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PPP2R5B (protein phosphatase 2 regulatory subunit B'beta)

Identity

Alias_namesprotein phosphatase 2, regulatory subunit B (B56), beta isoform
Alias_symbol (synonym)FLJ35411
B56B
PR61B
B56beta
Other alias
HGNC (Hugo) PPP2R5B
LocusID (NCBI) 5526
Atlas_Id 41819
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64924671 and ends at 64934478 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IGSF11 (3q13.32) / PPP2R5B (11q13.1)NUMA1 (11q13.4) / PPP2R5B (11q13.1)PPP2R5B (11q13.1) / KDM2A (11q13.2)
NUMA1 11q13.4 / PPP2R5B 11q13.1PPP2R5B 11q13.1 / KDM2A 11q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  NUMA1/PPP2R5B (11q13)
PPP2R5B/KDM2A (11q13)

External links

Nomenclature
HGNC (Hugo)PPP2R5B   9310
Cards
Entrez_Gene (NCBI)PPP2R5B  5526  protein phosphatase 2 regulatory subunit B'beta
AliasesB56B; B56beta; PR61B
GeneCards (Weizmann)PPP2R5B
Ensembl hg19 (Hinxton)ENSG00000068971 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068971 [Gene_View]  ENSG00000068971 [Sequence]  chr11:64924671-64934478 [Contig_View]  PPP2R5B [Vega]
ICGC DataPortalENSG00000068971
TCGA cBioPortalPPP2R5B
AceView (NCBI)PPP2R5B
Genatlas (Paris)PPP2R5B
WikiGenes5526
SOURCE (Princeton)PPP2R5B
Genetics Home Reference (NIH)PPP2R5B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R5B  -     chr11:64924671-64934478 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R5B  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathPPP2R5B - 11q13.1 [CytoView hg19]  PPP2R5B - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000068971
Mapping of homologs : NCBIPPP2R5B [Mapview hg19]  PPP2R5B [Mapview hg38]
OMIM601644   
Gene and transcription
Genbank (Entrez)AK092730 BC045619 BE883575 BM665417 L42374
RefSeq transcript (Entrez)NM_006244
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2R5B
Cluster EST : UnigeneHs.75199 [ NCBI ]
CGAP (NCI)Hs.75199
Alternative Splicing GalleryENSG00000068971
Gene ExpressionPPP2R5B [ NCBI-GEO ]   PPP2R5B [ EBI - ARRAY_EXPRESS ]   PPP2R5B [ SEEK ]   PPP2R5B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R5B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5526
GTEX Portal (Tissue expression)PPP2R5B
Human Protein AtlasENSG00000068971-PPP2R5B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15173   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15173  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15173
Splice isoforms : SwissVarQ15173
PhosPhoSitePlusQ15173
Domains : Interpro (EBI)ARM-like    ARM-type_fold    PP2A_B56   
Domain families : Pfam (Sanger)B56 (PF01603)   
Domain families : Pfam (NCBI)pfam01603   
Conserved Domain (NCBI)PPP2R5B
DMDM Disease mutations5526
Blocks (Seattle)PPP2R5B
SuperfamilyQ15173
Human Protein Atlas [tissue]ENSG00000068971-PPP2R5B [tissue]
Peptide AtlasQ15173
HPRD09038
IPIIPI00014980   IPI00219690   IPI00980454   IPI00978727   
Protein Interaction databases
DIP (DOE-UCLA)Q15173
IntAct (EBI)Q15173
FunCoupENSG00000068971
BioGRIDPPP2R5B
STRING (EMBL)PPP2R5B
ZODIACPPP2R5B
Ontologies - Pathways
QuickGOQ15173
Ontology : AmiGOprotein phosphatase type 2A complex  protein binding  nucleus  cytoplasm  cytosol  cytosol  protein dephosphorylation  regulation of signaling receptor activity  positive regulation of neuron projection development  regulation of phosphatidylinositol 3-kinase signaling  protein phosphatase regulator activity  positive regulation of protein complex assembly  regulation of protein autophosphorylation  IRE1-mediated unfolded protein response  regulation of phosphoprotein phosphatase activity  positive regulation of transcription by RNA polymerase II  regulation of peptidyl-tyrosine phosphorylation  positive regulation of DNA-binding transcription factor activity  positive regulation of neurotrophin TRK receptor signaling pathway  negative regulation of protein kinase B signaling  negative regulation of G0 to G1 transition  positive regulation of cell cycle arrest  cellular response to growth factor stimulus  protein phosphatase activator activity  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein binding  nucleus  cytoplasm  cytosol  cytosol  protein dephosphorylation  regulation of signaling receptor activity  positive regulation of neuron projection development  regulation of phosphatidylinositol 3-kinase signaling  protein phosphatase regulator activity  positive regulation of protein complex assembly  regulation of protein autophosphorylation  IRE1-mediated unfolded protein response  regulation of phosphoprotein phosphatase activity  positive regulation of transcription by RNA polymerase II  regulation of peptidyl-tyrosine phosphorylation  positive regulation of DNA-binding transcription factor activity  positive regulation of neurotrophin TRK receptor signaling pathway  negative regulation of protein kinase B signaling  negative regulation of G0 to G1 transition  positive regulation of cell cycle arrest  cellular response to growth factor stimulus  protein phosphatase activator activity  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    Dopaminergic synapse   
NDEx NetworkPPP2R5B
Atlas of Cancer Signalling NetworkPPP2R5B
Wikipedia pathwaysPPP2R5B
Orthology - Evolution
OrthoDB5526
GeneTree (enSembl)ENSG00000068971
Phylogenetic Trees/Animal Genes : TreeFamPPP2R5B
HOGENOMQ15173
Homologs : HomoloGenePPP2R5B
Homology/Alignments : Family Browser (UCSC)PPP2R5B
Gene fusions - Rearrangements
Fusion : MitelmanNUMA1/PPP2R5B [11q13.4/11q13.1]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPPP2R5B/KDM2A [11q13.1/11q13.2]  [t(11;11)(q13;q13)]  
Fusion PortalNUMA1 11q13.4 PPP2R5B 11q13.1 BRCA
Fusion PortalPPP2R5B 11q13.1 KDM2A 11q13.2 BRCA
Fusion : QuiverPPP2R5B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R5B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R5B
dbVarPPP2R5B
ClinVarPPP2R5B
1000_GenomesPPP2R5B 
Exome Variant ServerPPP2R5B
ExAC (Exome Aggregation Consortium)ENSG00000068971
GNOMAD BrowserENSG00000068971
Varsome BrowserPPP2R5B
Genetic variants : HAPMAP5526
Genomic Variants (DGV)PPP2R5B [DGVbeta]
DECIPHERPPP2R5B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R5B 
Mutations
ICGC Data PortalPPP2R5B 
TCGA Data PortalPPP2R5B 
Broad Tumor PortalPPP2R5B
OASIS PortalPPP2R5B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R5B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP2R5B
Mutations and Diseases : HGMDPPP2R5B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R5B
DgiDB (Drug Gene Interaction Database)PPP2R5B
DoCM (Curated mutations)PPP2R5B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R5B (select a term)
intoGenPPP2R5B
Cancer3DPPP2R5B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601644   
Orphanet
DisGeNETPPP2R5B
MedgenPPP2R5B
Genetic Testing Registry PPP2R5B
NextProtQ15173 [Medical]
TSGene5526
GENETestsPPP2R5B
Target ValidationPPP2R5B
Huge Navigator PPP2R5B [HugePedia]
snp3D : Map Gene to Disease5526
BioCentury BCIQPPP2R5B
ClinGenPPP2R5B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5526
Chemical/Pharm GKB GenePA33673
Clinical trialPPP2R5B
Miscellaneous
canSAR (ICR)PPP2R5B (select the gene name)
DataMed IndexPPP2R5B
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R5B
EVEXPPP2R5B
GoPubMedPPP2R5B
iHOPPPP2R5B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:02:13 CET 2019
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