Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha)

Identity

Alias_namesprotein phosphatase 2, regulatory subunit B (B56), alpha isoform
Alias_symbol (synonym)PR61A
B56A
B56alpha
Other alias
HGNC (Hugo) PPP2R5A
LocusID (NCBI) 5525
Atlas_Id 41818
Location 1q32.3  [Link to chromosome band 1q32]
Location_base_pair Starts at 212285537 and ends at 212361863 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NRF1 (7q32.2) / PPP2R5A (1q32.3)SMUG1 (12q13.13) / PPP2R5A (1q32.3)UBAP1 (9p13.3) / PPP2R5A (1q32.3)
NRF1 7q32.2 / PPP2R5A 1q32.3SMUG1 12q13.13 / PPP2R5A 1q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;7)(q32;q32) NRF1/PPP2R5A
t(1;12)(q32;q13) SMUG1/PPP2R5A

External links

Nomenclature
HGNC (Hugo)PPP2R5A   9309
Cards
Entrez_Gene (NCBI)PPP2R5A  5525  protein phosphatase 2 regulatory subunit B'alpha
AliasesB56A; B56alpha; PR61A
GeneCards (Weizmann)PPP2R5A
Ensembl hg19 (Hinxton)ENSG00000066027 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066027 [Gene_View]  ENSG00000066027 [Sequence]  chr1:212285537-212361863 [Contig_View]  PPP2R5A [Vega]
ICGC DataPortalENSG00000066027
TCGA cBioPortalPPP2R5A
AceView (NCBI)PPP2R5A
Genatlas (Paris)PPP2R5A
WikiGenes5525
SOURCE (Princeton)PPP2R5A
Genetics Home Reference (NIH)PPP2R5A
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R5A  -     chr1:212285537-212361863 +  1q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R5A  -     1q32.3   [Description]    (hg19-Feb_2009)
GoldenPathPPP2R5A - 1q32.3 [CytoView hg19]  PPP2R5A - 1q32.3 [CytoView hg38]
ImmunoBaseENSG00000066027
Mapping of homologs : NCBIPPP2R5A [Mapview hg19]  PPP2R5A [Mapview hg38]
OMIM601643   
Gene and transcription
Genbank (Entrez)AA425592 AK302202 AK312530 BC022474 BC110883
RefSeq transcript (Entrez)NM_001199756 NM_006243
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2R5A
Cluster EST : UnigeneHs.744012 [ NCBI ]
CGAP (NCI)Hs.744012
Alternative Splicing GalleryENSG00000066027
Gene ExpressionPPP2R5A [ NCBI-GEO ]   PPP2R5A [ EBI - ARRAY_EXPRESS ]   PPP2R5A [ SEEK ]   PPP2R5A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R5A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5525
GTEX Portal (Tissue expression)PPP2R5A
Human Protein AtlasENSG00000066027-PPP2R5A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15172   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15172  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15172
Splice isoforms : SwissVarQ15172
PhosPhoSitePlusQ15172
Domains : Interpro (EBI)ARM-like    ARM-type_fold    PP2A_B56   
Domain families : Pfam (Sanger)B56 (PF01603)   
Domain families : Pfam (NCBI)pfam01603   
Conserved Domain (NCBI)PPP2R5A
DMDM Disease mutations5525
Blocks (Seattle)PPP2R5A
SuperfamilyQ15172
Human Protein Atlas [tissue]ENSG00000066027-PPP2R5A [tissue]
Peptide AtlasQ15172
HPRD03384
IPIIPI00014978   IPI00983231   
Protein Interaction databases
DIP (DOE-UCLA)Q15172
IntAct (EBI)Q15172
FunCoupENSG00000066027
BioGRIDPPP2R5A
STRING (EMBL)PPP2R5A
ZODIACPPP2R5A
Ontologies - Pathways
QuickGOQ15172
Ontology : AmiGOprotein phosphatase type 2A complex  protein phosphatase type 2A complex  chromosome, centromeric region  phosphoprotein phosphatase activity  protein binding  nucleus  cytoplasm  centrosome  cytosol  cytosol  protein dephosphorylation  protein dephosphorylation  signal transduction  membrane  protein phosphatase regulator activity  kinase binding  Z disc  M band  regulation of protein autophosphorylation  positive regulation of protein dephosphorylation  regulation of phosphoprotein phosphatase activity  protein phosphatase activator activity  negative regulation of lipid kinase activity  negative regulation of protein localization to plasma membrane  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein phosphatase type 2A complex  chromosome, centromeric region  phosphoprotein phosphatase activity  protein binding  nucleus  cytoplasm  centrosome  cytosol  cytosol  protein dephosphorylation  protein dephosphorylation  signal transduction  membrane  protein phosphatase regulator activity  kinase binding  Z disc  M band  regulation of protein autophosphorylation  positive regulation of protein dephosphorylation  regulation of phosphoprotein phosphatase activity  protein phosphatase activator activity  negative regulation of lipid kinase activity  negative regulation of protein localization to plasma membrane  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    Dopaminergic synapse   
NDEx NetworkPPP2R5A
Atlas of Cancer Signalling NetworkPPP2R5A
Wikipedia pathwaysPPP2R5A
Orthology - Evolution
OrthoDB5525
GeneTree (enSembl)ENSG00000066027
Phylogenetic Trees/Animal Genes : TreeFamPPP2R5A
HOGENOMQ15172
Homologs : HomoloGenePPP2R5A
Homology/Alignments : Family Browser (UCSC)PPP2R5A
Gene fusions - Rearrangements
Fusion : MitelmanNRF1/PPP2R5A [7q32.2/1q32.3]  [t(1;7)(q32;q32)]  
Fusion : MitelmanSMUG1/PPP2R5A [12q13.13/1q32.3]  [t(1;12)(q32;q13)]  
Fusion PortalNRF1 7q32.2 PPP2R5A 1q32.3 PRAD
Fusion PortalSMUG1 12q13.13 PPP2R5A 1q32.3 PRAD
Fusion : QuiverPPP2R5A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R5A
dbVarPPP2R5A
ClinVarPPP2R5A
1000_GenomesPPP2R5A 
Exome Variant ServerPPP2R5A
ExAC (Exome Aggregation Consortium)ENSG00000066027
GNOMAD BrowserENSG00000066027
Varsome BrowserPPP2R5A
Genetic variants : HAPMAP5525
Genomic Variants (DGV)PPP2R5A [DGVbeta]
DECIPHERPPP2R5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R5A 
Mutations
ICGC Data PortalPPP2R5A 
TCGA Data PortalPPP2R5A 
Broad Tumor PortalPPP2R5A
OASIS PortalPPP2R5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R5A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP2R5A
Mutations and Diseases : HGMDPPP2R5A
intOGen PortalPPP2R5A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R5A
DgiDB (Drug Gene Interaction Database)PPP2R5A
DoCM (Curated mutations)PPP2R5A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R5A (select a term)
intoGenPPP2R5A
Cancer3DPPP2R5A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601643   
Orphanet
DisGeNETPPP2R5A
MedgenPPP2R5A
Genetic Testing Registry PPP2R5A
NextProtQ15172 [Medical]
TSGene5525
GENETestsPPP2R5A
Target ValidationPPP2R5A
Huge Navigator PPP2R5A [HugePedia]
snp3D : Map Gene to Disease5525
BioCentury BCIQPPP2R5A
ClinGenPPP2R5A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5525
Chemical/Pharm GKB GenePA33672
Clinical trialPPP2R5A
Miscellaneous
canSAR (ICR)PPP2R5A (select the gene name)
DataMed IndexPPP2R5A
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R5A
EVEXPPP2R5A
GoPubMedPPP2R5A
iHOPPPP2R5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:02:13 CET 2019
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