Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha)

Identity

Alias (NCBI)B56A
B56alpha
PR61A
HGNC (Hugo) PPP2R5A
HGNC Alias symbPR61A
B56A
B56alpha
HGNC Previous nameprotein phosphatase 2, regulatory subunit B (B56), alpha isoform
LocusID (NCBI) 5525
Atlas_Id 41818
Location 1q32.3  [Link to chromosome band 1q32]
Location_base_pair Starts at 212285410 and ends at 212361853 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NRF1 (7q32.2)::PPP2R5A (1q32.3)SMUG1 (12q13.13)::PPP2R5A (1q32.3)UBAP1 (9p13.3)::PPP2R5A (1q32.3)
NRF1 7q32.2::PPP2R5A 1q32.3SMUG1 12q13.13::PPP2R5A 1q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)PPP2R5A   9309
Cards
Entrez_Gene (NCBI)PPP2R5A    protein phosphatase 2 regulatory subunit B'alpha
AliasesB56A; B56alpha; PR61A
GeneCards (Weizmann)PPP2R5A
Ensembl hg19 (Hinxton)ENSG00000066027 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066027 [Gene_View]  ENSG00000066027 [Sequence]  chr1:212285410-212361853 [Contig_View]  PPP2R5A [Vega]
ICGC DataPortalENSG00000066027
TCGA cBioPortalPPP2R5A
AceView (NCBI)PPP2R5A
Genatlas (Paris)PPP2R5A
SOURCE (Princeton)PPP2R5A
Genetics Home Reference (NIH)PPP2R5A
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R5A  -     chr1:212285410-212361853 +  1q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R5A  -     1q32.3   [Description]    (hg19-Feb_2009)
GoldenPathPPP2R5A - 1q32.3 [CytoView hg19]  PPP2R5A - 1q32.3 [CytoView hg38]
ImmunoBaseENSG00000066027
Genome Data Viewer NCBIPPP2R5A [Mapview hg19]  
OMIM601643   
Gene and transcription
Genbank (Entrez)AA425592 AK302202 AK312530 BC022474 BC110883
RefSeq transcript (Entrez)NM_001199756 NM_006243
Consensus coding sequences : CCDS (NCBI)PPP2R5A
Gene ExpressionPPP2R5A [ NCBI-GEO ]   PPP2R5A [ EBI - ARRAY_EXPRESS ]   PPP2R5A [ SEEK ]   PPP2R5A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R5A [ Firebrowse - Broad ]
GenevisibleExpression of PPP2R5A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5525
GTEX Portal (Tissue expression)PPP2R5A
Human Protein AtlasENSG00000066027-PPP2R5A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15172   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15172  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15172
PhosPhoSitePlusQ15172
Domains : Interpro (EBI)ARM-like    ARM-type_fold    PP2A_B56   
Domain families : Pfam (Sanger)B56 (PF01603)   
Domain families : Pfam (NCBI)pfam01603   
Conserved Domain (NCBI)PPP2R5A
PDB (RSDB)6NTS   
PDB Europe6NTS   
PDB (PDBSum)6NTS   
PDB (IMB)6NTS   
Structural Biology KnowledgeBase6NTS   
SCOP (Structural Classification of Proteins)6NTS   
CATH (Classification of proteins structures)6NTS   
SuperfamilyQ15172
AlphaFold pdb e-kbQ15172   
Human Protein Atlas [tissue]ENSG00000066027-PPP2R5A [tissue]
HPRD03384
Protein Interaction databases
DIP (DOE-UCLA)Q15172
IntAct (EBI)Q15172
BioGRIDPPP2R5A
STRING (EMBL)PPP2R5A
ZODIACPPP2R5A
Ontologies - Pathways
QuickGOQ15172
Ontology : AmiGOprotein phosphatase type 2A complex  protein phosphatase type 2A complex  chromosome, centromeric region  phosphoprotein phosphatase activity  protein binding  nucleus  cytoplasm  centrosome  cytosol  cytosol  protein dephosphorylation  protein dephosphorylation  signal transduction  membrane  protein phosphatase regulator activity  kinase binding  Z disc  M band  positive regulation of protein dephosphorylation  protein phosphatase activator activity  negative regulation of lipid kinase activity  negative regulation of protein localization to plasma membrane  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein phosphatase type 2A complex  chromosome, centromeric region  phosphoprotein phosphatase activity  protein binding  nucleus  cytoplasm  centrosome  cytosol  cytosol  protein dephosphorylation  protein dephosphorylation  signal transduction  membrane  protein phosphatase regulator activity  kinase binding  Z disc  M band  positive regulation of protein dephosphorylation  protein phosphatase activator activity  negative regulation of lipid kinase activity  negative regulation of protein localization to plasma membrane  
Pathways : KEGGKEGG_OOCYTE_MEIOSIS    KEGG_WNT_SIGNALING   
NDEx NetworkPPP2R5A
Atlas of Cancer Signalling NetworkPPP2R5A
Wikipedia pathwaysPPP2R5A
Orthology - Evolution
OrthoDB5525
GeneTree (enSembl)ENSG00000066027
Phylogenetic Trees/Animal Genes : TreeFamPPP2R5A
Homologs : HomoloGenePPP2R5A
Homology/Alignments : Family Browser (UCSC)PPP2R5A
Gene fusions - Rearrangements
Fusion : MitelmanNRF1::PPP2R5A [7q32.2/1q32.3]  
Fusion : MitelmanSMUG1::PPP2R5A [12q13.13/1q32.3]  
Fusion : QuiverPPP2R5A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R5A
dbVarPPP2R5A
ClinVarPPP2R5A
MonarchPPP2R5A
1000_GenomesPPP2R5A 
Exome Variant ServerPPP2R5A
GNOMAD BrowserENSG00000066027
Varsome BrowserPPP2R5A
ACMGPPP2R5A variants
VarityQ15172
Genomic Variants (DGV)PPP2R5A [DGVbeta]
DECIPHERPPP2R5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R5A 
Mutations
ICGC Data PortalPPP2R5A 
TCGA Data PortalPPP2R5A 
Broad Tumor PortalPPP2R5A
OASIS PortalPPP2R5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R5A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP2R5A
Mutations and Diseases : HGMDPPP2R5A
intOGen PortalPPP2R5A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP2R5A
DgiDB (Drug Gene Interaction Database)PPP2R5A
DoCM (Curated mutations)PPP2R5A
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R5A
Cancer3DPPP2R5A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601643   
Orphanet
DisGeNETPPP2R5A
MedgenPPP2R5A
Genetic Testing Registry PPP2R5A
NextProtQ15172 [Medical]
GENETestsPPP2R5A
Target ValidationPPP2R5A
Huge Navigator PPP2R5A [HugePedia]
ClinGenPPP2R5A
Clinical trials, drugs, therapy
MyCancerGenomePPP2R5A
Protein Interactions : CTDPPP2R5A
Pharm GKB GenePA33672
PharosQ15172
Clinical trialPPP2R5A
Miscellaneous
canSAR (ICR)PPP2R5A
HarmonizomePPP2R5A
ARCHS4PPP2R5A
DataMed IndexPPP2R5A
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP2R5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:53:32 CET 2022
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