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PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha)

Identity

Other namesMRD36
PP2A-Aalpha
PP2AAALPHA
PR65A
HGNC (Hugo) PPP2R1A
LocusID (NCBI) 5518
Atlas_Id 41814
Location 19q13.41
Location_base_pair Starts at 52693055 and ends at 52729678 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAM12 (10q26.2) / PPP2R1A (19q13.41)KATNA1 (6q25.1) / PPP2R1A (19q13.41)PPP2R1A (19q13.41) / PPP2R1A (19q13.41)
PPP2R1A (19q13.41) / SULT2A1 (19q13.33)RPL32 (3p25.2) / PPP2R1A (19q13.41)WNT5B (12p13.33) / PPP2R1A (19q13.41)
KATNA1 6q25.1 / PPP2R1A 19q13.41

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Skin: Melanoma

External links

Nomenclature
HGNC (Hugo)PPP2R1A   9302
Cards
Entrez_Gene (NCBI)PPP2R1A  5518  protein phosphatase 2 regulatory subunit A, alpha
GeneCards (Weizmann)PPP2R1A
Ensembl hg19 (Hinxton)ENSG00000105568 [Gene_View]  chr19:52693055-52729678 [Contig_View]  PPP2R1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000105568 [Gene_View]  chr19:52693055-52729678 [Contig_View]  PPP2R1A [Vega]
ICGC DataPortalENSG00000105568
TCGA cBioPortalPPP2R1A
AceView (NCBI)PPP2R1A
Genatlas (Paris)PPP2R1A
WikiGenes5518
SOURCE (Princeton)PPP2R1A
Genomic and cartography
GoldenPath hg19 (UCSC)PPP2R1A  -     chr19:52693055-52729678 +  19q13.41   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP2R1A  -     19q13.41   [Description]    (hg38-Dec_2013)
EnsemblPPP2R1A - 19q13.41 [CytoView hg19]  PPP2R1A - 19q13.41 [CytoView hg38]
Mapping of homologs : NCBIPPP2R1A [Mapview hg19]  PPP2R1A [Mapview hg38]
OMIM605983   616362   
Gene and transcription
Genbank (Entrez)AK090488 AK091387 AK130000 AK290593 AK291932
RefSeq transcript (Entrez)NM_014225
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)PPP2R1A
Cluster EST : UnigeneHs.467192 [ NCBI ]
CGAP (NCI)Hs.467192
Alternative Splicing : Fast-db (Paris)GSHG0015144
Alternative Splicing GalleryENSG00000105568
Gene ExpressionPPP2R1A [ NCBI-GEO ]   PPP2R1A [ EBI - ARRAY_EXPRESS ]   PPP2R1A [ SEEK ]   PPP2R1A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)5518
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30153 (Uniprot)
NextProtP30153  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30153
Splice isoforms : SwissVarP30153 (Swissvar)
PhosPhoSitePlusP30153
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT    HEAT_type_2    PP2A_A_meta   
Domain families : Pfam (Sanger)HEAT (PF02985)   
Domain families : Pfam (NCBI)pfam02985   
DMDM Disease mutations5518
Blocks (Seattle)PPP2R1A
PDB (SRS)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
PDB (PDBSum)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
PDB (IMB)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
PDB (RSDB)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
Structural Biology KnowledgeBase1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
SCOP (Structural Classification of Proteins)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
CATH (Classification of proteins structures)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N    4LAC   
SuperfamilyP30153
Human Protein AtlasENSG00000105568
Peptide AtlasP30153
HPRD16184
IPIIPI00554737   IPI01014074   IPI00908543   IPI00910515   IPI00168184   IPI00798116   
Protein Interaction databases
DIP (DOE-UCLA)P30153
IntAct (EBI)P30153
FunCoupENSG00000105568
BioGRIDPPP2R1A
STRING (EMBL)PPP2R1A
ZODIACPPP2R1A
Ontologies - Pathways
QuickGOP30153
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  chromosome, centromeric region  antigen binding  protein serine/threonine phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  regulation of DNA replication  regulation of transcription, DNA-templated  protein complex assembly  protein dephosphorylation  ceramide metabolic process  apoptotic process  chromosome segregation  mitotic nuclear envelope reassembly  female meiotic division  RNA splicing  protein phosphatase type 2A regulator activity  response to organic substance  microtubule cytoskeleton  membrane  second-messenger-mediated signaling  regulation of Wnt signaling pathway  regulation of cell adhesion  negative regulation of cell growth  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  regulation of growth  negative regulation of tyrosine phosphorylation of Stat3 protein  regulation of cell differentiation  protein heterodimerization activity  meiotic spindle elongation  mitotic sister chromatid separation  meiotic sister chromatid cohesion, centromeric  extracellular exosome  peptidyl-serine dephosphorylation  regulation of meiotic cell cycle process involved in oocyte maturation  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  chromosome, centromeric region  antigen binding  protein serine/threonine phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  regulation of DNA replication  regulation of transcription, DNA-templated  protein complex assembly  protein dephosphorylation  ceramide metabolic process  apoptotic process  chromosome segregation  mitotic nuclear envelope reassembly  female meiotic division  RNA splicing  protein phosphatase type 2A regulator activity  response to organic substance  microtubule cytoskeleton  membrane  second-messenger-mediated signaling  regulation of Wnt signaling pathway  regulation of cell adhesion  negative regulation of cell growth  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  regulation of growth  negative regulation of tyrosine phosphorylation of Stat3 protein  regulation of cell differentiation  protein heterodimerization activity  meiotic spindle elongation  mitotic sister chromatid separation  meiotic sister chromatid cohesion, centromeric  extracellular exosome  peptidyl-serine dephosphorylation  regulation of meiotic cell cycle process involved in oocyte maturation  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    TGF-beta signaling pathway    Hippo signaling pathway    Tight junction    Dopaminergic synapse    Long-term depression    Chagas disease (American trypanosomiasis)    Hepatitis C   
NDEx Network
Atlas of Cancer Signalling NetworkPPP2R1A
Wikipedia pathwaysPPP2R1A
Orthology - Evolution
OrthoDB5518
GeneTree (enSembl)ENSG00000105568
Phylogenetic Trees/Animal Genes : TreeFamPPP2R1A
Homologs : HomoloGenePPP2R1A
Homology/Alignments : Family Browser (UCSC)PPP2R1A
Gene fusions - Rearrangements
Fusion: TCGAKATNA1 6q25.1 PPP2R1A 19q13.41 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPPP2R1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R1A
dbVarPPP2R1A
ClinVarPPP2R1A
1000_GenomesPPP2R1A 
Exome Variant ServerPPP2R1A
ExAC (Exome Aggregation Consortium)PPP2R1A (select the gene name)
SNP (GeneSNP Utah)PPP2R1A
SNP : HGBasePPP2R1A
Genetic variants : HAPMAPPPP2R1A
Genomic Variants (DGV)PPP2R1A [DGVbeta]
Mutations
ICGC Data PortalPPP2R1A 
TCGA Data PortalPPP2R1A 
Broad Tumor PortalPPP2R1A
OASIS PortalPPP2R1A [ Somatic mutations - Copy number]
Cancer Gene: CensusPPP2R1A 
Somatic Mutations in Cancer : COSMICPPP2R1A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R1A
DgiDB (Drug Gene Interaction Database)PPP2R1A
DoCM (Curated mutations)PPP2R1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R1A (select a term)
intoGenPPP2R1A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:52693055-52729678
CONAN: Copy Number AnalysisPPP2R1A 
Mutations and Diseases : HGMDPPP2R1A
OMIM605983    616362   
MedgenPPP2R1A
Genetic Testing Registry PPP2R1A
NextProtP30153 [Medical]
TSGene5518
GENETestsPPP2R1A
Huge Navigator PPP2R1A [HugePedia]  PPP2R1A [HugeCancerGEM]
snp3D : Map Gene to Disease5518
BioCentury BCIQPPP2R1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5518
Chemical/Pharm GKB GenePA33666
Clinical trialPPP2R1A
Miscellaneous
canSAR (ICR)PPP2R1A (select the gene name)
Probes
Litterature
PubMed170 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R1A
GoPubMedPPP2R1A
iHOPPPP2R1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:59:53 CEST 2016

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