PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta)

2007-02-01  

Identity

HGNC
LOCATION
5q32
LOCUSID
ALIAS
B55BETA,PP2AB55BETA,PP2ABBETA,PP2APR55B,PP2APR55BETA,PR2AB55BETA,PR2ABBETA,PR2APR55BETA,PR52B,PR55-BETA,PR55BETA,SCA12
FUSION GENES

Other Information

Locus ID:

NCBI: 5521
MIM: 604325
HGNC: 9305
Ensembl: ENSG00000156475

Variants:

dbSNP: 5521
ClinVar: 5521
TCGA: ENSG00000156475
COSMIC: PPP2R2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156475ENST00000336640Q00005
ENSG00000156475ENST00000394409Q00005
ENSG00000156475ENST00000394411Q00005
ENSG00000156475ENST00000394413Q00005
ENSG00000156475ENST00000394414Q00005
ENSG00000156475ENST00000453001Q00005
ENSG00000156475ENST00000504198Q00005
ENSG00000156475ENST00000504565E5RFC4
ENSG00000156475ENST00000508267D6RGF9
ENSG00000156475ENST00000508545Q00005
ENSG00000156475ENST00000512011D6RB57
ENSG00000156475ENST00000512639E9PCT7
ENSG00000156475ENST00000512984H0YA16
ENSG00000156475ENST00000515880D6RF04
ENSG00000156475ENST00000528601E9PCT7
ENSG00000156475ENST00000532154E9PCT7

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162862442005The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein.180
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
119561892002Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.72
200560072010Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer.65
119831682002Cyclin G recruits PP2A to dephosphorylate Mdm2.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
210753112010B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer.42
175299922007Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.38
241579192013Bod1 regulates protein phosphatase 2A at mitotic kinetochores.36

Citation

Dessen P

PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43587/ppp2r2b