Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPP2R2A (protein phosphatase 2 regulatory subunit Balpha)

Identity

Alias (NCBI)B55A
B55ALPHA
PR52A
PR55A
PR55alpha
HGNC (Hugo) PPP2R2A
HGNC Alias symbPR52A
PR55A
B55A
PR55alpha
B55alpha
HGNC Alias namePP2A subunit B isoform alpha
HGNC Previous nameprotein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
LocusID (NCBI) 5520
Atlas_Id 41815
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 26291508 and ends at 26372679 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKT3 (1q43)::PPP2R2A (8p21.2)ARL15 (5q11.2)::PPP2R2A (8p21.2)PPP2R2A (8p21.2)::CHEK2 (22q12.1)
PPP2R2A (8p21.2)::GEMIN2 (14q21.1)PPP2R2A (8p21.2)::MTUS1 (8p22)PPP2R2A (8p21.2)::PCMTD1 (8q11.23)
PPP2R2A (8p21.2)::PPP2R2A (8p21.2)PPP2R2A (8p21.2)::SH3KBP1 (Xp22.12)PPP2R2A (8p21.2)::ZDHHC2 (8p22)
SNX14 (6q14.3)::PPP2R2A (8p21.2)TSEN15 (1q25.3)::PPP2R2A (8p21.2)AKT3 1q43::PPP2R2A 8p21.2
PPP2R2A 8p21.2::MTUS1 8p22PPP2R2A 8p21.2::ZDHHC2 8p22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP2R2A   9304
Cards
Entrez_Gene (NCBI)PPP2R2A    protein phosphatase 2 regulatory subunit Balpha
AliasesB55A; B55ALPHA; PR52A; PR55A; 
PR55alpha
GeneCards (Weizmann)PPP2R2A
Ensembl hg19 (Hinxton)ENSG00000221914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000221914 [Gene_View]  ENSG00000221914 [Sequence]  chr8:26291508-26372679 [Contig_View]  PPP2R2A [Vega]
ICGC DataPortalENSG00000221914
TCGA cBioPortalPPP2R2A
AceView (NCBI)PPP2R2A
Genatlas (Paris)PPP2R2A
SOURCE (Princeton)PPP2R2A
Genetics Home Reference (NIH)PPP2R2A
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R2A  -     chr8:26291508-26372679 +  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R2A  -     8p21.2   [Description]    (hg19-Feb_2009)
GoldenPathPPP2R2A - 8p21.2 [CytoView hg19]  PPP2R2A - 8p21.2 [CytoView hg38]
ImmunoBaseENSG00000221914
Genome Data Viewer NCBIPPP2R2A [Mapview hg19]  
OMIM604941   
Gene and transcription
Genbank (Entrez)AI814790 AK095153 AK123721 AK303981 AK314823
RefSeq transcript (Entrez)NM_001177591 NM_002717
Consensus coding sequences : CCDS (NCBI)PPP2R2A
Gene ExpressionPPP2R2A [ NCBI-GEO ]   PPP2R2A [ EBI - ARRAY_EXPRESS ]   PPP2R2A [ SEEK ]   PPP2R2A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R2A [ Firebrowse - Broad ]
GenevisibleExpression of PPP2R2A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5520
GTEX Portal (Tissue expression)PPP2R2A
Human Protein AtlasENSG00000221914-PPP2R2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63151   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63151  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63151
PhosPhoSitePlusP63151
Domaine pattern : Prosite (Expaxy)PR55_1 (PS01024)    PR55_2 (PS01025)   
Domains : Interpro (EBI)PP2A_PR55    PP2A_PR55_CS    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)PPP2R2A
PDB (RSDB)3DW8   
PDB Europe3DW8   
PDB (PDBSum)3DW8   
PDB (IMB)3DW8   
Structural Biology KnowledgeBase3DW8   
SCOP (Structural Classification of Proteins)3DW8   
CATH (Classification of proteins structures)3DW8   
SuperfamilyP63151
AlphaFold pdb e-kbP63151   
Human Protein Atlas [tissue]ENSG00000221914-PPP2R2A [tissue]
HPRD09223
Protein Interaction databases
DIP (DOE-UCLA)P63151
IntAct (EBI)P63151
BioGRIDPPP2R2A
STRING (EMBL)PPP2R2A
ZODIACPPP2R2A
Ontologies - Pathways
QuickGOP63151
Ontology : AmiGOprotein phosphatase type 2A complex  protein phosphatase type 2A complex  protein binding  nucleoplasm  cytosol  cytosol  protein dephosphorylation  protein dephosphorylation  protein phosphatase regulator activity  protein phosphatase regulator activity  protein phosphatase regulator activity  response to morphine  regulation of catalytic activity  peptidyl-serine dephosphorylation  glutamatergic synapse  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein phosphatase type 2A complex  protein binding  nucleoplasm  cytosol  cytosol  protein dephosphorylation  protein dephosphorylation  protein phosphatase regulator activity  protein phosphatase regulator activity  protein phosphatase regulator activity  response to morphine  regulation of catalytic activity  peptidyl-serine dephosphorylation  glutamatergic synapse  
Pathways : KEGGKEGG_TIGHT_JUNCTION   
NDEx NetworkPPP2R2A
Atlas of Cancer Signalling NetworkPPP2R2A
Wikipedia pathwaysPPP2R2A
Orthology - Evolution
OrthoDB5520
GeneTree (enSembl)ENSG00000221914
Phylogenetic Trees/Animal Genes : TreeFamPPP2R2A
Homologs : HomoloGenePPP2R2A
Homology/Alignments : Family Browser (UCSC)PPP2R2A
Gene fusions - Rearrangements
Fusion : MitelmanAKT3::PPP2R2A [1q43/8p21.2]  
Fusion : MitelmanPPP2R2A::CHEK2 [8p21.2/22q12.1]  
Fusion : MitelmanPPP2R2A::MTUS1 [8p21.2/8p22]  
Fusion : MitelmanPPP2R2A::ZDHHC2 [8p21.2/8p22]  
Fusion : QuiverPPP2R2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R2A
dbVarPPP2R2A
ClinVarPPP2R2A
MonarchPPP2R2A
1000_GenomesPPP2R2A 
Exome Variant ServerPPP2R2A
GNOMAD BrowserENSG00000221914
Varsome BrowserPPP2R2A
ACMGPPP2R2A variants
VarityP63151
Genomic Variants (DGV)PPP2R2A [DGVbeta]
DECIPHERPPP2R2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R2A 
Mutations
ICGC Data PortalPPP2R2A 
TCGA Data PortalPPP2R2A 
Broad Tumor PortalPPP2R2A
OASIS PortalPPP2R2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R2A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP2R2A
Mutations and Diseases : HGMDPPP2R2A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP2R2A
DgiDB (Drug Gene Interaction Database)PPP2R2A
DoCM (Curated mutations)PPP2R2A
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R2A
Cancer3DPPP2R2A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604941   
Orphanet
DisGeNETPPP2R2A
MedgenPPP2R2A
Genetic Testing Registry PPP2R2A
NextProtP63151 [Medical]
GENETestsPPP2R2A
Target ValidationPPP2R2A
Huge Navigator PPP2R2A [HugePedia]
ClinGenPPP2R2A
Clinical trials, drugs, therapy
MyCancerGenomePPP2R2A
Protein Interactions : CTDPPP2R2A
Pharm GKB GenePA33668
PharosP63151
Clinical trialPPP2R2A
Miscellaneous
canSAR (ICR)PPP2R2A
HarmonizomePPP2R2A
ARCHS4PPP2R2A
DataMed IndexPPP2R2A
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP2R2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:53:31 CET 2022

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.