Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPP2R2C (protein phosphatase 2 regulatory subunit Bgamma)

Identity

Alias_namesprotein phosphatase 2 (formerly 2A)
Alias_symbol (synonym)PR52
IMYPNO
MGC33570
PR55G
Other aliasB55-GAMMA
B55gamma
IMYPNO1
HGNC (Hugo) PPP2R2C
LocusID (NCBI) 5522
Atlas_Id 46657
Location 4p16.1  [Link to chromosome band 4p16]
Location_base_pair Starts at 6320578 and ends at 6563600 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABLIM2 (4p16.1) / PPP2R2C (4p16.1)PPP2R2C (4p16.1) / CDK5RAP1 (20q11.21)SEC31A (4q21.22) / PPP2R2C (4p16.1)
ABLIM2 4p16.1 / PPP2R2C 4p16.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP2R2C   9306
Cards
Entrez_Gene (NCBI)PPP2R2C  5522  protein phosphatase 2 regulatory subunit Bgamma
AliasesB55-GAMMA; B55gamma; IMYPNO; IMYPNO1; 
PR52; PR55G
GeneCards (Weizmann)PPP2R2C
Ensembl hg19 (Hinxton)ENSG00000074211 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074211 [Gene_View]  chr4:6320578-6563600 [Contig_View]  PPP2R2C [Vega]
ICGC DataPortalENSG00000074211
TCGA cBioPortalPPP2R2C
AceView (NCBI)PPP2R2C
Genatlas (Paris)PPP2R2C
WikiGenes5522
SOURCE (Princeton)PPP2R2C
Genetics Home Reference (NIH)PPP2R2C
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R2C  -     chr4:6320578-6563600 -  4p16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R2C  -     4p16.1   [Description]    (hg19-Feb_2009)
EnsemblPPP2R2C - 4p16.1 [CytoView hg19]  PPP2R2C - 4p16.1 [CytoView hg38]
Mapping of homologs : NCBIPPP2R2C [Mapview hg19]  PPP2R2C [Mapview hg38]
OMIM605997   
Gene and transcription
Genbank (Entrez)AB209183 AF086924 AF145027 AK093115 AK122849
RefSeq transcript (Entrez)NM_001206994 NM_001206995 NM_001206996 NM_020416 NM_181876
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2R2C
Cluster EST : UnigeneHs.479069 [ NCBI ]
CGAP (NCI)Hs.479069
Alternative Splicing GalleryENSG00000074211
Gene ExpressionPPP2R2C [ NCBI-GEO ]   PPP2R2C [ EBI - ARRAY_EXPRESS ]   PPP2R2C [ SEEK ]   PPP2R2C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5522
GTEX Portal (Tissue expression)PPP2R2C
Human Protein AtlasENSG00000074211-PPP2R2C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2T4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2T4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2T4
Splice isoforms : SwissVarQ9Y2T4
PhosPhoSitePlusQ9Y2T4
Domaine pattern : Prosite (Expaxy)PR55_1 (PS01024)    PR55_2 (PS01025)   
Domains : Interpro (EBI)PP2A_PR55    PP2A_PR55_CS    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)PPP2R2C
DMDM Disease mutations5522
Blocks (Seattle)PPP2R2C
SuperfamilyQ9Y2T4
Human Protein Atlas [tissue]ENSG00000074211-PPP2R2C [tissue]
Peptide AtlasQ9Y2T4
HPRD09345
IPIIPI00032462   IPI00178803   IPI00871687   IPI00556132   IPI00964437   IPI00964445   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2T4
IntAct (EBI)Q9Y2T4
FunCoupENSG00000074211
BioGRIDPPP2R2C
STRING (EMBL)PPP2R2C
ZODIACPPP2R2C
Ontologies - Pathways
QuickGOQ9Y2T4
Ontology : AmiGOprotein phosphatase type 2A complex  protein phosphatase type 2A complex  mitotic cell cycle  protein serine/threonine phosphatase activity  protein binding  cytosol  protein phosphatase regulator activity  protein phosphatase regulator activity  developmental process  regulation of catalytic activity  peptidyl-serine dephosphorylation  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein phosphatase type 2A complex  mitotic cell cycle  protein serine/threonine phosphatase activity  protein binding  cytosol  protein phosphatase regulator activity  protein phosphatase regulator activity  developmental process  regulation of catalytic activity  peptidyl-serine dephosphorylation  
Pathways : KEGG   
NDEx NetworkPPP2R2C
Atlas of Cancer Signalling NetworkPPP2R2C
Wikipedia pathwaysPPP2R2C
Orthology - Evolution
OrthoDB5522
GeneTree (enSembl)ENSG00000074211
Phylogenetic Trees/Animal Genes : TreeFamPPP2R2C
HOVERGENQ9Y2T4
HOGENOMQ9Y2T4
Homologs : HomoloGenePPP2R2C
Homology/Alignments : Family Browser (UCSC)PPP2R2C
Gene fusions - Rearrangements
Fusion : MitelmanABLIM2/PPP2R2C [4p16.1/4p16.1]  [t(4;4)(p16;p16)]  
Fusion: TCGA_MDACCABLIM2 4p16.1 PPP2R2C 4p16.1 BLCA
Tumor Fusion PortalPPP2R2C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R2C
dbVarPPP2R2C
ClinVarPPP2R2C
1000_GenomesPPP2R2C 
Exome Variant ServerPPP2R2C
ExAC (Exome Aggregation Consortium)ENSG00000074211
GNOMAD BrowserENSG00000074211
Genetic variants : HAPMAP5522
Genomic Variants (DGV)PPP2R2C [DGVbeta]
DECIPHERPPP2R2C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R2C 
Mutations
ICGC Data PortalPPP2R2C 
TCGA Data PortalPPP2R2C 
Broad Tumor PortalPPP2R2C
OASIS PortalPPP2R2C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R2C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2R2C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R2C
DgiDB (Drug Gene Interaction Database)PPP2R2C
DoCM (Curated mutations)PPP2R2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R2C (select a term)
intoGenPPP2R2C
Cancer3DPPP2R2C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605997   
Orphanet
DisGeNETPPP2R2C
MedgenPPP2R2C
Genetic Testing Registry PPP2R2C
NextProtQ9Y2T4 [Medical]
TSGene5522
GENETestsPPP2R2C
Target ValidationPPP2R2C
Huge Navigator PPP2R2C [HugePedia]
snp3D : Map Gene to Disease5522
BioCentury BCIQPPP2R2C
ClinGenPPP2R2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5522
Chemical/Pharm GKB GenePA33670
Clinical trialPPP2R2C
Miscellaneous
canSAR (ICR)PPP2R2C (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R2C
EVEXPPP2R2C
GoPubMedPPP2R2C
iHOPPPP2R2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:29:59 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.