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PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta)

Identity

Alias_namesSCA12
spinocerebellar ataxia 12
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
Alias_symbol (synonym)PR55-BETA
PR52B
Other aliasB55BETA
PP2AB55BETA
PP2ABBETA
PP2APR55B
PP2APR55BETA
PR2AB55BETA
PR2ABBETA
PR2APR55BETA
PR55BETA
HGNC (Hugo) PPP2R2B
LocusID (NCBI) 5521
Atlas_Id 43587
Location 5q32  [Link to chromosome band 5q32]
Location_base_pair Starts at 146589505 and ends at 147081520 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GNPDA1 (5q31.3) / PPP2R2B (5q32)NRXN1 (2p16.3) / PPP2R2B (5q32)PPP2R2B (5q32) / PLCH2 (1p36.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP2R2B   9305
Cards
Entrez_Gene (NCBI)PPP2R2B  5521  protein phosphatase 2 regulatory subunit Bbeta
AliasesB55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B; 
PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B; PR55-BETA; PR55BETA; SCA12
GeneCards (Weizmann)PPP2R2B
Ensembl hg19 (Hinxton)ENSG00000156475 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156475 [Gene_View]  chr5:146589505-147081520 [Contig_View]  PPP2R2B [Vega]
ICGC DataPortalENSG00000156475
TCGA cBioPortalPPP2R2B
AceView (NCBI)PPP2R2B
Genatlas (Paris)PPP2R2B
WikiGenes5521
SOURCE (Princeton)PPP2R2B
Genetics Home Reference (NIH)PPP2R2B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R2B  -     chr5:146589505-147081520 -  5q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R2B  -     5q32   [Description]    (hg19-Feb_2009)
EnsemblPPP2R2B - 5q32 [CytoView hg19]  PPP2R2B - 5q32 [CytoView hg38]
Mapping of homologs : NCBIPPP2R2B [Mapview hg19]  PPP2R2B [Mapview hg38]
OMIM604325   604326   
Gene and transcription
Genbank (Entrez)AI621232 AK056192 AK289717 AK294659 AK295347
RefSeq transcript (Entrez)NM_001271899 NM_001271900 NM_001271948 NM_181674 NM_181675 NM_181676 NM_181677 NM_181678
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2R2B
Cluster EST : UnigeneHs.655213 [ NCBI ]
CGAP (NCI)Hs.655213
Alternative Splicing GalleryENSG00000156475
Gene ExpressionPPP2R2B [ NCBI-GEO ]   PPP2R2B [ EBI - ARRAY_EXPRESS ]   PPP2R2B [ SEEK ]   PPP2R2B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5521
GTEX Portal (Tissue expression)PPP2R2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00005   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00005  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00005
Splice isoforms : SwissVarQ00005
PhosPhoSitePlusQ00005
Domaine pattern : Prosite (Expaxy)PR55_1 (PS01024)    PR55_2 (PS01025)    WD_REPEATS_1 (PS00678)   
Domains : Interpro (EBI)PP2A_PR55    PP2A_PR55_CS    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)PPP2R2B
DMDM Disease mutations5521
Blocks (Seattle)PPP2R2B
SuperfamilyQ00005
Human Protein AtlasENSG00000156475
Peptide AtlasQ00005
HPRD05059
IPIIPI00020850   IPI00376972   IPI00944557   IPI00944548   IPI00376973   IPI00965513   IPI00964105   IPI00376974   IPI01012563   IPI00965093   IPI00965889   IPI00973871   IPI00973360   
Protein Interaction databases
DIP (DOE-UCLA)Q00005
IntAct (EBI)Q00005
FunCoupENSG00000156475
BioGRIDPPP2R2B
STRING (EMBL)PPP2R2B
ZODIACPPP2R2B
Ontologies - Pathways
QuickGOQ00005
Ontology : AmiGOprotein phosphatase type 2A complex  mitotic cell cycle  protein serine/threonine phosphatase activity  protein binding  mitochondrion  mitochondrial outer membrane  cytosol  cytoskeleton  apoptotic process  protein phosphatase regulator activity  developmental process  regulation of catalytic activity  peptidyl-serine dephosphorylation  
Ontology : EGO-EBIprotein phosphatase type 2A complex  mitotic cell cycle  protein serine/threonine phosphatase activity  protein binding  mitochondrion  mitochondrial outer membrane  cytosol  cytoskeleton  apoptotic process  protein phosphatase regulator activity  developmental process  regulation of catalytic activity  peptidyl-serine dephosphorylation  
Pathways : KEGG   
NDEx NetworkPPP2R2B
Atlas of Cancer Signalling NetworkPPP2R2B
Wikipedia pathwaysPPP2R2B
Orthology - Evolution
OrthoDB5521
GeneTree (enSembl)ENSG00000156475
Phylogenetic Trees/Animal Genes : TreeFamPPP2R2B
HOVERGENQ00005
HOGENOMQ00005
Homologs : HomoloGenePPP2R2B
Homology/Alignments : Family Browser (UCSC)PPP2R2B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R2B
dbVarPPP2R2B
ClinVarPPP2R2B
1000_GenomesPPP2R2B 
Exome Variant ServerPPP2R2B
ExAC (Exome Aggregation Consortium)PPP2R2B (select the gene name)
Genetic variants : HAPMAP5521
Genomic Variants (DGV)PPP2R2B [DGVbeta]
DECIPHERPPP2R2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R2B 
Mutations
ICGC Data PortalPPP2R2B 
TCGA Data PortalPPP2R2B 
Broad Tumor PortalPPP2R2B
OASIS PortalPPP2R2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2R2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R2B
DgiDB (Drug Gene Interaction Database)PPP2R2B
DoCM (Curated mutations)PPP2R2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R2B (select a term)
intoGenPPP2R2B
Cancer3DPPP2R2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604325    604326   
Orphanet13779   
MedgenPPP2R2B
Genetic Testing Registry PPP2R2B
NextProtQ00005 [Medical]
TSGene5521
GENETestsPPP2R2B
Target ValidationPPP2R2B
Huge Navigator PPP2R2B [HugePedia]
snp3D : Map Gene to Disease5521
BioCentury BCIQPPP2R2B
ClinGenPPP2R2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5521
Chemical/Pharm GKB GenePA33669
Clinical trialPPP2R2B
Miscellaneous
canSAR (ICR)PPP2R2B (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R2B
EVEXPPP2R2B
GoPubMedPPP2R2B
iHOPPPP2R2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:11:26 CEST 2017

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