Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPP2R5C (protein phosphatase 2 regulatory subunit B', gamma)

Identity

Alias_namesprotein phosphatase 2
Alias_symbol (synonym)B56G
PR61G
Other alias
HGNC (Hugo) PPP2R5C
LocusID (NCBI) 5527
Atlas_Id 46859
Location 14q32.31  [Link to chromosome band 14q32]
Location_base_pair Starts at 102228135 and ends at 102394328 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDKAL1 (6p22.3) / PPP2R5C (14q32.31)CRTAP (3p22.3) / PPP2R5C (14q32.31)DYNC1H1 (14q32.31) / PPP2R5C (14q32.31)
EZR (6q25.3) / PPP2R5C (14q32.31)HPN (19q13.12) / PPP2R5C (14q32.31)PPP2R5C (14q32.31) / ACAP2 (3q29)
PPP2R5C (14q32.31) / SCN1B (19q13.12)PPP2R5C (14q32.31) / UPF2 (10p14)RCOR1 (14q32.31) / PPP2R5C (14q32.31)
TTC7B (14q32.11) / PPP2R5C (14q32.31)DYNC1H1 14q32.31 / PPP2R5C 14q32.31HPN 19q13.12 / PPP2R5C 14q32.31
PPP2R5C 14q32.31 / SCN1B 19q13.12PPP2R5C 14q32.31 / UPF2 10p14RCOR1 14q32.31 / PPP2R5C 14q32.31
TTC7B 14q32.11 / PPP2R5C 14q32.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP2R5C   9311
Cards
Entrez_Gene (NCBI)PPP2R5C  5527  protein phosphatase 2 regulatory subunit B', gamma
AliasesB56G; PR61G
GeneCards (Weizmann)PPP2R5C
Ensembl hg19 (Hinxton)ENSG00000078304 [Gene_View]  chr14:102228135-102394328 [Contig_View]  PPP2R5C [Vega]
Ensembl hg38 (Hinxton)ENSG00000078304 [Gene_View]  chr14:102228135-102394328 [Contig_View]  PPP2R5C [Vega]
ICGC DataPortalENSG00000078304
TCGA cBioPortalPPP2R5C
AceView (NCBI)PPP2R5C
Genatlas (Paris)PPP2R5C
WikiGenes5527
SOURCE (Princeton)PPP2R5C
Genetics Home Reference (NIH)PPP2R5C
Genomic and cartography
GoldenPath hg19 (UCSC)PPP2R5C  -     chr14:102228135-102394328 +  14q32.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP2R5C  -     14q32.31   [Description]    (hg38-Dec_2013)
EnsemblPPP2R5C - 14q32.31 [CytoView hg19]  PPP2R5C - 14q32.31 [CytoView hg38]
Mapping of homologs : NCBIPPP2R5C [Mapview hg19]  PPP2R5C [Mapview hg38]
OMIM601645   
Gene and transcription
Genbank (Entrez)AA487513 AA716736 AB451341 AI282996 AI692258
RefSeq transcript (Entrez)NM_001161725 NM_001161726 NM_002719 NM_178586 NM_178587 NM_178588
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)PPP2R5C
Cluster EST : UnigeneHs.368264 [ NCBI ]
CGAP (NCI)Hs.368264
Alternative Splicing GalleryENSG00000078304
Gene ExpressionPPP2R5C [ NCBI-GEO ]   PPP2R5C [ EBI - ARRAY_EXPRESS ]   PPP2R5C [ SEEK ]   PPP2R5C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R5C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5527
GTEX Portal (Tissue expression)PPP2R5C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13362   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13362  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13362
Splice isoforms : SwissVarQ13362
PhosPhoSitePlusQ13362
Domains : Interpro (EBI)ARM-type_fold    PP2A_B56   
Domain families : Pfam (Sanger)B56 (PF01603)   
Domain families : Pfam (NCBI)pfam01603   
Conserved Domain (NCBI)PPP2R5C
DMDM Disease mutations5527
Blocks (Seattle)PPP2R5C
PDB (SRS)2IAE    2JAK    2NPP    2NYL    2NYM    3FGA   
PDB (PDBSum)2IAE    2JAK    2NPP    2NYL    2NYM    3FGA   
PDB (IMB)2IAE    2JAK    2NPP    2NYL    2NYM    3FGA   
PDB (RSDB)2IAE    2JAK    2NPP    2NYL    2NYM    3FGA   
Structural Biology KnowledgeBase2IAE    2JAK    2NPP    2NYL    2NYM    3FGA   
SCOP (Structural Classification of Proteins)2IAE    2JAK    2NPP    2NYL    2NYM    3FGA   
CATH (Classification of proteins structures)2IAE    2JAK    2NPP    2NYL    2NYM    3FGA   
SuperfamilyQ13362
Human Protein AtlasENSG00000078304
Peptide AtlasQ13362
HPRD03385
IPIIPI00012834   IPI00185637   IPI00220145   IPI00384127   IPI01026231   IPI01026342   IPI01026441   IPI01026567   IPI01025794   IPI01026019   IPI01025215   IPI01025329   IPI01025478   IPI01025594   IPI00935184   IPI00442098   
Protein Interaction databases
DIP (DOE-UCLA)Q13362
IntAct (EBI)Q13362
FunCoupENSG00000078304
BioGRIDPPP2R5C
STRING (EMBL)PPP2R5C
ZODIACPPP2R5C
Ontologies - Pathways
QuickGOQ13362
Ontology : AmiGOprotein phosphatase type 2A complex  protein phosphatase type 2A complex  chromosome, centromeric region  protein binding  nucleus  nucleoplasm  cytosol  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  signal transduction  negative regulation of cell proliferation  protein phosphatase type 2A regulator activity  protein phosphatase type 2A regulator activity  regulation of phosphatidylinositol 3-kinase signaling  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  proteasome-mediated ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein phosphatase type 2A complex  chromosome, centromeric region  protein binding  nucleus  nucleoplasm  cytosol  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  signal transduction  negative regulation of cell proliferation  protein phosphatase type 2A regulator activity  protein phosphatase type 2A regulator activity  regulation of phosphatidylinositol 3-kinase signaling  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  proteasome-mediated ubiquitin-dependent protein catabolic process  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    Dopaminergic synapse   
NDEx NetworkPPP2R5C
Atlas of Cancer Signalling NetworkPPP2R5C
Wikipedia pathwaysPPP2R5C
Orthology - Evolution
OrthoDB5527
GeneTree (enSembl)ENSG00000078304
Phylogenetic Trees/Animal Genes : TreeFamPPP2R5C
HOVERGENQ13362
HOGENOMQ13362
Homologs : HomoloGenePPP2R5C
Homology/Alignments : Family Browser (UCSC)PPP2R5C
Gene fusions - Rearrangements
Fusion : MitelmanDYNC1H1/PPP2R5C [14q32.31/14q32.31]  [t(14;14)(q32;q32)]  
Fusion : MitelmanHPN/PPP2R5C [19q13.12/14q32.31]  [t(14;19)(q32;q13)]  
Fusion : MitelmanPPP2R5C/SCN1B [14q32.31/19q13.12]  [t(14;19)(q32;q13)]  
Fusion : MitelmanPPP2R5C/UPF2 [14q32.31/10p14]  [t(10;14)(p14;q32)]  
Fusion : MitelmanRCOR1/PPP2R5C [14q32.31/14q32.31]  [t(14;14)(q32;q32)]  
Fusion : MitelmanTTC7B/PPP2R5C [14q32.11/14q32.31]  [t(14;14)(q32;q32)]  
Fusion: TCGADYNC1H1 14q32.31 PPP2R5C 14q32.31 BRCA
Fusion: TCGAHPN 19q13.12 PPP2R5C 14q32.31 BRCA
Fusion: TCGAPPP2R5C 14q32.31 SCN1B 19q13.12 BRCA
Fusion: TCGAPPP2R5C 14q32.31 UPF2 10p14 BRCA
Fusion: TCGARCOR1 14q32.31 PPP2R5C 14q32.31 OV
Fusion: TCGATTC7B 14q32.11 PPP2R5C 14q32.31 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R5C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R5C
dbVarPPP2R5C
ClinVarPPP2R5C
1000_GenomesPPP2R5C 
Exome Variant ServerPPP2R5C
ExAC (Exome Aggregation Consortium)PPP2R5C (select the gene name)
Genetic variants : HAPMAP5527
Genomic Variants (DGV)PPP2R5C [DGVbeta]
DECIPHER (Syndromes)14:102228135-102394328  ENSG00000078304
CONAN: Copy Number AnalysisPPP2R5C 
Mutations
ICGC Data PortalPPP2R5C 
TCGA Data PortalPPP2R5C 
Broad Tumor PortalPPP2R5C
OASIS PortalPPP2R5C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R5C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2R5C
intOGen PortalPPP2R5C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R5C
DgiDB (Drug Gene Interaction Database)PPP2R5C
DoCM (Curated mutations)PPP2R5C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R5C (select a term)
intoGenPPP2R5C
Cancer3DPPP2R5C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601645   
Orphanet
MedgenPPP2R5C
Genetic Testing Registry PPP2R5C
NextProtQ13362 [Medical]
TSGene5527
GENETestsPPP2R5C
Huge Navigator PPP2R5C [HugePedia]
snp3D : Map Gene to Disease5527
BioCentury BCIQPPP2R5C
ClinGenPPP2R5C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5527
Chemical/Pharm GKB GenePA33674
Clinical trialPPP2R5C
Miscellaneous
canSAR (ICR)PPP2R5C (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R5C
EVEXPPP2R5C
GoPubMedPPP2R5C
iHOPPPP2R5C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:22:37 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.