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PPP2R1B (protein phosphatase 2 scaffold subunit Abeta)

Identity

Alias_namesprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform
protein phosphatase 2 regulatory subunit A, beta
Alias_symbol (synonym)PR65B
PP2A-Abeta
Other alias
HGNC (Hugo) PPP2R1B
LocusID (NCBI) 5519
Atlas_Id 458
Location 11q23.1  [Link to chromosome band 11q23]
Location_base_pair Starts at 111737881 and ends at 111766445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LAD1 (1q32.1) / PPP2R1B (11q23.1)MLLT10 (10p12.31) / PPP2R1B (11q23.1)PPP2R1B (11q23.1) / ALG9 (11q23.1)
PPP2R1B (11q23.1) / SIK3 (11q23.3)PPP2R1B (11q23.1) / SNU13 (22q13.2)PPP2R1B (11q23.1) / TERT (5p15.33)
TAT (16q22.2) / PPP2R1B (11q23.1)PPP2R1B 11q23.1 / ALG9 11q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP2R1B   9303
Cards
Entrez_Gene (NCBI)PPP2R1B  5519  protein phosphatase 2 scaffold subunit Abeta
AliasesPP2A-Abeta; PR65B
GeneCards (Weizmann)PPP2R1B
Ensembl hg19 (Hinxton)ENSG00000137713 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137713 [Gene_View]  chr11:111737881-111766445 [Contig_View]  PPP2R1B [Vega]
ICGC DataPortalENSG00000137713
TCGA cBioPortalPPP2R1B
AceView (NCBI)PPP2R1B
Genatlas (Paris)PPP2R1B
WikiGenes5519
SOURCE (Princeton)PPP2R1B
Genetics Home Reference (NIH)PPP2R1B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R1B  -     chr11:111737881-111766445 -  11q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R1B  -     11q23.1   [Description]    (hg19-Feb_2009)
EnsemblPPP2R1B - 11q23.1 [CytoView hg19]  PPP2R1B - 11q23.1 [CytoView hg38]
Mapping of homologs : NCBIPPP2R1B [Mapview hg19]  PPP2R1B [Mapview hg38]
OMIM211980   603113   
Gene and transcription
Genbank (Entrez)AF087438 AF163473 AK292275 AK293388 AK294716
RefSeq transcript (Entrez)NM_001177562 NM_001177563 NM_002716 NM_181699 NM_181700
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2R1B
Cluster EST : UnigeneHs.584790 [ NCBI ]
CGAP (NCI)Hs.584790
Alternative Splicing GalleryENSG00000137713
Gene ExpressionPPP2R1B [ NCBI-GEO ]   PPP2R1B [ EBI - ARRAY_EXPRESS ]   PPP2R1B [ SEEK ]   PPP2R1B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5519
GTEX Portal (Tissue expression)PPP2R1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30154   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30154  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30154
Splice isoforms : SwissVarP30154
PhosPhoSitePlusP30154
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT    HEAT_type_2   
Domain families : Pfam (Sanger)HEAT (PF02985)   
Domain families : Pfam (NCBI)pfam02985   
Conserved Domain (NCBI)PPP2R1B
DMDM Disease mutations5519
Blocks (Seattle)PPP2R1B
SuperfamilyP30154
Human Protein AtlasENSG00000137713
Peptide AtlasP30154
HPRD04384
IPIIPI00294178   IPI00335449   IPI00973793   IPI01013427   IPI00939356   IPI00981965   IPI00910814   IPI00909011   IPI00978397   IPI00978819   IPI00982690   
Protein Interaction databases
DIP (DOE-UCLA)P30154
IntAct (EBI)P30154
FunCoupENSG00000137713
BioGRIDPPP2R1B
STRING (EMBL)PPP2R1B
ZODIACPPP2R1B
Ontologies - Pathways
QuickGOP30154
Ontology : AmiGOprotein binding  membrane raft  apoptotic process involved in morphogenesis  extracellular exosome  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIprotein binding  membrane raft  apoptotic process involved in morphogenesis  extracellular exosome  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGG   
NDEx NetworkPPP2R1B
Atlas of Cancer Signalling NetworkPPP2R1B
Wikipedia pathwaysPPP2R1B
Orthology - Evolution
OrthoDB5519
GeneTree (enSembl)ENSG00000137713
Phylogenetic Trees/Animal Genes : TreeFamPPP2R1B
HOVERGENP30154
HOGENOMP30154
Homologs : HomoloGenePPP2R1B
Homology/Alignments : Family Browser (UCSC)PPP2R1B
Gene fusions - Rearrangements
Fusion : MitelmanMLLT10/PPP2R1B [10p12.31/11q23.1]  [t(10;11)(p12;q23)]  
Fusion : MitelmanPPP2R1B/ALG9 [11q23.1/11q23.1]  [t(11;11)(q23;q23)]  
Fusion : MitelmanPPP2R1B/SIK3 [11q23.1/11q23.3]  [t(11;11)(q23;q23)]  
Fusion: TCGAPPP2R1B 11q23.1 ALG9 11q23.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R1B
dbVarPPP2R1B
ClinVarPPP2R1B
1000_GenomesPPP2R1B 
Exome Variant ServerPPP2R1B
ExAC (Exome Aggregation Consortium)PPP2R1B (select the gene name)
Genetic variants : HAPMAP5519
Genomic Variants (DGV)PPP2R1B [DGVbeta]
DECIPHERPPP2R1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R1B 
Mutations
ICGC Data PortalPPP2R1B 
TCGA Data PortalPPP2R1B 
Broad Tumor PortalPPP2R1B
OASIS PortalPPP2R1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2R1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R1B
DgiDB (Drug Gene Interaction Database)PPP2R1B
DoCM (Curated mutations)PPP2R1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R1B (select a term)
intoGenPPP2R1B
Cancer3DPPP2R1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM211980    603113   
Orphanet
MedgenPPP2R1B
Genetic Testing Registry PPP2R1B
NextProtP30154 [Medical]
TSGene5519
GENETestsPPP2R1B
Huge Navigator PPP2R1B [HugePedia]
snp3D : Map Gene to Disease5519
BioCentury BCIQPPP2R1B
ClinGenPPP2R1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5519
Chemical/Pharm GKB GenePA33667
Clinical trialPPP2R1B
Miscellaneous
canSAR (ICR)PPP2R1B (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R1B
EVEXPPP2R1B
GoPubMedPPP2R1B
iHOPPPP2R1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:32:26 CEST 2017

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