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PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha)

Identity

Alias_namesPPP2R3
protein phosphatase 2 (formerly 2A)
Other aliasPR130
PR72
HGNC (Hugo) PPP2R3A
LocusID (NCBI) 5523
Atlas_Id 41816
Location 3q22.2  [Link to chromosome band 3q22]
Location_base_pair Starts at 135965673 and ends at 136147910 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF4G3 (1p36.12) / PPP2R3A (3q22.2)FRMD4B (3p14.1) / PPP2R3A (3q22.2)HKR1 (19q13.12) / PPP2R3A (3q22.2)
MSL2 (3q22.3) / PPP2R3A (3q22.2)EIF4G3 1p36.12 / PPP2R3A 3q22.2FRMD4B 3p14.1 / PPP2R3A 3q22.2
HKR1 19q13.12 / PPP2R3A 3q22.2MSL2 3q22.3 / PPP2R3A 3q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP2R3A   9307
Cards
Entrez_Gene (NCBI)PPP2R3A  5523  protein phosphatase 2 regulatory subunit B''alpha
AliasesPPP2R3; PR130; PR72
GeneCards (Weizmann)PPP2R3A
Ensembl hg19 (Hinxton)ENSG00000073711 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073711 [Gene_View]  chr3:135965673-136147910 [Contig_View]  PPP2R3A [Vega]
ICGC DataPortalENSG00000073711
TCGA cBioPortalPPP2R3A
AceView (NCBI)PPP2R3A
Genatlas (Paris)PPP2R3A
WikiGenes5523
SOURCE (Princeton)PPP2R3A
Genetics Home Reference (NIH)PPP2R3A
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R3A  -     chr3:135965673-136147910 +  3q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R3A  -     3q22.2   [Description]    (hg19-Feb_2009)
EnsemblPPP2R3A - 3q22.2 [CytoView hg19]  PPP2R3A - 3q22.2 [CytoView hg38]
Mapping of homologs : NCBIPPP2R3A [Mapview hg19]  PPP2R3A [Mapview hg38]
OMIM604944   
Gene and transcription
Genbank (Entrez)AK293012 AK298059 AK299544 AK302163 AK314243
RefSeq transcript (Entrez)NM_001190447 NM_002718 NM_181897
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2R3A
Cluster EST : UnigeneHs.518155 [ NCBI ]
CGAP (NCI)Hs.518155
Alternative Splicing GalleryENSG00000073711
Gene ExpressionPPP2R3A [ NCBI-GEO ]   PPP2R3A [ EBI - ARRAY_EXPRESS ]   PPP2R3A [ SEEK ]   PPP2R3A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5523
GTEX Portal (Tissue expression)PPP2R3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ06190   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ06190  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ06190
Splice isoforms : SwissVarQ06190
PhosPhoSitePlusQ06190
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13499   
Conserved Domain (NCBI)PPP2R3A
DMDM Disease mutations5523
Blocks (Seattle)PPP2R3A
PDB (SRS)4I5J    4I5K   
PDB (PDBSum)4I5J    4I5K   
PDB (IMB)4I5J    4I5K   
PDB (RSDB)4I5J    4I5K   
Structural Biology KnowledgeBase4I5J    4I5K   
SCOP (Structural Classification of Proteins)4I5J    4I5K   
CATH (Classification of proteins structures)4I5J    4I5K   
SuperfamilyQ06190
Human Protein AtlasENSG00000073711
Peptide AtlasQ06190
HPRD09225
IPIIPI00029144   IPI00218930   IPI00909020   IPI00944998   
Protein Interaction databases
DIP (DOE-UCLA)Q06190
IntAct (EBI)Q06190
FunCoupENSG00000073711
BioGRIDPPP2R3A
STRING (EMBL)PPP2R3A
ZODIACPPP2R3A
Ontologies - Pathways
QuickGOQ06190
Ontology : AmiGOprotein phosphatase type 2A complex  protein phosphatase type 2A complex  calcium ion binding  protein binding  protein dephosphorylation  protein phosphatase regulator activity  regulation of catalytic activity  somite development  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein phosphatase type 2A complex  calcium ion binding  protein binding  protein dephosphorylation  protein phosphatase regulator activity  regulation of catalytic activity  somite development  
Pathways : KEGGmRNA surveillance pathway    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    Dopaminergic synapse   
NDEx NetworkPPP2R3A
Atlas of Cancer Signalling NetworkPPP2R3A
Wikipedia pathwaysPPP2R3A
Orthology - Evolution
OrthoDB5523
GeneTree (enSembl)ENSG00000073711
Phylogenetic Trees/Animal Genes : TreeFamPPP2R3A
HOVERGENQ06190
HOGENOMQ06190
Homologs : HomoloGenePPP2R3A
Homology/Alignments : Family Browser (UCSC)PPP2R3A
Gene fusions - Rearrangements
Fusion : MitelmanEIF4G3/PPP2R3A [1p36.12/3q22.2]  [t(1;3)(p36;q22)]  
Fusion : MitelmanFRMD4B/PPP2R3A [3p14.1/3q22.2]  [t(3;3)(p14;q22)]  
Fusion : MitelmanHKR1/PPP2R3A [19q13.12/3q22.2]  [t(3;19)(q22;q13)]  
Fusion : MitelmanMSL2/PPP2R3A [3q22.3/3q22.2]  [t(3;3)(q22;q22)]  
Fusion: TCGAEIF4G3 1p36.12 PPP2R3A 3q22.2 BRCA
Fusion: TCGAFRMD4B 3p14.1 PPP2R3A 3q22.2 LUSC
Fusion: TCGAHKR1 19q13.12 PPP2R3A 3q22.2 LUAD
Fusion: TCGAMSL2 3q22.3 PPP2R3A 3q22.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R3A
dbVarPPP2R3A
ClinVarPPP2R3A
1000_GenomesPPP2R3A 
Exome Variant ServerPPP2R3A
ExAC (Exome Aggregation Consortium)PPP2R3A (select the gene name)
Genetic variants : HAPMAP5523
Genomic Variants (DGV)PPP2R3A [DGVbeta]
DECIPHERPPP2R3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R3A 
Mutations
ICGC Data PortalPPP2R3A 
TCGA Data PortalPPP2R3A 
Broad Tumor PortalPPP2R3A
OASIS PortalPPP2R3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2R3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R3A
DgiDB (Drug Gene Interaction Database)PPP2R3A
DoCM (Curated mutations)PPP2R3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R3A (select a term)
intoGenPPP2R3A
Cancer3DPPP2R3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604944   
Orphanet
MedgenPPP2R3A
Genetic Testing Registry PPP2R3A
NextProtQ06190 [Medical]
TSGene5523
GENETestsPPP2R3A
Target ValidationPPP2R3A
Huge Navigator PPP2R3A [HugePedia]
snp3D : Map Gene to Disease5523
BioCentury BCIQPPP2R3A
ClinGenPPP2R3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5523
Chemical/Pharm GKB GenePA35523
Clinical trialPPP2R3A
Miscellaneous
canSAR (ICR)PPP2R3A (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R3A
EVEXPPP2R3A
GoPubMedPPP2R3A
iHOPPPP2R3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:04:09 CEST 2017

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