. Recently, Su et al. found that up-regulation of protein phosphatase 2 catalytic subunit (PPP2CB) is key to the meiotic arrest phenotype, which demonstrated that PP2A might be involved in the regulation of meiosis resumption. Qi et al. and Chambon et al. both found that I2PP2A, the inhibitor of PP2A, was essential for sister chromatid segregation, which also suggested the importance of PP2A in meiosis.
Homology The PPP2R1A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.

Mutations

Somatic Recently, somatic mutations in PPP2R1A have been reported in certain types of ovarian and uterine carcinoma. PPP2R1A mutations were demonstrated in 10 of 110 type I ovarian tumors (9.1%) including low grade serous, low-grade endometrioid, clear-cell, and mucinous carcinomas. Moreover, PPP2R1A mutations were observed in 2 of 30 type I uterine (endometrioid) carcinomas (6.7%) and 5 of 26 type II uterine (serous) carcinomas (19.2%). All mutations were located in the alpha-helix repeats near the interface between the A subunit and the regulatory B subunit of the enzyme complex. All mutations identified were heterozygous missense mutations.

Implicated in

Note Many researches in various cancers such as breast, lung, and colon have shown that the cancer-derived mutant form PPP2R1B (PP2Astructural subunit) may have an impaired function because of its inability to form a complex with the catalytic and regulatory subunits. Furthermore, Sablina et al (2007) have reported that the loss of the PP2A-A (scaffold) subunit can induce oncogenic transformation through activation of small GTPase RALA. Pandey et al (2013) observed a statistically significant reduction of the PP2A-Aα/β scaffold subunit in cancer specimens when compared with benign tissues. Similarly, the endogenous level of PP2A-Aα at both the protein and mRNA levels were significantly downregulated in C-33 and PC-3 cells as compared with C-81 and PC-3M high metastatic cell lines. Somatic mutations of the PP2A-Aα and -β subunits observed in colon, breast, and lung cancers, stating that alterations or loss of any of PP2A-Aα and -β subunits can lead to an inhibitory effect by interfering with the interaction of the PP2A scaffold subunit and the PP2A catalytic subunit or regulatory subunit. Also, earlier reports indicate that the loss of expression of the PP2A structural subunit may be an important factor for the failure of integrin dephosphorylation in breast cancer cells.
Entity Wilms tumorigenesis
Note PP2A plays a role in the Wnt signaling pathway and has been shown to be present in the multiprotein complex containing the adenomatous polyposis coli (APC) protein, the serine/threonine kinase GSK3B, and AXIN1 (axin) (Fagotto et al., 1999; Hsu et al., 1999; Seeling et al., 1999; Ikeda et al., 2000), suggesting that PP2A has a role in regulating the activity of this complex. Overexpression of the PP2A B56 regulatory subunit has been shown to markedly reduce CTNNB1 levels in mammalian cells (Seeling et al., 1999), which suggests that increased levels of PP2A accelerate the phosphorylation-dependent proteolysis of CTNNB1. Interestingly, CTNNB1 mutations have recently been reported to occur in about 15% of Wilms tumors (Koesters et al., 1999; Maiti et al., 2000), suggesting that the APC/CTNNB1/HNF4A (Tcf)- LEF1 pathway is involved in Wilms tumorigenesis. Since PP2A also plays a role in the Wnt signaling pathway, alterations in one or more of the PP2A subunits could plausibly affect this pathway and contribute to Wilms tumorigenesis.
  
Entity Mental retardation, autosomal dominant 36 (MRD36)
Note A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associate with impairments in adaptive behavior and manifested during the developmental period. The disease is identified 2 different de novo heterozygous missense mutation in the PPP2R1A gene (Hougo et al., 2015). The mutation were found by parent-child trio exome sequencing and confirmed by Sanger sequencing. In vitro functional expression study showed that the patients with MRD36, PPP2R1A mutation affected PP2A holoenzyme formation by variably interfering with interaction of the A-alpha subunit with the C subunit. All mutation resulted in decreased phosphatase activity, consisting with a dominant negative effect.
  

Bibliography

Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice
Ruediger R, Ruiz J, Walter G
Mol Cell Biol 2011 Sep;31(18):3832-44
PMID 21791616
 
Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells
Kremmer E, Ohst K, Kiefer J, Brewis N, Walter G
Mol Cell Biol 1997 Mar;17(3):1692-701
PMID 9032296
 
Effects of regulatory subunits on the kinetics of protein phosphatase 2A
Price NE, Mumby MC
Biochemistry 2000 Sep 19;39(37):11312-8
PMID 10985776
 
alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure
Hemmings BA, Adams-Pearson C, Maurer F, Müller P, Goris J, Merlevede W, Hofsteenge J, Stone SR
Biochemistry 1990 Apr 3;29(13):3166-73
PMID 2159327
 
Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution
Zhou J, Pham HT, Ruediger R, Walter G
Biochem J 2003 Jan 15;369(Pt 2):387-98
PMID 12370081
 
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms
Calin GA, di Iasio MG, Caprini E, Vorechovsky I, Natali PG, Sozzi G, Croce CM, Barbanti-Brodano G, Russo G, Negrini M
Oncogene 2000 Feb 24;19(9):1191-5
PMID 10713707
 
Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, induces premature separation of sister chromatids during meiosis I and aneuploidy in mouse oocytes in vitro
Mailhes JB, Hilliard C, Fuseler JW, London SN
Chromosome Res 2003;11(6):619-31
PMID 14516070
 
Pleiotropic effect of okadaic acid on maturing mouse oocytes
Alexandre H, Van Cauwenberge A, Tsukitani Y, Mulnard J
Development 1991 Aug;112(4):971-80
PMID 1718679
 
Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis
Lu Q, Dunn RL, Angeles R, Smith GD
Biol Reprod 2002 Jan;66(1):29-37
PMID 11751260
 
Specific inhibition of mouse oocyte nuclear protein phosphatase-1 stimulates germinal vesicle breakdown
Swain JE, Wang X, Saunders TL, Dunn R, Smith GD
Mol Reprod Dev 2003 May;65(1):96-103
PMID 12658638
 
Regulation of mitogen-activated protein kinase phosphorylation, microtubule organization, chromatin behavior, and cell cycle progression by protein phosphatases during pig oocyte maturation and fertilization in vitro
Sun QY, Wu GM, Lai L, Bonk A, Cabot R, Park KW, Day BN, Prather RS, Schatten H
Biol Reprod 2002 Mar;66(3):580-8
PMID 11870061
 
MARF1 regulates essential oogenic processes in mice
Su YQ, Sugiura K, Sun F, Pendola JK, Cox GA, Handel MA, Schimenti JC, Eppig JJ
Science 2012 Mar 23;335(6075):1496-9
PMID 22442484
 
Overexpression of SETβ, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes
Qi ST, Wang ZB, Ouyang YC, Zhang QH, Hu MW, Huang X, Ge Z, Guo L, Wang YP, Hou Y, Schatten H, Sun QY
J Cell Sci 2013 Apr 1;126(Pt 7):1595-603
PMID 23444375
 
The PP2A inhibitor I2PP2A is essential for sister chromatid segregation in oocyte meiosis II
Chambon JP, Touati SA, Berneau S, Cladière D, Hebras C, Groeme R, McDougall A, Wassmann K
Curr Biol 2013 Mar 18;23(6):485-90
PMID 23434280
 
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
Fagotto F, Jho Eh, Zeng L, Kurth T, Joos T, Kaufmann C, Costantini F
J Cell Biol 1999 May 17;145(4):741-56
 
Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
Hsu W, Zeng L, Costantini F
J Biol Chem 1999 Feb 5;274(6):3439-45
PMID 9920888
 
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM
Science 1999 Mar 26;283(5410):2089-91
PMID 10092233
 
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin
Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A
Oncogene 2000 Jan 27;19(4):537-45
PMID 10698523
 
Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors
Koesters R, Ridder R, Kopp-Schneider A, Betts D, Adams V, Niggli F, Briner J, von Knebel Doeberitz M
Cancer Res 1999 Aug 15;59(16):3880-2
PMID 10463574
 
Frequent association of beta-catenin and WT1 mutations in Wilms tumors
Maiti S, Alam R, Amos CI, Huff V
Cancer Res 2000 Nov 15;60(22):6288-92
PMID 11103785
 
The tumor suppressor PP2A Abeta regulates the RalA GTPase
Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, DeCaprio JA, Hahn WC
Cell 2007 Jun 1;129(5):969-82
PMID 17540176
 
Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway
Pandey P, Seshacharyulu P, Das S, Rachagani S, Ponnusamy MP, Yan Y, Johansson SL, Datta K, Fong Lin M, Batra SK
Br J Cancer 2013 Jun 25;108(12):2590-600
PMID 23598299
 

Citation

This paper should be referenced as such :
Sultana R, Nakayama K, Nakamura K, Kyo S
PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Genes/PPP2R1AID41814ch19q13.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Skin: Melanoma

External links

Nomenclature
HGNC (Hugo)PPP2R1A   9302
Cards
AtlasPPP2R1AID41814ch19q13
Entrez_Gene (NCBI)PPP2R1A  5518  protein phosphatase 2 regulatory subunit A, alpha
AliasesMRD36; PP2A-Aalpha; PP2AAALPHA; PR65A
GeneCards (Weizmann)PPP2R1A
Ensembl hg19 (Hinxton)ENSG00000105568 [Gene_View]  chr19:52693055-52729678 [Contig_View]  PPP2R1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000105568 [Gene_View]  chr19:52693055-52729678 [Contig_View]  PPP2R1A [Vega]
ICGC DataPortalENSG00000105568
TCGA cBioPortalPPP2R1A
AceView (NCBI)PPP2R1A
Genatlas (Paris)PPP2R1A
WikiGenes5518
SOURCE (Princeton)PPP2R1A
Genomic and cartography
GoldenPath hg19 (UCSC)PPP2R1A  -     chr19:52693055-52729678 +  19q13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP2R1A  -     19q13   [Description]    (hg38-Dec_2013)
EnsemblPPP2R1A - 19q13 [CytoView hg19]  PPP2R1A - 19q13 [CytoView hg38]
Mapping of homologs : NCBIPPP2R1A [Mapview hg19]  PPP2R1A [Mapview hg38]
OMIM605983   616362   
Gene and transcription
Genbank (Entrez)AK090488 AK091387 AK130000 AK290593 AK291932
RefSeq transcript (Entrez)NM_014225
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)PPP2R1A
Cluster EST : UnigeneHs.467192 [ NCBI ]
CGAP (NCI)Hs.467192
Alternative Splicing GalleryENSG00000105568
Gene ExpressionPPP2R1A [ NCBI-GEO ]   PPP2R1A [ EBI - ARRAY_EXPRESS ]   PPP2R1A [ SEEK ]   PPP2R1A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5518
GTEX Portal (Tissue expression)PPP2R1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30153 (Uniprot)
NextProtP30153  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30153
Splice isoforms : SwissVarP30153 (Swissvar)
PhosPhoSitePlusP30153
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT    HEAT_type_2    PP2A_A_meta   
Domain families : Pfam (Sanger)HEAT (PF02985)   
Domain families : Pfam (NCBI)pfam02985   
DMDM Disease mutations5518
Blocks (Seattle)PPP2R1A
PDB (SRS)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
PDB (PDBSum)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
PDB (IMB)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
PDB (RSDB)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
Structural Biology KnowledgeBase1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
SCOP (Structural Classification of Proteins)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
CATH (Classification of proteins structures)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
SuperfamilyP30153
Human Protein AtlasENSG00000105568
Peptide AtlasP30153
HPRD16184
IPIIPI00554737   IPI01014074   IPI00908543   IPI00910515   IPI00168184   IPI00798116   
Protein Interaction databases
DIP (DOE-UCLA)P30153
IntAct (EBI)P30153
FunCoupENSG00000105568
BioGRIDPPP2R1A
STRING (EMBL)PPP2R1A
ZODIACPPP2R1A
Ontologies - Pathways
QuickGOP30153
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  chromosome, centromeric region  antigen binding  protein serine/threonine phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  regulation of DNA replication  regulation of transcription, DNA-templated  protein complex assembly  protein dephosphorylation  ceramide metabolic process  apoptotic process  chromosome segregation  mitotic nuclear envelope reassembly  female meiotic division  RNA splicing  protein phosphatase type 2A regulator activity  response to organic substance  microtubule cytoskeleton  membrane  second-messenger-mediated signaling  regulation of Wnt signaling pathway  regulation of cell adhesion  negative regulation of cell growth  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  regulation of growth  negative regulation of tyrosine phosphorylation of Stat3 protein  regulation of cell differentiation  protein heterodimerization activity  meiotic spindle elongation  mitotic sister chromatid separation  meiotic sister chromatid cohesion, centromeric  extracellular exosome  peptidyl-serine dephosphorylation  regulation of meiotic cell cycle process involved in oocyte maturation  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  chromosome, centromeric region  antigen binding  protein serine/threonine phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  regulation of DNA replication  regulation of transcription, DNA-templated  protein complex assembly  protein dephosphorylation  ceramide metabolic process  apoptotic process  chromosome segregation  mitotic nuclear envelope reassembly  female meiotic division  RNA splicing  protein phosphatase type 2A regulator activity  response to organic substance  microtubule cytoskeleton  membrane  second-messenger-mediated signaling  regulation of Wnt signaling pathway  regulation of cell adhesion  negative regulation of cell growth  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  regulation of growth  negative regulation of tyrosine phosphorylation of Stat3 protein  regulation of cell differentiation  protein heterodimerization activity  meiotic spindle elongation  mitotic sister chromatid separation  meiotic sister chromatid cohesion, centromeric  extracellular exosome  peptidyl-serine dephosphorylation  regulation of meiotic cell cycle process involved in oocyte maturation  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    TGF-beta signaling pathway    Hippo signaling pathway    Tight junction    Dopaminergic synapse    Long-term depression    Chagas disease (American trypanosomiasis)    Hepatitis C   
REACTOMEP30153 [protein]
REACTOME PathwaysR-HSA-2465910 MASTL Facilitates Mitotic Progression [pathway]
REACTOME PathwaysR-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors [pathway]
REACTOME PathwaysR-HSA-68877 Mitotic Prometaphase [pathway]
REACTOME PathwaysR-HSA-163685 Integration of energy metabolism [pathway]
REACTOME PathwaysR-HSA-2467813 Separation of Sister Chromatids [pathway]
REACTOME PathwaysR-HSA-5467337 APC truncation mutants have impaired AXIN binding [pathway]
REACTOME PathwaysR-HSA-5339716 misspliced GSK3beta mutants stabilize beta-catenin [pathway]
REACTOME PathwaysR-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated [pathway]
REACTOME PathwaysR-HSA-202670 ERKs are inactivated [pathway]
REACTOME PathwaysR-HSA-70171 Glycolysis [pathway]
REACTOME PathwaysR-HSA-5675221 Negative regulation of MAPK pathway [pathway]
REACTOME PathwaysR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition [pathway]
REACTOME PathwaysR-HSA-4641262 disassembly of the destruction complex and recruitment of AXIN to the membrane [pathway]
REACTOME PathwaysR-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated [pathway]
REACTOME PathwaysR-HSA-195253 Degradation of beta-catenin by the destruction complex [pathway]
REACTOME PathwaysR-HSA-69273 Cyclin A/B1 associated events during G2/M transition [pathway]
REACTOME PathwaysR-HSA-5673000 RAF activation [pathway]
REACTOME PathwaysR-HSA-5663220 RHO GTPases Activate Formins [pathway]
REACTOME PathwaysR-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated [pathway]
REACTOME PathwaysR-HSA-380259 Loss of Nlp from mitotic centrosomes [pathway]
REACTOME PathwaysR-HSA-180024 DARPP-32 events [pathway]
REACTOME PathwaysR-HSA-196299 Beta-catenin phosphorylation cascade [pathway]
REACTOME PathwaysR-HSA-2995383 Initiation of Nuclear Envelope Reformation [pathway]
REACTOME PathwaysR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes [pathway]
REACTOME PathwaysR-HSA-1295596 Spry regulation of FGF signaling [pathway]
REACTOME PathwaysR-HSA-198753 ERK/MAPK targets [pathway]
REACTOME PathwaysR-HSA-5467348 truncations of AMER1 destabilize the destruction complex [pathway]
REACTOME PathwaysR-HSA-202670 ERKs are inactivated [pathway]
REACTOME PathwaysR-HSA-1295596 Spry regulation of FGF signaling [pathway]
REACTOME PathwaysR-HSA-389513 CTLA4 inhibitory signaling [pathway]
REACTOME PathwaysR-HSA-5467340 AXIN missense mutants destabilize the destruction complex [pathway]
REACTOME PathwaysR-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated [pathway]
REACTOME PathwaysR-HSA-5620912 Anchoring of the basal body to the plasma membrane [pathway]
REACTOME PathwaysR-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) [pathway]
REACTOME PathwaysR-HSA-1295596 Spry regulation of FGF signaling [pathway]
REACTOME PathwaysR-HSA-69231 Cyclin D associated events in G1 [pathway]
REACTOME PathwaysR-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome [pathway]
REACTOME PathwaysR-HSA-432142 Platelet sensitization by LDL [pathway]
REACTOME PathwaysR-HSA-2500257 Resolution of Sister Chromatid Cohesion [pathway]
REACTOME PathwaysR-HSA-198753 ERK/MAPK targets [pathway]
REACTOME PathwaysR-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 [pathway]
REACTOME PathwaysR-HSA-1295596 Spry regulation of FGF signaling [pathway]
NDEx Network
Atlas of Cancer Signalling NetworkPPP2R1A
Wikipedia pathwaysPPP2R1A
Orthology - Evolution
OrthoDB5518
GeneTree (enSembl)ENSG00000105568
Phylogenetic Trees/Animal Genes : TreeFamPPP2R1A
Homologs : HomoloGenePPP2R1A
Homology/Alignments : Family Browser (UCSC)PPP2R1A
Gene fusions - Rearrangements
Fusion : MitelmanKATNA1/PPP2R1A [6q25.1/19q13.41]  [t(6;19)(q25;q13)]  
Fusion: TCGAKATNA1 6q25.1 PPP2R1A 19q13.41 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPPP2R1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R1A
dbVarPPP2R1A
ClinVarPPP2R1A
1000_GenomesPPP2R1A 
Exome Variant ServerPPP2R1A
ExAC (Exome Aggregation Consortium)PPP2R1A (select the gene name)
Genetic variants : HAPMAP5518
Genomic Variants (DGV)PPP2R1A [DGVbeta]
Mutations
ICGC Data PortalPPP2R1A 
TCGA Data PortalPPP2R1A 
Broad Tumor PortalPPP2R1A
OASIS PortalPPP2R1A [ Somatic mutations - Copy number]
Cancer Gene: CensusPPP2R1A 
Somatic Mutations in Cancer : COSMICPPP2R1A 
intOGen PortalPPP2R1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R1A
DgiDB (Drug Gene Interaction Database)PPP2R1A
DoCM (Curated mutations)PPP2R1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R1A (select a term)
intoGenPPP2R1A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:52693055-52729678  ENSG00000105568
CONAN: Copy Number AnalysisPPP2R1A 
Mutations and Diseases : HGMDPPP2R1A
OMIM605983    616362   
MedgenPPP2R1A
Genetic Testing Registry PPP2R1A
NextProtP30153 [Medical]
TSGene5518
GENETestsPPP2R1A
Huge Navigator PPP2R1A [HugePedia]
snp3D : Map Gene to Disease5518
BioCentury BCIQPPP2R1A
ClinGenPPP2R1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5518
Chemical/Pharm GKB GenePA33666
Clinical trialPPP2R1A
Miscellaneous
canSAR (ICR)PPP2R1A (select the gene name)
Probes
Litterature
PubMed170 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R1A
EVEXPPP2R1A
GoPubMedPPP2R1A
iHOPPPP2R1A
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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