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PPP2R1A (protein phosphatase 2, regulatory subunit A, alpha)

Identity

Other namesPP2A-Aalpha
PP2AAALPHA
PR65A
HGNC (Hugo) PPP2R1A
LocusID (NCBI) 5518
Location 19q13.41
Location_base_pair Starts at 52693055 and ends at 52729678 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPP2R1A   9302
Cards
Entrez_Gene (NCBI)PPP2R1A  5518  protein phosphatase 2, regulatory subunit A, alpha
GeneCards (Weizmann)PPP2R1A
Ensembl (Hinxton) [Gene_View]  chr19:52693055-52729678 [Contig_View]  PPP2R1A [Vega]
AceView (NCBI)PPP2R1A
Genatlas (Paris)PPP2R1A
WikiGenes5518
SOURCE (Princeton)NM_014225
Genomic and cartography
GoldenPath (UCSC)PPP2R1A  -  19q13.41   chr19:52693055-52729678 +  19q13.41   [Description]    (hg19-Feb_2009)
EnsemblPPP2R1A - 19q13.41 [CytoView]
Mapping of homologs : NCBIPPP2R1A [Mapview]
OMIM605983   
Gene and transcription
Genbank (Entrez)AK090488 AK091387 AK130000 AK290593 AK291932
RefSeq transcript (Entrez)NM_014225
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838498 NW_004929415
Consensus coding sequences : CCDS (NCBI)PPP2R1A
Cluster EST : UnigeneHs.467192 [ NCBI ]
CGAP (NCI)Hs.467192
Alternative Splicing : Fast-db (Paris)GSHG0015144
Gene ExpressionPPP2R1A [ NCBI-GEO ]     PPP2R1A [ SEEK ]   PPP2R1A [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30153 (Uniprot)
NextProtP30153  [Medical]
With graphics : InterProP30153
Splice isoforms : SwissVarP30153 (Swissvar)
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT    HEAT_type_2   
Related proteins : CluSTrP30153
Domain families : Pfam (Sanger)HEAT (PF02985)   
Domain families : Pfam (NCBI)pfam02985   
DMDM Disease mutations5518
Blocks (Seattle)P30153
PDB (SRS)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N   
PDB (PDBSum)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N   
PDB (IMB)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N   
PDB (RSDB)1B3U    2IE3    2IE4    2NPP    2NYL    2NYM    2PKG    3C5W    3DW8    3K7V    3K7W    4I5L    4I5N   
Peptide AtlasP30153
HPRD16184
IPIIPI00554737   IPI01014074   IPI00908543   IPI00910515   IPI00168184   IPI00798116   
Protein Interaction databases
DIP (DOE-UCLA)P30153
IntAct (EBI)P30153
BioGRIDPPP2R1A
InParanoidP30153
Interologous Interaction database P30153
IntegromeDBPPP2R1A
STRING (EMBL)PPP2R1A
Ontologies - Pathways
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  mitotic cell cycle  chromosome, centromeric region  antigen binding  protein serine/threonine phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  regulation of DNA replication  regulation of transcription, DNA-dependent  protein complex assembly  protein dephosphorylation  ceramide metabolic process  apoptotic process  chromosome segregation  mitotic nuclear envelope reassembly  RNA splicing  fibroblast growth factor receptor signaling pathway  protein phosphatase type 2A regulator activity  response to organic substance  gene expression  microtubule cytoskeleton  membrane  RNA metabolic process  mRNA metabolic process  second-messenger-mediated signaling  regulation of Wnt receptor signaling pathway  regulation of cell adhesion  negative regulation of cell growth  regulation of growth  negative regulation of tyrosine phosphorylation of Stat3 protein  regulation of apoptotic process  regulation of cell differentiation  protein heterodimerization activity  peptidyl-serine dephosphorylation  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein phosphatase type 2A complex  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  inactivation of MAPK activity  mitotic cell cycle  chromosome, centromeric region  antigen binding  protein serine/threonine phosphatase activity  protein binding  nucleus  mitochondrion  cytosol  regulation of DNA replication  regulation of transcription, DNA-dependent  protein complex assembly  protein dephosphorylation  ceramide metabolic process  apoptotic process  chromosome segregation  mitotic nuclear envelope reassembly  RNA splicing  fibroblast growth factor receptor signaling pathway  protein phosphatase type 2A regulator activity  response to organic substance  gene expression  microtubule cytoskeleton  membrane  RNA metabolic process  mRNA metabolic process  second-messenger-mediated signaling  regulation of Wnt receptor signaling pathway  regulation of cell adhesion  negative regulation of cell growth  regulation of growth  negative regulation of tyrosine phosphorylation of Stat3 protein  regulation of apoptotic process  regulation of cell differentiation  protein heterodimerization activity  peptidyl-serine dephosphorylation  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    TGF-beta signaling pathway    Hippo signaling pathway    Tight junction    Dopaminergic synapse    Long-term depression    Chagas disease (American trypanosomiasis)    Hepatitis C   
REACTOMEPPP2R1A
Protein Interaction DatabasePPP2R1A
Wikipedia pathwaysPPP2R1A
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PPP2R1A
SNP (GeneSNP Utah)PPP2R1A
SNP : HGBasePPP2R1A
Genetic variants : HAPMAPPPP2R1A
1000_GenomesPPP2R1A 
Cancer Gene: CensusPPP2R1A 
Somatic Mutations in Cancer : COSMICPPP2R1A 
CONAN: Copy Number AnalysisPPP2R1A 
Mutations and Diseases : HGMDPPP2R1A
OMIM605983   
GENETestsPPP2R1A
Disease Genetic AssociationPPP2R1A
Huge Navigator PPP2R1A [HugePedia]  PPP2R1A [HugeCancerGEM]
Genomic VariantsPPP2R1A  PPP2R1A [DGVbeta]
Exome VariantPPP2R1A
dbVarPPP2R1A
ClinVarPPP2R1A
snp3D : Map Gene to Disease5518
General knowledge
Homologs : HomoloGenePPP2R1A
Homology/Alignments : Family Browser (UCSC)PPP2R1A
Phylogenetic Trees/Animal Genes : TreeFamPPP2R1A
Chemical/Protein Interactions : CTD5518
Chemical/Pharm GKB GenePA33666
Clinical trialPPP2R1A
Other databases
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
CoreMinePPP2R1A
iHOPPPP2R1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:24:05 CEST 2014

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