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PPP2R2A (protein phosphatase 2 regulatory subunit Balpha)

Identity

Alias_namesprotein phosphatase 2 (formerly 2A)
Alias_symbol (synonym)PR52A
PR55A
B55A
Other aliasB55ALPHA
PR55alpha
HGNC (Hugo) PPP2R2A
LocusID (NCBI) 5520
Atlas_Id 41815
Location 8p21.2  [Link to chromosome band 8p21]
Location_base_pair Starts at 26293216 and ends at 26372679 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKT3 (1q43) / PPP2R2A (8p21.2)ARL15 (5q11.2) / PPP2R2A (8p21.2)PPP2R2A (8p21.2) / CHEK2 (22q12.1)
PPP2R2A (8p21.2) / GEMIN2 (14q21.1)PPP2R2A (8p21.2) / MTUS1 (8p22)PPP2R2A (8p21.2) / PCMTD1 (8q11.23)
PPP2R2A (8p21.2) / PPP2R2A (8p21.2)PPP2R2A (8p21.2) / SH3KBP1 (Xp22.12)PPP2R2A (8p21.2) / ZDHHC2 (8p22)
SNX14 (6q14.3) / PPP2R2A (8p21.2)TSEN15 (1q25.3) / PPP2R2A (8p21.2)AKT3 1q43 / PPP2R2A 8p21.2
PPP2R2A 8p21.2 / MTUS1 8p22PPP2R2A 8p21.2 / ZDHHC2 8p22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Breast: Ductal carcinoma


External links

Nomenclature
HGNC (Hugo)PPP2R2A   9304
Cards
Entrez_Gene (NCBI)PPP2R2A  5520  protein phosphatase 2 regulatory subunit Balpha
AliasesB55A; B55ALPHA; PR52A; PR55A; 
PR55alpha
GeneCards (Weizmann)PPP2R2A
Ensembl hg19 (Hinxton)ENSG00000221914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000221914 [Gene_View]  chr8:26293216-26372679 [Contig_View]  PPP2R2A [Vega]
ICGC DataPortalENSG00000221914
TCGA cBioPortalPPP2R2A
AceView (NCBI)PPP2R2A
Genatlas (Paris)PPP2R2A
WikiGenes5520
SOURCE (Princeton)PPP2R2A
Genetics Home Reference (NIH)PPP2R2A
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R2A  -     chr8:26293216-26372679 +  8p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R2A  -     8p21.2   [Description]    (hg19-Feb_2009)
EnsemblPPP2R2A - 8p21.2 [CytoView hg19]  PPP2R2A - 8p21.2 [CytoView hg38]
Mapping of homologs : NCBIPPP2R2A [Mapview hg19]  PPP2R2A [Mapview hg38]
OMIM604941   
Gene and transcription
Genbank (Entrez)AI814790 AK095153 AK123721 AK303981 AK314823
RefSeq transcript (Entrez)NM_001177591 NM_002717
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2R2A
Cluster EST : UnigeneHs.146339 [ NCBI ]
CGAP (NCI)Hs.146339
Alternative Splicing GalleryENSG00000221914
Gene ExpressionPPP2R2A [ NCBI-GEO ]   PPP2R2A [ EBI - ARRAY_EXPRESS ]   PPP2R2A [ SEEK ]   PPP2R2A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5520
GTEX Portal (Tissue expression)PPP2R2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63151   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63151  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63151
Splice isoforms : SwissVarP63151
PhosPhoSitePlusP63151
Domaine pattern : Prosite (Expaxy)PR55_1 (PS01024)    PR55_2 (PS01025)   
Domains : Interpro (EBI)PP2A_PR55    PP2A_PR55_CS    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)PPP2R2A
DMDM Disease mutations5520
Blocks (Seattle)PPP2R2A
PDB (SRS)3DW8   
PDB (PDBSum)3DW8   
PDB (IMB)3DW8   
PDB (RSDB)3DW8   
Structural Biology KnowledgeBase3DW8   
SCOP (Structural Classification of Proteins)3DW8   
CATH (Classification of proteins structures)3DW8   
SuperfamilyP63151
Human Protein AtlasENSG00000221914
Peptide AtlasP63151
HPRD09223
IPIIPI00332511   IPI00983353   IPI00798041   IPI00974337   IPI00973931   IPI00789032   IPI00981689   IPI00984847   IPI00973878   
Protein Interaction databases
DIP (DOE-UCLA)P63151
IntAct (EBI)P63151
FunCoupENSG00000221914
BioGRIDPPP2R2A
STRING (EMBL)PPP2R2A
ZODIACPPP2R2A
Ontologies - Pathways
QuickGOP63151
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  mitotic cell cycle  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleoplasm  cytosol  cytosol  protein dephosphorylation  mitotic nuclear envelope reassembly  protein phosphatase regulator activity  protein complex binding  developmental process  response to morphine  tau protein binding  regulation of catalytic activity  protein phosphatase 2A binding  peptidyl-serine dephosphorylation  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein phosphatase type 2A complex  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  mitotic cell cycle  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleoplasm  cytosol  cytosol  protein dephosphorylation  mitotic nuclear envelope reassembly  protein phosphatase regulator activity  protein complex binding  developmental process  response to morphine  tau protein binding  regulation of catalytic activity  protein phosphatase 2A binding  peptidyl-serine dephosphorylation  
Pathways : KEGG   
NDEx NetworkPPP2R2A
Atlas of Cancer Signalling NetworkPPP2R2A
Wikipedia pathwaysPPP2R2A
Orthology - Evolution
OrthoDB5520
GeneTree (enSembl)ENSG00000221914
Phylogenetic Trees/Animal Genes : TreeFamPPP2R2A
HOVERGENP63151
HOGENOMP63151
Homologs : HomoloGenePPP2R2A
Homology/Alignments : Family Browser (UCSC)PPP2R2A
Gene fusions - Rearrangements
Fusion : MitelmanAKT3/PPP2R2A [1q43/8p21.2]  [t(1;8)(q44;p21)]  
Fusion : MitelmanPPP2R2A/CHEK2 [8p21.2/22q12.1]  [t(8;22)(p21;q12)]  
Fusion : MitelmanPPP2R2A/MTUS1 [8p21.2/8p22]  [t(8;8)(p21;p22)]  
Fusion : MitelmanPPP2R2A/ZDHHC2 [8p21.2/8p22]  [t(8;8)(p21;p22)]  
Fusion: TCGAAKT3 1q43 PPP2R2A 8p21.2 PRAD
Fusion: TCGAPPP2R2A 8p21.2 MTUS1 8p22 PRAD
Fusion: TCGAPPP2R2A 8p21.2 ZDHHC2 8p22 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R2A
dbVarPPP2R2A
ClinVarPPP2R2A
1000_GenomesPPP2R2A 
Exome Variant ServerPPP2R2A
ExAC (Exome Aggregation Consortium)PPP2R2A (select the gene name)
Genetic variants : HAPMAP5520
Genomic Variants (DGV)PPP2R2A [DGVbeta]
DECIPHERPPP2R2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R2A 
Mutations
ICGC Data PortalPPP2R2A 
TCGA Data PortalPPP2R2A 
Broad Tumor PortalPPP2R2A
OASIS PortalPPP2R2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2R2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R2A
DgiDB (Drug Gene Interaction Database)PPP2R2A
DoCM (Curated mutations)PPP2R2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R2A (select a term)
intoGenPPP2R2A
Cancer3DPPP2R2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604941   
Orphanet
MedgenPPP2R2A
Genetic Testing Registry PPP2R2A
NextProtP63151 [Medical]
TSGene5520
GENETestsPPP2R2A
Target ValidationPPP2R2A
Huge Navigator PPP2R2A [HugePedia]
snp3D : Map Gene to Disease5520
BioCentury BCIQPPP2R2A
ClinGenPPP2R2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5520
Chemical/Pharm GKB GenePA33668
Clinical trialPPP2R2A
Miscellaneous
canSAR (ICR)PPP2R2A (select the gene name)
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R2A
EVEXPPP2R2A
GoPubMedPPP2R2A
iHOPPPP2R2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 25 19:26:06 CEST 2017

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